KEGG   ENZYME: 1.5.1.7Help
Entry
EC 1.5.1.7                  Enzyme                                 
Name
saccharopine dehydrogenase (NAD+, L-lysine-forming);
lysine-2-oxoglutarate reductase;
dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming);
epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming);
N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming);
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+ [RN:R00715]
Reaction(KEGG)
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
L-lysine [CPD:C00047];
2-oxoglutarate [CPD:C00026];
NADH [CPD:C00004];
H+ [CPD:C00080]
Pathway
Lysine biosynthesis
Lysine degradation
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K00290  
saccharopine dehydrogenase (NAD+, L-lysine forming)
Genes
NVE: 
SCE: 
YIR034C(LYS1)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A08650(NCAS0A08650)
NDI: 
NDAI_0G02840(NDAI0G02840)
TPF: 
TPHA_0N01860(TPHA0N01860)
TDL: 
TDEL_0B07590(TDEL0B07590)
DHA: 
DEHA2C07018g
PIC: 
PICST_86170(LYS1)
PGU: 
PGUG_05365
LEL: 
LELG_05624
CAL: 
CaO19.1790(LYS1) CaO19.9356(LYS1)
CTP: 
CTRG_03875
CDU: 
CD36_44980
YLI: 
YALI0B15444g
CLU: 
CLUG_04507
NCR: 
NCU03118
SMP: 
SMAC_02849
PAN: 
PODANSg5796
TTT: 
THITE_2113543
MTM: 
MYCTH_2088454
MGR: 
MGG_01359
FGR: 
FG10925.1
VAL: 
VDBG_07364
SSL: 
SS1G_06166
BFU: 
BC1G_01354
NFI: 
NFIA_065620
AFM: 
AFUA_3G11710
AOR: 
AOR_1_1290154(AO090003000729)
ANG: 
ANI_1_1044024(An02g07500)
AFV: 
AFLA_030890
ACT: 
ACLA_039590
PCS: 
Pc18g01240
CIM: 
CIMG_00116
CPW: 
CPC735_060200
PBL: 
PAAG_05847
URE: 
UREG_00224
ABE: 
ARB_05726
TVE: 
TRV_03009
AJE: 
HCAG_01145
PNO: 
SNOG_13323
PTE: 
PTT_12058
ZTR: 
MYCGRDRAFT_60912
TML: 
GSTUM_00005842001
SPO: 
SPAC227.18(lys3)
CNE: 
CND06290
CNB: 
CNBD0140
CGI: 
CGB_I0170W
LBC: 
LACBIDRAFT_228788
MPR: 
MPER_10902
CCI: 
CC1G_03693
SCM: 
SCHCODRAFT_64086
UMA: 
UM04268.1
MGL: 
MGL_0554
PGR: 
PGTG_12721
MBR: 
MONBRDRAFT_32342
NGR: 
NAEGRDRAFT_78399
PPR: 
PBPRB1102
PFL: 
PFL_3539(lys1_2)
CJA: 
CJA_1512
SVO: 
SVI_3927
ILO: 
IL1999
PAT: 
Patl_0748
SDE: 
Sde_1597
AMC: 
MADE_1015600
ALT: 
ambt_01855
GAG: 
Glaag_0753
TTU: 
TERTU_1609(lys1)
FTN: 
FTN_0964
GPB: 
HDN1F_21040(LYS1)
BPM: 
BURPS1710b_2269
BPL: 
BURPS1106A_2136(lys1)
BPD: 
BURPS668_2080
BAM: 
Bamb_1645
BXE: 
Bxe_A1992
BGE: 
BC1002_6948
HPY: 
HP1507
HPJ: 
jhp1400
HPA: 
HPAG1_1405
HPS: 
HPSH_07735
HPG: 
HPG27_1431
HPP: 
HPP12_1485
HPB: 
HELPY_1480
HPL: 
HPB8_22(lys1)
HPC: 
HPPC_07395
HPM: 
HPSJM_07690
HHE: 
HH1098
HAC: 
Hac_0077(lys1)
HMS: 
HMU04660
HFE: 
HFELIS_11070
WSU: 
WS0167
TDN: 
Suden_1181
SKU: 
Sulku_1352
CJE: 
Cj0172c
CJJ: 
CJJ81176_0208
CJU: 
C8J_0166
CJN: 
ICDCCJ_166
CJR: 
CJE0165
CJD: 
JJD26997_0186
CFF: 
CFF8240_0285(lys)
CCV: 
CCV52592_0415(lys1)
CHA: 
CHAB381_0061(lys1)
CCO: 
CCC13826_0747(lys1)
CLA: 
Cla_0458
ABU: 
Abu_1706
ANT: 
Arnit_2426
SDL: 
Sdel_2142
NSA: 
Nitsa_1494
NIS: 
NIS_1295
SUN: 
