Entry
Name
hydroxymethylbilane synthase;
HMB-synthase;
porphobilinogen deaminase;
pre-uroporphyrinogen synthase;
uroporphyrinogen I synthase;
uroporphyrinogen I synthetase;
uroporphyrinogen synthase;
uroporphyrinogen synthetase;
porphobilinogen ammonia-lyase (polymerizing);
(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)
Reaction(IUBMB)
4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3 [RN:
R00084 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme works by stepwise addition of pyrrolylmethyl groups until a hexapyrrole is present at the active centre. The terminal tetrapyrrole is then hydrolysed to yield the product, leaving a cysteine-bound dipyrrole on which assembly continues. In the presence of a second enzyme, EC
4.2.1.75 uroporphyrinogen-III synthase, which is often called cosynthase, the product is cyclized to form uroporphyrinogen-III. If EC
4.2.1.75 is absent, the hydroxymethylbilane cyclizes spontaneously to form uroporphyrinogen I.
History
EC 2.5.1.61 created 1972 as EC 4.3.1.8, transferred 2003 to EC 2.6.1.61
Pathway
ec01110 Biosynthesis of secondary metabolites
ec01120 Microbial metabolism in diverse environments
Orthology
K01749 hydroxymethylbilane synthase
Genes
CJC : 100413357 100415146(HMBS)
MBEZ : 129547952 129554407(HMBS)
PCAD : 102979611 102991359(HMBS)
PSIU : 116758729(HMBS) 116763572
XLA : 495094(hmbs.2.S) 734761(hmbs.L)
DRE : 338290(hmbsb) 394129(hmbsa)
SRX : 107717875 107718294 107722788 107743703
SANH : 107677419 107683832
SGH : 107585552 107587344 107597563
CCAR : 109075114 109090089 109103214
CAUA : 113049457 113058444 113115069(hmbs)
CGIB : 127957693 127972470 128028557
PTET : 122345866(hmbsa) 122359470(hmbsb)
LROH : 127165191(hmbsa) 127177708(hmbsb)
OMC : 131520394(hmbsb) 131540173(hmbsa)
PPRM : 120469617(hmbsa) 120478559(hmbsb)
RKG : 130079624(hmbsa) 130096745(hmbsb)
MAMB : 125248907(hmbsb) 125266765(hmbsa)
CIDE : 127495452 127512059
MASI : 127422507 127429774 127437517
TROS : 130547644(hmbsa) 130564716(hmbsb)
TDW : 130419242(hmbsa) 130428980(hmbsb)
MANU : 129438006(hmbsb) 129440197(hmbsa)
IPU : 108260104(hmbsa) 108278907
IFU : 128603705(hmbsa) 128622305
PHYP : 113531371 113541385
SMEO : 124379159(hmbsa) 124397910
TFD : 113643545(hmbsb) 113655179(hmbsa)
TVC : 132840674(hmbsa) 132860244
AMEX : 103032521(hmbs) 103033329
CMAO : 118814730(hmbsa) 118819966
EEE : 113570276(hmbs) 113573383
TNG : GSTEN00000647G001 GSTEN00006749G001 GSTEN00026829G001
SASA : 106602870(HEM3) 106612480(HEM3)
STRU : 115154961(hmbs) 115162949 115205906
OTW : 112228989(hmbsa) 112244707 112266732(hmbsb)
OMY : 110503548 110507390 110534248(hmbsa)
OGO : 123993102 124005181(hmbsa) 124005485(hmbsb)
ONE : 115135396 115137111 115141505
OKI : 109873005(hmbs) 109905390 109908873
OKE : 118386197 118390609(hmbsa) 118397101
SALP : 111949643 111950347(hmbs) 111960575
SNH : 120018828 120028752 120057382(hmbsa)
CCLU : 121567061 121567362 121579708(hmbsa)
ELS : 105010811(hmbs) 105011804
SFM : 108928797(hmbs) 108936288
PKI : 111833822(hmbs) 111846256
AANG : 118210459 118235552(hmbsa)
ARUT : 117397321 117966672
SCLV : 120325648 120325649
DSI : Dsimw501_GD13613(Dsim_GD13613)
AMER : 121599335 121602222
CFEL : 113372497 113372504
BTAB : 109029820 109042840
CANU : 128156174 128156638 128163148
