KEGG   ENZYME: 1.8.1.12Help
Entry
EC 1.8.1.12                 Enzyme                                 

Name
trypanothione-disulfide reductase;
trypanothione reductase;
NADPH2:trypanothione oxidoreductase
Class
Oxidoreductases;
Acting on a sulfur group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
trypanothione:NADP+ oxidoreductase
Reaction(IUBMB)
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ [RN:R03821]
Reaction(KEGG)
R03821;
(other) R08356 R08357
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Substrate
trypanothione [CPD:C02090];
NADP+ [CPD:C00006]
Product
trypanothione disulfide [CPD:C03170];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Trypanothione disulfide is the oxidized form of N1,N8-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. The enzyme from Crithidia fasciculata is a flavoprotein (FAD), whose activity is dependent on a redox-active cystine at the active centre. (cf. EC 1.8.1.7, glutathione-disulfide reductase)
History
EC 1.8.1.12 created 1989 as EC 1.6.4.8, transferred 2002 to EC 1.8.1.12
Pathway
Glutathione metabolism
Metabolic pathways
Orthology
K04283  
trypanothione-disulfide reductase
Genes
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
Taxonomy
Reference
1  [PMID:3718941]
  Authors
Shames SL, Fairlamb AH, Cerami A, Walsh CT.
  Title
Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases.
  Journal
Biochemistry. 25 (1986) 3519-26.
  Sequence
[up:P39040]
Reference
2  [PMID:9057833]
  Authors
Marsh IR, Bradley M.
  Title
Substrate specificity of trypanothione reductase.
  Journal
Eur. J. Biochem. 243 (1997) 690-4.
Reference
3  [PMID:7607216]
  Authors
Cunningham ML, Fairlamb AH.
  Title
Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials.
  Journal
Eur. J. Biochem. 230 (1995) 460-8.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
102210-35-5

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