KEGG   ENZYME: 2.1.1.43Help
Entry
EC 2.1.1.43                 Enzyme                                 

Name
histone-lysine N-methyltransferase;
protein methylase III;
protein methylase 3;
protein (lysine) methyltransferase;
protein methyltransferase II;
protein-lysine N-methyltransferase;
histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase;
S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine [RN:R03938]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
histone L-lysine
Product
S-adenosyl-L-homocysteine [CPD:C00021];
histone N6-methyl-L-lysine [CPD:C03702]
Comment
One of a group of enzymes methylating proteins; see also EC 2.1.1.59, [cytochrome-c]-lysine N-methyltransferase and EC 2.1.1.60, calmodulin-lysine N-methyltransferase.
Pathway
Lysine degradation
Orthology
K06101  
histone-lysine N-methyltransferase ASH1L
K09186  
histone-lysine N-methyltransferase MLL1
K09187  
histone-lysine N-methyltransferase MLL2
K09188  
histone-lysine N-methyltransferase MLL3
K09189  
histone-lysine N-methyltransferase MLL5
K11419  
histone-lysine N-methyltransferase SUV39H
K11420  
euchromatic histone-lysine N-methyltransferase
K11421  
histone-lysine N-methyltransferase SETDB
K11422  
histone-lysine N-methyltransferase SETD1
K11423  
histone-lysine N-methyltransferase SETD2
K11424  
histone-lysine N-methyltransferase NSD2
K11425  
histone-lysine N-methyltransferase NSD3
K11427  
histone-lysine N-methyltransferase, H3 lysine-79 specific
K11428  
histone-lysine N-methyltransferase SETD8
K11429  
histone-lysine N-methyltransferase SUV420H
K11430  
enhancer of zeste
K11431  
histone-lysine N-methyltransferase SETD7
K11433  
histone-lysine N-methyltransferase SETMAR
K14959  
histone-lysine N-methyltransferase MLL4
K15588  
histone-lysine N-methyltransferase NSD1
Genes
HSA: 
10919(EHMT2) 2145(EZH1) 2146(EZH2) 23067(SETD1B) 29072(SETD2) 387893(SETD8) 4297(MLL) 51111(SUV420H1) 54904(WHSC1L1) 55870(ASH1L) 55904(MLL5) 58508(MLL3) 6419(SETMAR) 64324(NSD1) 6839(SUV39H1) 7468(WHSC1) 79723(SUV39H2) 79813(EHMT1) 8085(MLL2) 80854(SETD7) 83852(SETDB2) 84444(DOT1L) 84787(SUV420H2) 9739(SETD1A) 9757(MLL4) 9869(SETDB1)
PTR: 
100610362 101058641(ASH1L) 451378(SUV420H1) 451587(MLL) 451873(MLL2) 452343(SETD8) 452719(SETDB2) 454697(EZH1) 455566(DOT1L) 455959 460331(SETD2) 461070(WHSC1) 462572(EHMT2) 463640(MLL5) 463875(MLL3) 464119(WHSC1L1) 464891(EHMT1) 465618 466014(SUV39H2) 468101(SETD1A) 469481(SETDB1) 470738(SETMAR) 471754(NSD1) 473295 735868(SUV420H2) 737682(SETD7) 745437(EZH2)
PPS: 
100967877(EZH1) 100968253(EHMT1) 100969530(DOT1L) 100971244(EZH2) 100972839(SETDB1) 100972983(SETD1A) 100977497(SUV39H1) 100978154 100979249 100979709(ASH1L) 100981554(SETD7) 100982469(SUV39H2) 100982828(MLL5) 100984020(SUV420H2) 100984332(MLL) 100986203(SETMAR) 100986737(SETD8) 100986951(SETDB2) 100989573(WHSC1L1) 100991724(EHMT2) 100991882(NSD1) 100992231(MLL3) 100993006(SETD2) 100993332(WHSC1) 100995372(SUV420H1) 100995808(MLL2)
GGO: 
101124677 101126338(SUV39H2) 101126515(EZH1) 101126745 101127408(WHSC1L1) 101129366(MLL) 101132140(SETD2) 101134264(ASH1L) 101134599(MLL3) 101134931(DOT1L) 101136477(SETD7) 101139439(SUV420H2) 101139808(EHMT2) 101139923 101140725(WHSC1) 101141713(SETDB2) 101143612 101144774(MLL2) 101145513(SETD8) 101146215(SETDB1) 101146540(SUV39H1) 101147968(EZH2) 101150409(SETMAR) 101151252(SUV420H1) 101151843(EHMT1)
