KEGG   ENZYME: 1.3.1.74Help
Entry
EC 1.3.1.74                 Enzyme                                 

Name
2-alkenal reductase [NAD(P)+];
NAD(P)H-dependent alkenal/one oxidoreductase;
NADPH:2-alkenal alpha,beta-hydrogenase;
2-alkenal reductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
n-alkanal:NAD(P)+ 2-oxidoreductase
Reaction(IUBMB)
a n-alkanal + NAD(P)+ = an alk-2-enal + NAD(P)H + H+ [RN:R07349 R07350]
Reaction(KEGG)
Substrate
n-alkanal [CPD:C15596];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
alk-2-enal [CPD:C15597];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Highly specific for 4-hydroxynon-2-enal and non-2-enal. Alk-2-enals of shorter chain have lower affinities. Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one. Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid. Involved in the detoxication of alpha,beta-unsaturated aldehydes and ketones [cf. EC 1.3.1.102, 2-alkenal reductase (NADP+)].
History
EC 1.3.1.74 created 2003, modified 2014
Orthology
K08070  
2-alkenal reductase
K13948  
prostaglandin reductase 1
Genes
HSA: 
22949(PTGR1)
PTR: 
740274(PTGR1)
PPS: 
100979208(PTGR1)
GGO: 
101147031(PTGR1)
PON: 
100461388(PTGR1)
MCC: 
708725(LTB4DH)
MCF: 
MMU: 
67103(Ptgr1)
RNO: 
192227(Ptgr1)
CGE: 
100756865(Ptgr1)
HGL: 
101699930(Ptgr1)
TUP: 
102470772(PTGR1)
CFA: 
474802(PTGR1)
AML: 
FCA: 
101093468(PTGR1)
PTG: 
102969809(PTGR1)
BTA: 
513177(PTGR1)
BOM: 
102271298(PTGR1)
PHD: 
102315207(PTGR1)
CHX: 
102190414(PTGR1)
OAS: 
101112113(PTGR1)
SSC: 
397678(PTGR1)
CFR: 
102522787(PTGR1)
BACU: 
103020505(PTGR1)
LVE: 
103090270(PTGR1)
ECB: 
100058059(PTGR1)
MYB: 
102257971(PTGR1)
MYD: 
102763537(PTGR1)
PALE: 
102892647(PTGR1)
MDO: 
SHR: 
OAA: 
100092763(PTGR1)
GGA: 
427337(PTGR1)
MGP: 
TGU: 
FAB: 
101819125(PTGR1)
PHI: 
APLA: 
101802303(PTGR1)
FPG: 
FCH: 
CLV: 
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CMY: 
ACS: 
PBI: 
XLA: 
446864(ptgr1.2) 495998(ptgr1.1)
XTR: 
100135160(ptgr1.2) 100485344 493462(ltb4dh)
DRE: 
494108(ptgr1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103187214(ptgr1)
BFO: 
CIN: 
SPU: 
AGA: 
AAG: 
CQU: 
AME: 
411378(GB17125)
NVI: 
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HMG: 
TAD: 
AQU: 
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BUR: 
LCH: 
RPT: 
MEX: 
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MRD: 
MET: 
MPO: 
ACR: 
SAH: 
SAJ: 
AMT: 
CTH: 
CDF: 
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Taxonomy
Reference
1  [PMID:12514241]
  Authors
Mano J, Torii Y, Hayashi S, Takimoto K, Matsui K, Nakamura K, Inze D, Babiychuk E, Kushnir S, Asada K.
  Title
The NADPH:quinone oxidoreductase P1-zeta-crystallin in Arabidopsis catalyzes the alpha,beta-hydrogenation of 2-alkenals: detoxication of the lipid peroxide-derived reactive aldehydes.
  Journal
Plant. Cell. Physiol. 43 (2002) 1445-55.
  Organism
Arabidopsis thaliana
Reference
2  [PMID:11524419]
  Authors
Dick RA, Kwak MK, Sutter TR, Kensler TW.
  Title
Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase.
  Journal
J. Biol. Chem. 276 (2001) 40803-10.
  Organism
Rattus norvegicus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
52227-95-9

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