| Entry |
|
| Name |
GDP-L-fucose synthase;
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase;
GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)
|
| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
| Sysname |
GDP-beta-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)
|
| Reaction(IUBMB) |
GDP-beta-L-fucose + NADP+ = GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+ [RN: R05692]
|
| Reaction(KEGG) |
|
| Substrate |
|
| Product |
|
| Comment |
Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.
|
| Pathway |
| Fructose and mannose metabolism | | Amino sugar and nucleotide sugar metabolism | | Metabolic pathways |
|
| Orthology |
|
| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | MCC: | | MMU: | | RNO: | | CFA: | | AML: | | FCA: | | BTA: | | SSC: | | ECB: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | ACS: | | XTR: | | DRE: | | TRU: | | OLA: | | BFO: | | CIN: | | SPU: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | AGA: | | AAG: | | CQU: | | AME: | | NVI: | | TCA: | | API: | | PHU: | | ISC: | | CEL: | | CBR: | | BMY: | | SMM: | | NVE: | | HMG: | | TAD: | | AQU: | | ATH: | | ALY: | | GMX: | | MTR: | | CSV: | | RCU: | | POP: | | VVI: | | OSA: | | DOSA: | | BDI: | | SBI: | | ZMA: | | SMO: | | PPP: | | OLU: | | OTA: | | LBC: | | CCI: | | SCM: | | PGR: | | MBR: | | NGR: | | DDI: | | DPP: | | PFA: | | PFH: | | PBE: | | PKN: | | PVX: | | PCY: | | TGO: | | TBR: | | TCR: | | PTI: | | TPS: | | PIF: | | ECO: | | ECJ: | | ECD: | | EBW: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | EFE: | | STY: | | STT: | | SEX: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SEE: | | SEW: | | SEA: | | SED: | | SEG: | | SEL: | | SET: | | SENJ: | | SES: | | SBG: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPD: | | YPX: | | YPH: | | YPS: | | YPI: | | YPY: | | YEN: | | SFL: | | SFX: | | SFV: | | SFE: | | SSN: | | SSJ: | | SBO: | | SBC: | | PCT: | | PCC: | | SGL: | | ENT: | | ENC: | | ENO: | | ECLO: | | ESC: | | EEC: | | ENL: | | EAS: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPU: | | KPP: | | CKO: | | CRO: | | DDD: | | PLF: | | PSI: | | EBF: | | PSD: | | VVY: | | VPB: | | PFS: | | PSJ: | | PSH: | | PFV: | | SVO: | | CPS: | | SDE: | | AMAC: | | AMB: | | AMK: | | GPS: | | PIN: | | CBU: | | CBS: | | CBD: | | CBG: | | CBC: | | LLO: | | MCA: | | MMT: | | MAH: | | FCN: | | FPH: | | FRT: | | FNA: | | CYQ: | | NOC: | | NHL: | | NWA: | | TGR: | | TNI: | | MPC: | | TOL: | | TAU: | | SAGA: | | RMA: | | PSE: | | RME: | | CTI: | | CNC: | | BVI: | | BAM: | | BXE: | | BPH: | | BPY: | | BUG: | | BGF: | | BUK: | | BPX: | | PNU: | | AXY: | | RFR: | | POL: | | PNA: | | AAA: | | VAP: | | VPE: | | MPT: | | HSE: | | LCH: | | RGE: | | AZO: | | DSU: | | TBD: | | MMB: | | SLT: | | GCA: | | BPRC: | | HPY: | | HEO: | | HPJ: | | HPA: | | HPS: | | HHP: | | HHQ: | | HHR: | | HPG: | | HPP: | | HPB: | | HPL: | | HPC: | | HCA: | | HPM: | | HPE: | | HPO: | | HPI: | | HPQ: | | HPW: | | HPU: | | HEF: | | HPF: | | HEQ: | | HEX: | | HPT: | | HPZ: | | HPV: | | HPX: | | HEN: | | HPH: | | HEG: | | HPN: | | HEP: | | HEU: | | HES: | | HCN: | | HPD: | | HEY: | | HER: | | HEI: | | HPYA: | | HPYK: | | HPYO: | | HPYL: | | HHE: | | HAC: | | HMS: | | HFE: | | HBI: | | HCE: | | HCM: | | HCP: | | HCB: | | SUA: | | SULR: | | CJE: | | CJB: | | CJJ: | | CJN: | | CJS: | | CJR: | | CJD: | | ANT: | | SDL: | | NSA: | | SUN: | | NAM: | | GSU: | | GSK: | | GME: | | GUR: | | GLO: | | GBM: | | GEO: | | GEM: | | GEB: | | PPD: | | DVU: | | DVL: | | DVM: | | DVG: | | DDE: | | DDS: | | DMA: | | DAS: | | DAF: | | LIP: | | LIR: | | DBA: | | DPS: | | DAK: | | DSF: | | DOL: | | ADE: | | ACP: | | AFW: | | ANK: | | SAT: | | DTI: | | PUB: | | MLO: | | RHI: | | SFH: | | SFD: | | ATU: | | AGR: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | RTR: | | BME: | | BMZ: | | BMG: | | BMW: | | BMC: | | BAA: | | BMS: | | BSI: | | BMT: | | BSV: | | BCS: | | BSK: | | BMR: | | BPP: | | OAN: | | BJA: | | BJU: | | BRA: | | BBT: | | BRS: | | RPB: | | NWI: | | AOL: | | AZC: | | MEX: | | MEA: | | MDI: | | MCH: | | MRD: | | MPO: | | MNO: | | MSL: | | HDN: | | HMC: | | CCS: | | CAK: | | CSE: | | SIT: | | RSP: | | PDE: | | DSH: | | KVU: | | KVL: | | PSF: | | PGA: | | PGL: | | HBA: | | SSY: | | ELI: | | RRU: | | RRF: | | RCE: | | MAG: | | AZL: | | ALI: | | ABS: | | PBR: | | APB: | | MAI: | | MAN: | | APM: | | MGM: | | BSUB: | | GWC: | | BBE: | | PJD: | | GYM: | | PPY: | | PPM: | | PPO: | | PMS: | | PMQ: | | PMW: | | PTA: | | EFU: | | CAC: | | CAE: | | CAY: | | CCE: | | CLB: | | CSS: | | CSD: | | SWO: | | DRM: | | DAE: | | HMO: | | BPB: | | RHO: | | RIM: | | EHA: | | CKI: | | CKN: | | TOC: | | TTO: | | SSG: | | SRI: | | MTU: | | MTV: | | MTC: | | MRA: | | MTF: | | MTB: | | MTK: | | MTZ: | | MTG: | | MTI: | | MTE: | | MTL: | | MTO: | | MTD: | | MTN: | | MTJ: | | MTUB: | | MAF: | | MCE: | | MCQ: | | MCV: | | MCX: | | MCZ: | | MPA: | | MIT: | | MIR: | | MIA: | | MID: | | MSA: | | MKM: | | MRH: | | MMM: | | RHA: | | RER: | | ROP: | | GOR: | | TPR: | | SGR: | | SSX: | | SFA: | | STRP: | | CMI: | | CMS: | | CMC: | | MTS: | | AAU: | | ARR: | | KRH: | | KFL: | | FRI: | | ACE: | | KRA: | | AMI: | | AYM: | | EYY: | | TBE: | | TPI: | | SSM: | | STA: | | STQ: | | LIL: | | LIE: | | LIC: | | LBJ: | | LBL: | | LBI: | | LBF: | | BHY: | | BPO: | | BPJ: | | BPIP: | | BPW: | | BIP: | | SGP: | | ABA: | | TSA: | | TRS: | | SUS: | | CTM: | | BTH: | | BFR: | | BFS: | | BFG: | | BVU: | | BHL: | | BSA: | | BXY: | | PGI: | | PGN: | | PGT: | | PAH: | | PDI: | | PPN: | | TFO: | | PRU: | | PMZ: | | PDN: | | PIT: | | PDT: | | RMG: | | CPI: | | NKO: | | PHE: | | PSN: | | SHG: | | SCN: | | HHY: | | SGN: | | CMR: | | BBD: | | EVI: | | CHU: | | DFE: | | SLI: | | LBY: | | RSI: | | FLI: | | EOL: | | FAE: | | GFO: | | FJO: | | FBR: | | FIN: | | RBI: | | ZPR: | | CAT: | | CAO: | | CLY: | | KDI: | | ZGA: | | PTQ: | | NDO: | | POM: | | IPO: | | OTE: | | CAA: | | AMU: | | RBA: | | PLM: | | PBS: | | IPA: | | SACI: | | PHM: | | TAI: | | SBR: | | SYN: | | SYZ: | | SYY: | | SYT: | | SYS: | | SYQ: | | SYW: | | SYC: | | SYF: | | SYG: | | SYR: | | SYX: | | SYP: | | CYA: | | CYB: | | SYNE: | | SYNP: | | TEL: | | MAR: | | CYT: | | CYP: | | CYC: | | CYN: | | CYH: | | CYJ: | | AMR: | | CGC: | | CAN: | | CSN: | | DSL: | | HAO: | | GLP: | | CMP: | | CYU: | | GVI: | | ANA: | | NPU: | | NOS: | | NOP: | | AVA: | | ANB: | | ACY: | | NAZ: | | CSG: | | CALO: | | CALT: | | RIV: | | PMA: | | PMM: | | PMI: | | PMB: | | PMC: | | PMG: | | PMH: | | TER: | | LEP: | | GEI: | | OAC: | | ONI: | | PSEU: | | CEP: | | MIC: | | ARP: | | CTHE: | | PLP: | | SCS: | | CCH: | | CPH: | | CPB: | | PVI: | | PLT: | | PPH: | | CTS: | | IAL: | | CAU: | | CAG: | | CHL: | | ATM: | | DGE: | | DPD: | | SUL: | | SAF: | | MPZ: | | MPG: | | TYE: | | NDE: | | LFI: | | DAP: | | CNI: | | FSI: | | MOX: | | MMZ: | | MBA: | | MMA: | | MMH: | | MZH: | | MPI: | | MPL: | | MPD: | | NKR: | | » show all
 |
| Reference |
|
| Authors |
Chang S, Duerr B, Serif G. |
| Title |
An epimerase-reductase in L-fucose synthesis. |
| Journal |
J. Biol. Chem. 263 (1988) 1693-7. |
| Organism |
|
| Reference |
|
| Authors |
Mattila P, Rabina J, Hortling S, Helin J, Renkonen R. |
| Title |
Functional expression of Escherichia coli enzymes synthesizing GDP-L-fucose from inherent GDP-D-mannose in Saccharomyces cerevisiae. |
| Journal |
Glycobiology. 10 (2000) 1041-7. |
| Organism |
Escherichia coli [GN: eco] |
| Reference |
|
| Authors |
Menon S, Stahl M, Kumar R, Xu GY, Sullivan F. |
| Title |
Stereochemical course and steady state mechanism of the reaction catalyzed by the GDP-fucose synthetase from Escherichia coli. |
| Journal |
J. Biol. Chem. 274 (1999) 26743-50. |
| Organism |
Escherichia coli [GN: eco] |
| Reference |
|
| Authors |
Somers WS, Stahl ML, Sullivan FX. |
| Title |
GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site. |
| Journal |
Structure. 6 (1998) 1601-12. |
| Organism |
Escherichia coli [GN: eco] |
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 113756-18-6 |