PON: 
100171872(EZH1) 100172621(SUV39H1) 100173903(MLL5) 100432076(SETD1A) 100433116(SETD2) 100433878(WHSC1) 100436926(SUV39H2) 100437200 100441102(MLL) 100441715(MLL2) 100447447(EZH2) 100447656(SETMAR) 100449956(SETD7) 100450271(SUV420H1) 100450564(DOT1L) 100450936 100451228(MLL3) 100451760(SETD8) 100459660(WHSC1L1) 100460372(EHMT2) 100461473(NSD1) 100461671(SETDB1)
MCC: 
697233 697378(SUV39H2) 699963(SUV420H2) 700254(WHSC1L1) 700426(SETD7) 703717 703880(SETMAR) 705511(MLL) 706131(NSD1) 706277(SETDB2) 709075(EZH2) 709345(SETD8) 710033(DOT1L) 710481(SUV420H1) 710795(MLL2) 711040(SUV39H1) 711173(EZH1) 711825(SETD2) 712416 712618 715824(EHMT2) 716141(SETDB1) 716753(MLL3) 718835(MLL4) 721470
MMU: 
107823(Whsc1) 110147(Ehmt2) 14055(Ezh1) 14056(Ezh2) 18193(Nsd1) 192195(Ash1l) 208043(Setd1b) 208266(Dot1l) 20937(Suv39h1) 214162(Mll1) 225888(Suv420h1) 231051(Mll3) 232811(Suv420h2) 233904(Setd1a) 234135(Whsc1l1) 235626(Setd2) 239122(Setdb2) 381022(Mll2) 64707(Suv39h2) 67956(Setd8) 69188(Mll5) 73251(Setd7) 74729(Setmar) 75410(Wbp7) 77683(Ehmt1) 84505(Setdb1)
RNO: 
100359816 100361710(Setdb2) 100362634 100909949 288346(RGD1561853) 290831(Whsc1l1) 302553(Suv39h1) 303547(Ezh1) 306764(Nsd1) 308345(Suv420h2) 310638(Ash1l) 311968(Mll5) 312299(Ezh2) 315606(Mll) 316013(Setd2) 361688(Suv420h1) 361798(Ehmt2) 362078(Ehmt1) 362831(Dot1l) 362996(Mll2) 364785(Suv39h2) 500281(Setmar) 502710 680537(Whsc1) 689820(Setd8) 689883(Setdb1) 689954(Setd7)
CFA: 
100684608 100688666(MLL4) 474851(EHMT2) 475511(EZH2) 475584(WHSC1L1) 475895(MLL5) 476079(SETD7) 476549(SETMAR) 476643(SETD2) 477995(SUV39H2) 479077(WHSC1) 479417(MLL) 480128(ASH1L) 480516(EZH1) 483186(SETDB1) 483690(SUV420H1) 484295(SUV420H2) 485073(DOT1L) 485441(SETDB2) 486257(SETD1B) 486558(MLL2) 489094(NSD1) 489916(SETD1A) 491224(EHMT1) 491868(SUV39H1) 610615(SETD8) 611094(MLL3)
AML: 
FCA: 
101083169(WHSC1) 101083571(SUV39H1) 101084095(MLL3) 101084945(MLL5) 101085029(SETD2) 101086008(SETD8) 101086114(ASH1L) 101086901 101087111(EHMT1) 101087309(EZH2) 101088560(SETMAR) 101090288(MLL) 101091070(SETD1A) 101091191(SETD7) 101091322(SUV420H2) 101091940(EHMT2) 101094118(SETDB1) 101094702(SUV420H1) 101095268(MLL2) 101096419 101099218(SUV39H2) 101099602(EZH1) 101100356(SETDB2) 101100618(NSD1) 101101194(DOT1L)
BTA: 
100138100(SETDB1) 506805(MLL2) 508330(MLL) 509106(EZH2) 509382(SETDB2) 510442 511299(SETMAR) 513054(WHSC1L1) 514062(EHMT2) 514102(SETD1B) 515928(SETD7) 519777(SUV420H2) 523047(SUV39H1) 528606(EHMT1) 532622(SETD8) 533087(EZH1) 534913 536936(SUV39H2) 539121(MLL5) 539860(SETD2) 540197(NSD1) 540563(ASH1L) 540769(WHSC1) 767828(SUV420H1) 782887(SETD1A) 785776
SSC: 
ECB: 
100051090(WHSC1) 100051290(EZH2) 100052411(EZH1) 100053438(SUV420H1) 100055743(SUV420H2) 100056120 100057386(ASH1L) 100057692(WHSC1L1) 100058570(NSD1) 100058869(EHMT1) 100058928(MLL5) 100059118(EHMT2) 100059254(SETDB1) 100059905 100060853 100063257 100063523(SETD1A) 100064812 100064888(SETD2) 100068506(DOT1L) 100068891
MDO: 
SHR: 
