KEGG   ENZYME: 2.3.1.97Help
Entry
EC 2.3.1.97                 Enzyme                                 

Name
glycylpeptide N-tetradecanoyltransferase;
peptide N-myristoyltransferase;
myristoyl-CoA-protein N-myristoyltransferase;
myristoyl-coenzyme A:protein N-myristoyl transferase;
myristoylating enzymes;
protein N-myristoyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase
Reaction(IUBMB)
tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide [RN:R03992]
Reaction(KEGG)
Substrate
tetradecanoyl-CoA [CPD:C02593];
glycylpeptide [CPD:C02038]
Product
CoA [CPD:C00010];
N-tetradecanoylglycylpeptide [CPD:C03881]
Comment
The enzyme from yeast is highly specific for tetradecanoyl-CoA, and highly specific for N-terminal glycine in oligopeptides containing serine in the 5-position. The enzyme from mammalian heart transfers acyl groups to a specific 51 kDa acceptor protein.
History
EC 2.3.1.97 created 1989, modified 1990
Orthology
K00671  glycylpeptide N-tetradecanoyltransferase
Genes
HSA: 4836(NMT1) 9397(NMT2)
PTR: 450321(NMT2) 454744(NMT1)
PPS: 100972009(NMT2) 100981120(NMT1)
GGO: 101132237(NMT2) 101143947(NMT1)
PON: 100174462(NMT1) 100438396(NMT2)
NLE: 100602350(NMT2) 100604682(NMT1)
MCC: 703394(NMT2) 715885(NMT1)
MCF: 102132842(NMT1) 102143732(NMT2)
CSAB: 103237937(NMT2) 103243298(NMT1)
RRO: 104654735(NMT1) 104664161 104664481(NMT2)
RBB: 108530958(NMT2) 108532210(NMT1)
CJC: 100394723(NMT1) 100403561(NMT2)
SBQ: 101044627(NMT2) 101048199(NMT1)
MMU: 18107(Nmt1) 18108(Nmt2)
RNO: 259274(Nmt1) 291318(Nmt2)
CGE: 100756019(Nmt2) 100759338(Nmt1)
NGI: 103735179(Nmt2) 103738312(Nmt1)
HGL: 101697570(Nmt2) 101706184(Nmt1)
CCAN: 109691355(Nmt2) 109691569(Nmt1)
OCU: 100340182(NMT1) 100348670(NMT2)
TUP: 102494402(NMT1) 102494701(NMT2)
CFA: 480494(NMT1) 487120(NMT2)
AML: 100465245(NMT1) 100479016(NMT2)
UMR: 103664240(NMT2) 103665877(NMT1)
ORO: 101365018(NMT1) 101376568(NMT2)
FCA: 101082703(NMT1) 101090271(NMT2)
PTG: 102957537(NMT1) 102963277(NMT2)
AJU: 106970997(NMT2) 106988151(NMT1)
BTA: 281351(NMT1) 282049(NMT2)
BOM: 102269914(NMT1) 102273686(NMT2) 102276941
BIU: 109573525(NMT1)
PHD: 102324029(NMT1) 102324080(NMT2)
CHX: 102180607(NMT2) 102187801(NMT1)
OAS: 101117182(NMT2) 101117775(NMT1) 101122794
SSC: 100524705(NMT1) 100627249(NMT2)
CFR: 102503609(NMT1) 102522093(NMT2)
CDK: 105094410(NMT1) 105104530(NMT2)
BACU: 103017535(NMT1) 103021054(NMT2)
LVE: 103080943(NMT1) 103083512(NMT2)
OOR: 101271335(NMT1) 101280336(NMT2)
ECB: 100050277(NMT1) 100068766(NMT2)
EPZ: 103554678(NMT1) 103556819(NMT2)
EAI: 106836473(NMT1) 106840449(NMT2)
