KEGG   ENZYME: 2.4.1.37Help
Entry
EC 2.4.1.37                 Enzyme                                 

Name
fucosylgalactoside 3-alpha-galactosyltransferase;
UDP-galactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase;
UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase;
[blood group substance] alpha-galactosyltransferase;
blood-group substance B-dependent galactosyltransferase;
glycoprotein-fucosylgalactoside alpha-galactosyltransferase;
histo-blood group B transferase;
histo-blood substance B-dependent galactosyltransferase;
UDP-galactose:alpha-L-fucosyl-1,2-D-galactoside 3-alpha-D-galactosyltransferase;
UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R04548]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
alpha-L-fucosyl-(1->2)-D-galactosyl-R [CPD:C04648]
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R [CPD:C04866]
Comment
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
History
EC 2.4.1.37 created 1972, modified 1999, modified 2002
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec01100  Metabolic pathways
Orthology
K00709  histo-blood group ABO system transferase
Genes
HSA: 28(ABO)
PTR: 450164(ABO)
PPS: 100970130(ABO)
GGO: 101125978(ABO) 109025275
PON: 100454822(ABO)
MCC: 722252(ABO)
MCF: 102118138(ABO)
CSAB: 103239700(ABO)
RRO: 104669731(ABO)
RBB: 108512581 108513461(ABO)
CJC: 100414456(ABO)
MMU: 80908(Abo)
RNO: 100301568(Abo) 296504(Abo2) 65270(Gbgt1)
NGI: 103740691(Abo)
HGL: 106010599
CCAN: 109683353 109696117(Abo)
CFA: 100685413 491265(ABO)
AML: 100466091(ABO) 105235331
PTG: 107181109
AJU: 106989205
BTA: 515340(ABO)
BOM: 102283688(ABO)
BIU: 109565683(ABO)
PHD: 102327867
CHX: 102168916(ABO)
OAS: 101114008(ABO)
SSC: 396713(ABO)
CFR: 102523444(ABO)
CDK: 105105838(ABO)
BACU: 102997485
ECB: 102149124(ABO)
MYB: 102239108(ABO) 102250048
MYD: 102751691 102765942(ABO)
HAI: 109381041
RSS: 109445968(ABO)
LAV: 100670655(ABO)
MDO: 100017917(ABO)
OAA: 100075215
TGU: 100223725
GFR: 102039105
FAB: 101817249
PHI: 102113787
PMAJ: 107215091
CCW: 104697784
AAM: 106488041
GJA: 107119149(ABO) 107125123
DRE: 100005704(si:dkey-110k5.10)
ELS: 105009969
FPT: BZ13_510
HMS: HMU12050
 » show all
Taxonomy
Reference
1  [PMID:16742598]
  Authors
Race C, Ziderman D, Watkins WM.
  Title
An alpha-d-galactosyltransferase associated with the blood-group B character.
  Journal
Biochem. J. 107 (1968) 733-735.
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.37
IUBMB Enzyme Nomenclature: 2.4.1.37
ExPASy - ENZYME nomenclature database: 2.4.1.37
BRENDA, the Enzyme Database: 2.4.1.37
CAS: 37257-33-3

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