KEGG   ENZYME: 2.1.1.57Help
Entry
EC 2.1.1.57                 Enzyme                                 

Name
methyltransferase cap1;
messenger ribonucleate nucleoside 2'-methyltransferase;
messenger RNA (nucleoside-2'-)-methyltransferase;
MTR1;
cap1-MTase;
mRNA (nucleoside-2'-O)-methyltransferase (ambiguous);
S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:5-(N7-methyl 5-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] 2-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA] [RN:R03922]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] [CPD:C02339]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA] [CPD:C04802]
Comment
This enzyme catalyses the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine. This methylation event is known as cap1, and occurrs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine [6].
History
EC 2.1.1.57 created 1981 (EC 2.1.1.58 created 1981, incorporated 1984), modified 2014
Orthology
K14589  
cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Genes
HSA: 
23070(CMTR1)
PTR: 
471998(FTSJD2)
PPS: 
100973075(FTSJD2)
GGO: 
101137720(FTSJD2)
PON: 
100172922(CMTR1)
MCC: 
719402(FTSJD2)
MCF: 
102122892(CMTR1)
MMU: 
74157(Cmtr1)
RNO: 
309656(Cmtr1)
CGE: 
100755381(Cmtr1)
HGL: 
101702635(Ftsjd2)
TUP: 
102486149(CMTR1)
CFA: 
100683999(FTSJD2)
AML: 
100464010(FTSJD2)
FCA: 
101082907(CMTR1)
PTG: 
102959389(CMTR1)
BTA: 
509620(CMTR1)
BOM: 
102286518(CMTR1)
PHD: 
102330710(CMTR1)
CHX: 
102183833(CMTR1)
SSC: 
100154061(CMTR1)
CFR: 
102519501(CMTR1)
BACU: 
102999368(CMTR1)
LVE: 
103084086(CMTR1)
ECB: 
100064496(CMTR1)
MYB: 
102239315(CMTR1)
MYD: 
102752437(CMTR1)
PALE: 
102890551(CMTR1)
MDO: 
100029458(CMTR1)
SHR: 
100932113(FTSJD2)
OAA: 
100080325(CMTR1)
GGA: 
421434(FTSJD2)
MGP: 
TGU: 
100221592(FTSJD2)
FAB: 
101813808(FTSJD2)
PHI: 
102100817(CMTR1)
APLA: 
101791717(FTSJD2)
FPG: 
101914346(CMTR1)
FCH: 
CLV: 
102095138(CMTR1)
ASN: 
102369625(CMTR1)
AMJ: 
102558730(CMTR1)
PSS: 
102451122(CMTR1)
CMY: 
102946212(CMTR1)
ACS: 
PBI: 
103059677(CMTR1)
XLA: 
443938(cmtr1)
XTR: 
100170565(cmtr1)
DRE: 
393102(cmtr1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102345363(CMTR1)
CMK: 
103177927(cmtr1)
BFO: 
CIN: 
100185668(ftsjd2)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
411249(GB11084)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CBR: 
BMY: 
LOA: 
TSP: 
SMM: 
HMG: 
TAD: 
AQU: 
DDI: 
DPP: 
DFA: 
PTI: 
TPS: 
PIF: 
NGD: 
EHX: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:701281]
  Authors
Barbosa E, Moss B.
  Title
mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Purification and physical properties.
  Journal
J. Biol. Chem. 253 (1978) 7692-7.
  Organism
vaccinia virus
Reference
2  [PMID:701282]
  Authors
Barbosa E, Moss B.
  Title
mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Characteristics and substrate specificity.
  Journal
J. Biol. Chem. 253 (1978) 7698-702.
  Organism
vaccinia virus
Reference
3  [PMID:833934]
  Authors
Boone RF, Ensinger MJ, Moss B.
  Title
Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus.
  Journal
J. Virol. 21 (1977) 475-83.
  Organism
vaccinia virus
Reference
4  [PMID:1058472]
  Authors
Ensinger MJ, Martin SA, Paoletti E, Moss B.
  Title
Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 72 (1975) 2525-9.
  Organism
vaccinia virus
Reference
5  [PMID:629955]
  Authors
Groner Y, Gilboa E, Aviv H.
  Title
Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates.
  Journal
Biochemistry. 17 (1978) 977-82.
  Organism
Homo sapiens
Reference
6  [PMID:21310715]
  Authors
Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM
  Title
2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.
  Journal
Nucleic. Acids. Res. 39 (2011) 4756-68.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
61970-02-3

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