MYB: 102239257(NMT2) 102259380(NMT1)
MYD: 102754083 102759111(NMT2) 102760509(NMT1)
HAI: 109393804(NMT2) 109394977(NMT1)
RSS: 109441220 109450705(NMT2) 109458500(NMT1)
PALE: 102895637(NMT2) 102896428(NMT1)
LAV: 100661077(NMT1) 100675378(NMT2)
MDO: 100020457(NMT1) 100020704(NMT2)
SHR: 100914067(NMT2) 100916560(NMT1)
OAA: 100077553(NMT2)
GGA: 419966(NMT1) 420529(NMT2)
MGP: 100546804(NMT2) 100550671(NMT1)
CJO: 107309020(NMT2) 107325008(NMT1)
APLA: 101795652(NMT1) 101796368(NMT2)
ACYG: 106039667(NMT2) 106046932(NMT1)
TGU: 100218058(NMT2) 100226494(NMT1)
GFR: 102037477(NMT2) 102038594(NMT1)
FAB: 101808830(NMT1) 101819865(NMT2)
PHI: 102109880(NMT2) 102113086(NMT1)
PMAJ: 107199973(NMT2) 107215290(NMT1)
CCW: 104689202(NMT2) 104698535(NMT1)
FPG: 101919223(NMT2) 101919935(NMT1)
FCH: 102048284(NMT1) 102058808(NMT2)
CLV: 102084902(NMT2) 102087955(NMT1)
EGZ: 104128742(NMT2) 104132241(NMT1)
AAM: 106482872 106483500(NMT2) 106495648(NMT1)
ASN: 102385616(NMT2) 102386761(NMT1)
AMJ: 102576715(NMT1) 106736799(NMT2)
PSS: 102462346(NMT2)
CMY: 102931451(NMT2) 102940056(NMT1)
CPIC: 101933923(NMT1) 101946890(NMT2)
ACS: 100555077(nmt2) 100559200(nmt1)
PVT: 110070294(NMT2) 110081387(NMT1)
PBI: 103052935(NMT1) 103065880(NMT2)
GJA: 107120602(NMT1) 107120952(NMT2)
XLA: 108702554 108706069 108719884 379884(nmt2.L) 444545(nmt1.L)
XTR: 100380009(nmt2) 779719(nmt1)
NPR: 108785979(NMT1) 108795076(NMT2)
DRE: 323956(nmt1a) 556483(nmt2)
IPU: 108256512(nmt2) 108260599(nmt1) 108273814
AMEX: 103042142(nmt2) 103044353(nmt1) 103045678
TRU: 101065497 101075895(nmt2) 101076413(nmt1)
LCO: 104923046(nmt2) 104926429(nmt1) 104930723
NCC: 104946858(nmt1) 104953571 104959140(nmt2)
XMA: 102218082(nmt1) 102227956 102228322(nmt2)
PRET: 103469337(nmt1) 103478683(nmt2) 103481311
NFU: 107378558(nmt1) 107379648(nmt2) 107396746
LCF: 108872771(nmt1) 108873429 108889590(nmt2)
HCQ: 109506793(nmt1) 109523896 109528980(nmt2)
BPEC: 110159280(nmt1) 110163117(nmt2) 110171043
LCM: 102346969(NMT1) 102357978(NMT2)
CMK: 103187068(nmt2) 103189700(nmt1)
CIN: 100181870
APLC: 110973435
SKO: 100378935
DME: Dmel_CG7436(Nmt)
DSI: Dsimw501_GD13014(Dsim_GD13014)
MDE: 101900950
AAG: 5565981
AME: 552485(Nmt)
BIM: 100749273
BTER: 100652054
SOC: 105196777
AEC: 105148711
ACEP: 105623311
PBAR: 105426306
HST: 105188714
CFO: 105251111
LHU: 105669889
PGC: 109854928
NVI: 100115755
TCA: 661933
DPA: 109542013
NVL: 108560391
BMOR: 101735807
PMAC: 106708997
PRAP: 111003236
PXY: 105389467
API: 100163432
DNX: 107169641
ZNE: 110837394
FCD: 110845885
TUT: 107368114
CEL: CELE_T17E9.2(nmt-1)
CBR: CBG21106(Cbr-nmt-1)
