KEGG   ENZYME: 1.1.1.213Help
Entry
EC 1.1.1.213                Enzyme                                 
Name
3alpha-hydroxysteroid 3-dehydrogenase (A-specific);
3alpha-hydroxysteroid dehydrogenase;
AKR1C2 (gene name);
Akr1c9 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (A-specific)
Reaction(IUBMB)
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:R02476 R02477]
Reaction(KEGG)
Substrate
3alpha-hydroxysteroid [CPD:C03072];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3alpha-hydroxysteroids. A-specific with respect to NAD+ or NADP+ [cf. EC 1.1.1.50, 3alpha-hydroxysteroid 3-dehydrogenase (B-specific)].
Pathway
Steroid hormone biosynthesis
Orthology
K00089  
3alpha-hydroxysteroid dehydrogenase (A-specific)
K04119  
aldo-keto reductase family 1 member C3
Genes
HSA: 
1109(AKR1C4) 1645(AKR1C1) 1646(AKR1C2) 8644(AKR1C3)
PTR: 
100612718(AKR1C3) 450274(AKR1C4)
PPS: 
100986388(AKR1C3)
GGO: 
PON: 
100174617(AKR1C3)
MCC: 
711440(AKR1C3)
BTA: 
Taxonomy
Reference
1  [PMID:4392180]
  Authors
Bjorkhem I, Danielsson H.
  Title
Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by delta-4-3-oxosteroid 5-beta-reductase and 3-alpha-hydroxysteroid dehydrogenase from rat liver.
  Journal
Eur. J. Biochem. 12 (1970) 80-4.
  Organism
Rattus norvegicus [GN:rno]
Reference
2  [PMID:13278351]
  Authors
TOMKINS GM.
  Title
A mammalian 3alpha-hydroxysteroid dehydrogenase.
  Journal
J. Biol. Chem. 218 (1956) 437-47.
  Organism
Rattus norvegicus [GN:rno]
Reference
3  [PMID:8920937]
  Authors
Dufort I, Soucy P, Labrie F, Luu-The V
  Title
Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids.
  Journal
Biochem. Biophys. Res. Commun. 228 (1996) 474-9.
Reference
4  [PMID:11514561]
  Authors
Nahoum V, Gangloff A, Legrand P, Zhu DW, Cantin L, Zhorov BS, Luu-The V, Labrie F, Breton R, Lin SX
  Title
Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.
  Journal
J. Biol. Chem. 276 (2001) 42091-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-56-2
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