Lyases;
Carbon-oxygen lyases;
Acting on phosphates

geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-camphene-forming]

geranyl diphosphate = (+)-camphene + diphosphate [RN:R09971]

R09971

geranyl diphosphate [CPD:C00341]

Cyclase I of Salvia officinalis (sage) gives about equal parts (+)-camphene and (+)-alpha-pinene. (3R)-Linalyl diphosphate can also be used by the enzyme in preference to (3S)-linalyl diphosphate. Requires Mg2+ (preferred to Mn2+). See also EC 4.2.3.121 (+)-alpha-pinene synthase.

EC 4.2.3.116 created 2012

1  [PMID:6693393]

Gambliel H, Croteau R

Pinene cyclases I and II. Two enzymes from sage (Salvia officinalis) which catalyze stereospecific cyclizations of geranyl pyrophosphate to monoterpene olefins of opposite configuration.

J. Biol. Chem. 259 (1984) 740-8.

2  [PMID:3392006]

Croteau R, Satterwhite DM, Cane DE, Chang CC

Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of  (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-pinene and (+)- and (-)-camphene.

J. Biol. Chem. 263 (1988) 10063-71.

3  [PMID:8109978]

Wagschal KC, Pyun HJ, Coates RM, Croteau R.

Monoterpene biosynthesis: isotope effects associated with bicyclic olefin formation catalyzed by pinene synthases from sage (Salvia officinalis).

Arch. Biochem. Biophys. 308 (1994) 477-87.

4  [PMID:8109979]

Pyun HJ, Wagschal KC, Jung DI, Coates RM, Croteau R

Stereochemistry of the proton elimination in the formation of (+)- and (-)-alpha-pinene by monoterpene cyclases from sage (Salvia officinalis).

Arch. Biochem. Biophys. 308 (1994) 488-96.