100913201(NSD1) 100913447(WHSC1) 100913907(WHSC1L1) 100917457(SUV420H1) 100918271(SETMAR) 100918350(DOT1L) 100920575(MLL3) 100922144(MLL5) 100922258 100924557(MLL) 100926678(EZH2) 100927672 100928096 100928575(MLL2) 100928904(SETDB1) 100929066(SUV420H2) 100929261(SETD7) 100929291(SETD1A) 100930822 100931147(EHMT2) 100931585(ASH1L) 100931646(SETD2) 100932535(EZH1) 100932927(EHMT1) 100933547(SETD8) 100933751(SUV39H2) 100934863(SETDB2)
OAA: 
GGA: 
100857640 395847(SETDB1) 414897(MLL) 416214(NSD1) 416825(SETD8) 416851(SETD1B) 417250(EHMT1) 417712(MLL5) 418866(SETDB2) 420023(EZH1) 420078(DOT1L) 420404(SETD2) 420437(MLL3) 420784(EZH2) 422443(SETD7) 422897(WHSC1) 425064(ASH1L) 425119(SUV420H1) 426314(SUV39H2) 426778(WHSC1L1)
MGP: 
TGU: 
100217666(EHMT1) 100219478 100219515(NSD1) 100219994(SETD7) 100222310(DOT1L) 100222344 100222807(WHSC1) 100222904(SUV420H1) 100224170(WHSC1L1) 100224614(SETD2) 100225643(SETD8) 100225647(SETD1B) 100225827(SUV39H2) 100226399(MLL5) 100226728(EZH2) 100226907 100227122 100227193(MLL3) 100227472(EZH1) 100229714 100231049(MLL) 100231131(SETDB2) 100231651(SETDB1)
ACS: 
XLA: 
100037174(suv39h2) 100158384(setd8) 398318(mp36) 398711(setdb2) 399174(ezh2-a) 431943(suv39h1) 431996(whsc1) 432147(setdb1) 444204(suv420h1-a) 447454(setd1b) 495826(suv420h1-b) 779432(suv420h2)
XTR: 
100038141(suv420h1) 100124713(ehmt1) 100124743(setdb2) 100125213(whsc1) 100135006(mll) 100135741(setmar) 100144721(mll4) 100145675(nsd1) 100145748 100216035(whsc1l1) 100486829(mll3) 100487270 100490309(setdb1) 100492584 100492810 100493532 100494109 100496979 100497594 549262(suv39h2) 550047(ezh2) 613102(setd7) 779539(mll5) 780106(setd1b) 780276(setd8)
DRE: 
100000709(whsc1) 100004770(setd8b) 100005761(ehmt1a) 100006350(whsc1l1) 100535983 325395(mll5) 326906(suv39h1b) 335153(setdb2) 402830(ehmt1b) 436729(setd7) 445198(suv39h1a) 556086(nsd1a) 556535(setd1a) 557048(mll) 559945(dot1l) 560793(mll3a) 560856(mll4a) 563799(ash1l) 564575(setmar) 566825(mll4b) 567970(setd1ba) 569041(suv420h2) 569250(ehmt2) 571274(setd1bb) 572849(suv420h1) 664754(ezh1) 751629(setd8a) 768131(setdb1b) 768133(ezh2)
TRU: 
OLA: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
NVI: 
100113526(E(z)) 100114564(NV16583) 100116149(Mes-4) 100116648(Dot1l) 100116736(SUV39H1) 100120014(Setdb1) 100120205(Trr) 100121025(Setd1a) 100121084(Ehmt1) 100123008(NV11709) 100123115(Set2) 100123305(ash1) 100679733
TCA: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG02629(Cbr-set-4) CBG03979 CBG03980 CBG04290 CBG10210 CBG10211 CBG10214 CBG10216 CBG10271 CBG11099(Cbr-mes-2) CBG12017(Cbr-lin-59) CBG13569(Cbr-set-23) CBG16281 CBG16282 CBG18157(Cbr-met-2) CBG18244(Cbr-set-16) CBG19678(Cbr-set-1)
BMY: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G02580(MEA) AT1G17770(SUVH7) AT1G73100(SUVH3) AT2G22740(SUVH6) AT2G23380(CLF) AT2G24740(SDG21) AT2G33290(SUVH2) AT2G35160(SUVH5) AT2G44150(ASHH3) AT3G59960(ASHH4) AT4G02020(SWN) AT4G13460(SUVH9) AT5G04940(SUVH1) AT5G13960(SUVH4)
ALY: 
GMX: 
MTR: 
CSV: 
RCU: 
POP: 
POPTR_229952(SDG915) POPTR_246290(SDG940) POPTR_255095(SDG921) POPTR_264791(SDG920) POPTR_409038(SDG939) POPTR_419224(SDG949) POPTR_562064(SDG918) POPTR_585029(SDG919) POPTR_590678(SDG950) POPTR_708413(SDG948) POPTR_719252(SDG910) POPTR_731686(SDG913) POPTR_758229(SDG906)
VVI: 
OSA: 
DOSA: 
