KEGG   ENZYME: 1.1.99.7Help
Entry
EC 1.1.99.7                 Enzyme                                 
Name
lactate---malate transhydrogenase;
malate-lactate transhydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other acceptors
BRITE hierarchy
Sysname
(S)-lactate:oxaloacetate oxidoreductase
Reaction(IUBMB)
(S)-lactate + oxaloacetate = pyruvate + malate [RN:R01447]
Reaction(KEGG)
Substrate
(S)-lactate [CPD:C00186];
oxaloacetate [CPD:C00036]
Product
pyruvate [CPD:C00022];
malate [CPD:C00149]
Comment
Catalyses hydrogen transfer from C3 or C4 (S)-2-hydroxy acids to 2-oxo acids. It contains tightly bound nicotinamide nucleotide in its active centre. This prosthetic group cannot be removed without denaturation of the protein.
Pathway
Pyruvate metabolism
Metabolic pathways
Reference
1  [PMID:4289051]
  Authors
Allen SH.
  Title
The isolation and characterization of malate-lactate transhydrogenase from Micrococcus lactilyticus.
  Journal
J. Biol. Chem. 241 (1966) 5266-75.
  Organism
Micrococcus lactilyticus
Reference
2  [PMID:4333516]
  Authors
Allen SH, Patil JR.
  Title
Studies on the structure and mechanism of action of the malate-lactate transhydrogenase.
  Journal
J. Biol. Chem. 247 (1972) 909-16.
  Organism
Micrococcus lactilyticus, Veillonella alcalescens
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9077-15-0
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