KEGG   ENZYME: 1.1.1.213Help
Entry
EC 1.1.1.213                Enzyme                                 

Name
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific);
3alpha-hydroxysteroid dehydrogenase;
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (A-specific);
3alpha-hydroxysteroid 3-dehydrogenase (A-specific)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Re-specific)
Reaction(IUBMB)
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:R10422 R10423]
Reaction(KEGG)
Substrate
3alpha-hydroxysteroid [CPD:C03072];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3alpha-hydroxysteroids. Re-specific with respect to NAD+ or NADP+ [cf. EC 1.1.1.50, 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)]. Enzymes whose stereo-specificity with respect to NAD+ or NADP+ is not known are described by EC 1.1.1.357, 3alpha-hydroxysteroid 3-dehydrogenase.
History
EC 1.1.1.213 created 1986, modified 2012
Pathway
Steroid hormone biosynthesis
Orthology
K00089  
3alpha-hydroxysteroid dehydrogenase (A-specific)
K04119  
aldo-keto reductase family 1 member C3
Genes
HSA: 
1109(AKR1C4) 1645(AKR1C1) 1646(AKR1C2) 8644(AKR1C3)
PTR: 
100612718(AKR1C3) 450274(AKR1C4)
PPS: 
GGO: 
PON: 
100174617(AKR1C3)
MCC: 
711440(AKR1C3)
MCF: 
102117205(AKR1C4) 102142023(HSD17B5)
CGE: 
HGL: 
TUP: 
CFA: 
497070(AKR1C3)
FCA: 
100510801(AKR1C3)
PTG: 
BTA: 
BOM: 
PHD: 
CHX: 
OAS: 
CFR: 
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
OAA: 
PSS: 
CMY: 
XTR: 
779627(akr1c3)
 » show all
Taxonomy
Reference
1  [PMID:4392180]
  Authors
Bjorkhem I, Danielsson H.
  Title
Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by delta-4-3-oxosteroid 5-beta-reductase and 3-alpha-hydroxysteroid dehydrogenase from rat liver.
  Journal
Eur. J. Biochem. 12 (1970) 80-4.
Reference
2  [PMID:13278351]
  Authors
TOMKINS GM.
  Title
A mammalian 3alpha-hydroxysteroid dehydrogenase.
  Journal
J. Biol. Chem. 218 (1956) 437-47.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-56-2

DBGET integrated database retrieval system