KEGG   ENZYME: 2.3.2.13Help
Entry
EC 2.3.2.13                 Enzyme                                 

Name
protein-glutamine gamma-glutamyltransferase;
transglutaminase;
Factor XIIIa;
fibrinoligase;
fibrin stabilizing factor;
glutaminylpeptide gamma-glutamyltransferase;
polyamine transglutaminase;
tissue transglutaminase;
R-glutaminyl-peptide:amine gamma-glutamyl transferase
Class
Transferases;
Acyltransferases;
Aminoacyltransferases
BRITE hierarchy
Sysname
protein-glutamine:amine gamma-glutamyltransferase
Reaction(IUBMB)
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 [RN:R03983]
Reaction(KEGG)
Substrate
protein glutamine [CPD:C02583];
alkylamine [CPD:C01664]
Product
protein N5-alkylglutamine [CPD:C03636];
NH3 [CPD:C00014]
Comment
Requires Ca2+. The gamma-carboxamide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N6-(5-glutamyl)-lysine crosslinks. Formed by proteolytic cleavage from plasma Factor XIII
History
EC 2.3.2.13 created 1978, modified 1981, modified 1983
Orthology
K00686  
protein-glutamine gamma-glutamyltransferase
K03917  
coagulation factor XIII A1 polypeptide
K05619  
transglutaminase 1
K05620  
transglutaminase 3
K05621  
transglutaminase 4
K05622  
transglutaminase 5
K05623  
transglutaminase 7
K05624  
transglutaminase 6
K05625  
transglutaminase 2
Genes
HSA: 
116179(TGM7) 2162(F13A1) 343641(TGM6) 7047(TGM4) 7051(TGM1) 7052(TGM2) 7053(TGM3) 9333(TGM5)
PTR: 
452814(TGM1) 453375(TGM5) 458043(TGM3) 458044(TGM6) 460311(TGM4) 462413(F13A1) 467667(TGM7) 469937(TGM2)
PPS: 
100977152(TGM7) 100977828(TGM5) 100978535(TGM1) 100980699(TGM4) 100982798(F13A1) 100994168(TGM3) 100994169(TGM2) 100995088(TGM6)
GGO: 
101124803(TGM1) 101138298(TGM4) 101143373(TGM6) 101144333 101149000(TGM5) 101149948(TGM7) 101154327(TGM2)
PON: 
100189556(TGM4) 100440931 100441290(TGM2) 100453552(TGM6) 100454156(TGM3) 100457869(TGM1) 100459707(TGM5) 100460447(TGM7)
NLE: 
100581513(F13A1) 100584804(TGM1) 100589876(TGM6) 100592355(TGM3) 100602130(TGM4) 100604663(TGM5) 100605556(TGM7) 100606817(TGM2)
MCC: 
100430348(TGM6) 706777(TGM2) 711264(F13A1) 712605(TGM5) 712676(TGM7) 714883(TGM4) 715854(TGM1) 716498(TGM3)
MCF: 
102118894(TGM1) 102122746(TGM2) 102124679(TGM4) 102126128(F13A1) 102129616(TGM5) 102130654(TGM7) 102134146(TGM6) 102141556(TGM3)
CJC: 
100390001(TGM2) 100390536(TGM7) 100401849(F13A1) 100402216(TGM3) 100402574(TGM6) 100406524(TGM4) 100410848(TGM1) 100415505(TGM5)
MMU: 
21816(Tgm1) 21817(Tgm2) 21818(Tgm3) 241636(Tgm6) 331046(Tgm4) 640543(Tgm7) 74145(F13a1) 74176(Tgm5)
RNO: 
296152(Tgm6) 366189(Tgm3) 56083(Tgm2) 60327(F13a1) 60335(Tgm1) 64679(Tgm4) 691932
CGE: 
100751827(Tgm6) 100752403(Tgm3) 100756034(Tgm7) 100756318(Tgm5) 100757784(Tgm1) 100759289(Tgm2) 100761709(F13a1) 100762929(Tgm4)