DPOL : 127859381 127860916
SPIS : 111320056 111329862
CSAT : 104708270 104737889 104769031
BRP : 103847145 103850687 103855770
BNA : 106380526 106384978 106390310 106406147 106419256 111210448
BOE : 106319151 106327858 106328867
GHI : 107886892 107898868 107909031
HSYR : 120115907 120171424 120215008
GMX : 100779132 100810357 100812733 100818391
GSJ : 114376208 114380226 114425650
PVU : PHAVU_002G034500g PHAVU_011G1771000
CCAJ : 109798748 109810978
APRC : 113868815 113869593
LJA : Lj2g3v2099820.1(Lj2g3v2099820.1) Lj4g3v2313680.1(Lj4g3v2313680.1)
AIP : 107629558 107632968 107643140
AHF : 112737187 112749747 112789259 112801395
LANG : 109331744 109332367
QSA : O6P43_017087 O6P43_026796
MSYL : 126597731 126608515
CMAX : 111481450 111493083
CMOS : 111441758 111452689
CPEP : 111787740 111791833
PALZ : 118038655 118049726
NTA : 107767993 107802603 107802823 107830132
SSPL : 121742403 121756244 121759381
ATRI : 130800635 130818849
PSOM : 113280224 113290029
DOSA : Os02t0168800-01(Os02g0168800)
TAES : 123136516 123144012 543063
PVIR : 120654762 120663874
ZOF : 122012331 122015750 122021268 122024807
NCOL : 116264846 116267607
SMO : SELMODRAFT_164683 SELMODRAFT_447969
PPP : 112282646 112283846 112292703
CRE : CHLRE_02g113850v5 CHLRE_16g663900v5
VCN : VOLCADRAFT_119454 VOLCADRAFT_85406
MNG : MNEG_13064 MNEG_6565
MPP : MICPUCDRAFT_31842(HEMC)
NCS : NCAS_0C02590(NCAS0C02590)
NDI : NDAI_0E03290(NDAI0E03290)
TPF : TPHA_0L01160(TPHA0L01160)
TBL : TBLA_0A01470(TBLA0A01470)
TDL : TDEL_0B01790(TDEL0B01790)
KAF : KAFR_0H01650(KAFR0H01650)
KNG : KNAG_0A02430(KNAG0A02430)
CAL : CAALFM_C210360CA(HEM3)
PBEL : QC761_206210(HEM3_1)
PPSD : QC762_206210(HEM3_1)
PPSP : QC763_206210(HEM3_1)
PPSA : QC764_206210(HEM3_1)
NHE : NECHADRAFT_46061 NECHADRAFT_81309
FFC : NCS54_00786800 NCS54_01000600
FKR : NCS57_00829500 NCS57_00994700
TRE : TRIREDRAFT_110890 TRIREDRAFT_3596
TRR : M419DRAFT_128965 M419DRAFT_133213
PCHM : VFPPC_06727 VFPPC_14058
AMUS : LMH87_002207 LMH87_010874
PLJ : VFPFJ_06683 VFPFJ_10680
PTKZ : JDV02_005637(HEM3) JDV02_005928
ELA : UCREL1_3580 UCREL1_3893
BFU : BCIN_03g07300(Bchem3)
AFM : AFUA_3G13120 AFUA_5G11760
ACT : ACLA_014820 ACLA_061420
NFI : NFIA_064210 NFIA_075520 NFIA_083770
AOR : AO090012000205 AO090103000151 AO090120000294
ANG : An01g08640 An18g02970
AFV : AFLA_001924 AFLA_009511 AFLA_013369
ALUC : AKAW2_20916S AKAW2_31287S(HEM3)
APUU : APUU_10345A(HEM3_1) APUU_12034S(HEM3_2)
PCS : N7525_004721 N7525_006307 N7525_007157
POU : POX_d05283 POX_f08325
ZTR : MYCGRDRAFT_68361 MYCGRDRAFT_86044
NPA : UCRNP2_1574 UCRNP2_8928
TASA : A1Q1_03899 A1Q1_03900
CCAC : CcaHIS019_0407820(HEM3)
DSQ : DICSQDRAFT_110089 DICSQDRAFT_66851
SHS : STEHIDRAFT_157864 STEHIDRAFT_88841
ADL : AURDEDRAFT_188927 AURDEDRAFT_86960
LBC : LACBIDRAFT_181601 LACBIDRAFT_248667
ABP : AGABI1DRAFT110307(AGABI1DRAFT_110307)
ABV : AGABI2DRAFT189797(AGABI2DRAFT_189797)
SCM : SCHCO_02140623(SCHCODRAFT_02140623)
PSTR : Pst134EA_013811 Pst134EA_013826 Pst134EA_013828 Pst134EA_013830
PMAL : PMUG01_13019500(PBGD)
PREL : PRELSG_1102000(PBGD)
SMIN : v1.2.013126.t1(symbB.v1.2.013126.t1)
PTI : PHATRDRAFT_51811(hemC)
FCY : FRACYDRAFT_205101(PBGD)
TPS : THAPSDRAFT_9021(PbgD)
AAF : AURANDRAFT_27306 AURANDRAFT_59094
