| Entry |
|
|---|
| Name |
Proguanil hydrochloride (JAN/USP);
Chloroguanide hydrochloride;
Paludrine (TN) |
|---|
| Formula |
C11H16ClN5. HCl
|
|---|
| Exact mass |
289.0861
|
|---|
| Mol weight |
290.1922
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiparasitic
DG01932 Antifolate, antiprotozoal
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
|
|---|
| Remark |
| Product (mixture): | D02472<JP/US> |
|
|---|
| Efficacy |
Antimalarial |
|---|
| Comment |
Biguanide
|
|---|
| Target |
dihydrofolate reductase [KO: K13998] |
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2C19 [HSA: 1557]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
P01 ANTIPROTOZOALS
P01B ANTIMALARIALS
P01BB Biguanides
P01BB01 Proguanil
D02487 Proguanil hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Antiparasitic
DG01932 Antifolate, antiprotozoal
DG01018 Proguanil
D02487 Proguanil hydrochloride
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01018 Proguanil
D02487 Proguanil hydrochloride
Antimicrobials [BR:br08307]
Antiparasitics
Antmalarials
Biguanide
D02487 Proguanil hydrochloride (JAN/USP)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02487
Drug groups [BR:br08330]
Antiparasitic
DG01932 Antifolate, antiprotozoal
DG01018 Proguanil
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01018 Proguanil
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 18
1 X Cl 30.2397 -16.7532
2 C8x C 16.2400 -16.0300
3 C8y C 16.2400 -17.4300
4 C8x C 17.4300 -18.1300
5 C8x C 18.6200 -17.4300
6 C8y C 18.6200 -16.0300
7 C8x C 17.4300 -15.3300
8 X Cl 14.9800 -18.1300
9 N1b N 19.8800 -15.3300
10 C2c C 21.0700 -16.0300
11 N1b N 22.2600 -15.3300
12 N2a N 21.0700 -17.4300
13 C2c C 23.4500 -16.0300
14 N1b N 24.7100 -15.3300
15 N2a N 23.4500 -17.4300
16 C1c C 25.9000 -16.0300
17 C1a C 27.0900 -15.3300
18 C1a C 25.9000 -17.4300
BOND 17
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 3 8 1
8 6 9 1
9 9 10 1
10 10 11 1
11 10 12 2
12 11 13 1
13 13 14 1
14 13 15 2
15 14 16 1
16 16 17 1
17 16 18 1
|
|---|
