KEGG   ENZYME: 1.3.1.74Help
Entry
EC 1.3.1.74                 Enzyme                                 
Name
2-alkenal reductase;
NAD(P)H-dependent alkenal/one oxidoreductase;
NADPH:2-alkenal alpha,beta-hydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
n-alkanal:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+ [RN:R07349 R07350]
Reaction(KEGG)
Substrate
n-alkanal [CPD:C15596];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
alk-2-enal [CPD:C15597];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Highly specific for 4-hydroxynon-2-enal and non-2-enal. 2-Alkenals of shorter chain have lower affinities. Exhibits high activities also for 2-alkenones such as but-3-en-2-one and pent-3-en-2-one. Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. Involved in the detoxication of alpha,beta-unsaturated aldehydes and ketones.
Orthology
K08070  
2-alkenal reductase
K13948  
prostaglandin reductase 1
Genes
HSA: 
22949(PTGR1)
PTR: 
740274(PTGR1)
PPS: 
100979208(PTGR1)
GGO: 
101147031(PTGR1)
PON: 
100461388(PTGR1)
MCC: 
708725(LTB4DH)
MMU: 
67103(Ptgr1)
RNO: 
192227(Ptgr1)
CFA: 
474802(PTGR1)
AML: 
FCA: 
101093468(PTGR1)
BTA: 
513177(PTGR1)
SSC: 
397678(PTGR1)
ECB: 
100058059
MDO: 
100017288
SHR: 
100920365
OAA: 
100092763
GGA: 
427337(PTGR1)
MGP: 
100540778
TGU: 
100229401
ACS: 
100559950
XLA: 
446864(ptgr1.2) 495998(ptgr1.1)
XTR: 
100135160(ptgr1.2) 100485344 493462(ltb4dh)
DRE: 
494108(ptgr1)
TRU: 
101078055
OLA: 
101158478
BFO: 
BRAFLDRAFT_115255 BRAFLDRAFT_90405
CIN: 
100179413 100182376
SPU: 
585482 589330 762500
AGA: 
AgaP_AGAP000288 AgaP_AGAP000414
AAG: 
AaeL_AAEL012455 AaeL_AAEL012457 AaeL_AAEL015034
CQU: 
CpipJ_CPIJ003801 CpipJ_CPIJ003802 CpipJ_CPIJ014058
AME: 
411378
NVI: 
100119006(NV17112) 100120078(NV14581)
TCA: 
657348
API: 
100162222
TSP: 
Tsp_01072
HMG: 
100199266
TAD: 
TRIADDRAFT_28673
AQU: 
100637260 100638523
ATH: 
AT1G26320 AT1G65560 AT3G03080 AT3G59845 AT5G16960 AT5G16970(AER) AT5G16980 AT5G16990 AT5G17000 AT5G37940 AT5G37980 AT5G38000
ALY: 
ARALYDRAFT_661540 ARALYDRAFT_671051 ARALYDRAFT_894134 ARALYDRAFT_909685 ARALYDRAFT_909687
SSE: 
Ssed_0744
BUR: 
Bcep18194_B1551 Bcep18194_B1574
LCH: 
Lcho_2947
RPT: 
Rpal_3736
MEX: 
Mext_4798
MCH: 
Mchl_5265
MRD: 
Mrad2831_0793
MET: 
M446_3040
MPO: 
Mpop_5341
ACR: 
Acry_1324
SAH: 
SaurJH1_1668
SAJ: 
SaurJH9_1634
CTH: 
Cthe_0150
CDF: 
CD630_24480
CST: 
CLOST_2551
AMT: 
Amet_3044
CSC: 
Csac_1847 Csac_2307
FJO: 
Fjoh_0019 Fjoh_5039
DEB: 
DehaBAV1_0919 DehaBAV1_1096
RRS: 
RoseRS_2119 RoseRS_3025 RoseRS_3714
RCA: 
Rcas_1750 Rcas_2149 Rcas_3537
CAU: 
Caur_2204 Caur_2693
CAG: 
Cagg_0935 Cagg_2913
CHL: 
Chy400_2375 Chy400_2910
HAU: 
Haur_0347 Haur_3226
STI: 
Sthe_0612
NMR: 
Nmar_1146
 » show all
Taxonomy
Reference
1  [PMID:12514241]
  Authors
Mano J, Torii Y, Hayashi S, Takimoto K, Matsui K, Nakamura K, Inze D, Babiychuk E, Kushnir S, Asada K.
  Title
The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes.
  Journal
Plant. Cell. Physiol. 43 (2002) 1445-55.
  Organism
Arabidopsis thaliana [GN:ath]
Reference
2  [PMID:11524419]
  Authors
Dick RA, Kwak MK, Sutter TR, Kensler TW.
  Title
Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase.
  Journal
J. Biol. Chem. 276 (2001) 40803-10.
  Organism
Rattus norvegicus [GN:rno]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52227-95-9
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