PSOJ : PHYSODRAFT_328896 PHYSODRAFT_336580 PHYSODRAFT_340850
ECOO : ECRM13514_4868(hemC)
ECOH : ECRM13516_4652(hemC)
ELR : ECO55CA74_22055(hemC)
ECW : EcE24377A_4320(hemC)
ECOA : APECO78_22855(hemC)
EDJ : ECDH1ME8569_3684(hemC)
ECOI : ECOPMV1_04141(hemC)
SEM : STMDT12_C40880(hemC)
SETC : CFSAN001921_20740(hemC)
SEEN : SE451236_01210(hemC)
SENH : CFSAN002069_12350(hemC)
SEEH : SEEH1578_05785(hemC)
SENJ : CFSAN001992_13990(hemC)
SEEC : CFSAN002050_02575(hemC)
SEEB : SEEB0189_022645(hemC)
SENC : SEET0819_03545(hemC)
REE : electrica_04884(hemC)
RTG : NCTC13098_07016(hemC)
BEC : GN160_02505(hemC) GN160_02580(hemC)
CLAP : NCTC11466_04421(hemC)
KIE : NCTC12125_03588(hemC)
AHN : NCTC12129_04747(hemC)
METY : MRY16398_54420(hemC)
PTF : PROFFT_A_06940(hemC)
PSHI : SAMEA2665130_2972(hemC)
YPG : YpAngola_A0536(hemC)
YPI : YpsIP31758_0198(hemC)
SMW : SMWW4_v1c01870(hemC)
SERS : SERRSCBI_00785(hemC)
SFJ : SAMEA4384070_0147(hemC)
SOF : NCTC11214_01937(hemC)
PAQU : DMB82_0019125(hemC)
DIC : Dpoa569_000282(hemC)
EHD : ERCIPSTX3056_312(hemC)
BAPF : BUMPF009_CDS00014(hemc)
BAPG : BUMPG002_CDS00014(hemc)
BAPU : BUMPUSDA_CDS00014(hemc)
BAPW : BUMPW106_CDS00014(hemc)
TPTY : NCTC11468_03515(hemC)
PHEI : NCTC12003_03716(hemC)
PRJ : NCTC6933_03730(hemC)
LRI : NCTC12151_03570(hemC)
HPIT : NCTC13334_00783(hemC)
PDAG : 4362423_01975(hemC)
ADP : NCTC12871_01148(hemC)
ALIG : NCTC10568_00291(hemC)
ASEG : NCTC10977_00163(hemC)
AVT : NCTC3438_00188(hemC)
RPNE : NCTC8284_00480(hemC)
PAET : NCTC13378_00300(hemC)
XFH : XFHB_07260 XFHB_07795
XFU : XFF4834R_chr06330(hemC)
XPH : XppCFBP6546_08530(hemC)
XHD : LMG31886_07360(hemC)
LLZ : LYB30171_02433(hemC)
VAU : VANGNB10_cI0071c(hemC)
VPL : SA104470976_02616(hemC)
PPR : PBPRA3527(HEMC) PBPRA3528(S3879)
PAEB : NCGM1900_6059(hemC)
PPRC : PFLCHA0_c59610(hemC)
PMUD : NCTC8068_05212(hemC)
PFW : PF1751_v1c53420(hemC)
PPUU : PputUW4_05275(hemC)
POJ : PtoMrB4_02100(hemC_1)
PTRT : HU722_0028620(hemC)
PTW : TUM18999_03480(hemC)
PTAE : NCTC10697_04374(hemC)
MSHE : MAALD49_05480(hemC)
PSYC : DABAL43B_0109(hemC)
MCAT : MC25239_00058(hemC)
MCUN : NCTC10297_00487(hemC)
SCAA : TUM17387_35320(hemC)
SALH : HMF8227_02894(hemC)
CBS : COXBURSA331_A0011(hemC)
LLG : 44548918_02320(hemC)
LJR : NCTC11533_02408(hemC)
LCJ : NCTC11976_00286(hemC)
LWA : SAMEA4504053_3241(hemC)
LSS : NCTC12082_01517(hemC)
LANT : TUM19329_32020(hemC)
MISZ : MishRS11D_40410(hemC)
TIB : THMIRHAM_01150(hemC)
TSE : THMIRHAS_01230(hemC)
TZO : THMIRHAT_01190(hemC)
TFRI : Thiofri_01579(hemC)
TNI : TVNIR_3829(hemC_[H])
GAI : IMCC3135_12325(hemC)
THIC : TspCOW1_24150(hemC)
HAXI : HAALTHF_11290n HAALTHF_11300n
ALCA : ASALC70_02783(hemC)
AEL : NCTC12917_00381(hemC)
CHJ : NCTC10426_01754(hemC)
CDIZ : CEDIAZO_03684(hemC)
NMM : NMBM01240149_1564(hemC)
NMS : NMBM01240355_0537(hemC)
NMQ : NMBM04240196_1626(hemC)
NMZ : NMBNZ0533_0577(hemC)
NMX : NMA510612_0807(hemC)
NWE : SAMEA3174300_1066(hemC)
NZO : SAMEA4504057_1533(hemC)
NCI : NCTC10296_02142(hemC)
NCZ : NCTC10294_00189(hemC)
NANI : NCTC12227_01367(hemC)
ECOR : SAMEA4412678_0398(hemC)
CARI : FNU76_08780(hemC) FNU76_11955(hemC)
BMV : BMASAVP1_A2284(hemC)
BML : BMA10229_A3000(hemC)
BPM : BURPS1710b_1229(hemC)
BPL : BURPS1106A_1077(hemC)
BUE : BRPE67_ACDS06230(hemC)
PHS : C2L64_12240 C2L64_47705
