KEGG DRUG: Fluoxymesterone

DRUG: Fluoxymesterone

Entry

D00327                      Drug

Name

Fluoxymesterone (JAN/USP/INN);
Androxy (TN);
Halotestin (TN)

Formula

C20H29FO3

Exact mass

336.2101

Mol weight

336.4409

Structure

Simcomp

Class

Hormonal agent
DG01590 Androgen receptor agonist
DG02006 Testosterone

Remark

ATC code:

G03BA01

Efficacy

Antineoplastic, Replenisher (androgen), Androgen receptor agonist

Disease

Primary hypogonadism (males) [DS:H02027]
Hypogonadotropic hypogonadism [DS:H00255]
Mammary cancer [DS:H00031]

Target

NR3C4 (AR) [HSA:367] [KO:K08557]

Pathway

hsa04114

Oocyte meiosis

hsa05200

Pathways in cancer

Interaction

Structure map

map07043

Antineoplastics - hormones

map07226

Progesterone, androgen and estrogen receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03B ANDROGENS
    G03BA 3-oxoandrosten (4) derivatives
     G03BA01 Fluoxymesterone
      D00327  Fluoxymesterone (JAN/USP/INN)
Drug groups [BR:br08330]
Hormonal agent
  DG01590  Androgen receptor agonist
   D00327  Fluoxymesterone
  DG02006  Testosterone
   D00327  Fluoxymesterone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C4 (AR)
     D00327  Fluoxymesterone (JAN/USP/INN)

Other DBs

CAS:

76-43-7

PubChem:

ChEBI:

LigandBox:

NIKKAJI:

KCF data

ATOM        24
            1   C1z C    25.3393  -14.6650
            2   C1y C    26.5073  -15.3440
            3   C1z C    24.1655  -15.3324
            4   C1y C    25.3508  -13.3071
            5   X   F    25.3852  -16.0920
            6   C1y C    27.6754  -14.6821
            7   C1x C    26.5073  -16.7019
            8   C2y C    24.1597  -16.6904
            9   C1x C    22.9916  -14.6592
            10  C1a C    24.1481  -14.0323
            11  C1x C    26.5247  -12.6395
            12  O1a O    24.1828  -12.6222
            13  C1z C    27.6227  -13.3242
            14  C1x C    30.0115  -14.6995
            15  C1x C    25.3278  -17.3750
            16  C2x C    22.9916  -17.3694
            17  C1x C    21.8179  -15.3324
            18  C1z C    28.8665  -12.6683
            19  C1a C    27.6466  -12.0531
            20  C1x C    30.0288  -13.3530
            21  C5x C    21.8179  -16.6904
            22  C1a C    30.1266  -11.9145
            23  O5x O    20.6384  -17.3694
            24  O1a O    28.8665  -11.0147
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     3   9 1
            9     3  10 1 #Up
            10    4  11 1
            11    4  12 1 #Up
            12    6  13 1
            13    6  14 1
            14    7  15 1
            15    8  16 2
            16    9  17 1
            17   13  18 1
            18   13  19 1 #Up
            19   14  20 1
            20   16  21 1
            21   18  22 1 #Down
            22   21  23 2
            23    8  15 1
            24   11  13 1
            25   17  21 1
            26   18  20 1
            27   18  24 1 #Up

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