KEGG   DRUG: Valsartan and amlodipine besilate
Entry
D09745            Mixture   Drug                                   
Name
Valsartan and amlodipine besilate;
Exforge (TN)
Product
EXFORGE (Novartis Pharmaceuticals Corporation)
  Generic
AMLODIPINE AND VALSARTAN (Alembic Pharmaceuticals Limited), AMLODIPINE AND VALSARTAN (Alembic Pharmaceuticals), AMLODIPINE AND VALSARTAN (Aurobindo Pharma Limited), AMLODIPINE AND VALSARTAN (Golden State Medical Supply), AMLODIPINE AND VALSARTAN (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), AMLODIPINE AND VALSARTAN (Lupin Pharmaceuticals), AMLODIPINE AND VALSARTAN (Lupin Pharmaceuticals), AMLODIPINE AND VALSARTAN (Mylan Pharmaceuticals), AMLODIPINE AND VALSARTAN (Strides Pharma Science Limited)
Component
Valsartan [DR:D00400], Amlodipine besilate [DR:D00615]
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
 DG03231  Antihypertensive
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2149
ATC code: C09DB01
Product: D09745<JP/US>
Efficacy
Antihypertensive
  Disease
Hypertension [DS:H01633]
Comment
Anmlodipine is metabolized by CYP3A4.
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09D ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
    C09DB Angiotensin II receptor blockers (ARBs) and calcium channel blockers
     C09DB01 Valsartan and amlodipine
      D09745  Valsartan and amlodipine besilate <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Cardiovascular Agents, Combinations
   Amlodipine Besylate/ Valsartan
    D09745  Valsartan and amlodipine besilate
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D09745  Valsartan and amlodipine besilate
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   D09745  Valsartan and amlodipine besilate
  DG03231  Antihypertensive
   D09745  Valsartan and amlodipine besilate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D09745  Valsartan and amlodipine besilate
Drug classes [BR:br08332]
 Cardiovascular agent
  DG03231  Antihypertensive
   D09745  Valsartan and amlodipine besilate
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09745
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09745
Other DBs
PubChem: 124490485

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Ontology (7)   
   KEGG BRITE (7)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (3)   
   KEGG DGROUP (3)   
Chemical substance (1)   
   PubChem (1)   
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