PEW : KZJ38_12155(hemC) KZJ38_15395(hemC)
PWU : A8O14_07175 A8O14_08285
PLG : NCTC10937_00114(hemC)
LMIR : NCTC12852_01596(hemC)
BUO : BRPE64_ACDS06850(hemC)
BTRM : SAMEA390648703981(hemC)
AXX : ERS451415_01756(hemC)
LIM : L103DPR2_00965(hemC_1) L103DPR2_02447(hemC_2)
LIH : L63ED372_00800(hemC)
DUG : HH213_00025(hemC) HH213_21100(hemC)
URU : DSM104443_04211(hemC)
UPL : DSM104440_03731(hemC)
FPHO : SHINM1_015310(HemC)
RTT : RTTH1527_02225(hemC)
RTB : RTB9991CWPP_02235(hemC)
ERW : ERWE_CDS_03800(hemC)
ERG : ERGA_CDS_03750(hemC)
MAMO : A6B35_03015 A6B35_32890
RBS : RHODOSMS8_02992(hemC)
SMEL : SM2011_c03231(hemC)
SFD : USDA257_c55940(hemC)
SAME : SAMCFNEI73_Ch3514(hemC)
EMX : FKV68_19345(hemC) FKV68_21975(hemC)
ECAA : J3R84_16635(hemC) J3R84_37940(hemC)
AGR : AGROH133_08877(hemC)
ALF : CFBP5473_02140(hemC)
AVV : RvVAT039_14650(hemC)
AVF : RvVAR031_01690(hemC)
ASAL : CFBP5507_12030(hemC)
RPUS : CFBP5875_11675(hemC)
ALEG : CFBP4996_12075(hemC)
REC : RHECIAT_CH0004188(hemC)
REL : REMIM1_CH03997(hemC)
REP : IE4803_CH04289(hemC)
REI : IE4771_CH04231(hemC)
RTR : RTCIAT899_CH16915(hemC)
RGA : RGR602_CH03824(hemC)
RPHA : AMC79_CH04122(hemC)
RGR : FZ934_15195(hemC) FZ934_20700(hemC)
RLW : RlegWSM1455_20165(hemC)
RBW : RLCC275e_20670(hemC) RLCC275e_34020(hemC)
NGL : RG1141_CH36250(hemC)
NEN : NCHU2750_34360(hemC)
LAS : CLIBASIA_04695(hemC)
BIO : BR141012304_10831(hemC)
BRS : S23_19030(hemC) S23_56100(hemC)
BRQ : CIT40_06485 CIT40_24010
BBET : F8237_07925(hemC) F8237_24605(hemC)
BSEP : HAP48_0028640(hemC)
BCAN : BcanWSM471_11040(hemC)
VGO : GJW-30_1_00045(hemC)
MAQU : Maq22A_c12240(hemC)
MMES : MMSR116_13515(hemC)
MTUN : MTUNDRAET4_0006(hemC)
FIL : BN1229_v1_1177(hemC)
FIY : BN1229_v1_1176(hemC)
BVY : NCTC9239_03208(hemC)
TSV : DSM104635_03720(hemC)
RLI : RLO149_c034980(hemC)
SINL : DSM14862_00132(hemC)
SPSE : SULPSESMR1_02757(hemC)
RMM : ROSMUCSMR3_00748(hemC)
AHT : ANTHELSMS3_01589(hemC)
LVS : LOKVESSMR4R_00753(hemC)
AALK : LGT41_0004250(hemC)
SBIN : SBA_ch1_07050(hemC)
SFLA : SPHFLASMR4Y_01770(hemC)
ABG : Asbog_00133(hemC) Asbog_01798(hemC)
RGI : RGI145_05985 RGI145_17645
ROS : CTJ15_11400 CTJ15_16495
RMUC : FOB66_07810(hemC) FOB66_21980(hemC)
RMT : IAI58_07640(hemC) IAI58_08715(hemC)
RFL : Rmf_06230(hemC_1) Rmf_21920(hemC_2)
RCV : PFY06_05985(hemC) PFY06_18305(hemC)
SRF : LHU95_02730(hemC) LHU95_14015(hemC)
ABF : AMK58_02025 AMK58_28545
AZZ : DEW08_17260 DEW08_19075
ELIO : KO353_02760(hemC) KO353_07670(hemC)
HPO : HMPREF4655_20481(hemC)
HPX : HMPREF0462_0291(hemC)
HPYA : HPAKL117_01190(hemC)
HPYK : HPAKL86_02160(hemC)
HCL : NCTC13205_00197(hemC)
HSH : NHP194022_13300(hemC)
HPUL : NCTC13154_01414(hemC)
CJV : MTVDSCj20_0562(hemC)
CFV : CFVI03293_0659(hemC)
CAMP : CFT03427_0682(hemC)
CCOC : CCON33237_0799(hemC)
CLR : UPTC16701_0781(hemC)
CLM : UPTC16712_0785(hemC)
CAMR : CAQ16704_0773(hemC)
CHV : CHELV3228_1466(hemC)
CPIN : CPIN18020_0464(hemC)
CAMZ : CVIC12175_0973(hemC)
GBN : GEOBRER4_04020(hemC)
PPOR : JCM14722_13000(hemC)
DEK : DSLASN_26350(hemC_1) DSLASN_31460(hemC_2)
MFB : MFUL124B02_16675(hemC)
BAZ : BAMTA208_13815(hemC)
BAE : BATR1942_11845(hemC)
BSON : S101395_01544(hemC)
BTHR : YBT1520_23670(hemC)
BTHU : YBT1518_24775(hemC)
BFD : NCTC4823_01492(hemC)
BACI : B1NLA3E_16800(hemC)
