KEGG DRUG: Repaglinide

DRUG: Repaglinide

Entry

D00594                      Drug

Name

Repaglinide (JAN/USP/INN);
Prandin (TN);
Surepost (TN)

Product

Generic

REPAGLINIDE (American Health Packaging), REPAGLINIDE (Aurobindo Pharma Limited), REPAGLINIDE (Bryant Ranch Prepack), REPAGLINIDE (Bryant Ranch Prepack), REPAGLINIDE (Bryant Ranch Prepack), REPAGLINIDE (Bryant Ranch Prepack), REPAGLINIDE (Bryant Ranch Prepack), REPAGLINIDE (Bryant Ranch Prepack), REPAGLINIDE (Bryant Ranch Prepack), REPAGLINIDE (Macleods Pharmaceuticals Limited), REPAGLINIDE (Padagis US LLC), REPAGLINIDE (Rising Health), REPAGLINIDE (Sun Pharmaceutical Industries)

Formula

C27H36N2O4

Exact mass

452.2675

Mol weight

452.5857

Structure

Simcomp

Class

Antidiabetic agent
DG01508  Sulfonylurea receptor agonist
  DG01735  Glinide
DG02044  Hypoglycemic agent
  DG01735  Glinide
Metabolizing enzyme substrate
DG02918  CYP2C8 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Same as:

C07670

Therapeutic category:

3969

ATC code:

A10BX02

Product:

D00594<JP/US>

Efficacy

Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist

Disease

Type 2 diabetes mellitus [DS:H00409]

Comment

Glinide derivative

Target

ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]

Pathway

hsa02010

ABC transporters

hsa04911

Insulin secretion

hsa04930

Type II diabetes mellitus

Metabolism

Enzyme: CYP2C8 [HSA:1558]; CYP3A4 [HSA:1576]

Interaction

Structure map

map07051

Antidiabetics

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BX Other blood glucose lowering drugs, excl. insulins
     A10BX02 Repaglinide
      D00594  Repaglinide (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Blood Glucose Regulators
  Antidiabetic Agents
   Glucose Control Agents, Other
    Repaglinide
     D00594  Repaglinide (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D00594  Repaglinide (JAN/USP/INN)
Drug groups [BR:br08330]
Antidiabetic agent
  DG01508  Sulfonylurea receptor agonist
   DG01735  Glinide
    D00594  Repaglinide
  DG02044  Hypoglycemic agent
   DG01735  Glinide
    D00594  Repaglinide
Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   D00594  Repaglinide
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00594  Repaglinide
Drug classes [BR:br08332]
Antidiabetic agent
  DG01735  Glinide
   D00594  Repaglinide
  DG02044  Hypoglycemic agent
   D00594  Repaglinide
Target-based classification of drugs [BR:br08310]
Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D00594  Repaglinide (JAN/USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00594
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00594
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D00594
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00594

Other DBs

CAS:	135062-02-1

PubChem:

7847660

ChEBI:

8805

PDB-CCD:

BJX[PDBj]

LigandBox:

D00594

NIKKAJI:

J555.407A

KCF data

ATOM        33
            1   C8y C    29.5484  -19.4440
            2   C8y C    29.5543  -20.8486
            3   N1y N    28.3361  -18.7446
            4   C8x C    30.7608  -18.7446
            5   C1c C    28.3478  -21.5481
            6   C8x C    30.7608  -21.5423
            7   C1x C    28.3361  -17.3457
            8   C1x C    27.1296  -19.4497
            9   C8x C    31.9790  -19.4440
            10  N1b N    27.1296  -20.8486
            11  C1b C    28.3478  -22.9469
            12  C8x C    31.9790  -20.8486
            13  C1x C    27.1238  -16.6520
            14  C1x C    25.9114  -18.7503
            15  C5a C    25.9173  -21.5481
            16  C1c C    29.5543  -23.6521
            17  C1x C    25.9114  -17.3514
            18  C1b C    24.7049  -20.8486
            19  O5a O    25.9173  -22.9469
            20  C1a C    29.5543  -25.0569
            21  C1a C    30.7666  -22.9469
            22  C8y C    23.4867  -21.5481
            23  C8x C    22.2744  -20.8486
            24  C8x C    23.4867  -22.9469
            25  C8y C    21.0679  -21.5538
            26  C8x C    22.2744  -23.6521
            27  C8y C    21.0562  -22.9469
            28  O2a O    19.8556  -20.8603
            29  C6a C    19.8497  -23.6521
            30  C1b C    18.6432  -21.5538
            31  O6a O    18.6375  -22.9410
            32  O6a O    19.9140  -25.0510
            33  C1a C    17.4309  -20.8603
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1 #Down
            11    6  12 1
            12    7  13 1
            13    8  14 1
            14   10  15 1
            15   11  16 1
            16   13  17 1
            17   15  18 1
            18   15  19 2
            19   16  20 1
            20   16  21 1
            21   18  22 1
            22   22  23 2
            23   22  24 1
            24   23  25 1
            25   24  26 2
            26   25  27 2
            27   25  28 1
            28   27  29 1
            29   28  30 1
            30   29  31 1
            31   29  32 2
            32   30  33 1
            33    9  12 2
            34   14  17 1
            35   26  27 1

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