KEGG   ENZYME: 2.3.1.108Help
Entry
EC 2.3.1.108                Enzyme                                 

Name
alpha-tubulin N-acetyltransferase;
alpha-tubulin acetylase;
TAT;
alpha-tubulin acetyltransferase;
tubulin N-acetyltransferase;
acetyl-CoA:alpha-tubulin-L-lysine N-acetyltransferase;
acetyl-CoA:[alpha-tubulin]-L-lysine 6-N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:[alpha-tubulin]-L-lysine N6-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N6-acetyl-L-lysine [RN:R04192]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
[alpha-tubulin]-L-lysine [CPD:C03318]
Product
CoA [CPD:C00010];
[alpha-tubulin]-N6-acetyl-L-lysine [CPD:C04149]
Comment
The enzyme from Chlamydomonas flagella also acetylates mammalian brain alpha-tubulin.
History
EC 2.3.1.108 created 1989
Reference
1  [PMID:4066751]
  Authors
Greer K, Maruta H, L'Hernault SW, Rosenbaum JL.
  Title
Alpha-tubulin acetylase activity in isolated Chlamydomonas flagella.
  Journal
J. Cell. Biol. 101 (1985) 2081-4.
  Organism
Chlamydomonas flagella
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
99889-90-4

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