| Entry |
|
|---|
| Name |
Levobunolol (INN) |
|---|
| Formula |
C17H25NO3
|
|---|
| Exact mass |
291.1834
|
|---|
| Mol weight |
291.3853
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
|---|
| Remark |
| Product (DG01136): | D01025<JP/US> |
|
|---|
| Efficacy |
Antiglaucoma, alpha1/beta-Adrenergic receptor antagonist |
|---|
| Comment |
Propranolol derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01ED Beta blocking agents
S01ED03 Levobunolol
D08115 Levobunolol (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01136 Levobunolol
D08115 Levobunolol
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01136 Levobunolol
D08115 Levobunolol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D08115 Levobunolol (INN)
ADRB
D08115 Levobunolol (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01136 Levobunolol
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01136 Levobunolol
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 21
1 C1d C 25.2700 -14.2800
2 C1a C 26.4600 -15.0500
3 N1b N 24.0100 -15.0500
4 C1b C 22.8200 -14.3500
5 C1c C 21.6300 -14.9800
6 C1b C 20.4400 -14.3500
7 O2a O 19.2500 -14.9800
8 C1a C 25.2700 -12.8800
9 C1a C 26.4600 -13.5800
10 O1a O 21.6300 -16.4500
11 C8y C 19.2500 -16.3800
12 C8y C 18.0600 -17.0800
13 C8y C 18.0600 -18.4800
14 C8x C 19.2500 -19.2500
15 C8x C 20.4400 -18.5500
16 C8x C 20.4400 -17.1500
17 C1x C 16.8000 -16.3800
18 C1x C 15.6100 -17.0800
19 C1x C 15.6100 -18.4800
20 C5x C 16.8000 -19.2500
21 O5x O 16.8000 -20.6500
BOND 22
1 1 2 1
2 1 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 6 7 1
7 1 8 1
8 1 9 1
9 5 10 1 #Down
10 7 11 1
11 11 12 2
12 12 13 1
13 13 14 2
14 14 15 1
15 15 16 2
16 11 16 1
17 12 17 1
18 17 18 1
19 18 19 1
20 19 20 1
21 13 20 1
22 20 21 2
|
|---|