SUN_1368
NAM: 
NAMH_0224(lys)
GSU: 
GSU2539
GME: 
Gmet_0902
GUR: 
Gura_0981
GLO: 
Glov_1676
GBM: 
Gbem_2918
GEO: 
Geob_1676
GEM: 
GM21_1307
PCA: 
Pcar_2095
PPD: 
Ppro_2607
DVU: 
DVU0418(lys1)
DVL: 
Dvul_2516
DVM: 
DvMF_1535
DDE: 
Dde_0572
DDS: 
Ddes_0125
DAS: 
Daes_0893
DBA: 
Dbac_2320
BMX: 
BMS_1042 BMS_3023
DAK: 
DaAHT2_0112
DPR: 
Despr_3035
DAL: 
Dalk_4658
DAT: 
HRM2_01410(lysA1)
MXA: 
MXAN_0831(lys1)
HOH: 
Hoch_6504
SFU: 
Sfum_1922
RLE: 
RL0376
BBK: 
BARBAKC583_0028(lys1)
HDN: 
Hden_1144
CAK: 
Caul_4440
SIL: 
SPO0601 SPO3307
SIT: 
TM1040_0107
RSP: 
RSP_1086(sdh)
RSH: 
Rsph17029_2749
RSQ: 
Rsph17025_2942
RSK: 
RSKD131_2484
JAN: 
Jann_4015
RDE: 
RD1_0698
PDE: 
Pden_2709
HNE: 
HNE_0588(lys1)
HBA: 
Hbal_0824
NAR: 
Saro_1790
SAL: 
Sala_1201
SJP: 
SJA_C1-17240
ELI: 
ELI_04720
MGM: 
Mmc1_1081
DIN: 
Selin_1523
BHA: 
BH3957
BCO: 
Bcell_0577
LSP: 
Bsph_3480
PPY: 
PPE_01639
PPM: 
PPSC2_c1839
SPN: 
SP_0919
SPD: 
SPD_0812(lys1)
SPR: 
spr0820
SPW: 
SPCG_0896
SPX: 
SPG_0845
SNE: 
SPN23F_08430
SPV: 
SPH_1028(lys)
SNM: 
SP70585_0958(lys)
SJJ: 
SPJ_0860(lys)
SPP: 
SPP_0927(lys)
SNT: 
SPT_1280(lys)
SNC: 
HMPREF0837_11566
SNB: 
SP670_1400(lys)
SNP: 
SPAP_0951
SUB: 
SUB1319
SOR: 
SOR_1016
STD: 
SPPN_06435
CBK: 
CLL_A1014
CBT: 
CLH_0948
CBE: 
Cbei_4409
CPY: 
Cphy_3052
CCE: 
Ccel_1128
CSH: 
Closa_0376
DSY: 
DSY3821
DHD: 
Dhaf_1555
SGY: 
Sgly_3179
EEL: 
EUBELI_01424
ERE: 
EUBREC_3343
BPB: 
bpr_I1198
CLE: 
Clole_1553
RHO: 
RHOM_05380
EHA: 
Ethha_0734
RAL: 
Rumal_1234
OVA: 
OBV_12680
CLO: 
HMPREF0868_0009(lys1)
SSG: 
Selsp_1259
AFN: 
Acfer_1887
MAV: 
MAV_1723
MSM: 
MSMEG_4632 MSMEG_6311(lys1)
SMA: 
SAV_1788
SCB: 
SCAB_15871
SEN: 
SACE_1566(lys1)
AMI: 
Amir_3541
SAQ: 
Sare_1048
SSM: 
Spirs_0908
BTH: 
BT_4612
BFR: 
BF1215
BFS: 
BF1182
BVU: 
BVU_2379
BSA: 
Bacsa_1569
PGI: 
PG0677(LYS1)
PGN: 
PGN_0713
PDI: 
BDI_1450
PPN: 
Palpr_2822
OSP: 
Odosp_1637
APS: 
CFPG_304
PRU: 
PRU_0067(lys1)
PMZ: 
HMPREF0659_A5557(lys1)
SRU: 
SRU_1725(lys1) SRU_2554(lys1)
HHY: 
Halhy_6334
CHU: 
CHU_2707(lys)
DFE: 
Dfer_2888
SLI: 
Slin_3519
LBY: 
Lbys_1539
RSI: 
Runsl_3483
FSU: 
Fisuc_0500
LBA: 
Lebu_0786
CAA: 
Caka_0667
AMU: 
Amuc_0148
SYN: 
slr0049
DGE: 
Dgeo_0999
DDR: 
Deide_08910
DDF: 
DEFDS_1287
DAP: 
Dacet_2596
CNI: 
Calni_0886
MPI: 
Mpet_0844
 » show all
Taxonomy
Reference
1  [PMID:4339117]
  Authors
Fujioka M, Nakatani Y.
  Title
Saccharopine dehydrogenase. Interaction with substrate analogues.
  Journal
Eur. J. Biochem. 25 (1972) 301-7.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
2  [PMID:4287986]
  Authors
Saunders PP, Broquist HP.
  Title
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. IV. Saccharopine dehydrogenase.
  Journal
J. Biol. Chem. 241 (1966) 3435-40.
  Organism
Saccharomyces cerevisiae [GN:sce], Neurospora crassa [GN:ncr]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9073-96-5
DBGET integrated database retrieval system