KEGG   DRUG: Methdilazine
Entry
D04979                      Drug                                   
Name
Methdilazine (INN);
Tacaryl (TN)
Formula
C18H20N2S
Exact mass
296.1347
Mol weight
296.4298
Structure
Simcomp
Remark
Same as: C07175
ATC code: R06AD04
Chemical structure group: DG01103
Efficacy
Antipruritic
Comment
Phenothiazine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD04 Methdilazine
      D04979  Methdilazine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Methdilazine
    D04979  Methdilazine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D04979  Methdilazine (INN)
Other DBs
CAS: 1982-37-2
PubChem: 47206710
ChEBI: 6823
LigandBox: D04979
NIKKAJI: J7.838G
KCF data

ATOM        21
            1   C8x C    27.8907  -19.7061
            2   C8x C    27.8907  -18.3036
            3   C8x C    29.0828  -17.6023
            4   C8y C    30.3451  -18.3036
            5   C8y C    30.3451  -19.7061
            6   C8x C    29.0828  -20.4074
            7   N4y N    31.5373  -17.6023
            8   C8y C    32.7295  -18.3036
            9   C8y C    32.7295  -19.7061
            10  S2x S    31.5373  -20.4074
            11  C8x C    33.9918  -17.6023
            12  C8x C    35.1839  -18.3036
            13  C8x C    35.1839  -19.7061
            14  C8x C    33.9918  -20.4074
            15  C1b C    31.5373  -16.1998
            16  C1y C    32.7519  -15.4985
            17  C1x C    34.0647  -15.9394
            18  N1y N    34.8882  -14.8296
            19  C1x C    34.0872  -13.7034
            20  C1x C    32.7687  -14.1172
            21  C1a C    36.3217  -14.8448
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17    7  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   16  20 1
            24   18  21 1

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (6)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   MASSBANK (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (14)   

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