| Entry |
|
|---|
| Name |
Guanethidine (INN) |
|---|
| Formula |
C10H22N4
|
|---|
| Exact mass |
198.1844
|
|---|
| Mol weight |
198.3085
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01739 Peripherally-acting antiadrenergic
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, Miotic, Noradrenaline release inhibitor |
|---|
| Comment |
Guanidine derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C02 ANTIHYPERTENSIVES
C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
C02CC Guanidine derivatives
C02CC02 Guanethidine
D08030 Guanethidine (INN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EX Other antiglaucoma preparations
S01EX01 Guanethidine
D08030 Guanethidine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01739 Peripherally-acting antiadrenergic
DG00258 Guanethidine
D08030 Guanethidine
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
DG00258 Guanethidine
D08030 Guanethidine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00258 Guanethidine
D08030 Guanethidine
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D08030 Guanethidine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01739 Peripherally-acting antiadrenergic
DG00258 Guanethidine
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
DG00258 Guanethidine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG00258 Guanethidine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 14
1 N1y N 25.4100 -17.2200
2 C1b C 24.2200 -16.5200
3 C1x C 25.3400 -18.6900
4 C1x C 26.3900 -16.2400
5 C1b C 23.0300 -17.2200
6 C1x C 26.3900 -19.6700
7 C1x C 27.8600 -16.2400
8 N1b N 21.8400 -16.5200
9 C1x C 27.7900 -19.6700
10 C1x C 28.8400 -17.2200
11 C2c C 20.7200 -17.2200
12 C1x C 28.8400 -18.6900
13 N1a N 19.5300 -16.5200
14 N2a N 20.7200 -18.5500
BOND 14
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 1
6 4 7 1
7 5 8 1
8 6 9 1
9 7 10 1
10 8 11 1
11 9 12 1
12 11 13 1
13 11 14 2
14 10 12 1
|
|---|
