Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

(6E)-8-hydroxygeraniol:NADP+ oxidoreductase

(6E)-8-hydroxygeraniol + 2 NADP+ = (6E)-8-oxogeranial + 2 NADPH + 2 H+ (overall reaction) [RN:R08499];
(1a) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-hydroxygeranial + NADPH + H+ [RN:R09926];
(1b) (6E)-8-hydroxygeraniol + NADP+ = (6E)-8-oxogeraniol + NADPH + H+  [RN:R09927];
(1c) (6E)-8-hydroxygeranial + NADP+ = (6E)-8-oxogeranial + NADPH + H+  [RN:R09928];
(1d) (6E)-8-oxogeraniol + NADP+ = (6E)-8-oxogeranial + NADPH + H+ [RN:R09929]

R08499 R09926 R09927 R09928 R09929

(6E)-8-hydroxygeraniol [CPD:C17621];
NADP+ [CPD:C00006];
(6E)-8-hydroxygeranial [CPD:C20222];
(6E)-8-oxogeraniol [CPD:C20223]

Contains Zn2+. The enzyme catalyses the oxidation of (6E)-8-hydroxygeraniol to (6E)-8-oxogeranial via either (6E)-8-hydroxygeranial or (6E)-8-oxogeraniol. Also acts on geraniol, nerol and citronellol. May be identical to EC 1.1.1.183 geraniol dehydrogenase. The recommended numbering of geraniol gives 8-hydroxygeraniol as the substrate rather than 10-hydroxygeraniol as used by references 1 and 2. See prenol nomenclature {iupac/misc/prenol#p1::Pr-1}.

EC 1.1.1.324 created 2012

1  [PMID:1864846]

Ikeda H, Esaki N, Nakai S, Hashimoto K, Uesato S, Soda K, Fujita T.

Acyclic monoterpene primary alcohol:NADP+ oxidoreductase of Rauwolfia serpentina cells: the key enzyme in biosynthesis of monoterpene alcohols.

J. Biochem. 109 (1991) 341-7.

2  [PMID:7726550]

Hallahan DL, West JM, Wallsgrove RM, Smiley DW, Dawson GW, Pickett JA, Hamilton JG

Purification and characterization of an acyclic monoterpene primary alcohol:NADP+ oxidoreductase from catmint (Nepeta racemosa).

Arch. Biochem. Biophys. 318 (1995) 105-12.