KEGG   ENZYME: 1.5.1.6Help
Entry
EC 1.5.1.6                  Enzyme                                 
Name
formyltetrahydrofolate dehydrogenase;
10-formyl tetrahydrofolate:NADP oxidoreductase;
10-formyl-H2PtGlu:NADP oxidoreductase ;
10-formyl-H4folate dehydrogenase;
N10-formyltetrahydrofolate dehydrogenase ;
10-formyltetrahydrofolate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
10-formyltetrahydrofolate:NADP+ oxidoreductase
Reaction(IUBMB)
10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH + H+ [RN:R00941]
Reaction(KEGG)
Substrate
10-formyltetrahydrofolate [CPD:C00234];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
tetrahydrofolate [CPD:C00101];
CO2 [CPD:C00011];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Pathway
One carbon pool by folate
Orthology
K00289  
formyltetrahydrofolate dehydrogenase
Genes
HSA: 
10840(ALDH1L1) 160428(ALDH1L2)
PTR: 
452195(ALDH1L2) 460655(ALDH1L1)
PPS: 
100978685(ALDH1L2) 100989341(ALDH1L1)
GGO: 
101134299(ALDH1L1) 101139377(ALDH1L2)
PON: 
100189626(ALDH1L1) 100459691(ALDH1L2)
MCC: 
701242(ALDH1L2) 716977(ALDH1L1)
MMU: 
107747(Aldh1l1) 216188(Aldh1l2)
RNO: 
299699(Aldh1l2) 64392(Aldh1l1)
CFA: 
474534(ALDH1L2) 476506(ALDH1L1)
AML: 
100476798(ALDH1L2)
FCA: 
101088592(ALDH1L2) 101091432(ALDH1L1)
BTA: 
505677(ALDH1L1) 516864(ALDH1L2)
SSC: 
100151976(ALDH1L2) 100622210(ALDH1L1)
ECB: 
100053705(ALDH1L2) 100061108
MDO: 
100022528(ALDH1L2)
SHR: 
100918967(ALDH1L1) 100922488(ALDH1L2)
OAA: 
100074128(ALDH1L2)
GGA: 
100857360 418078(ALDH1L2)
MGP: 
100545356(ALDH1L2)
TGU: 
100230131(ALDH1L2)
ACS: 
100552265(aldh1l2)
XLA: 
444321(aldh1l1)
XTR: 
100127737(aldh1l2) 496436(aldh1l1)
DRE: 
100333269(aldh1l2) 100526683(aldh1l1)
TRU: 
101063025 101078185
OLA: 
101167504 101174660
BFO: 
BRAFLDRAFT_290865
CIN: 
100184767(aldh1l2)
SPU: 
579576(ALDH1L2)
DME: 
Dmel_CG8665
DPO: 
Dpse_GA21245
DAN: 
Dana_GF14331
DER: 
Dere_GG21301
DPE: 
Dper_GL26664
DSE: 
Dsec_GM23412
DSI: 
Dsim_GD24321
DWI: 
Dwil_GK18741
DYA: 
Dyak_GE12917
DGR: 
Dgri_GH13317
DMO: 
Dmoj_GI12253
DVI: 
Dvir_GJ17852
AGA: 
AgaP_AGAP009591
AAG: 
AaeL_AAEL010764
CQU: 
CpipJ_CPIJ011996
AME: 
551401(ALDH1L2)
NVI: 
100119020(NV10044)
TCA: 
658435
API: 
100164524
CEL: 
CELE_F36H1.6(alh-3)
CBR: 
CBG05984(Cbr-alh-3)
NVE: 
NEMVE_v1g200699
TAD: 
TRIADDRAFT_37496
AQU: 
100636359
 » show all
Taxonomy
Reference
1  [PMID:4384443]
  Authors
Kutzbach C, Stokstad EL.
  Title
Partial purification of a 10-formyl-tetrahydrofolate: NADP oxidoreductase from mammalian liver.
  Journal
Biochem. Biophys. Res. Commun. 30 (1968) 111-7.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-25-0
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