NGI: 
103725088(Tgm7) 103726570(Tgm5) 103728480(Tgm2) 103732915(F13a1) 103739419(Tgm1) 103747165(Tgm4) 103751142(Tgm3) 103751150(Tgm6)
HGL: 
101699097(Tgm2) 101715346(F13a1) 101716908(Tgm7) 101720615(Tgm5) 101721908(Tgm3) 101722232(Tgm4) 101722267(Tgm6) 101723323(Tgm1)
OCU: 
TUP: 
102484022(TGM6) 102491834(TGM3) 102496909(TGM2) 102497321(F13A1) 102501064(TGM1) 102502596(TGM7) 102503026(TGM5)
CFA: 
403630(TGM1) 477180(TGM3) 478711(F13A1) 485807(TGM6) 485867(TGM2) 487522(TGM5) 487523(TGM7)
AML: 
100468726(TGM7) 100468973 100471855(TGM6) 100472103(TGM3) 100473377(TGM1) 100477542(TGM2) 100479900(F13A1)
UMR: 
103664944(F13A1) 103669768(TGM2) 103673406(TGM5) 103673528(TGM7) 103674507(TGM3) 103674509(TGM6) 103679327(TGM1)
FCA: 
101080534(F13A1) 101080542(TGM7) 101080797(TGM5) 101082066(TGM1) 101083506(TGM6) 101083762(TGM3) 101098215(TGM2)
PTG: 
102954308(F13A1) 102963634(TGM1) 102965789(TGM7) 102967219(TGM5) 102972509(TGM3) 102972783(TGM6) 102972819(TGM2)
BTA: 
281528(TGM2) 407997(TGM1) 505080(TGM3) 514767(TGM5) 536356(TGM6) 538521(TGM7) 617881(F13A1)
BOM: 
102268247(TGM3) 102268807(TGM6) 102278981(TGM5) 102279262(TGM7) 102282269(TGM2) 102282528(F13A1) 102287783(TGM1)
PHD: 
102325869(TGM3) 102332777(TGM5) 102333383(TGM7) 102336314(TGM2) 102337526(F13A1) 102339860(TGM1) 102341793(TGM6)
CHX: 
102169238(F13A1) 102177982(TGM1) 102179888(TGM5) 102180159(TGM7) 102185477(TGM2) 102187690(TGM6) 102188149(TGM3)
OAS: 
101105177(TGM3) 101106629(TGM7) 101108612(F13A1) 101109916(TGM5) 101114043(TGM6) 101114274(TGM1) 101123140(TGM2)
SSC: 
100152931(TGM7) 100153504(F13A1) 100154530 100155471(TGM6) 100156489(TGM1) 100158178(TGM5)
CFR: 
102506156(TGM3) 102512777(TGM6) 102521823(TGM2) 102522024(TGM5) 102522457(TGM7) 102522644(F13A1) 102522761(TGM1)
BACU: 
102999141(TGM2) 103003688(TGM1) 103005699(F13A1) 103011508(TGM7) 103017852(TGM3) 103019607(TGM4)
LVE: 
103069042(TGM2) 103074098(TGM1) 103076844(TGM4) 103084172(TGM3) 103084459(TGM6) 103084825(TGM7) 103085096(TGM5) 103086768(F13A1)
ECB: 
100053068(TGM3) 100054584(TGM1) 100060428(F13A1) 100067214(TGM6) 100070046(TGM2) 100070842(TGM5) 100630434(TGM7)
MYB: 
102247111(TGM7) 102248755(TGM6) 102249978(TGM1) 102253096(F13A1) 102256943(TGM2) 102261311(TGM3) 102264061(TGM5)
MYD: 
102761285(TGM3) 102761564(TGM6) 102762892(TGM7) 102763189(TGM5) 102763968(TGM1) 102766538(F13A1) 102767031(TGM2)
PALE: 
102880919(F13A1) 102882668(TGM5) 102882669(TGM7) 102886109(TGM6) 102886354(TGM3) 102892263(TGM1) 102892954(TGM2)
MDO: 
100011026(TGM5) 100011115(TGM7) 100020636(F13A1) 100022632(TGM6) 100022686(TGM3) 100030812(TGM1) 100032853(TGM2)
SHR: 
100913640(TGM6) 100913906(TGM3) 100918933(TGM1) 100926340(TGM5) 100926605(TGM7) 100930830(TGM2) 100931287(F13A1)
