| Entry |
|
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| Name |
Halofantrine hydrochloride (USAN);
Halfan (TN) |
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| Formula |
C26H30Cl2F3NO. HCl
|
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| Exact mass |
535.1423
|
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| Mol weight |
536.8847
|
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| Structure |
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| Simcomp |
|
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| Class |
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
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| Remark |
|
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| Efficacy |
Antimalarial |
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
P01 ANTIPROTOZOALS
P01B ANTIMALARIALS
P01BX Other antimalarials
P01BX01 Halofantrine
D02485 Halofantrine hydrochloride (USAN)
Drug groups [BR:br08330]
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG01021 Halofantrine
D02485 Halofantrine hydrochloride
Antimicrobials [BR:br08307]
Antiparasitics
Antmalarials
Other antimalarials
D02485 Halofantrine hydrochloride (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02485
Drug groups [BR:br08330]
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG01021 Halofantrine
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| Other DBs |
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| KCF data |
ATOM 34
1 X Cl 41.0900 -12.8100
2 C8y C 24.3600 -13.9300
3 C8x C 24.3600 -15.3300
4 C8y C 25.5724 -16.0300
5 C8y C 26.7849 -15.3300
6 C8y C 26.7849 -13.9300
7 C8x C 25.5724 -13.2300
8 C8x C 27.9973 -16.0300
9 C8y C 29.2097 -15.3300
10 C8y C 29.2097 -13.9300
11 C8y C 27.9973 -13.2300
12 C8x C 30.4222 -13.2300
13 C8x C 30.4222 -11.8300
14 C8y C 29.2097 -11.1300
15 C8x C 27.9973 -11.8300
16 X Cl 23.1476 -13.2300
17 X Cl 25.5724 -17.4298
18 C1d C 29.2097 -9.7301
19 X F 29.2097 -8.3301
20 X F 27.7900 -9.7301
21 X F 30.5900 -9.7301
22 C1c C 30.4073 -16.0215
23 C1b C 31.5956 -15.3355
24 O1a O 30.4074 -17.4297
25 C1b C 32.7864 -16.0231
26 N1c N 33.9760 -15.3363
27 C1b C 35.1661 -16.0235
28 C1b C 33.9762 -13.9302
29 C1b C 36.3562 -15.3365
30 C1b C 37.5461 -16.0237
31 C1a C 38.7362 -15.3365
32 C1b C 35.1690 -13.2415
33 C1b C 35.1693 -11.8303
34 C1a C 36.3598 -11.1429
BOND 35
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 5 8 1
8 8 9 2
9 9 10 1
10 10 11 2
11 6 11 1
12 10 12 1
13 12 13 2
14 13 14 1
15 14 15 2
16 11 15 1
17 2 16 1
18 4 17 1
19 14 18 1
20 18 19 1
21 18 20 1
22 18 21 1
23 9 22 1
24 22 23 1
25 22 24 1
26 23 25 1
27 25 26 1
28 26 27 1
29 26 28 1
30 27 29 1
31 29 30 1
32 30 31 1
33 28 32 1
34 32 33 1
35 33 34 1
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