KEGG   DRUG: D08163Help
Entry
D08163                      Drug                                   

Name
Meclozine (BAN);
Meclizine;
Nevidoxine (TN)
Formula
C25H27ClN2
Exact mass
390.1863
Mol weight
390.9483
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiemetic;
H1-receptor antagonist
Remark
Same as: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AE Piperazine derivatives
     R06AE05 Meclozine
      D08163  Meclozine (BAN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Meclizine
    D08163  Meclozine (BAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Meclizine hydrochloride
    D08163  Meclozine (BAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Meclozine
      D08163  Meclozine (BAN)
BRITE hierarchy
Other DBs
CAS: 
569-65-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8x C    20.5100  -21.4200
            2   C8y C    20.5100  -22.8200
            3   C8x C    21.7000  -23.5200
            4   C8x C    22.9600  -22.8200
            5   C8y C    22.9600  -21.4200
            6   C8x C    21.7000  -20.7200
            7   C8x C    25.3400  -22.8200
            8   C8y C    25.3400  -21.4200
            9   C1c C    24.1500  -20.7200
            10  C8x C    26.6000  -23.5200
            11  C8x C    27.7900  -22.8200
            12  C8x C    27.7900  -21.4200
            13  C8x C    26.6000  -20.7200
            14  N1y N    24.1500  -19.3200
            15  C1x C    25.3400  -18.6200
            16  C1x C    25.3400  -17.2200
            17  N1y N    24.1500  -16.5200
            18  C1x C    22.9600  -17.2200
            19  C1x C    22.9600  -18.6200
            20  C1b C    24.1500  -15.1200
            21  C8y C    25.3400  -14.4200
            22  C8x C    26.5300  -15.1200
            23  C8y C    27.7900  -14.4200
            24  C8x C    27.7900  -13.0200
            25  C8x C    26.6000  -12.3200
            26  C8x C    25.3400  -13.0200
            27  C1a C    28.9800  -15.1200
            28  X   Cl   19.3200  -23.5200
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   14  19 1
            22   17  20 1
            23   20  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   21  26 1
            30   23  27 1
            31    2  28 1

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KEGG   DRUG: D01317Help
Entry
D01317                      Drug                                   

Name
Meclizine hydrochloride (JAN/USP);
Meclizine dihydrochloride monohydrate;
Antivert (TN)
Product
  Generic
MECLIZINE HYDROCHLORIDE (A-S Medication Solutions LLC), MECLIZINE HYDROCHLORIDE (Amneal Pharmaceuticals), MECLIZINE HYDROCHLORIDE (AvKARE), MECLIZINE HYDROCHLORIDE (AvPAK), MECLIZINE HYDROCHLORIDE (Mylan Pharmaceuticals), MECLIZINE HYDROCHLORIDE (A-S Medication Solutions LLC), MECLIZINE HYDROCHLORIDE (American Health Packaging), MECLIZINE HYDROCHLORIDE (Blenheim Pharmacal), MECLIZINE HYDROCHLORIDE (Bryant Ranch Prepack), MECLIZINE HYDROCHLORIDE (Cardinal Health), MECLIZINE HYDROCHLORIDE (Cardinal Health), MECLIZINE HYDROCHLORIDE (DIRECT RX), MECLIZINE HYDROCHLORIDE (Epic Pharma), MECLIZINE HYDROCHLORIDE (Golden State Medical Supply), MECLIZINE HYDROCHLORIDE (H.J. Harkins Company), MECLIZINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), MECLIZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), MECLIZINE HYDROCHLORIDE (Liberty Pharmaceuticals), MECLIZINE HYDROCHLORIDE (Life Line Home Care Services), MECLIZINE HYDROCHLORIDE (McKesson Contract Packaging), MECLIZINE HYDROCHLORIDE (NCS HealthCare of KY), MECLIZINE HYDROCHLORIDE (Northwind Pharmaceuticals), MECLIZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), MECLIZINE HYDROCHLORIDE (Par Pharmaceutical), MECLIZINE HYDROCHLORIDE (Physicians Total Care), MECLIZINE HYDROCHLORIDE (REMEDYREPACK), MECLIZINE HYDROCHLORIDE (Rebel Distributors Corp.), MECLIZINE HYDROCHLORIDE (STAT Rx USA LLC), MECLIZINE HYDROCHLORIDE (St Marys Medical Park Pharmacy.), MECLIZINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), MECLIZINE HYDROCHLORIDE (UDL Laboratories), MECLIZINE HYDROCHLORIDE (Unit Dose Services), MECLIZINE HYDROCHLORIDE (Unit Dose Services), MECLIZINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), MECLIZINE HYDROCHLORIDE (Clinical Solutions Wholesale), MECLIZINE HYDROCHLORIDE (H.J. Harkins Company), MECLIZINE HYDROCHLORIDE (JUBILANT CADISTA PHARMACEUTICALS), MECLIZINE HYDROCHLORIDE (REMEDYREPACK)
Formula
C25H27ClN2. 2HCl. H2O
Exact mass
480.1502
Mol weight
481.8854
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-emetic
Remark
ATC code: 
Drug group: 
Comment
Meclizine is called Meclozine in INN.
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AE Piperazine derivatives
     R06AE05 Meclozine
      D01317  Meclizine hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Meclizine
    D01317  Meclizine hydrochloride (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D01317  Meclizine hydrochloride (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Meclizine hydrochloride
    D01317  Meclizine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Meclozine
      D01317  Meclizine hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
31884-77-2
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        31
            1   X   Cl   36.2600  -17.3418
            2   O0  O    36.9062  -20.2833
            3   C8x C    25.6200  -20.5100
            4   C8y C    25.6200  -21.9100
            5   C8x C    26.8324  -22.6100
            6   C8x C    28.0449  -21.9100
            7   C8y C    28.0449  -20.5100
            8   C8x C    26.8324  -19.8100
            9   C8x C    30.4697  -21.9100
            10  C8y C    30.4697  -20.5100
            11  C1c C    29.2573  -19.8100
            12  C8x C    31.6822  -22.6100
            13  C8x C    32.8946  -21.9100
            14  C8x C    32.8946  -20.5100
            15  C8x C    31.6822  -19.8100
            16  N1y N    29.2573  -18.4100
            17  C1x C    30.4718  -17.7088
            18  C1x C    30.4718  -16.3088
            19  N1y N    29.2593  -15.6088
            20  C1x C    28.0449  -16.3100
            21  C1x C    28.0449  -17.7100
            22  C1b C    29.2593  -14.2100
            23  C8y C    30.4723  -13.5097
            24  C8x C    31.6680  -14.2002
            25  C8y C    32.8805  -13.5004
            26  C8x C    32.8807  -12.1004
            27  C8x C    31.6849  -11.4098
            28  C8x C    30.4724  -12.1097
            29  C1a C    34.1116  -14.2114
            30  X   Cl   24.4076  -22.6100
            31  X   Cl   36.2600  -17.3418
BOND        31
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     3   8 1
            7     9  10 1
            8    10  11 1
            9     7  11 1
            10    9  12 2
            11   12  13 1
            12   13  14 2
            13   14  15 1
            14   10  15 2
            15   11  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   16  21 1
            22   19  22 1
            23   22  23 1
            24   23  24 2
            25   24  25 1
            26   25  26 2
            27   26  27 1
            28   27  28 2
            29   23  28 1
            30   25  29 1
            31    4  30 1
BRACKET     1    34.5100  -18.3400   34.5100  -16.2400
            1    37.2400  -16.2400   37.2400  -18.3400
            1  2
 ORIGINAL  1    1
 REPEAT    1   31

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