KEGG   ENZYME: 1.20.4.3Help
Entry
EC 1.20.4.3                 Enzyme                                 

Name
mycoredoxin;
Mrx1;
MrxI
Class
Oxidoreductases;
Acting on phosphorus or arsenic in donors;
With disulfide as acceptor
BRITE hierarchy
Sysname
arseno-mycothiol:mycoredoxin oxidoreductase
Reaction(IUBMB)
arseno-mycothiol + mycoredoxin = arsenite + mycothiol-mycoredoxin disulfide
Substrate
arseno-mycothiol;
mycoredoxin
Product
arsenite [CPD:C06697];
mycothiol-mycoredoxin disulfide
Comment
Reduction of arsenate is part of a defense mechanism of the cell against toxic arsenate. The substrate arseno-mycothiol is formed by EC 2.8.4.2 (arsenate:mycothiol transferase). A second mycothiol recycles mycoredoxin and forms mycothione.
History
EC 1.20.4.3 created 2010
Reference
1  [PMID:19286650]
  Authors
Ordonez E, Van Belle K, Roos G, De Galan S, Letek M, Gil JA, Wyns L, Mateos LM, Messens J
  Title
Arsenate reductase, mycothiol, and mycoredoxin concert thiol/disulfide exchange.
  Journal
J. Biol. Chem. 284 (2009) 15107-16.
  Organism
Corynebacterium glutamicum
  Sequence
[cgl:NCgl0808]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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