KEGG   ENZYME: 2.4.1.37Help
Entry
EC 2.4.1.37                 Enzyme                                 
Name
fucosylgalactoside 3-alpha-galactosyltransferase;
UDP-galactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase;
UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase;
[blood group substance] alpha-galactosyltransferase;
blood-group substance B-dependent galactosyltransferase;
glycoprotein-fucosylgalactoside alpha-galactosyltransferase;
histo-blood group B transferase;
histo-blood substance B-dependent galactosyltransferase;
UDP-galactose:alpha-L-fucosyl-1,2-D-galactoside 3-alpha-D-galactosyltransferase;
UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R04548]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
alpha-L-fucosyl-(1->2)-D-galactosyl-R [CPD:C04648]
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R (where R can be OH, an oligosaccharide;
a glycoconjugate)
Comment
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K00709  
histo-blood group ABO system transferase
Genes
HSA: 
28(ABO)
PTR: 
450164(ABO)
PPS: 
GGO: 
PON: 
MCC: 
722252(ABO)
MMU: 
80908(Abo)
RNO: 
100301568(Abo) 296504(Abo2) 65270(Abol1)
CFA: 
491265(ABO)
AML: 
BTA: 
515340(ABO)
SSC: 
396713(A)
ECB: 
100058033 100058525
MDO: 
100017917
OAA: 
100075215
XLA: 
495825
XTR: 
100491908 549437(abo) 549858 550054(abo)
DRE: 
100005704
 » show all
Taxonomy
Reference
1  [PMID:16742598]
  Authors
Race C, Ziderman D, Watkins WM.
  Title
An alpha-d-galactosyltransferase associated with the blood-group B character.
  Journal
Biochem. J. 107 (1968) 733-735.
  Organism
Homo sapiens [GN:hsa], Papio sp.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37257-33-3
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