KEGG   ENZYME: 1.13.11.8Help
Entry
EC 1.13.11.8                Enzyme                                 

Name
protocatechuate 4,5-dioxygenase;
protocatechuate 4,5-oxygenase;
protocatechuic 4,5-dioxygenase;
protocatechuic 4,5-oxygenase
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
BRITE hierarchy
Sysname
protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)
Reaction(IUBMB)
protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde [RN:R01632]
Reaction(KEGG)
Substrate
protocatechuate [CPD:C00230];
O2 [CPD:C00007]
Product
4-carboxy-2-hydroxymuconate semialdehyde [CPD:C04484]
Comment
Requires Fe2+.
Pathway
Benzoate degradation
Polycyclic aromatic hydrocarbon degradation
Aminobenzoate degradation
Microbial metabolism in diverse environments
Orthology
K04100  
protocatechuate 4,5-dioxygenase, alpha chain
K04101  
protocatechuate 4,5-dioxygenase, beta chain
Genes
XCC: 
XCC0804(pcaH) XCC0805(ligA)
XCB: 
XCA: 
XCV: 
XCV0913(ligB) XCV0914(ligA)
XCP: 
XAC: 
XAC0878(pcaH) XAC0879(ligA)
XAX: 
XAO: 
XOO: 
XOO3734(pcaH)
XOM: 
XOP: 
XOR: 
XCI: 
VEJ: 
PPUT: 
AVN: 
AVL: 
AVD: 
PAT: 
ALT: 
TTU: 
CSA: 
MMW: 
MME: 
MPC: 
BPH: 
BGE: 
BGF: 
BPX: 
PPK: 
PRB: 
RFR: 
PNA: 
ACK: 
VEI: 
DAC: 
DEL: 
CTT: 
RTA: 
LCH: 
AZO: 
azo2522(ligB1) azo2523(ligA1) azo2537(ligB2) azo2538(ligA2)
DAR: 
ARA: 
RTR: 
BRA: 
BBT: 
RPA: 
RPA1006 RPA1007(mhpB) RPA4701(ligA) RPA4702(ligB)
RPB: 
RPD: 
RPE: 
RPT: 
RPX: 
AOL: 
BSB: 
HBA: 
NAR: 
NPP: 
SCH: 
SSY: 
MAG: 
ABS: 
TMO: 
APB: 
SRO: 
NML: 
BSD: 
MMAR: 
SVI: 
PDX: 
AMS: 
ACTN: 
AFS: 
AFO: 
PYR: 
POG: 
 » show all
Taxonomy
Reference
1
  Authors
Trippett, S., Dagley, S. and Stopher, D.A.
  Title
The bacterial oxidation of nicotinic acid.
  Journal
Biochem. J. 76 (1960) 9.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9029-56-5

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