PARG : PspKH34_08390(hemC)
BLEN : NCTC4824_01531(hemC)
SAX : USA300HOU_1662(hemC)
SUQ : HMPREF0772_11480(hemC)
SUX : SAEMRSA15_15810(hemC)
SUF : SARLGA251_15630(hemC)
SAUT : SAI1T1_2012130(hemC)
SAUJ : SAI2T2_1012150(hemC)
SAUK : SAI3T3_1012130(hemC)
SAUQ : SAI4T8_1012140(hemC)
SAUV : SAI7S6_1012150(hemC)
SAUW : SAI5S5_1012100(hemC)
SAUX : SAI6T6_1012110(hemC)
SAUY : SAI8T7_1012140(hemC)
SDP : NCTC12225_01342(hemC)
SPIC : SAMEA4384060_1288(hemC)
SSH : NCTC13712_01659(hemC)
SSIM : SAMEA4384339_1552(hemC)
SSTE : SAMEA4384403_1084(hemC)
LMOC : LMOSLCC5850_1620(hemC)
LMW : LMOSLCC2755_1564(hemC)
LMX : LMOSLCC2372_1619(hemC)
LMZ : LMOSLCC2482_1613(hemC)
LMON : LMOSLCC2376_1512(hemC)
LMOS : LMOSLCC7179_1530(hemC)
LMOO : LMOSLCC2378_1574(hemC)
LMOY : LMOSLCC2479_1618(hemC)
LMOT : LMOSLCC2540_1636(hemC)
LMOA : LMOATCC19117_1567(hemC)
LGZ : NCTC10812_01545(hemC)
BAYD : BSPP4475_14105(hemC)
PPQ : PPSQR21_039220(hemC)
PNK : AASFL403_01785(hemC)
COHN : KCTCHS21_19160(hemC)
SMEN : SAMEA4412692_0374(hemC)
LRU : HMPREF0538_20889(hemC)
EAV : EH197_12740 EH197_14035
AUR : HMPREF9243_1726(hemC)
AMIT : DBT49_0001595(hemC)
CCOH : SAMEA4530647_0611(hemC)
CGEL : psyc5s11_37480(hemC)
CCL : Clocl_1785 Clocl_3589
RHER : EHE19_014870(hemC) EHE19_016080(hemC)
BLUI : Blut17040_11630(hemC)
CHYL : CE91St63_25700(hemC)
ACEL : acsn021_29350(hemC)
ACHT : bsdcttw_40580(hemC)
AMIC : Ami3637_03200(hemC)
ABUT : Ami103574_05925(hemC)
ETM : CE91St48_21080(hemC)
PDF : CD630DERM_34210(hemC)
PHX : KGNDJEFE_00490(hemC)
EAC : EAL2_808p01100(hemC)
CDIA : CaldiYA01_13100(hemC)
PIV : NCTC13079_00961(hemC)
VRM : 44547418_01502(hemC)
VDN : NCTC11831_01531(hemC)
DHO : Dia5BBH33_07110(hemC)
MANA : MAMMFC1_00903(hemC)
PFAC : PFJ30894_00527(hemC)
MMAE : MMARE11_07930(hemC)
MBAI : MB901379_00722(hemC)
MHEK : JMUB5695_04140(hemC)
MKY : IWGMT90018_08390(hemC)
MPHL : MPHLCCUG_04494(hemC)
MTHN : 4412656_00602(hemC)
MAUU : NCTC10437_00706(hemC)
MFLV : NCTC10271_04466(hemC)
MSAL : DSM43276_03808(hemC)
MTER : 4434518_00497(hemC)
CDIP : ERS451417_00324(hemC)
COI : CPCIP5297_01460(hemC)
CUN : Cul210932_0333(hemC)
CUQ : Cul210931_0318(hemC)
CUJ : CUL131002_0319(hemC)
CMIN : NCTC10288_02230(hemC)
CRL : NCTC7448_01143(HemC)
CCYS : SAMEA4530656_2169(hemC)
NFR : ERS450000_04715(hemC)
NBR : O3I_017610 O3I_038840(hemC)
NOZ : DMB37_17625 DMB37_39275(hemC)
NAH : F5544_10300(hemC) F5544_41320(hemC)
NAD : NCTC11293_00087(hemC)
NWL : NWFMUON74_65800(hemC)
NIE : KV110_09010(hemC) KV110_38010(hemC)
NSPU : IFM12276_57450(hemC)
RCR : NCTC10994_03575(hemC)
RANT : RHODO2019_01735(hemC)
TPUL : TPB0596_06780(hemC)
SCO : SCO3318(hemC) SCO7343(hemC)
SMA : SAVERM_1038(hemC2) SAVERM_4740(hemC1)
SCYE : R2B67_20580(hemC) R2B67_21685(hemC)
SCB : SCAB_39071(hemC1) SCAB_7581(hemC)
SSX : SACTE_2779 SACTE_6475
SVL : Strvi_0705 Strvi_2485
SHO : SHJGH_1852 SHJGH_5368
SRC : M271_13350 M271_22470 M271_24175
SMAL : SMALA_4305 SMALA_6081
SSOI : I1A49_25610(hemC) I1A49_34260(hemC)
SBH : SBI_02854 SBI_06011(hemC)
SDV : BN159_3978(hemC1) BN159_7764 BN159_8330(hemC2)
STRP : F750_3175 F750_6820
SCI : B446_04085 B446_21045(hemC)
SLV : SLIV_02580(hemC2) SLIV_21205(hemC1)
SGU : SGLAU_02490(hemC2) SGLAU_19170(hemC1)
STRE : GZL_04932 GZL_08398
SCW : TU94_01715 TU94_18645
