KEGG ENZYME: 1.1.1.47

ENZYME: 1.1.1.47

Entry

EC 1.1.1.47 Enzyme

Name

glucose 1-dehydrogenase;
D-glucose dehydrogenase (NAD(P)+);
hexose phosphate dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

beta-D-glucose:NAD(P)+ 1-oxidoreductase

Reaction(IUBMB)

beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H + H+ [RN:R01520 R01521]

Reaction(KEGG)

R01520 R01521

Substrate

beta-D-glucose [CPD:C00221];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

D-glucono-1,5-lactone [CPD:C00198];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Also oxidizes D-xylose.

Pathway

ec00030	Pentose phosphate pathway
ec01120	Microbial metabolism in diverse environments

Orthology

K00034	glucose 1-dehydrogenase
K13937	hexose-6-phosphate dehydrogenase

Genes

HSA:	9563(H6PD)
PTR:	100610187(H6PD)
PPS:	100993268(H6PD)
GGO:	101142424(H6PD)
PON:	100438428(H6PD)
MCC:	710107(H6PD)
MMU:	100198(H6pd)
RNO:	298655(H6pd)
CFA:	489642(H6PD)
AML:	100476557(H6PD)
FCA:	101098066(H6PD)
BTA:	541220(H6PD)
ECB:	100057646(H6PD)
MDO:	100009940(H6PD)
SHR:	100924302(H6PD)
OAA:	100082409
GGA:	428188(H6PD)
MGP:	100545189
TGU:	100228049(H6PD)
ACS:	100551772
XTR:	100127695(h6pd)
DRE:	569348
TRU:	101073312
OLA:	101167199
BFO:	BRAFLDRAFT_65130
SPU:	590387(h6pd)
NVE:	NEMVE_v1g31531
TAD:	TRIADDRAFT_20384
ETA:	ETA_30410(gdh)
EPY:	EpC_32460(gdh)
EPR:	EPYR_03494(gdh)
EAM:	EAMY_3245(gdh)
EAY:	EAM_0356(gdh)
ERJ:	EJP617_07310(gdh)
PMR:	PMI1532
PVA:	Pvag_pPag30134
PST:	PSPTO_2492
PSB:	Psyr_2297
PSP:	PSPPH_2879
PFL:	PFL_4100(gdh)
PFO:	Pfl01_1840
PFS:	PFLU2089
PFE:	PSF113_1833
PFC:	PflA506_1991(gdh)
PPZ:	H045_06050
PSA:	PST_3895
PSZ:	PSTAB_3853
PSR:	PSTAA_4020
PSC:	A458_01850
PSJ:	PSJM300_01960
PSH:	Psest_0357
PBA:	PSEBR_a3926
PFV:	Psefu_3139
LLO:	LLO_1657
MAH:	MEALZ_1699(gdhI)
TCY:	Thicy_0019
NWA:	Nwat_1326
AFE:	Lferr_1535 Lferr_1879
AFR:	AFE_1857 AFE_2225
ACU:	Atc_1440
AFI:	Acife_3156
BMU:	Bmul_0907
BMJ:	BMULJ_02351(gdh)
BXE:	Bxe_B0443
BPH:	Bphy_4761
BPY:	Bphyt_7232
BUG:	BC1001_4605
BGE:	BC1002_4763
BGF:	BC1003_4892
BGD:	bgla_2g20240
BYI:	BYI23_B007160
BPX:	BUPH_01169
BPT:	Bpet0388(gdH)
AXY:	AXYL_03471
AAV:	Aave_1089
AAA:	Acav_1071
TBD:	Tbd_0924
DAF:	Desaf_0077
SCL:	sce7442
HOH:	Hoch_0357
BJA:	bll7157 bll7185(gdh)
BJU:	BJ6T_22230
BRA:	BRADO1396
BBT:	BBta_6708
BRS:	S23_11440(gdh)
AOL:	S58_15170
MRD:	Mrad2831_1756
MPO:	Mpop_1521
RDE:	RD1_3328
NPP:	PP1Y_AT5493
SWI:	Swit_0697
SPHM:	G432_13485
GOX:	GOX2015
GOH:	B932_3505
ACR:	Acry_2603 Acry_3136
AMV:	ACMV_29280
GDI:	GDI_2625(gdh)
GDJ:	Gdia_0840
BSU:	BSU02830(ycdF) BSU03930(gdh)
BSR:	I33_0324 I33_0450
BSL:	A7A1_1915 A7A1_3085
BSH:	BSU6051_02830(ycdF) BSU6051_03930(gdh)
BSY:	I653_01395 I653_02000
BSS:	BSUW23_01450(ycdF) BSUW23_02030(gdh)
BST:	GYO_0485 GYO_0610
BSO:	BSNT_00502(ycdF) BSNT_00690(gdh)
BSN:	BSn5_12995 BSn5_13570
BSQ:	B657_02830(ycdF) B657_03930(gdh)
BSUB:	BEST7613_0282(ycdF) BEST7613_0394(gdh) BEST7613_2550(gdh)
BSX:	C663_0274(ycdF) C663_0386(gdh)
BLI:	BL01382(gdh) BL01687(ycdF)
BLD:	BLi00341(ycdF) BLi02566(gdh)
BAO:	BAMF_0254(ycdF) BAMF_0361(gdh)
BAY:	RBAM_003090(ycdF) RBAM_004180(gdh)
BAQ:	BACAU_0250(ycdF) BACAU_0354(gdh)
BYA:	BANAU_0251(ycdF) BANAU_0354(gdh)
BAMP:	B938_01295 B938_01860
BAML:	BAM5036_0264(ycdF) BAM5036_0377(gdh)
BAZ:	BAMTA208_01290(ycdF) BAMTA208_01830(gdh)
BQL:	LL3_00265(ycdF) LL3_00376(gdh)
BXH:	BAXH7_00268(ycdF) BAXH7_00379(gdh)
BQY:	MUS_0266(ycdF) MUS_0382(gdh)
BAMI:	KSO_017595 KSO_018115
BAE:	BATR1942_20045 BATR1942_20675
BAN:	BA_4968(gdH)
BAR:	GBAA_4968(gdH)
BAT:	BAS4612
BAH:	BAMEG_4999(gdH)
BAI:	BAA_4978(gdH)
BAX:	H9401_4743
BAL:	BACI_c47130(gdh)
