KEGG   ENZYME: 2.4.1.37Help
Entry
EC 2.4.1.37                 Enzyme                                 

Name
fucosylgalactoside 3-alpha-galactosyltransferase;
UDP-galactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase;
UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase;
[blood group substance] alpha-galactosyltransferase;
blood-group substance B-dependent galactosyltransferase;
glycoprotein-fucosylgalactoside alpha-galactosyltransferase;
histo-blood group B transferase;
histo-blood substance B-dependent galactosyltransferase;
UDP-galactose:alpha-L-fucosyl-1,2-D-galactoside 3-alpha-D-galactosyltransferase;
UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R04548]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
alpha-L-fucosyl-(1->2)-D-galactosyl-R [CPD:C04648]
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R [CPD:C04866]
Comment
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
History
EC 2.4.1.37 created 1972, modified 1999, modified 2002
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K00709  
histo-blood group ABO system transferase
Genes
HSA: 
28(ABO)
PTR: 
450164(ABO)
PPS: 
GGO: 
PON: 
MCC: 
722252(ABO)
MCF: 
CJC: 
MMU: 
80908(Abo)
RNO: 
100301568(Abo) 296504(Abo2) 65270(Gbgt1)
CGE: 
TUP: 
CFA: 
AML: 
UMR: 
BTA: 
515340(ABO)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
BACU: 
ECB: 
MYB: 
MYD: 
MDO: 
OAA: 
TGU: 
FAB: 
PHI: 
PSS: 
XLA: 
XTR: 
DRE: 
 » show all
Taxonomy
Reference
1  [PMID:16742598]
  Authors
Race C, Ziderman D, Watkins WM.
  Title
An alpha-d-galactosyltransferase associated with the blood-group B character.
  Journal
Biochem. J. 107 (1968) 733-735.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37257-33-3

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