KEGG   ENZYME: 1.13.11.8Help
Entry
EC 1.13.11.8                Enzyme                                 

Name
protocatechuate 4,5-dioxygenase;
protocatechuate 4,5-oxygenase;
protocatechuic 4,5-dioxygenase;
protocatechuic 4,5-oxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)
Reaction(IUBMB)
protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde [RN:R01632]
Reaction(KEGG)
Substrate
protocatechuate [CPD:C00230];
O2 [CPD:C00007]
Product
4-carboxy-2-hydroxymuconate semialdehyde [CPD:C04484]
Comment
Requires Fe2+.
History
EC 1.13.11.8 created 1965 as EC 1.13.1.8, transferred 1972 to EC 1.13.11.8
Pathway
Benzoate degradation
Polycyclic aromatic hydrocarbon degradation
Aminobenzoate degradation
Microbial metabolism in diverse environments
Orthology
K04100  
protocatechuate 4,5-dioxygenase, alpha chain
K04101  
protocatechuate 4,5-dioxygenase, beta chain
Genes
XCC: 
XCC0804(pcaH) XCC0805(ligA)
XCB: 
XCA: 
XCP: 
XCV: 
XCV0913(ligB) XCV0914(ligA)
XAC: 
XAC0878(pcaH) XAC0879(ligA)
XCI: 
XAX: 
XAO: 
XOO: 
XOO3734(pcaH)
XOM: 
XOP: 
XOR: 
XFU: 
VEJ: 
PPUT: 
AVN: 
AVL: 
AVD: 
PAT: 
ALT: 
TTU: 
CSA: 
MMW: 
MME: 
MPC: 
RPJ: 
BPH: 
BGE: 
BGF: 
BPX: 
PPK: 
PPNO: 
PRB: 
CDN: 
RFR: 
PNA: 
ACK: 
VEI: 
DAC: 
DEL: 
CTT: 
CTES: 
RTA: 
LCH: 
AZO: 
azo2522(ligB1) azo2523(ligA1) azo2537(ligB2) azo2538(ligA2)
DAR: 
ARA: 
RTR: 
NGL: 
BRA: 
BBT: 
AOL: 
RPA: 
RPA1006 RPA1007(mhpB) RPA4701(ligA) RPA4702(ligB)
RPB: 
RPD: 
RPE: 
RPT: 
RPX: 
BSB: 
HBA: 
NAR: 
NPP: 
SCH: 
SSY: 
MAG: 
ABS: 
TMO: 
APB: 
SRO: 
NML: 
BSD: 
MMAR: 
SVI: 
AMQ: 
PDX: 
AMS: 
ACTN: 
AFS: 
AFO: 
PYR: 
POG: 
 » show all
Taxonomy
Reference
1
  Authors
Trippett, S., Dagley, S. and Stopher, D.A.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
Biochem. J. 76 (1960) 9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9029-56-5

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