BCE:	BC4715
BCA:	BCE_4858(gdH)
BCZ:	BCZK4466(gdh) pE33L466_0368(gdh)
BCR:	BCAH187_A4852(gdH)
BCB:	BCB4264_A4828(gdH)
BCU:	BCAH820_4834(gdH)
BCG:	BCG9842_B0408(gdH)
BCQ:	BCQ_4529(gdh)
BCX:	BCA_4839(gdH)
BNC:	BCN_4625
BCF:	bcf_23665
BCER:	BCK_11600
BCY:	Bcer98_3132
BTK:	BT9727_4448(gdh)
BTL:	BALH_4289(gdh)
BTB:	BMB171_C4353(gdH)
BTT:	HD73_5025
BTC:	CT43_CH4738(gdH)
BTF:	YBT020_23225
BTM:	MC28_3995
BTG:	BTB_c48700
BTI:	BTG_25270
BTN:	BTF1_22140
BTHT:	H175_ch4816
BWE:	BcerKBAB4_4547
BPU:	BPUM_0257(ycdF) BPUM_2122(gdh)
BMQ:	BMQ_0838(gdh) BMQ_1051 BMQ_3371
BMD:	BMD_0838(gdh) BMD_1054 BMD_3374
BMH:	BMWSH_1813 BMWSH_4190 BMWSH_4406(gdh)
BJS:	MY9_0289 MY9_0409
OIH:	OB3183
SAA:	SAUSA300_2416
SEP:	SE1830
SER:	SERP1839(gdh)
SHA:	SH0795
SSP:	SSP0656
SCA:	Sca_1743(gdh)
SWA:	A284_03280
ESI:	Exig_0211
EAT:	EAT1b_1955
EAN:	Eab7_0200(gdh)
MCL:	MCCL_0186 MCCL_1630
PJD:	Pjdr2_4221
LPS:	LPST_C2363
LAC:	LBA1098
LAD:	LA14_1110
LSL:	LSL_0144(gdh)
LSI:	HN6_00123(gdh)
LCA:	LSEI_2180
LCB:	LCABL_23550(gdh)
LCZ:	LCAZH_2141
LCS:	LCBD_2346(yohF)
LCE:	LC2W_2328(yohF)
LCW:	BN194_23130(gdhII)
LRH:	LGG_02189(gdh)
LRG:	LRHM_2106
LRL:	LC705_02185(gdh)
LRA:	LRHK_2188(gdhB)
PPE:	PEPE_0073
EFA:	EF2382(gdh)
EFL:	EF62_2577
EFI:	OG1RF_11820(gdh)
EFD:	EFD32_2003
EFC:	EFAU004_01709(gdh)
EFU:	HMPREF0351_11664(gdh)
EFM:	M7W_1207
EHR:	EHR_10355
ENE:	ENT_15570
MPS:	MPTP_0171
MPX:	MPD5_0160
CRN:	CAR_c18210(gdh)
SCO:	SCO1335(2SCG61.17c)
SMA:	SAV_1922(gdh)
SVL:	Strvi_3883
FRA:	Francci3_2849
NML:	Namu_1837
STP:	Strop_0661
SAQ:	Sare_0635
VMA:	VAB18032_17610
RXY:	Rxyl_0551
CWO:	Cwoe_1554
ELE:	Elen_0198
EYY:	EGYY_17230(FabG)
GPA:	GPA_17990
PUV:	PUV_21460(gdhII)
WCH:	wcw_0442
SNG:	SNE_A07830(gdh)
ABA:	Acid345_3509
ACA:	ACP_3015(gdh)
ACM:	AciX9_1360
GMA:	AciX8_1265
TSA:	AciPR4_1785
TRS:	Terro_1806
SUS:	Acid_2336 Acid_7577
CTM:	Cabther_B0727
CPI:	Cpin_0947
SHG:	Sph21_3176
CHU:	CHU_1661(gdh)
DFE:	Dfer_1228
SLI:	Slin_2303 Slin_2520
RSI:	Runsl_4968
FAE:	FAES_4123(gdh3)
ZPR:	ZPR_1651
CAO:	Celal_1811
ZGA:	zobellia_1102(gdhA)
OTE:	Oter_3349
RBA:	RB7294(gdh)
PSL:	Psta_3574
PBS:	Plabr_0832 Plabr_3757
SACI:	Sinac_0374
PHM:	PSMK_03410(gdh)
SYN:	sll1709(gdh)
SYY:	SYNGTS_1154(gdh)
SYT:	SYNGTI_1154(gdh)
SYS:	SYNPCCN_1153(gdh)
SYQ:	SYNPCCP_1153(gdh)
SYC:	syc0030_d
SYF:	Synpcc7942_1573
SYG:	sync_1918
SYR:	SynRCC307_1928(gdh)
SYX:	SynWH7803_0725(gdh)
SYNP:	Syn7502_03218
CYT:	cce_0222
CYC:	PCC7424_3932
CYN:	Cyan7425_1811 Cyan7425_4436
CYJ:	Cyan7822_5687 Cyan7822_6114
CGC:	Cyagr_2793
GLP:	Glo7428_3808
CMP:	Cha6605_1455
GVI:	gll1114
ANA:	all3836
NPU:	Npun_F1792 Npun_F2211
NOP:	Nos7524_0251
AVA:	Ava_1863
ACY:	Anacy_3139
CSG:	Cylst_4206
CALO:	Cal7507_3674
RIV:	Riv7116_4408 Riv7116_5340
GEI:	GEI7407_1545
OAC:	Oscil6304_3251
ONI:	Osc7112_1283
CEP:	Cri9333_4028
CTHE:	Chro_2174 Chro_3615 Chro_4252
SCS:	Sta7437_2944
DMR:	Deima_1274
DPD:	Deipe_2470 Deipe_4345
TTR:	Tter_2119
HMA:	rrnAC2741(ywfD2)
TAC:	Ta0897
TVO:	TVN1019
PTO:	PTO0639 PTO1070
PHO:	PH1809
PFU:	PF1853
TKO:	TK0673
HBU:	Hbut_1375
SSO:	SSO3003(dhg-1) SSO3042(dhg-2) SSO3204(dhg-3)
SOL:	Ssol_0792 Ssol_0941
STO:	ST1704
SAI:	Saci_1079
SACN:	SacN8_05250
SACR:	SacRon12I_05240
SIS:	LS215_2319 LS215_2487 LS215_2525
SIA:	M1425_2156 M1425_2315 M1425_2353
SIM:	M1627_2236 M1627_2394 M1627_2431
SID:	M164_2160 M164_2317 M164_2360
SIY:	YG5714_2283 YG5714_2452 YG5714_2497
SIN:	YN1551_0407 YN1551_0458 YN1551_0633
SII:	LD85_2423 LD85_2603 LD85_2656
SIH:	SiH_2102 SiH_2256 SiH_2295
SIR:	SiRe_2034 SiRe_2200 SiRe_2243
SIC:	SiL_2009 SiL_2165 SiL_2203
MSE:	Msed_1301
MCN:	Mcup_0902
AHO:	Ahos_2067
CMA:	Cmaq_1714
NGA:	Ngar_c06980(gdh)
HAH:	Halar_0302

