KEGG   DRUG: D02122Help
Entry
D02122                      Drug                                   

Name
Tetracycline hydrochloride (JP16/USP);
TC;
Bristacycline (TN)
Product
  Generic
TETRACYCLINE HYDROCHLORIDE (Blenheim Pharmacal), TETRACYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), TETRACYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), TETRACYCLINE HYDROCHLORIDE (Contract Pharmacy Services-PA), TETRACYCLINE HYDROCHLORIDE (H.J. Harkins Company), TETRACYCLINE HYDROCHLORIDE (IVAX Pharmaceuticals), TETRACYCLINE HYDROCHLORIDE (Liberty Pharmaceuticals), TETRACYCLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TETRACYCLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TETRACYCLINE HYDROCHLORIDE (Physicians Total Care), TETRACYCLINE HYDROCHLORIDE (REMEDYREPACK), TETRACYCLINE HYDROCHLORIDE (REMEDYREPACK), TETRACYCLINE HYDROCHLORIDE (REMEDYREPACK), TETRACYCLINE HYDROCHLORIDE (Rebel Distributors Corp), TETRACYCLINE HYDROCHLORIDE (STAT Rx USA LLC), TETRACYCLINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), TETRACYCLINE HYDROCHLORIDE (Watson Laboratories)
Formula
C22H24N2O8. HCl
Exact mass
480.1299
Mol weight
480.8955
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-amebic;
Antibacterial;
Antirickettsial [DS:H00312 H00319 H00322 H00324 H00325 H00328 H00336 H00427]
Remark
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB13 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AA Tetracycline and derivatives
     D06AA04 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA07 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA09 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA08 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA02 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Tetracycline
    D02122  Tetracycline hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D02122  Tetracycline hydrochloride (JP16/USP)
  26  Epidermides
   263  Suppurative dermatosis agents
    2634  Antibiotics for external use
     D02122  Tetracycline hydrochloride (JP16/USP)
  27  Dental preparations
   276  Antibiotics
    2760  Antibiotics
     D02122  Tetracycline hydrochloride (JP16/USP)
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6152  Tetracycline antibiotics
     D02122  Tetracycline hydrochloride (JP16/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  56 Purulent skin remedies
   D02122  Tetracycline hydrochloride (JP16/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Tetracycline
    D02122  Tetracycline hydrochloride (JP16/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Tetracyclines
     Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02122  Tetracycline hydrochloride
BRITE hierarchy
Other DBs
CAS: 
64-75-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C1y C    26.1816  -17.5899
            2   C1z C    26.1641  -18.9900
            3   C1x C    24.9807  -16.8809
            4   C1y C    27.4061  -16.9103
            5   C2y C    24.9515  -19.6756
            6   C5x C    27.3652  -19.7048
            7   O1a O    26.1465  -20.3845
            8   C1y C    23.7621  -17.5665
            9   C2y C    28.6013  -17.6251
            10  N1c N    27.4236  -15.5100
            11  C2y C    23.7504  -18.9666
            12  O1a O    24.9455  -21.0816
            13  C2y C    28.6538  -19.0252
            14  O5x O    27.3418  -21.1050
            15  C1z C    22.5493  -16.8634
            16  O1a O    29.8258  -16.9455
            17  C1a C    28.6481  -14.8247
            18  C1a C    26.2226  -14.7894
            19  C5x C    22.5376  -19.6639
            20  C5a C    29.7847  -19.7401
            21  C8y C    21.3366  -17.5605
            22  C1a C    22.5551  -15.4632
            23  C8y C    21.3306  -18.9608
            24  O5x O    22.5376  -21.0700
            25  N1a N    31.0092  -19.0605
            26  O5a O    29.7672  -21.1461
            27  C8x C    20.1239  -16.8575
            28  C8y C    20.1239  -19.6639
            29  C8x C    18.9053  -17.5605
            30  C8x C    18.9053  -18.9608
            31  O1a O    21.3365  -16.1632
            32  O1a O    20.1239  -21.0639
            33  X   Cl   33.8800  -17.3600
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Down
            7     3   8 1
            8     4   9 1
            9     4  10 1 #Down
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    6  14 2
            14    8  15 1
            15    9  16 1
            16   10  17 1
            17   10  18 1
            18   11  19 1
            19   13  20 1
            20   15  21 1
            21   15  22 1 #Down
            22   19  23 1
            23   19  24 2
            24   20  25 1
            25   20  26 2
            26   21  27 2
            27   23  28 2
            28   27  29 1
            29   28  30 1
            30    8  11 1
            31    9  13 2
            32   21  23 1
            33   29  30 2
            34   15  31 1 #Up
            35   28  32 1

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