OAA: 
GGA: 
395420(F13A1) 396432(TGM2) 419215(TGM3) 420706(TGM4) 771144(TGM6)
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
102085082(TGM3) 102085908(TGM6) 102088344(TGM4) 102091064(TGM2) 102096858 102098736(F13A1)
ASN: 
AMJ: 
102558174(F13A1) 102560199(TGM4) 102560672(TGM1) 102564446(TGM6) 102566325(TGM5) 102566555(TGM3) 102569676(TGM2) 102571839
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
386605(tgm2) 443836(tgm2)
XTR: 
DRE: 
323856(tgm2b) 447909(tgm2a) 559012(tgm2l) 559691 561287(f13a1b) 566581(tgm1l1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
578380(etg)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
411132(Tg)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
TSP: 
LGI: 
NVE: 
HMG: 
AQU: 
BSU: 
BSR: 
BSL: 
BSH: 
BSY: 
BSS: 
BST: 
BSO: 
BSN: 
BSQ: 
BSUB: 
BSX: 
BSP: 
BLI: 
BL02523(tgl)
BLD: 
BLH: 
BAO: 
BAY: 
BAQ: 
BYA: 
BAMP: 
BAML: 
BAMA: 
BAMN: 
BAMB: 
BAMT: 
BAZ: 
BQL: 
BXH: 
BQY: 
BAMI: 
BAMC: 
BAMF: 
BAMY: 
BAE: 
BHA: 
BH3970(tgl)
BAN: 
BA_4173(tgl)
BAR: 
BAT: 
BAS3875(tgl)
BAH: 
BAI: 
BAX: 
BANT: 
BANR: 
BANS: 
BANH: 
BAL: 
BCE: 
BC3963(tgl)
BCZ: 
BCR: 
BCB: 
BCU: 
BCG: 
BCQ: 
BCX: 
BNC: 
BCF: 
BCER: 
BCEF: 
BCY: 
BTK: 
BTL: 
BTB: 
BTT: 
BTC: 
BTF: 
BTM: 
BTG: 
BTI: 
BTN: 
BTHT: 
BTHU: 
BWE: 
BTY: 
BMYC: 
BCL: 
ABC2191(tgl)
BPU: 
BPUM: 
BPF: 
BMQ: 
BMD: 
BMH: 
BJS: 
BACI: 
BIF: 
BLE: 
BMET: 
BMP: 
GKA: 
GK2914(tgl)
GTN: 
GTH: 
GTE: 
GYC: 
GYA: 
GCT: 
GMC: 
GGH: 
GJF: 
GST: 
HHD: 
BBE: 
PJD: 
PPY: 
PPM: 
PPO: 
PPOL: 
PPQ: 
PMS: 
PMQ: 
PMW: 
PTA: 
PSAB: 
PDU: 
PBD: 
PGM: 
POD: 
PAEF: 
PAEA: 
PAEE: 
PAEH: 
PAEJ: 
CBO: 
CBO2291(tgl)
CBA: 
CBH: 
CBY: 
CBL: 
CBB: 
CBI: 
CBF: 
CBM: 
CBJ: 
CKL: 
CKR: 
CPAS: 
CCL: 
CSS: 
CSD: 
MEZ: 
 » show all
Taxonomy
Reference
1  [PMID:4151471]
  Authors
Folk JE, Chung SI.
  Title
Molecular and catalytic properties of transglutaminases.
  Journal
Adv. Enzymol. Relat. Areas. Mol. Biol. 38 (1973) 109-91.
Reference
2  [PMID:5928192]
  Authors
Folk JE, Cole PW.
  Title
Mechanism of action of guinea pig liver transglutaminase. I. Purification and properties of the enzyme: identification of a functional cysteine essential for activity.
  Journal
J. Biol. Chem. 241 (1966) 5518-25.
Reference
3  [PMID:73346]
  Authors
Folk JE, Finlayson JS.
  Title
The epsilon-(gamma-glutamyl)lysine crosslink and the catalytic role of transglutaminases.
  Journal
Adv. Protein. Chem. 31 (1977) 1-133.
Reference
4  [PMID:2877456]
  Authors
Takahashi N, Takahashi Y, Putnam FW.
  Title
Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 83 (1986) 8019-23.
  Sequence
[hsa:2162]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
80146-85-6

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