KEGG   ENZYME: 1.14.99.1Help
Entry
EC 1.14.99.1                Enzyme                                 

Name
prostaglandin-endoperoxide synthase;
prostaglandin synthase;
prostaglandin G/H synthase;
(PG)H synthase;
PG synthetase;
prostaglandin synthetase;
fatty acid cyclooxygenase;
prostaglandin endoperoxide synthetase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
BRITE hierarchy
Sysname
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
Reaction(IUBMB)
arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O [RN:R01599]
Reaction(KEGG)
R01599;
(other) R00073 R01590
Show
Substrate
arachidonate [CPD:C00219];
AH2 [CPD:C00030];
O2 [CPD:C00007]
Product
prostaglandin H2 [CPD:C00427];
A [CPD:C00028];
H2O [CPD:C00001]
Comment
This enzyme acts both as a dioxygenase and as a peroxidase.
History
EC 1.14.99.1 created 1972, modified 1990
Pathway
Arachidonic acid metabolism
Metabolic pathways
Orthology
K00509  
prostaglandin-endoperoxide synthase 1
K11987  
prostaglandin-endoperoxide synthase 2
Genes
HSA: 
5742(PTGS1) 5743(PTGS2)
PTR: 
464713(PTGS1) 469616(PTGS2)
PPS: 
100985650(PTGS2) 100993705(PTGS1)
GGO: 
101141060(PTGS1) 101146681(PTGS2)
PON: 
100436566(PTGS2) 100437175(PTGS1)
NLE: 
100585600(PTGS1) 100591090(PTGS2)
MCC: 
698213(PTGS1) 716671(PTGS2)
MCF: 
102143028(PTGS2) 102144094(PTGS1)
CJC: 
100393715(PTGS1) 100407639(PTGS2)
MMU: 
19224(Ptgs1) 19225(Ptgs2)
RNO: 
24693(Ptgs1) 29527(Ptgs2)
CGE: 
100751220(Ptgs2) 100770867(Ptgs1)
NGI: 
103726651(Ptgs2) 103734478(Ptgs1)
HGL: 
101698854(Ptgs1) 101704771(Ptgs2)
OCU: 
100009248(PTGS2) 100009407(PTGS1)
TUP: 
102478264(PTGS2) 102497535(PTGS1)
CFA: 
403544(PTGS1) 442942(PTGS2)
AML: 
UMR: 
103668648(PTGS2) 103670355(PTGS1)
FCA: 
100126581(PTGS2) 101092557(PTGS1)
PTG: 
102948685(PTGS2) 102964670(PTGS1)
BTA: 
282022(PTGS1) 282023(PTGS2)
BOM: 
102271174(PTGS2) 102287995(PTGS1)
PHD: 
102319508(PTGS1) 102326874(PTGS2)
CHX: 
100860905(PTGS2) 102170328(PTGS1)
OAS: 
443460(PTGS2) 443551(PTGS1)
SSC: 
397541(PTGS1) 397590(PTGS2)
CFR: 
102507716(PTGS1) 102509586(PTGS2)
BACU: 
102999195(PTGS2) 103003952(PTGS1)
LVE: 
103070077(PTGS1) 103088613(PTGS2)
ECB: 
100034087(PTGS1) 791253(PTGS2)
MYB: 
102259554(PTGS1) 102259598(PTGS2)
MYD: 
102755037(PTGS1) 102774808(PTGS2)
PALE: 
102886561(PTGS2) 102889003(PTGS1)
MDO: 
SHR: 
100914094(PTGS1) 100926756(PTGS2)
OAA: 
100081492(PTGS1) 100086096(PTGS2)
GGA: 
396451(PTGS2) 427752(PTGS1)
MGP: 
APLA: 
101790135(PTGS2) 101798526(PTGS1)
TGU: 
100221909(PTGS2) 100226968(PTGS1)
FAB: 
101806256(PTGS1) 101816125(PTGS2)
PHI: 
102105209(PTGS2) 102109794(PTGS1)
FPG: 
101918755(PTGS2) 101919862(PTGS1)
FCH: 
102046609(PTGS1) 102050356(PTGS2)
CLV: 
102088222(PTGS1) 102088650(PTGS2)
ASN: 
102369126(PTGS2) 102386481(PTGS1)
AMJ: 
102567925(PTGS2) 102569562(PTGS1)
PSS: 
CMY: 
102933336(PTGS1) 102934690(PTGS2)
ACS: 
100558584(ptgs1) 100560130(ptgs2)
PBI: 
103060436(PTGS1) 103063043(PTGS2)
XLA: 
100037245(ptgs1) 446781(ptgs2)
XTR: 
100493073(ptgs1) 595089(ptgs2)
DRE: 
246226(ptgs1) 246227(ptgs2a) 559020(ptgs2b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102352257(PTGS2) 102361862(PTGS1)
CMK: 
103179983(ptgs2) 103184666(ptgs1)
BFO: 
CIN: 
API: 
PHU: 
LGI: 
NCR: 
MGR: 
FGR: 
SSL: 
BFU: 
TML: 
PPL: 
NEU: 
NE1240(Ptgs1)
MET: 
MNO: 
RSH: 
RSK: 
RDE: 
MVA: 
SRO: 
GOB: 
NPU: 
 » show all
Taxonomy
Reference
1  [PMID:3125548]
  Authors
DeWitt DL, Smith WL.
  Title
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 85 (1988) 1412-6.
  Sequence
[up:P05979]
Reference
2  [PMID:104998]
  Authors
Ohki S, Ogino N, Yamamoto S, Hayaishi O.
  Title
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.
  Journal
J. Biol. Chem. 254 (1979) 829-36.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
39391-18-9

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