Os01t0811300-01(Os01g0811300) Os01t0927000-01(Os01g0927000) Os03t0307800-01(Os03g0307800) Os03t0320400-01(Os03g0320400) Os04t0544100-01(Os04g0544100) Os05t0490700-01(Os05g0490700) Os06t0275500-01(Os06g0275500) Os07t0435900-01(Os07g0435900) Os08t0400200-00(Os08g0400200) Os08t0565700-01(Os08g0565700) Os09t0307800-01(Os09g0307800) Os09t0362900-01(Os09g0362900) Os11t0131600-00(Os11g0131600) Os11t0602200-01(Os11g0602200)
BDI: 
SBI: 
SORBI_01g037450(SORBIDRAFT_01g037450) SORBI_02g006620(SORBIDRAFT_02g006620) SORBI_02g010210(SORBIDRAFT_02g010210) SORBI_02g020844(SORBIDRAFT_02g020844) SORBI_02g022936(SORBIDRAFT_02g022936) SORBI_03g037660(SORBIDRAFT_03g037660) SORBI_03g044580(SORBIDRAFT_03g044580) SORBI_04g025725(SORBIDRAFT_04g025725) SORBI_04g033260(SORBIDRAFT_04g033260) SORBI_06g001340(SORBIDRAFT_06g001340) SORBI_06g024160(SORBIDRAFT_06g024160) SORBI_07g019850(SORBIDRAFT_07g019850) SORBI_07g019860(SORBIDRAFT_07g019860) SORBI_07g019863(SORBIDRAFT_07g019863) SORBI_07g023560(SORBIDRAFT_07g023560) SORBI_08g001570(SORBIDRAFT_08g001570) SORBI_09g019060(SORBIDRAFT_09g019060) SORBI_09g024010(SORBIDRAFT_09g024010) SORBI_10g004560(SORBIDRAFT_10g004560)
ZMA: 
100194312 100280164(sdg101) 100282875 100382441 541954(mez1) 541955(mez3) 541980(sdg113) 542085(cl3507_2a) 542089(sdg118) 542090(SET104) 542102 542659(mez2) 542662(sdg110a)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
OSTLU_18587(SDG3502)
CME: 
SCE: 
YDR440W(DOT1) YHR119W(SET1) YJL168C(SET2)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0B07030(NCAS0B07030) NCAS_0F01220(NCAS0F01220) NCAS_0I02880(NCAS0I02880)
NDI: 
NDAI_0B00260(NDAI0B00260) NDAI_0B04360(NDAI0B04360) NDAI_0H01750(NDAI0H01750)
TPF: 
TPHA_0A02720(TPHA0A02720) TPHA_0D02550(TPHA0D02550) TPHA_0I01480(TPHA0I01480)
TBL: 
TBLA_0C05500(TBLA0C05500) TBLA_0D01440(TBLA0D01440) TBLA_0E03030(TBLA0E03030) TBLA_0J01040(TBLA0J01040)
TDL: 
TDEL_0A04190(TDEL0A04190) TDEL_0B05100(TDEL0B05100) TDEL_0G02090(TDEL0G02090)
KAF: 
KAFR_0F00700(KAFR0F00700) KAFR_0F01770(KAFR0F01770) KAFR_0I00880(KAFR0I00880)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CaO19.13430(SET1) CaO19.1755(SET2) CaO19.6009(SET1) CaO19.7402(DOT1) CaO19.9324(SET2)
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_1110184(AO090009000660) AOR_1_176084(AO090020000101) AOR_1_4154(AO090003000002) AOR_1_500074(AO090038000300) AOR_1_578094(AO090120000327)
ANG: 
ANI_1_1490164(An18g06840) ANI_1_1828074(An08g03380) ANI_1_2518094(An11g09860) ANI_1_296084(An09g02720) ANI_1_476104(An12g03880) ANI_1_490154(An17g01825)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
MPR: 
CCI: 
SCM: 
UMA: 
MGL: 
PGR: 
NCE: 
MBR: 
NGR: 
DDI: 
DPP: 
PFA: 
PFD: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_IV004680(23.m06513)
CPV: 
PTM: 
GLA: 
TVA: 
PTI: 
TPS: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:5484460]
  Authors
Paik WK, Kim S.
  Title
Solubilization and partial purification of protein methylase 3 from calf thymus nuclei.
  Journal
J. Biol. Chem. 245 (1970) 6010-5.
  Organism
Bos taurus [GN:bta]
Reference
2  [PMID:391266]
  Authors
Venkatesan M, McManus IR.
  Title
Partial purification and characterization of a protein lysine methyltransferase from plasmodia of Physarum polycephalum.
  Journal
Biochemistry. 18 (1979) 5365-71.
  Organism
Physarum polycephalum
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9055-08-7

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