KEGG   ENZYME: 1.14.15.4Help
Entry
EC 1.14.15.4                Enzyme                                 

Name
steroid 11beta-monooxygenase;
steroid 11beta-hydroxylase;
steroid 11beta/18-hydroxylase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
steroid,reduced-adrenodoxin:oxygen oxidoreductase (11beta-hydroxylating)
Reaction(IUBMB)
a steroid + reduced adrenodoxin + O2 = an 11beta-hydroxysteroid + oxidized adrenodoxin + H2O [RN:R02726]
Reaction(KEGG)
Substrate
steroid [CPD:C00377];
reduced adrenodoxin [CPD:C00662];
O2 [CPD:C00007]
Product
11beta-hydroxysteroid [CPD:C01058];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]
Comment
A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone.
History
EC 1.14.15.4 created 1961 as EC 1.99.1.7, transferred 1965 to EC 1.14.1.6, transferred 1972 to EC 1.14.15.4, modified 1989
Pathway
Steroid hormone biosynthesis
Metabolic pathways
Orthology
K00497  
steroid 11beta-monooxygenase
K07433  
steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Genes
HSA: 
1584(CYP11B1) 1585(CYP11B2)
PTR: 
PPS: 
GGO: 
PON: 
MCC: 
695793(CYP11B1) 695914(CYP11B2)
MCF: 
MMU: 
110115(Cyp11b1) 13072(Cyp11b2)
RNO: 
24294(Cyp11b2) 353498(Cyp11b3) 500892(Cyp11b1)
CGE: 
HGL: 
TUP: 
CFA: 
482071(CYP11B2)
AML: 
FCA: 
BTA: 
282422(CYP11B1)
BOM: 
PHD: 
CHX: 
CFR: 
ECB: 
MDO: 
SHR: 
OAA: 
PHI: 
FPG: 
FCH: 
ASN: 
ACS: 
XTR: 
DRE: 
791124(cyp11c1)
TRU: 
MZE: 
OLA: 
100125822(cyp11b)
XMA: 
LCM: 
 » show all
Taxonomy
Reference
1  [PMID:13276417]
  Authors
GRANT JK, BROWNIE AC.
  Title
The role of fumarate and TPN in steroid enzymic 11beta-hydroxylation.
  Journal
Biochim. Biophys. Acta. 18 (1955) 433-4.
Reference
2  [PMID:13211659]
  Authors
HAYANO M, DORFMAN RI.
  Title
On the mechanism of the C11 beta-hydroxylation of steroids.
  Journal
J. Biol. Chem. 211 (1954) 227-35.
  Organism
Bos taurus [GN:bta]
Reference
3  [PMID:13426185]
  Authors
TOMKINS GM, MICHAEL PJ, CURRAN JF.
  Title
Studies on the nature of steroid 11-beta hydroxylation.
  Journal
Biochim. Biophys. Acta. 23 (1957) 655-6.
  Organism
Bos taurus [GN:bta], Oryctolagus cuniculus
Reference
4  [PMID:3485096]
  Authors
Yanagibashi K, Haniu M, Shively JE, Shen WH, Hall P.
  Title
The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.
  Journal
J. Biol. Chem. 261 (1986) 3556-62.
  Organism
Bos taurus [GN:bta], Sus scofa [GN:ssc]
Reference
5  [PMID:4967077]
  Authors
Zuidweg MH.
  Title
Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata.
  Journal
Biochim. Biophys. Acta. 152 (1968) 144-58.
  Organism
Curvularia lunata
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9029-66-7

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