SLC : SL103_01510 SL103_17805
STRM : M444_02885 M444_19955
STRC : AA958_20200 AA958_24485
SAMB : SAM23877_0864(hemC) SAM23877_4241(hemC)
SPRI : SPRI_0557 SPRI_3354
SCZ : ABE83_13075 ABE83_20980
SCX : AS200_21390 AS200_41230
SRW : TUE45_00867(hemC_1) TUE45_04986(hemC_2)
STRF : ASR50_04140 ASR50_20300
SLE : sle_31480(sle_31480) sle_65430(sle_65430)
SPAV : Spa2297_01960 Spa2297_18590
STRT : A8713_02315 A8713_17745
SCLF : BB341_07150 BB341_16685 BB341_21020
SGS : AVL59_03185 AVL59_27040
STSI : A4E84_02055 A4E84_23080
SALW : CP975_20055 CP975_32790(hemC)
SGM : GCM10017557_06170(hemC2) GCM10017557_47230(hemC1)
SCAD : DN051_17790 DN051_34860(hemC)
SPHW : NFX46_02780(hemC) NFX46_15435(hemC)
SLS : SLINC_0412 SLINC_4835
SNR : SNOUR_22535(hemC1) SNOUR_37970(hemC2)
SALL : SAZ_04975 SAZ_20950
SPLU : LK06_013380 LK06_030865
STRD : NI25_16735 NI25_35050
SNW : BBN63_02135 BBN63_13865
SAUO : BV401_25370 BV401_34205
SSIA : A7J05_03395 A7J05_15935
SVU : B1H20_16185 B1H20_20090
SPUN : BFF78_18745 BFF78_39520
SGV : B1H19_07170 B1H19_19675
SLAU : SLA_2163 SLA_3242 SLA_4726
SALF : SMD44_00648(hemC) SMD44_04941(hemC)
SLX : SLAV_00365(hemC1) SLAV_21510(hemC2) SLAV_39025(hemC3)
STRO : STRMOE7_01025 STRMOE7_18350
SNZ : DC008_19765 DC008_32050(hemC)
SGE : DWG14_03701(hemC_1) DWG14_07970(hemC_2)
SLK : SLUN_22780 SLUN_23465(hemC)
SDX : C4B68_06865(hemC) C4B68_17400
SGD : ELQ87_09315(hemC) ELQ87_16885 ELQ87_37200(hemC)
SQZ : FQU76_07620(hemC) FQU76_19375(hemC) FQU76_19800(hemC)
SCYA : EJ357_26490 EJ357_44930(hemC)
SAST : CD934_01880(hemC) CD934_17300
SNQ : CP978_19270 CP978_28540(hemC)
SKA : CP970_00640(hemC) CP970_18725
SNK : CP967_19340 CP967_33495(hemC)
SHAW : CEB94_02545(hemC) CEB94_23350
SRK : FGW37_05515(hemC) FGW37_05525(hemC) FGW37_14865(hemC) FGW37_17155(hemC)
SGAL : CP966_20855 CP966_34140(hemC)
SVR : CP971_18870 CP971_25840(hemC)
SPAD : DVK44_05320 DVK44_12960
SFY : GFH48_18320(hemC) GFH48_25830(hemC)
SAQU : EJC51_05475(hemC) EJC51_17800(hemC) EJC51_27755
SGF : HEP81_03465 HEP81_07092(hemC)
SSEO : D0Z67_06010(hemC) D0Z67_16495
SBY : H7H31_14135(hemC) H7H31_18515(hemC)
SRIM : CP984_00850(hemC) CP984_10325 CP984_21380
SSUB : CP968_01055 CP968_14835
SPHV : F9278_29460(hemC) F9278_44080(hemC)
SFUG : CNQ36_19820 CNQ36_32290(hemC)
SPAC : B1H29_16235 B1H29_33935
STSU : B7R87_07600 B7R87_18900 B7R87_19330
SCHA : CP983_18600 CP983_41190(hemC)
SCOE : CP976_24795 CP976_40580(hemC)
SBAT : G4Z16_13165(hemC) G4Z16_16250(hemC)
SSPB : CP982_24070 CP982_39450(hemC)
SNF : JYK04_00564(hemC_1) JYK04_04904(hemC_2)
SPLA : CP981_01000(hemC) CP981_18130
SBRO : GQF42_05600(hemC) GQF42_25115(hemC)
STUI : GCM10017668_39850(hemC1) GCM10017668_66800(hemC2)
SATA : C5746_18510 C5746_41495(hemC)
SCHF : IPT68_02760(hemC) IPT68_20655(hemC)
SCYG : S1361_02900(hemC1) S1361_22410(hemC2)
SFEU : IM697_25465(hemC) IM697_41765(hemC)
SLIA : HA039_14330(hemC) HA039_31780(hemC)
SDW : K7C20_01690(hemC) K7C20_17335(hemC)
SCAL : I6J39_16140(hemC) I6J39_19905(hemC)
SAUH : SU9_001245(hemC) SU9_015500(hemC)
SMOB : J7W19_14690(hemC) J7W19_28210(hemC)
SPRA : CP972_02865(hemC) CP972_20405
SPEU : CGZ69_10930(hemC) CGZ69_20220
SROI : IAG44_02440(hemC) IAG44_17010(hemC)
SGJ : IAG43_17920(hemC) IAG43_25095(hemC)
SHK : J2N69_21085(hemC) J2N69_34865(hemC)
