KEGG   ENZYME: 2.3.1.5Help
Entry
EC 2.3.1.5                  Enzyme                                 

Name
arylamine N-acetyltransferase;
arylamine acetylase;
beta-naphthylamine N-acetyltransferase;
4-aminobiphenyl N-acetyltransferase;
acetyl CoA-arylamine N-acetyltransferase;
2-naphthylamine N-acetyltransferase;
arylamine acetyltransferase;
indoleamine N-acetyltransferase;
N-acetyltransferase (ambiguous);
p-aminosalicylate N-acetyltransferase;
serotonin acetyltransferase;
serotonin N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:arylamine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine [RN:R02387]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
arylamine [CPD:C00292]
Product
CoA [CPD:C00010];
N-acetylarylamine [CPD:C07565]
Comment
Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA.
History
EC 2.3.1.5 created 1961
Pathway
Caffeine metabolism
Nitrotoluene degradation
Drug metabolism - other enzymes
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Orthology
K00622  
arylamine N-acetyltransferase
Genes
HSA: 
10(NAT2) 9(NAT1)
PTR: 
464023(NAT1) 464024(NAT2)
PPS: 
100990661(NAT2) 100991667(NAT1)
GGO: 
101150362(NAT1) 101152545(NAT2)
PON: 
MCC: 
704019(NAT1) 704357(NAT2)
MCF: 
102119914(NAT1) 102121561(NAT2)
MMU: 
17960(Nat1) 17961(Nat2) 17962(Nat3)
RNO: 
116631(Nat1) 116632(Nat2) 290681(Nat3)
CGE: 
HGL: 
TUP: 
102486411(NAT1)
AML: 
FCA: 
101095575(NAT1)
PTG: 
102955781(NAT1)
BTA: 
512603(NAT1)
BOM: 
102275700(NAT1)
PHD: 
CHX: 
102169935(NAT1)
SSC: 
CFR: 
102510309(NAT1)
ECB: 
100049837(NAT1)
MYB: 
MYD: 
MDO: 
SHR: 
OAA: 
GGA: 
396283(PNAT10) 396537(NAT) 415809(PNAT3)
MGP: 
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XMA: 
BEQ: 
MTU: 
Rv3566c(nat)
MTV: 
MTC: 
MT3671(nhoA)
MRA: 
MTF: 
MTB: 
MTK: 
MTZ: 
MTG: 
MTI: 
MTE: 
MTUR: 
MTL: 
MTO: 
MTD: 
MTN: 
MTJ: 
MTUB: 
MTUC: 
MTUE: 
MTX: 
MTUH: 
MTUL: 
MBO: 
Mb3596c(nat)
MBB: 
MBT: 
MBM: 
MBK: 
MAF: 
MCE: 
MCQ: 
MCV: 
MCX: 
MCZ: 
MPA: 
MAP0501(nhoA)
MAO: 
MAV: 
MIT: 
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 » show all
Taxonomy
Reference
1  [PMID:12980945]
  Authors
CHOU TC, LIPMANN F.
  Title
Separation of acetyl transfer enzymes in pigeon liver extract.
  Journal
J. Biol. Chem. 196 (1952) 89-103.
  Organism
pigeon
Reference
2  [PMID:4748369]
  Authors
Paul RC, Ratledge C.
  Title
Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes.
  Journal
Biochim. Biophys. Acta. 320 (1973) 9-15.
  Organism
Klebsiella pneumoniae
Reference
3  [PMID:13084583]
  Authors
TABOR H, MEHLER AH, STADTMAN ER.
  Title
The enzymatic acetylation of amines.
  Journal
J. Biol. Chem. 204 (1953) 127-38.
  Organism
pigeon
Reference
4  [PMID:14005907]
  Authors
WEISSBACH H, REDFIELD BG, AXELROD J.
  Title
The exzymic acetylation of serotonin and other naturally occurring amines.
  Journal
Biochim. Biophys. Acta. 54 (1961) 190-2.
  Organism
Rattus norvegicus, Bos taurus, Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
CAS: 
9027-33-2

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