KEGG   ENZYME: 1.12.7.2Help
Entry
EC 1.12.7.2                 Enzyme                                 
Name
ferredoxin hydrogenase;
H2 oxidizing hydrogenase;
H2 producing hydrogenase [ambiguous];
bidirectional hydrogenase;
hydrogen-lyase [ambiguous];
hydrogenase (ferredoxin);
hydrogenase I;
hydrogenase II;
hydrogenlyase [ambiguous];
uptake hydrogenase [ambiguous]
Class
Oxidoreductases;
Acting on hydrogen as donor;
With an iron-sulfur protein as acceptor
BRITE hierarchy
Sysname
hydrogen:ferredoxin oxidoreductase
Reaction(IUBMB)
H2 + 2 oxidized ferredoxin = 2 reduced ferredoxin + 2 H+ [RN:R00019]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
oxidized ferredoxin [CPD:C00139]
Product
reduced ferredoxin [CPD:C00138];
H+ [CPD:C00080]
Comment
Contains iron-sulfur clusters. The enzymes from some sources contains nickel. Can use molecular hydrogen for the reduction of a variety of substances.
Pathway
Methane metabolism
Orthology
K00532  
ferredoxin hydrogenase
K00533  
ferredoxin hydrogenase large subunit
K00534  
ferredoxin hydrogenase small subunit
K06441  
ferredoxin hydrogenase gamma subunit
Genes
AFM: 
TPV: 
TET: 
SON: 
SO_3920(hydA) SO_3921(hydB)
SHE: 
SHN: 
SHL: 
RFR: 
PNA: 
MPT: 
DAR: 
Daro_3961
PCA: 
Pcar_2502(hndD-1)
DVU: 
DVU1769(hydA) DVU1770(hydB) DVU1771(hydC) DVU1917(hysB) DVU1918(hysA) DVU1921(hynB-1) DVU2525(hynB-2) DVU2526(hynA-2)
DVL: 
Dvul_0718 Dvul_0719 Dvul_1384 Dvul_1385 Dvul_1386
DDE: 
Dde_0081 Dde_0082 Dde_0475 Dde_2280 Dde_2281 Dde_3755 Dde_3756
DDS: 
Ddes_1502
DSA: 
Desal_1333
DPS: 
DP0159 DP0160 DP0479
SFU: 
Sfum_0847 Sfum_0848
BJA: 
bll6944(hupU)
BRA: 
BRADO1682(hupU)
BBT: 
BBta_1994(hupU)
RPA: 
RPA0134(hydC) RPA0959(hupU)
RPE: 
RPE_1229 RPE_3860
RSP: 
RSP_0492(hupU)
RSH: 
Rsph17029_2143
RRU: 
Rru_A0310
CPR: 
CPR_0261 CPR_0938 CPR_2341(hydA)
CTC: 
CTC02417
CNO: 
NT01CX_0464 NT01CX_1006 NT01CX_1699 NT01CX_2259
CTH: 
Cthe_3003
CBE: 
Cbei_3796
CPY: 
Cphy_0090
CDF: 
CD630_33140(hydA)
SWO: 
Swol_1925
EEL: 
EUBELI_01405
ERE: 
EUBREC_2390
CHY: 
CHY_1545
MTA: 
Moth_1883
NTH: 
Nther_0884
HOR: 
Hore_02090
 » show all
Taxonomy
Reference
1
  Authors
Shug, A.L., Wilson, P.W., Green, D.E. and Mahler, H.R.
  Title
The role of molybdenum and flavin in hydrogenase.
  Journal
J. Am. Chem. Soc. 76 (1954) 3355-3356.
Reference
2
  Authors
Tagawa, K. and Arnon, D.I.
  Title
Ferredoxin as electron carriers in photosynthesis and in the bioogical production and consumption of hydrogen gas.
  Journal
Nature (Lond.) 195 (1962) 537-543.
Reference
3
  Authors
Valentine, R.C., Mortenson, L.E. and Carnahan, J.E.
  Title
The hydrogenase system of Clostridium pasteurianum.
  Journal
J. Biol. Chem. 238 (1963) 1141-1144.
Reference
4  [PMID:164247]
  Authors
Zumft WG, Mortenson LE.
  Title
The nitrogen-fixing complex of bacteria.
  Journal
Biochim. Biophys. Acta. 416 (1975) 1-52.
  Organism
Clostridium pasteurianum
Reference
5  [PMID:2173950]
  Authors
Adams MW.
  Title
The structure and mechanism of iron-hydrogenases.
  Journal
Biochim. Biophys. Acta. 1020 (1990) 115-45.
  Organism
Desulfovibrio vulgaris, Clostridium pasteurianum, Megasphaera elsdenii
Reference
6  [PMID:9836629]
  Authors
Peters JW, Lanzilotta WN, Lemon BJ, Seefeldt LC.
  Title
X-ray crystal structure of the Fe-only hydrogenase (CpI) from Clostridium pasteurianum to 1.8 angstrom resolution.
  Journal
Science. 282 (1998) 1853-8.
  Organism
Clostridium pasteurianum
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9027-05-8
DBGET integrated database retrieval system