» show all

Reference

1 [PMID:810982]

Authors

Banauch D, Brummer W, Ebeling W, Metz H, Rindfrey H, Lang H, Leybold K, Rick W, Staudinger HJ.

Title

[A glucose dehydrogenase for the determination of glucose concentrations in body fluids (author's transl)]

Journal

Z. Klin. Chem. Klin. Biochem. 13 (1975) 101-7.

Organism

Bacillus megaterium

Reference

Authors

Brink, N.G.

Title

Beef liver glucose dehydrogenase. 1. Purification and properties.

Journal

Acta Chem. Scand. 7 (1953) 1081-1089.

Reference

Authors

Pauly, H.E. and Pfleiderer, G.

Title

D-Glucose dehydrogenase from Bacillus megaterium M 1286: purification, properties and structure.

Journal

Hoppe-Seyler's Z. Physiol. Chem. 356 (1976) 1613-1623.

Reference

4 [PMID:12981017]

Authors

STRECKER HJ, KORKES S.

Title

Glucose dehydrogenase.

Journal

J. Biol. Chem. 196 (1952) 769-84.

Organism

Bos taurus [GN:bta]

Reference

5 [PMID:4392298]

Authors

Thompson RE, Carper WR.

Title

Glucose dehydrogenase from pig liver. I. Isolation and purification.

Journal

Biochim. Biophys. Acta. 198 (1970) 397-406.

Organism

Sus scofa [GN:ssc]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.47

IUBMB Enzyme Nomenclature:

1.1.1.47

ExPASy - ENZYME nomenclature database:

1.1.1.47

BRENDA, the Enzyme Database:

1.1.1.47

CAS:

9028-53-9

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