BMY: Bm1_22900
TSP: Tsp_00547
CRG: 105326790
MYI: 110457073
OBI: 106875636
LAK: 106162072
SHX: MS3_09237
EPA: 110254670
ADF: 107329364
AQU: 100637114
ATH: AT5G57020(NMT1)
CPAP: 110816817
ADU: 107464435
AIP: 107618291
LJA: Lj3g3v2664340.1(Lj3g3v2664340.1) Lj6g3v1226280.1(Lj6g3v1226280.1)
FVE: 101304413
CSV: 101203401
CMO: 103492341
MCHA: 111016535
BVG: 104888039
SOE: 110775579
OSA: 4327681
DOSA: Os01t0708100-01(Os01g0708100)
OBR: 102704564
ATS: 109744913(LOC109744913)
SBI: 8059165
SITA: 101777188
AOF: 109833399
CRE: CHLREDRAFT_97790(NMT1)
MNG: MNEG_5641
MIS: MICPUN_58555(nmt)
APRO: F751_3117
SCE: YLR195C(NMT1)
ERC: Ecym_4716
KMX: KLMA_50308(NMT1)
NCS: NCAS_0E02830(NCAS0E02830)
NDI: NDAI_0E04430(NDAI0E04430)
TPF: TPHA_0F03040(TPHA0F03040)
TBL: TBLA_0C05020(TBLA0C05020)
TDL: TDEL_0C01910(TDEL0C01910)
KAF: KAFR_0L01530(KAFR0L01530)
PIC: PICST_80771(NMT1)
CAL: CAALFM_C401440WA(NMT1)
CDU: CD36_41450(NMT1)
CAUR: QG37_01962
SLB: AWJ20_4856(NMT1)
NCR: NCU17177
NTE: NEUTE1DRAFT123655(NEUTE1DRAFT_123655)
MGR: MGG_07229
MAW: MAC_08789
MAJ: MAA_08962
BFU: BCIN_01g02420(Bcnmt1)
MBE: MBM_00920
ANI: AN3839.2
ANG: ANI_1_508184(An04g02500)
PTE: PTT_14787
CNE: CNN00080
CNB: CNBN0070
ABP: AGABI1DRAFT34763(AGABI1DRAFT_34763)
ABV: AGABI2DRAFT148548(AGABI2DRAFT_148548)
MGL: MGL_0604
DDI: DDB_G0275863(nmt)
DFA: DFA_10733(nmt)
EHI: EHI_159730(88.t00002)
PYO: PY17X_1032200(PY01548)
PCB: PCHAS_103060(PC300802.00.0)
TAN: TA13465
TPV: TP02_0057
BBO: BBOV_III010870(17.m07935)
CPV: cgd3_320
SMIN: v1.2.001977.t1(symbB.v1.2.001977.t1) v1.2.001979.t1(symbB.v1.2.001979.t1) v1.2.039797.t1(symbB.v1.2.039797.t1) v1.2.039797.t2(symbB.v1.2.039797.t2)
TPS: THAPSDRAFT_3304(MNT1)
LMA: LMJF_32_0080(NMT)
LIF: LINJ_32_0080(NMT)
 » show all
Taxonomy
Reference
1  [PMID:3566958]
  Authors
Guertin D, Grise-Miron L, Riendeau D.
  Title
Identification of a 51-kilodalton polypeptide fatty acyl chain acceptor in soluble extracts from mouse cardiac tissue.
  Journal
Biochem. Cell. Biol. 64 (1986) 1249-55.
Reference
2  [PMID:3123489]
  Authors
Heuckeroth RO, Towler DA, Adams SP, Glaser L, Gordon JI.
  Title
11-(Ethylthio)undecanoic acid. A myristic acid analogue of altered hydrophobicity which is functional for peptide N-myristoylation with wheat germ and yeast acyltransferase.
  Journal
J. Biol. Chem. 263 (1988) 2127-33.
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.97
IUBMB Enzyme Nomenclature: 2.3.1.97
ExPASy - ENZYME nomenclature database: 2.3.1.97
BRENDA, the Enzyme Database: 2.3.1.97
CAS: 110071-61-9

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