KEGG   DRUG: D02122Help
Entry
D02122                      Drug                                   

Name
Tetracycline hydrochloride (JP16/USP);
TC;
Bristacycline (TN)
Product
  Generic
Formula
C22H24N2O8. HCl
Exact mass
480.1299
Mol weight
480.8955
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-amebic;
Antibacterial;
Antirickettsial [DS:H00312 H00319 H00322 H00324 H00325 H00328 H00336 H00427]
Remark
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB13 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AA Tetracycline and derivatives
     D06AA04 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA07 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA09 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA08 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA02 Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Tetracycline
    D02122  Tetracycline hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   239  Miscellaneous
    2399  Others
     D02122  Tetracycline hydrochloride (JP16/USP)
  26  Epidermides
   263  Suppurative dermatosis agents
    2634  Antibiotics for external use
     D02122  Tetracycline hydrochloride (JP16/USP)
  27  Dental preparations
   276  Antibiotics
    2760  Antibiotics
     D02122  Tetracycline hydrochloride (JP16/USP)
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6152  Tetracycline antibiotics
     D02122  Tetracycline hydrochloride (JP16/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  56 Purulent skin remedies
   D02122  Tetracycline hydrochloride (JP16/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Tetracycline
    D02122  Tetracycline hydrochloride (JP16/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Tetracyclines
     Tetracycline
      D02122  Tetracycline hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02122  Tetracycline hydrochloride
BRITE hierarchy
Other DBs
CAS: 
64-75-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C1y C    26.1816  -17.5899
            2   C1z C    26.1641  -18.9900
            3   C1x C    24.9807  -16.8809
            4   C1y C    27.4061  -16.9103
            5   C2y C    24.9515  -19.6756
            6   C5x C    27.3652  -19.7048
            7   O1a O    26.1465  -20.3845
            8   C1y C    23.7621  -17.5665
            9   C2y C    28.6013  -17.6251
            10  N1c N    27.4236  -15.5100
            11  C2y C    23.7504  -18.9666
            12  O1a O    24.9455  -21.0816
            13  C2y C    28.6538  -19.0252
            14  O5x O    27.3418  -21.1050
            15  C1z C    22.5493  -16.8634
            16  O1a O    29.8258  -16.9455
            17  C1a C    28.6481  -14.8247
            18  C1a C    26.2226  -14.7894
            19  C5x C    22.5376  -19.6639
            20  C5a C    29.7847  -19.7401
            21  C8y C    21.3366  -17.5605
            22  C1a C    22.5551  -15.4632
            23  C8y C    21.3306  -18.9608
            24  O5x O    22.5376  -21.0700
            25  N1a N    31.0092  -19.0605
            26  O5a O    29.7672  -21.1461
            27  C8x C    20.1239  -16.8575
            28  C8y C    20.1239  -19.6639
            29  C8x C    18.9053  -17.5605
            30  C8x C    18.9053  -18.9608
            31  O1a O    21.3365  -16.1632
            32  O1a O    20.1239  -21.0639
            33  X   Cl   33.8800  -17.3600
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Down
            7     3   8 1
            8     4   9 1
            9     4  10 1 #Down
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    6  14 2
            14    8  15 1
            15    9  16 1
            16   10  17 1
            17   10  18 1
            18   11  19 1
            19   13  20 1
            20   15  21 1
            21   15  22 1 #Down
            22   19  23 1
            23   19  24 2
            24   20  25 1
            25   20  26 2
            26   21  27 2
            27   23  28 2
            28   27  29 1
            29   28  30 1
            30    8  11 1
            31    9  13 2
            32   21  23 1
            33   29  30 2
            34   15  31 1 #Up
            35   28  32 1

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