KEGG   ENZYME: 2.3.1.108Help
Entry
EC 2.3.1.108                Enzyme                                 

Name
alpha-tubulin N-acetyltransferase;
alpha-tubulin acetylase;
TAT;
alpha-tubulin acetyltransferase;
tubulin N-acetyltransferase;
acetyl-CoA:alpha-tubulin-L-lysine N-acetyltransferase;
acetyl-CoA:[alpha-tubulin]-L-lysine 6-N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:[alpha-tubulin]-L-lysine N6-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N6-acetyl-L-lysine [RN:R04192]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
[alpha-tubulin]-L-lysine [CPD:C03318]
Product
CoA [CPD:C00010];
[alpha-tubulin]-N6-acetyl-L-lysine [CPD:C04149]
Comment
The enzyme from Chlamydomonas flagella also acetylates mammalian brain alpha-tubulin.
History
EC 2.3.1.108 created 1989
Orthology
K19573  
alpha-tubulin N-acetyltransferase 1
Genes
HSA: 
79969(ATAT1)
PTR: 
100612548(ATAT1)
PPS: 
100975033(ATAT1)
GGO: 
101125931(ATAT1)
PON: 
100190967(ATAT1)
NLE: 
100595319(ATAT1)
MCC: 
100141388(ATAT1)
MCF: 
102135176(ATAT1)
CSAB: 
103221829(ATAT1)
RRO: 
104666191(ATAT1)
CJC: 
100388531(ATAT1)
SBQ: 
101037052(ATAT1)
MMU: 
73242(Atat1)
RNO: 
361789(Atat1)
CGE: 
100764669(Atat1)
NGI: 
103740567(Atat1)
HGL: 
101705887(Atat1)
OCU: 
100358006(ATAT1)
TUP: 
102486128(ATAT1)
CFA: 
477580(ATAT1) 609464
AML: 
100473989(ATAT1)
UMR: 
103664999(ATAT1)
FCA: 
101093356(ATAT1)
PTG: 
102966181(ATAT1)
BTA: 
786491(ATAT1)
BOM: 
102275558(ATAT1)
PHD: 
102332142(ATAT1)
CHX: 
102183555(ATAT1)
OAS: 
101106803(ATAT1)
SSC: 
100144480(ATAT1)
CFR: 
102504889(ATAT1)
BACU: 
103016955(ATAT1)
LVE: 
103083275(ATAT1)
ECB: 
100055595(ATAT1)
MYB: 
102240400(ATAT1)
MYD: 
102762964(ATAT1)
PALE: 
102879916(ATAT1)
LAV: 
100664992(ATAT1)
MDO: 
100024215(ATAT1)
SHR: 
100919522(ATAT1)
OAA: 
103166272(ATAT1)
PHI: 
102104188(ATAT1)
ASN: 
102379630(ATAT1)
AMJ: 
102573069(ATAT1)
PSS: 
102444571(ATAT1)
CMY: 
102941891(ATAT1)
ACS: 
100561358(atat1)
PBI: 
GJA: 
107111806(ATAT1)
XLA: 
735057(atat1.S)
XTR: 
100038151(atat1)
DRE: 
406389(atat1)
TRU: 
101074501(atat1)
TNG: 
MZE: 
101473057(atat1)
OLA: 
101172832(atat1)
XMA: 
102224331(atat1)
SASA: 
106589060(atat1)
LCM: 
102353700(ATAT1)
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD12926(Dsim_GD12926) Dsimw501_GD15558(Dsim_GD15558)
DWI: 
DYA: 
Dyak_GE17347(dyak_GLEANR_18685) Dyak_GE21245(dyak_GLEANR_5020)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
CEL: 
CBR: 
CBG17726(Cbr-mec-17)
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
OBI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
SMO: 
PPP: 
VCN: 
MIS: 
MPP: 
CSL: 
SRE: 
PFA: 
PFD: 
PFH: 
PKN: 
PVX: 
PCY: 
TGO: 
TET: 
PTM: 
SMIN: 
v1.2.037027.t1(symbB.v1.2.037027.t1) v1.2.037027.t2(symbB.v1.2.037027.t2)
NGD: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
TBR: 
Tb927.3.1400(Tb03.1J15.450)
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
Taxonomy
Reference
1  [PMID:4066751]
  Authors
Greer K, Maruta H, L'Hernault SW, Rosenbaum JL.
  Title
Alpha-tubulin acetylase activity in isolated Chlamydomonas flagella.
  Journal
J. Cell. Biol. 101 (1985) 2081-4.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
99889-90-4

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