KEGG   DRUG: Estrogens, conjugated
Entry
D04070            Mixture   Drug                                   
Name
Estrogens, conjugated (JAN/USP);
Conjugated estrogens;
Premarin (TN)
Product
PREMARIN (A-S Medication Solutions), PREMARIN (A-S Medication Solutions), PREMARIN (Wyeth Pharmaceuticals LLC), PREMARIN (Wyeth Pharmaceuticals LLC), PREMARIN (Wyeth Pharmaceuticals LLC)
Component
Sodium estrone sulfate [DR:D00312], Sodium equilin sulfate, Sodium 17alfa-dihydroequilin sulfate
Class
Hormonal agent
 DG01986  Estrogen
 DG01584  Estrogen receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Transporter inhibitor
 DG02882  ABCB11 inhibitor
Remark
Therapeutic category: 2479
ATC code: G03CA57
Chemical structure group: DG00465
Product (DG00465): D04070<JP/US>
Product (mixture): D10579<US>
Efficacy
Replenisher (estrogen), Estrogen receptor agonist
Comment
Component of Cenestin (TN)
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Transporter inhibition: ABCB11 [HSA:8647]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03C ESTROGENS
    G03CA Natural and semisynthetic estrogens, plain
     G03CA57 Conjugated estrogens
      D04070  Estrogens, conjugated (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Estrogens
   Conjugated Estrogens
    D04070  Estrogens, conjugated (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2479  Others
     D04070  Estrogens, conjugated (JAN/USP)
Drug groups [BR:br08330]
 Hormonal agent
  DG01986  Estrogen
   DG00465  Conjugated estrogen
    D04070  Estrogens, conjugated
  DG01584  Estrogen receptor agonist
   DG00465  Conjugated estrogen
    D04070  Estrogens, conjugated
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00465  Conjugated estrogen
     D04070  Estrogens, conjugated
 Transporter inhibitor
  DG02882  ABCB11 inhibitor
   DG00465  Conjugated estrogen
    D04070  Estrogens, conjugated
Drug classes [BR:br08332]
 Endocrine and hormonal agent
  DG01986  Estrogen
   D04070  Estrogens, conjugated
  DG01584  Estrogen receptor agonist
   D04070  Estrogens, conjugated
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04070
 Drug transporters
  D04070
Drug groups [BR:br08330]
 Hormonal agent
  DG01986  Estrogen
   DG00465  Conjugated estrogen
  DG01584  Estrogen receptor agonist
   DG00465  Conjugated estrogen
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00465  Conjugated estrogen
 Transporter inhibitor
  DG02882  ABCB11 inhibitor
   DG00465  Conjugated estrogen
Other DBs
CAS: 12126-59-9
PubChem: 17398021

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Ontology (6)   
   KEGG BRITE (6)   
Drug (2)   
   KEGG DGROUP (1)   
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Chemical substance (1)   
   PubChem (1)   
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