KEGG   ENZYME: 1.1.1.188Help
Entry
EC 1.1.1.188                Enzyme                                 
Name
prostaglandin-F synthase;
prostaglandin-D2 11-reductase;
reductase, 15-hydroxy-11-oxoprostaglandin;
PGD2 11-ketoreductase;
PGF2alpha synthetase;
prostaglandin 11-ketoreductase;
prostaglandin D2-ketoreductase;
prostaglandin F synthase;
prostaglandin F synthetase;
synthetase, prostaglandin F2alpha;
PGF synthetase;
NADPH-dependent prostaglandin D2 11-keto reductase;
prostaglandin 11-keto reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP+ 11-oxidoreductase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH + H+ [RN:R02684]
Reaction(KEGG)
R02684;
(other) R02799
Show
Substrate
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate [CPD:C00639];
NADP+ [CPD:C00006]
Product
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate [CPD:C00696];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
Pathway
Arachidonic acid metabolism
Orthology
K04119  
aldo-keto reductase family 1 member C3
Genes
HSA: 
8644(AKR1C3)
PTR: 
100612718(AKR1C3)
PPS: 
100986388(AKR1C3)
GGO: 
PON: 
100174617(AKR1C3)
MCC: 
711440(AKR1C3)
BTA: 
Taxonomy
Reference
1  [PMID:7248318]
  Authors
Reingold DF, Kawasaki A, Needleman P.
  Title
A novel prostaglandin 11-keto reductase found in rabbit liver.
  Journal
Biochim. Biophys. Acta. 659 (1981) 179-88.
  Organism
Oryctolagus cuniculus
Reference
2
  Authors
Watanabe, K., Shimizu, T. and Hayaishi, O.
  Title
Enzymatic conversion of prostaglandin-D2 to prostaglandin-F2alpha in the rat lung.
  Journal
Biochem. Int. 2 (1981) 603-610.
Reference
3  [PMID:3858278]
  Authors
Watanabe K, Yoshida R, Shimizu T, Hayaishi O.
  Title
Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lung.
  Journal
J. Biol. Chem. 260 (1985) 7035-41.
  Organism
Bos taurus [GN:bta]
Reference
4  [PMID:7248317]
  Authors
Wong PY.
  Title
Purification and partial characterization of prostaglandin D2 11-keto reductase in rabbit liver.
  Journal
Biochim. Biophys. Acta. 659 (1981) 169-78.
  Organism
Oryctolagus cuniculus
Reference
5  [PMID:7132748]
  Authors
Wong PY.
  Title
Purification of PGD2 11-ketoreductase from rabbit liver.
  Journal
Methods. Enzymol. 86 (1982) 117-25.
  Organism
Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
55976-95-9
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