KEGG   DRUG: Eflornithine hydrochloride
Entry
D00829                      Drug                                   
Name
Eflornithine hydrochloride (USAN);
Iwilfin (TN);
Vaniqa (TN)
Product
IWILFIN (USWM)
Formula
C6H12F2N2O2. HCl. H2O
Exact mass
236.0739
Mol weight
236.6447
Structure
Simcomp
Remark
ATC code: D11AX16 L01XX79 P01CX03
Chemical structure group: DG00440
Product (DG00440): D00829<US>
Efficacy
Antineoplastic, Antiprotozoal, Ornithine decarboxylase inhibitor
  Disease
Neuroblastoma [DS:H00043]
Target
ODC1 [HSA:4953] [KO:K01581]
  Pathway
hsa00330  Arginine and proline metabolism
hsa00480  Glutathione metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX16 Eflornithine
      D00829  Eflornithine hydrochloride (USAN) <US>
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XX Other antineoplastic agents
     L01XX79 Eflornithine
      D00829  Eflornithine hydrochloride (USAN) <US>
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P01 ANTIPROTOZOALS
   P01C AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS
    P01CX Other agents against leishmaniasis and trypanosomiasis
     P01CX03 Eflornithine
      D00829  Eflornithine hydrochloride (USAN) <US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatological Agents, Other
   Dermatological Agents, Miscellaneous
    Eflornithine
     D00829  Eflornithine hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Carboxy-lyases
    ODC1
     D00829  Eflornithine hydrochloride (USAN) <US>
Antimicrobials [BR:br08307]
 Antiparasitics
  Agents against Leishmaniasis and Trypanosomiasis
   Others
    D00829  Eflornithine hydrochloride (USAN) <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00829
Other DBs
CAS: 96020-91-6
PubChem: 7847894
ChEBI: 4762
LigandBox: D00829
NIKKAJI: J2.208.704E
KCF data

ATOM        14
            1   C1d C    18.3240  -17.0568
            2   C1b C    19.5346  -17.7586
            3   C6a C    18.3123  -15.6532
            4   C1c C    17.1193  -17.7586
            5   N1a N    18.3123  -18.4428
            6   C1b C    20.7452  -17.0568
            7   O6a O    19.5229  -14.9339
            8   O6a O    17.0900  -14.9573
            9   X   F    15.9028  -17.0626
            10  X   F    17.1193  -19.1563
            11  C1b C    21.9558  -17.7586
            12  N1a N    23.1722  -17.0568
            13  O0  O    27.7514  -16.7234
            14  X   Cl   27.3700  -18.6200
BOND        11
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     4  10 1
            10    6  11 1
            11   11  12 1

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Ontology (5)   
   KEGG BRITE (5)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (14)   

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