SANU : K7396_19465(hemC) K7396_34570(hemC)
SDD : D9753_15240 D9753_33410(hemC)
SACT : DMT42_02535(hemC) DMT42_22175
SGOB : test1122_15150(hemC)
SINE : KI385_01960(hemC) KI385_21300(hemC)
SLF : JEQ17_26430(hemC) JEQ17_46100(hemC)
SDEC : L3078_27005(hemC) L3078_41910(hemC)
SAOV : G3H79_15690(hemC) G3H79_35350(hemC)
SDUR : M4V62_19565(hemC) M4V62_38325(hemC)
SAKB : K1J60_01800(hemC) K1J60_18390(hemC)
SNIG : HEK616_29160(hemC2) HEK616_72590(hemC1)
SCAE : IHE65_02755(hemC) IHE65_18680(hemC)
SSPN : LXH13_02075(hemC) LXH13_18540(hemC)
SCIR : STRCI_000356(hemC) STRCI_004619(hemC)
SXT : KPP03845_103442(hemC_1) KPP03845_107271(hemC_2)
SLON : LGI35_07295(hemC) LGI35_25520(hemC)
STUD : STRTU_003847(hemC) STRTU_006942(hemC)
STEE : F3L20_02225(hemC) F3L20_21360(hemC)
SGK : PET44_01415(hemC) PET44_18630(hemC)
SANT : QR300_11150(hemC) QR300_19730(hemC)
SYUN : MOV08_22950(hemC) MOV08_38960(hemC)
SARG : HKX69_14975(hemC) HKX69_32430(hemC)
SJN : RI060_17755(hemC) RI060_41215(hemC)
SOV : QZH56_19485(hemC) QZH56_32020(hemC)
SFIY : F0344_20585(hemC) F0344_23750(hemC)
SHAU : K9S39_24460(hemC) K9S39_40320(hemC)
SKG : KJK29_15520(hemC) KJK29_38035(hemC)
SCOA : QU709_17765(hemC) QU709_43610(hemC)
SLAI : P8A22_01170(hemC) P8A22_22275(hemC)
SFP : QUY26_16550(hemC) QUY26_37300(hemC)
SINN : ABB07_16755 ABB07_35230
STRZ : OYE22_13945(hemC) OYE22_18090(hemC)
SCT : SCAT_3426(hemC) SCAT_p1331(hemC)
SCY : SCATT_34120 SCATT_p03920
KSK : KSE_17950(hemC3) KSE_23210(hemC2) KSE_33620(hemC1)
KAB : B7C62_12910 B7C62_14170
KAU : B6264_13650 B6264_20395
KIT : CFP65_0117 CFP65_3145 CFP65_3314
KIS : HUT16_08050(hemC) HUT16_14385(hemC)
STRI : C7M71_012675 C7M71_017535 C7M71_026435(hemC)
STRH : GXP74_03870(hemC) GXP74_36670(hemC)
ABRY : NYE86_05990(hemC) NYE86_18280(hemC) NYE86_32370(hemC)
AGLA : OIE69_18490(hemC) OIE69_38615(hemC)
FSB : GCM10025867_10300(hemC1)
AMAU : DSM26151_01580(hemC)
AMAV : GCM10025877_17270(hemC1)
PSEV : USB125703_00797(hemC)
LYH : FrondiHNR_02615(hemC)
AAGI : NCTC2676_1_02087(hemC)
PSNI : NIBR502771_11800(hemC)
GCR : GcLGCM259_1916(hemC)
MICK : B1A86_00007625(hemC)
RDN : HMPREF0733_10110(hemC)
DCO : SAMEA4475696_0681(hemC)
DSS : GCM25873_04050(hemC1)
PAK : HMPREF0675_3347(hemC)
PAV : TIA2EST22_01535(hemC)
PAX : TIA2EST36_01520(hemC)
PAZ : TIA2EST2_01455(hemC)
CGRN : 4412665_00202(hemC)
PAUS : NCTC13651_02440(hemC)
PPC : HMPREF9154_1799(hemC) HMPREF9154_1805
ARUB : J5A65_06585 J5A65_06615(hemC)
TFL : RPIT_04730 RPIT_04745
TFA : BW733_01180 BW733_01195
TES : BW730_03975 BW730_03990
TEZ : BKM78_13700 BKM78_13715
TDF : H9L22_02870(hemC) H9L22_03770(hemC)
TLA : TLA_TLA_02761(hemC_1) TLA_TLA_02764(hemC_2)
RAIN : Rai3103_10005(hemC)
BROO : brsh051_09680(hemC) brsh051_09940
NAQU : ENKNEFLB_04155(hemC)
THAO : NI17_016725(hemC) NI17_021325(hemC)
TALX : FOF52_14095(hemC) FOF52_18490(hemC)
STRR : EKD16_01650(hemC1) EKD16_25155(hemC2)
ACTW : F7P10_24255(hemC) F7P10_28750(hemC)
AGRA : AGRA3207_004712(hemC)
AMAZ : LUW76_30460(hemC) LUW76_33185(hemC)
SPIQ : OHA34_13180(hemC) OHA34_20465(hemC) OHA34_26085(hemC)
ACTQ : OG417_35245(hemC) OG417_49580(hemC)
NOA : BKM31_07865 BKM31_43125
NGN : LCN96_02230(hemC) LCN96_33440(hemC)
SACG : FDZ84_08660(hemC) FDZ84_09550(hemC)
KBU : Q4V64_24655(hemC) Q4V64_28070(hemC) Q4V64_30060(hemC) Q4V64_32290(hemC) Q4V64_52305(hemC)
