KEGG   ENZYME: 1.2.1.75Help
Entry
EC 1.2.1.75                 Enzyme                                 

Name
malonyl-CoA reductase (malonate semialdehyde-forming);
NADP-dependent malonyl CoA reductase;
malonyl CoA reductase (NADP);
malonyl CoA reductase (malonate semialdehyde-forming)
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
malonate semialdehyde:NADP+ oxidoreductase (malonate semialdehyde-forming)
Reaction(IUBMB)
malonate semialdehyde + CoA + NADP+ = malonyl-CoA + NADPH + H+ [RN:R00740]
Reaction(KEGG)
Substrate
malonate semialdehyde [CPD:C00222];
CoA [CPD:C00010];
NADP+ [CPD:C00006]
Product
malonyl-CoA [CPD:C00083];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Requires Mg2+. Catalyses the reduction of malonyl-CoA to malonate semialdehyde, a key step in the 3-hydroxypropanoate and the 3-hydroxypropanoate/4-hydroxybutanoate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and some thermoacidophilic archaea, respectively [1,2]. The enzyme from Sulfolobus tokodaii has been purified, and found to contain one RNA molecule per two subunits [3]. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the next reaction in the pathway, EC 1.1.1.298 [3-hydroxypropionate dehydrogenase (NADP+)] [4].
History
EC 1.2.1.75 created 2009
Pathway
Propanoate metabolism
Carbon fixation pathways in prokaryotes
Metabolic pathways
Orthology
K14468  
malonyl-CoA reductase / 3-hydroxypropionate dehydrogenase (NADP+)
K15017  
malonyl-CoA/succinyl-CoA reductase (NADPH)
Genes
CTM: 
RRS: 
RCA: 
CAU: 
CAG: 
CHL: 
SSO: 
SSO2178(asd-2)
SOL: 
STO: 
SAI: 
SACN: 
SACR: 
SIS: 
SIA: 
SIM: 
SID: 
SIY: 
SIN: 
SII: 
SIH: 
SIR: 
SIC: 
MSE: 
MCN: 
AHO: 
 » show all
Taxonomy
Reference
1  [PMID:8354269]
  Authors
Strauss G, Fuchs G
  Title
Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle.
  Journal
Eur. J. Biochem. 215 (1993) 633-43.
Reference
2  [PMID:18079405]
  Authors
Berg IA, Kockelkorn D, Buckel W, Fuchs G
  Title
A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea.
  Journal
Science. 318 (2007) 1782-6.
  Organism
Metallosphaera sedula
  Sequence
[mse:Msed_0709]
Reference
3  [PMID:17041055]
  Authors
Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hugler M, Fuchs G
  Title
Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp.
  Journal
J. Bacteriol. 188 (2006) 8551-9.
  Organism
Metallosphaera sedula, Sulfolobus tokodaii
  Sequence
[mse:Msed_0709] [sto:ST2171]
Reference
4  [PMID:11948153]
  Authors
Hugler M, Menendez C, Schagger H, Fuchs G
  Title
Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation.
  Journal
J. Bacteriol. 184 (2002) 2404-10.
  Organism
Chloroflexus aurantiacus
  Sequence
[cau:Caur_2614]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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