KEGG   ENZYME: 2.4.1.40Help
Entry
EC 2.4.1.40                 Enzyme                                 

Name
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase;
A-transferase;
histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase);
UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase;
alpha-3-N-acetylgalactosaminyltransferase;
blood-group substance alpha-acetyltransferase;
blood-group substance A-dependent acetylgalactosaminyltransferase;
fucosylgalactose acetylgalactosaminyltransferase;
histo-blood group A acetylgalactosaminyltransferase;
histo-blood group A transferase;
UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-D-galactose [RN:R04423]
Reaction(KEGG)
R04423;
(other) R06167(G) R06187(G) R06191(G) R06193(G) R06197(G)
Show
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose
Product
UDP [CPD:C00015];
glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactose [CPD:C06483]
Comment
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
History
EC 2.4.1.40 created 1972, modified 1999
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series
Metabolic pathways
Orthology
K00709  
histo-blood group ABO system transferase
Genes
HSA: 
28(ABO)
PTR: 
450164(ABO)
PPS: 
GGO: 
PON: 
MCC: 
722252(ABO)
MCF: 
MMU: 
80908(Abo)
RNO: 
100301568(Abo) 296504(Abo2) 65270(Gbgt1)
CGE: 
TUP: 
CFA: 
AML: 
BTA: 
515340(ABO)
BOM: 
PHD: 
CHX: 
SSC: 
ECB: 
MYB: 
MDO: 
OAA: 
FAB: 
PSS: 
XLA: 
XTR: 
DRE: 
 » show all
Taxonomy
Reference
1  [PMID:5661629]
  Authors
Kobata A, Grollman EF, Ginsburg V.
  Title
An enzymic basis for blood type A in humans.
  Journal
Arch. Biochem. Biophys. 124 (1968) 609-12.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:2341371]
  Authors
Takeya A, Hosomi O, Ishiura M.
  Title
Complete purification and characterization of alpha-3-N-acetylgalactosaminyltransferase encoded by the human blood group A gene.
  Journal
J. Biochem. (Tokyo). 107 (1990) 360-8.
  Organism
Homo sapiens [GN:hsa]
Reference
3  [PMID:6434182]
  Authors
Yates AD, Feeney J, Donald AS, Watkins WM.
  Title
Characterisation of a blood-group A-active tetrasaccharide synthesised by a blood-group B gene-specified glycosyltransferase.
  Journal
Carbohydr. Res. 130 (1984) 251-60.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9067-69-0

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