| Entry |
|
|---|
| Name |
Trimethoprim (JAN/USP/INN);
Proloprim (TN);
Trimpex (TN)
|
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C14H18N4O3
|
|---|
| Exact mass |
290.1379
|
|---|
| Mol weight |
290.3177
|
|---|
| Structure |
     |
|---|
| Activity |
Antibacterial
|
|---|
| Remark |
|
|---|
| Target |
dihydrofolate reductase inhibitor [KO: K13938] |
|---|
| Pathway |
|
|---|
| Interaction |
CYP inhibition: CYP2C8 [HSA: 1558]
 |
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01E SULFONAMIDES AND TRIMETHOPRIM
J01EA Trimethoprim and derivatives
J01EA01 Trimethoprim
D00145 Trimethoprim (JAN/USP/INN)
USP drug classification [BR:br08302]
Antibacterials
Antibacterials, Other
Dihydrofolate reductase inhibitor antibacterial
Trimethoprim
D00145 Trimethoprim (JAN/USP/INN)
Antiinfectives [BR:br08307]
Antibacterials
Folic acid biosynthesis inhibitor
dihydrofolate reductase inhibitor [KO:K13938]
Trimethoprim derivatives
Trimethoprim [ATC:J01EA01]
D00145 Trimethoprim (JAN/USP/INN)
 |
|---|
| Other DBs |
CAS: 738-70-5 PubChem: DrugBank: PDB-CCD: LigandBox: NIKKAJI: |
|---|
| KCF data |
ATOM 21
1 C8y C 15.9128 -15.6038
2 C1b C 17.1236 -16.2959
3 C8x C 14.6954 -16.3150
4 C8x C 15.9128 -14.1943
5 C8y C 18.3218 -15.5974
6 C8y C 13.4846 -15.6038
7 C8y C 14.6954 -13.4961
8 C8y C 19.5327 -16.3085
9 C8x C 18.3218 -14.1880
10 C8y C 13.4846 -14.1943
11 O2a O 12.2737 -16.2959
12 O2a O 14.6891 -12.1057
13 N5x N 20.7563 -15.5974
14 N1a N 19.5262 -17.6988
15 N5x N 19.5327 -13.4896
16 O2a O 12.2800 -13.5661
17 C1a C 11.0757 -15.5909
18 C1a C 15.8936 -11.4010
19 C8y C 20.7563 -14.1880
20 C1a C 12.2800 -12.1057
21 N1a N 21.9609 -13.4833
BOND 22
1 1 2 1
2 1 3 1
3 1 4 2
4 2 5 1
5 3 6 2
6 4 7 1
7 5 8 2
8 5 9 1
9 6 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 8 14 1
14 9 15 2
15 10 16 1
16 11 17 1
17 12 18 1
18 13 19 2
19 16 20 1
20 19 21 1
21 7 10 2
22 15 19 1
|
|---|
