KEGG   ENZYME: 1.14.15.5Help
Entry
EC 1.14.15.5                Enzyme                                 
Name
corticosterone 18-monooxygenase;
corticosterone 18-hydroxylase;
corticosterone methyl oxidase
Class
Oxidoreductases;
Acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
corticosterone,reduced-adrenodoxin:oxygen oxidoreductase (18-hydroxylating)
Reaction(IUBMB)
corticosterone + reduced adrenodoxin + O2 = 18-hydroxycorticosterone + oxidized adrenodoxin + H2O [RN:R03262]
Reaction(KEGG)
R03262;
(other) R03263
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Substrate
corticosterone [CPD:C02140];
reduced adrenodoxin [CPD:C00662];
O2 [CPD:C00007]
Product
18-hydroxycorticosterone [CPD:C01124];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001]
Pathway
Steroid hormone biosynthesis
Metabolic pathways
Orthology
K07433  
cytochrome P450, family 11, subfamily B2 (steroid 11beta-monooxygenase / corticosterone 18-monooxygenase)
Genes
HSA: 
1585(CYP11B2)
PTR: 
PPS: 
MCC: 
695914(CYP11B2)
MMU: 
110115(Cyp11b1)
RNO: 
500892(Cyp11b1)
Taxonomy
Reference
1  [PMID:4381410]
  Authors
Raman PB, Sharma DC, Dorfman RI.
  Title
Studies on aldosterone biosynthesis in vitro.
  Journal
Biochemistry. 5 (1966) 1795-804.
  Organism
Bos taurus [GN:bta], Cavia porcellus, Ovis aries
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-75-0
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