KEGG   ENZYME: 1.6.99.5Help
Entry
EC 1.6.99.5                 Enzyme                                 

Name
NADH dehydrogenase (quinone);
reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase;
NADH-quinone oxidoreductase;
DPNH-menadione reductase;
D-diaphorase;
NADH2 dehydrogenase (quinone)
Class
Oxidoreductases;
Acting on NADH or NADPH;
With other acceptors
BRITE hierarchy
Sysname
NADH:(quinone-acceptor) oxidoreductase
Reaction(IUBMB)
NADH + H+ + acceptor = NAD+ + reduced acceptor [RN:R00281]
Reaction(KEGG)
Substrate
NADH [CPD:C00004];
H+ [CPD:C00080];
acceptor [CPD:C00028]
Product
NAD+ [CPD:C00003];
reduced acceptor [CPD:C00030]
Comment
Menaquinone can act as acceptor. Inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives.
History
EC 1.6.99.5 created 1972
Pathway
Oxidative phosphorylation
Orthology
K05903  
NADH dehydrogenase (quinone)
Genes
PSA: 
SFR: 
SSE: 
MCA: 
TCY: 
NOC: 
NHL: 
NWA: 
ALV: 
AEH: 
HHA: 
TGR: 
TKM: 
AFE: 
AFR: 
AFE_2149(hyfB)
REU: 
REH: 
H16_A2196(h16_A2196)
RME: 
Rmet_4300(nuoF) Rmet_4671(hyfB)
BML: 
BMN: 
BPS: 
BPH: 
BGE: 
RFR: 
POL: 
NMU: 
EBA: 
ebA4193(hyfB)
DAR: 
APP: 
GUR: 
PPD: 
DVL: 
DAK: 
ADE: 
ACP: 
AFW: 
ANK: 
SCL: 
sce8744(ndhF2)
RLE: 
pRL110297(hyfB)
BJA: 
blr6339(hyfB)
RPB: 
RPC: 
RPD: 
RPE: 
XAU: 
AZC: 
BID: 
MSL: 
RVA: 
MMR: 
ACR: 
RRU: 
RCE: 
RC1_1420(hyfB)
MAG: 
MGM: 
SLP: 
DAU: 
SGY: 
ADG: 
CSC: 
ATE: 
MJL: 
ASD: 
CEF: 
ART: 
SKE: 
NCA: 
ACE: 
PDX: 
STP: 
SAQ: 
RXY: 
ELE: 
OTE: 
MIN: 
Minf_0510(hyfB)
DEB: 
TRA: 
MSV: 
DIN: 
MHU: 
MEM: 
MPI: 
MBN: 
MPL: 
RCI: 
SMR: 
 » show all
Taxonomy
Reference
1  [PMID:4388793]
  Authors
Koli AK, Yearby C, Scott W, Donaldson KO.
  Title
Purification and properties of three separate menadione reductases from hog liver.
  Journal
J. Biol. Chem. 244 (1969) 621-9.
  Organism
Sus scofa
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37256-36-3

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