KEGG   ENZYME: 1.1.1.64Help
Entry
EC 1.1.1.64                 Enzyme                                 
Name
testosterone 17beta-dehydrogenase (NADP+);
17-ketoreductase;
NADP-dependent testosterone-17beta-oxidoreductase;
testosterone 17beta-dehydrogenase (NADP)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
17beta-hydroxysteroid:NADP+ 17-oxidoreductase
Reaction(IUBMB)
testosterone + NADP+ = androstenedione + NADPH + H+ [RN:R01838]
Reaction(KEGG)
Substrate
testosterone [CPD:C00535];
NADP+ [CPD:C00006]
Product
androstenedione [CPD:C00280];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.
Pathway
Steroid hormone biosynthesis
Metabolic pathways
Orthology
K04119  
aldo-keto reductase family 1 member C3
K10207  
testosterone 17beta-dehydrogenase (NADP+)
Genes
HSA: 
3293(HSD17B3) 8644(AKR1C3)
PTR: 
100612718(AKR1C3) 742116(HSD17B3)
PPS: 
100972788(HSD17B3) 100986388(AKR1C3)
GGO: 
PON: 
100174617(AKR1C3) 100433175(HSD17B3)
MCC: 
709843(HSD17B3) 711440(AKR1C3)
MMU: 
15487(Hsd17b3)
RNO: 
117182(Hsd17b3)
CFA: 
AML: 
FCA: 
101085324(HSD17B3)
BTA: 
100337056 616934(HSD17B3)
SSC: 
100513224(HSD17B3)
ECB: 
100062795
MDO: 
100014335
SHR: 
100935109(HSD17B3)
GGA: 
427474(ZNF367)
ACS: 
100561157
DRE: 
393335(hsd17b3)
TRU: 
101070933
OLA: 
100125485(hsd17b3)
TET: 
TTHERM_00706280
 » show all
Taxonomy
Reference
1  [PMID:13696735]
  Authors
ENDAHL GL, KOCHAKIAN CD, HAMM D.
  Title
Separation of a triphosphopyridine nucleotide-specific from a diphosphopyridine nucleotide-specific 17 beta-hydroxy-(testosterone) dehydrogenase of guinea pig liver.
  Journal
J. Biol. Chem. 235 (1960) 2792-6.
  Organism
Cavia porcellus
Reference
2  [PMID:15436478]
  Authors
SWEAT ML, SAMUELS LT, LUMRY R.
  Title
Preparation and characterization of the enzyme which converts testosterone to androstenedione.
  Journal
J. Biol. Chem. 185 (1950) 75-84.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:13781425]
  Authors
VILLEE CA, SPENCER JM.
  Title
Some properties of the pyridine nucleotide-specific 17 beta-hydroxy steroid dehydrogenases of guinea pig liver.
  Journal
J. Biol. Chem. 235 (1960) 3615-9.
  Organism
Cavia porcellus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9028-63-1
DBGET integrated database retrieval system