| Entry |
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| Name |
sabinene-hydrate synthase;
sabinene hydrate cyclase
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| Class |
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
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| Sysname |
geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)
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| Reaction(IUBMB) |
geranyl diphosphate + H2O = sabinene hydrate + diphosphate [RN: R02006]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Both cis- and trans- isomers of sabinene hydrate are formed. (3R)-Linalyl diphosphate is an intermediate in the reaction
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| History |
EC 4.2.3.11 created 1992 as EC 4.6.1.9, transferred 2000 to EC 4.2.3.11
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| Pathway |
| Monoterpenoid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Reference |
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| Authors |
Hallahan TW, Croteau R. |
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| Title |
Monoterpene biosynthesis: demonstration of a geranyl pyrophosphate:sabinene hydrate cyclase in soluble enzyme preparations from sweet marjoram (Majorana hortensis). |
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| Journal |
Arch. Biochem. Biophys. 264 (1988) 618-31. |
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| Reference |
|
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| Authors |
Hallahan TW, Croteau R. |
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| Title |
Monoterpene biosynthesis: mechanism and stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (+)-cis- and (+)-trans-sabinene hydrate. |
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| Journal |
Arch. Biochem. Biophys. 269 (1989) 313-26. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 117164-95-1 |
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