KEGG   DRUG: Methyldopa
Entry
D00405                      Drug                                   
Name
Methyldopa (USP);
Methyldopa hydrate (JP18);
Aldomet (TN)
Product
METHYLDOPA (Chartwell RX)
Formula
(C10H13NO4)2. 3H2O
Exact mass
476.2006
Mol weight
476.4749
Structure
Simcomp
Class
Cardiovascular agent
 DG01738  Centrally-acting antiadrenergic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
 DG01617  Catecholamine synthesis inhibitors
 DG03231  Antihypertensive
Remark
Therapeutic category: 2145
ATC code: C02AB01
Chemical structure group: DG00248
Product (DG00248): D00405<JP/US>
Efficacy
Antihypertensive, alpha2-Adrenergic receptor agonist
  Disease
Hypertension [DS:H01633]
Comment
Dopamine derivative
Methyldopa is metabolited to alpha-Methylnorepinephrine which is agonist of alpha2 receptor.
Peripheral aromatic L-amino acid decarboxylase inhibitors (DCI)
Target
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING
    C02AB Methyldopa
     C02AB01 Methyldopa (levorotatory)
      D00405  Methyldopa (USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Agonists
   Methyldopa
    D00405  Methyldopa (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2145  Methyldopas
     D00405  Methyldopa (USP); Methyldopa hydrate (JP18)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01738  Centrally-acting antiadrenergic
   DG00248  Methyldopa (levorotatory)
    D00405  Methyldopa
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00248  Methyldopa (levorotatory)
      D00405  Methyldopa
  DG01951  Catecholamine adrenergic receptor agonist
   DG00248  Methyldopa (levorotatory)
    D00405  Methyldopa
  DG01617  Catecholamine synthesis inhibitors
   DG00248  Methyldopa (levorotatory)
    D00405  Methyldopa
  DG03231  Antihypertensive
   DG00248  Methyldopa (levorotatory)
    D00405  Methyldopa
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D00405  Methyldopa
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D00405  Methyldopa (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00405  Methyldopa hydrate
  D00405  Methyldopa tablets
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01738  Centrally-acting antiadrenergic
   DG00248  Methyldopa (levorotatory)
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG00248  Methyldopa (levorotatory)
  DG01951  Catecholamine adrenergic receptor agonist
   DG00248  Methyldopa (levorotatory)
  DG01617  Catecholamine synthesis inhibitors
   DG00248  Methyldopa (levorotatory)
  DG03231  Antihypertensive
   DG00248  Methyldopa (levorotatory)
Other DBs
CAS: 41372-08-1
PubChem: 7847471
LigandBox: D00405
NIKKAJI: J244.493C
KCF data

ATOM        33
            1   C1d C    25.1300  -15.7500
            2   C6a C    26.3200  -15.0500
            3   C1b C    23.9400  -15.0500
            4   C1a C    24.6400  -17.1500
            5   N1a N    26.1100  -17.1500
            6   O6a O    27.5100  -15.7500
            7   O6a O    26.3200  -13.7200
            8   C8y C    22.7500  -15.7500
            9   C8x C    21.5600  -15.0500
            10  C8x C    22.7500  -17.1500
            11  C8y C    20.3700  -15.7500
            12  C8x C    21.5600  -17.7800
            13  C8y C    20.3700  -17.1500
            14  O1a O    19.1800  -15.0500
            15  O1a O    19.1800  -17.7800
            16  O0  O    32.5500  -15.9600
            17  C1d C    25.1300  -15.7500
            18  C6a C    26.3200  -15.0500
            19  O6a O    27.5100  -15.7500
            20  O6a O    26.3200  -13.7200
            21  C1b C    23.9400  -15.0500
            22  C8y C    22.7500  -15.7500
            23  C8x C    21.5600  -15.0500
            24  C8y C    20.3700  -15.7500
            25  C8y C    20.3700  -17.1500
            26  O1a O    19.1800  -17.7800
            27  C8x C    21.5600  -17.7800
            28  C8x C    22.7500  -17.1500
            29  O1a O    19.1800  -15.0500
            30  C1a C    24.6400  -17.1500
            31  N1a N    26.1100  -17.1500
            32  O0  O    32.5500  -15.9600
            33  O0  O    32.5500  -15.9600
BOND        30
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 2
            7     3   8 1
            8     8   9 1
            9     8  10 2
            10    9  11 2
            11   10  12 1
            12   11  13 1
            13   11  14 1
            14   13  15 1
            15   12  13 2
            16   17  18 1
            17   17  21 1
            18   17  30 1 #Down
            19   17  31 1 #Up
            20   18  19 1
            21   18  20 2
            22   21  22 1
            23   22  23 1
            24   22  28 2
            25   23  24 2
            26   28  27 1
            27   24  25 1
            28   24  29 1
            29   25  26 1
            30   27  25 2
BRACKET     1    17.9900  -18.8300   17.9900  -12.8100
            1    28.7000  -12.8100   28.7000  -18.8300
            1  2
 ORIGINAL  1    1   2   6   7   3   8   9  11  13  15  12  10  14   4   5
 REPEAT    1   17  18  19  20  21  22  23  24  25  26  27  28  29  30  31
            2    30.8000  -16.8700   30.8000  -15.0500
            2    32.9700  -15.0500   32.9700  -16.8700
            2  3
 ORIGINAL  2   16
 REPEAT    2   32  33

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