KEGG   ENZYME: 1.1.1.239Help
Entry
EC 1.1.1.239                Enzyme                                 

Name
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+);
3alpha,17beta-hydroxy steroid dehydrogenase;
3alpha(17beta)-HSD;
17-ketoreductase (ambiguous);
17beta-HSD (ambiguous);
HSD17B6 (gene name);
HSD17B8 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase
Reaction(IUBMB)
testosterone + NAD+ = androstenedione + NADH + H+ [RN:R01836]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NAD+ [CPD:C00003]
Product
androstenedione [CPD:C00280];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also acts on other 17beta-hydroxysteroids and on the 3alpha-hydroxy group of pregnanes and bile acids. Different from EC 1.1.1.50 3alpha-hydroxysteroid dehydrogenase (Si-specific) or EC 1.1.1.213 3alpha-hydroxysteroid dehydrogenase (Re-specific).
History
EC 1.1.1.239 created 1992, modified 2012 (EC 1.1.1.63 created 1965, incorporated 2012)
Pathway
Steroid hormone biosynthesis
Metabolic pathways
Orthology
K13368  
17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13369  
17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K13370  
17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
Genes
HSA: 
3294(HSD17B2) 7923(HSD17B8) 8630(HSD17B6)
PTR: 
454269(HSD17B2) 746685(HSD17B8)
PPS: 
100983435(HSD17B2) 100993294(HSD17B8) 100996145(HSD17B6)
GGO: 
101131453(HSD17B2) 101143846(HSD17B8) 101153072(HSD17B6)
PON: 
100456547(HSD17B2) 100458219(HSD17B6) 100461538(HSD17B8)
NLE: 
100588757(HSD17B2) 100606923(HSD17B6) 100607728(HSD17B8)
MCC: 
713549(HSD17B6) 714282 718119(HSD17B8)
MCF: 
101926544 102119721(HSD17B2) 102134563(HSD17B8)
CJC: 
100387390(HSD17B6) 100390710(HSD17B2) 100415565(HSD17B8)
MMU: 
14979(H2-Ke6) 15486(Hsd17b2) 27400(Hsd17b6)
RNO: 
100362350 286964(Hsd17b6) 361802(Hsd17b8) 79243(Hsd17b2)
CGE: 
100751897(Hsd17b2) 100762147(Hsd17b6) 100766230(Hsd17b8)
HGL: 
101699287(Hsd17b6) 101719685(Hsd17b2) 101726130(Hsd17b8)
TUP: 
102481564(HSD17B2) 102485005(HSD17B6) 102494154(HSD17B8)
CFA: 
481118(HSD17B6) 489690(HSD17B2) 607895(HSD17B8)
AML: 
UMR: 
103656323(HSD17B6) 103662132(HSD17B2) 103665501(HSD17B8)
FCA: 
101085592(HSD17B2) 101086309(HSD17B8) 101088341(HSD17B6)
PTG: 
102958819(HSD17B2) 102968797(HSD17B8) 102971783(HSD17B6)
BTA: 
515710(HSD17B2) 532422(HSD17B8) 533086(HSD17B6)
BOM: 
102278674(HSD17B2) 102283510(HSD17B6) 102286352(HSD17B8)
PHD: 
102332625(HSD17B6) 102336871(HSD17B2) 102340413(HSD17B8)
CHX: 
102182621(HSD17B2) 102185066(HSD17B6) 102189913(HSD17B8)
OAS: 
100913161(HSD17B2) 101105400 101116612(HSD17B8)
SSC: 
100154372(HSD17B8) 100312973(HSD17B2) 100620470(HSD17B6)
CFR: 
102504651(HSD17B8) 102508382 102514993(HSD17B2)
BACU: 
103006419(HSD17B8) 103008169(HSD17B6) 103014202(HSD17B2)
LVE: 
103070446(HSD17B2) 103076064(HSD17B6) 103088201(HSD17B8)
ECB: 
100052840(HSD17B6) 100061414(HSD17B8) 100146214(HSD17B2)
MYB: 
102252900(HSD17B8) 102260774(HSD17B2)
MYD: 
102751454(HSD17B2) 102766664(HSD17B8)
PALE: 
102882881(HSD17B2) 102883634(HSD17B6) 102889883(HSD17B8)
MDO: 
SHR: 
OAA: 
100076931(HSD17B2)
GGA: 
415807(HSD17B2)
MGP: 
APLA: 
101792379(HSD17B2)
TGU: 
FAB: 
101810951(HSD17B2)
PHI: 
102103079(HSD17B2)
FPG: 
101915382(HSD17B2)
FCH: 
102048922(HSD17B2)
CLV: 
102095570(HSD17B2)
ASN: 
AMJ: 
PSS: 
CMY: 
102929636(HSD17B8) 102941631(HSD17B2) 102944543(HSD17B6)
ACS: 
PBI: 
XLA: 
398882(rdh16)
XTR: 
100135184(rdh16) 100497002(hsd17b2) 549425(hsd17b8)
DRE: 
449537(hsd17b2) 64815(hsd17b8)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102360275(HSD17B2) 102361445(HSD17B8)
CMK: 
BFO: 
CIN: 
SPU: 
DPE: 
ISC: 
CBR: 
CBG18334(Cbr-dhs-11)
NVE: 
HMG: 
 » show all
Taxonomy
Reference
1  [PMID:15436478]
  Authors
SWEAT ML, SAMUELS LT, LUMRY R.
  Title
Preparation and characterization of the enzyme which converts testosterone to androstenedione.
  Journal
J. Biol. Chem. 185 (1950) 75-84.
Reference
2  [PMID:13781425]
  Authors
VILLEE CA, SPENCER JM.
  Title
Some properties of the pyridine nucleotide-specific 17 beta-hydroxy steroid dehydrogenases of guinea pig liver.
  Journal
J. Biol. Chem. 235 (1960) 3615-9.
Reference
3  [PMID:13696735]
  Authors
ENDAHL GL, KOCHAKIAN CD, HAMM D.
  Title
Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver.
  Journal
J. Biol. Chem. 235 (1960) 2792-6.
Reference
4  [PMID:2317205]
  Authors
Ohmura M, Hara A, Nakagawa M, Sawada H.
  Title
Demonstration of 3 alpha(17 beta)-hydroxysteroid dehydrogenase distinct from 3 alpha-hydroxysteroid dehydrogenase in hamster liver.
  Journal
Biochem. J. 266 (1990) 583-9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
126469-82-7

DBGET integrated database retrieval system