ACTA : C1701_01760(hemC) C1701_12810
MSAG : GCM10017556_19000(hemC)
AMS : AMIS_5580 AMIS_75810
ACTR : Asp14428_53420(hemC)
ACTL : L3i22_021020(hemC2) L3i22_101930(hemC)
ASIC : Q0Z83_082660(hemC_1) Q0Z83_094060(hemC_2)
CATI : CS0771_08490(hemC) CS0771_41160(hemC2)
MCU : HMPREF0573_10731(hemC)
TBW : NCTC13354_01101(hemC)
ANE : ATCC27039_20590(hemC)
AHW : NCTC11636_01881(hemC)
AIR : NCTC12972_02069(hemC)
ASLA : NCTC11923_00428(hemC)
AVC : NCTC10951_02027(hemC)
ACAP : MANAM107_12690(hemC)
FSL : EJO69_07165 EJO69_07200
BALA : DSM104299_05757(hemC)
SBAE : DSM104329_05680(hemC)
SYR : SynRCC307_0896(hemC)
SYX : SynWH7803_0609(hemC)
SYH : Syncc8109_0746(hemC)
SYNW : SynWH8103_02040(hemC)
TVN : NIES2134_115610(hemC)
LET : O77CONTIG1_00633(hemC)
CHON : NIES4102_20040(hemC)
SYP : SYNPCC7002_A1610(hemC)
SYNN : NIES970_25460(hemC)
MVZ : myaer102_17060(hemC)
PAGH : NIES204_42060(hemC)
PRUN : PCC7821_00076(hemC)
NFL : COO91_04621 COO91_11140
NED : HUN01_04260(hemC) HUN01_15280(hemC)
NSPH : BDGGKGIB_04461(hemC)
NCN : BZZ01_10345 BZZ01_12160 BZZ01_22065
DEIN : DAAJ005_06360(hemC)
MRE : K649_03275(hemC) K649_06650
MTAI : Mtai_v1c04600 Mtai_v1c15780
MSV : Mesil_0353 Mesil_2984
OBG : Verru16b_03096(hemC)
ABIW : Abiwalacus_18390(hemC)
LCRE : Pla8534_32300(hemC)
TRS : Terro_2214 Terro_2578
FPOL : ERS445057_01615(hemC)
PPIO : CE91St28_12100(hemC)
PCRE : NCTC12858_00575(hemC)
PCAG : NCTC12856_00731(hemC)
SMIZ : 4412673_00613(hemC)
SDJ : NCTC13534_00678(hemC)
STHA : NCTC11429_00963(hemC)
PSEZ : HME7025_02037(hemC)
FOK : KK2020170_07710(hemC)
ZGA : ZOBELLIA_1862(hemCD)
PHG : KCTC32516_01501(hemC)
AALG : AREALGSMS7_01521(hemC)
KOS : KORDIASMS9_01338(hemC)
KAN : IMCC3317_27140(hemC)
SPON : HME9304_01666(hemC)
FBU : UJ101_00576(hemC|HMBS)
OHM : MSHRCOH1_01210(hemC)
CGLE : NCTC11432_03496(hemC)
CTAI : NCTC12078_02023(hemC)
CTAK : 4412677_01476(hemC)
CJG : NCTC13459_02117(hemC)
CANT : NCTC13489_02116(hemC)
KFA : Q73A0000_12155(hemC)
PTAN : CRYO30217_02112(hemC)
PROC : Ptc2401_00663(hemC)
HALQ : Hrr1229_009400(hemC)
HACB : Hbl1158_01705(hemC)
TVO : TVG0625731(TVG0625731)
SACR : SacRon12I_03770(hemC)
LOKI : Lokiarch_29910(hemC_1) Lokiarch_30550(hemC_2)
» show all
Taxonomy
Reference
Authors
Battersby AR, Fookes CJ, Matcham GW, McDonald E.
Title
Biosynthesis of the pigments of life: formation of the macrocycle.
Journal
Reference
Authors
Frydman RB, Feinstein G.
Title
Studies on porphobilinogen deaminase and uroporphyrinogen 3 cosynthase from human erythrocytes.
Journal
Reference
Authors
Levin EY, Coleman DL.
Title
The enzymatic conversion of porphobilinogen to uroporphyrinogen catalyzed by extracts of hematopoietic mouse spleen.
Journal
J Biol Chem 242:4247-53 (1967)
Reference
Authors
Warren MJ, Jordan PM.
Title
Investigation into the nature of substrate binding to the dipyrromethane cofactor of Escherichia coli porphobilinogen deaminase.
Journal
Reference
Authors
Miller AD, Hart GJ, Packman LC, Battersby AR.
Title
Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242.
Journal
Sequence
Reference
Authors
Battersby AR.
Title
Tetrapyrroles: the pigments of life.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.61
ExPASy - ENZYME nomenclature database: 2.5.1.61