KEGG   ENZYME: 2.6.1.81Help
Entry
EC 2.6.1.81                 Enzyme                                 

Name
succinylornithine transaminase;
succinylornithine aminotransferase;
N2-succinylornithine 5-aminotransferase;
AstC;
SOAT;
2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase
Reaction(IUBMB)
N2-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate [RN:R04217]
Reaction(KEGG)
Substrate
N2-succinyl-L-ornithine [CPD:C03415];
2-oxoglutarate [CPD:C00026]
Product
N-succinyl-L-glutamate 5-semialdehyde [CPD:C05932];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Also acts on N2-acetyl-L-ornithine and L-ornithine, but more slowly [3]. In Pseudomonas aeruginosa, the arginine-inducible succinylornithine transaminase, acetylornithine transaminase (EC 2.6.1.11) and ornithine aminotransferase (EC 2.6.1.13) activities are catalysed by the same enzyme, but this is not the case in all species [5]. This is the third enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [3,6].
History
EC 2.6.1.81 created 2006
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K00840  succinylornithine aminotransferase
Genes
ECO: b1748(astC)
ECJ: JW1737(astC)
ECD: ECDH10B_1886(astC)
EBW: BWG_1561(astC)
ECOK: ECMDS42_1423(astC)
ECE: Z2780(cstC)
ECS: ECs2454(argD)
ECF: ECH74115_2466(astC)
ETW: ECSP_2316(astC)
ELX: CDCO157_2288(argD)
EOJ: ECO26_2523(astC)
EOI: ECO111_2259(astC)
EOH: ECO103_1941(astC)
ECG: E2348C_1876(astC)
EOK: G2583_2194(astC)
ECC: c2148(cstC)
ECP: ECP_1694
ECI: UTI89_C1943(astC)
ECV: APECO1_817(cstC)
ECX: EcHS_A1831(astC)
ECW: EcE24377A_1970(astC)
ECM: EcSMS35_1443(astC)
ECY: ECSE_1918
ECR: ECIAI1_1809(astC)
ECQ: ECED1_1950(astC)
ECK: EC55989_1916(astC)
ECT: ECIAI39_1306(astC)
EOC: CE10_2027(astC)
EUM: ECUMN_2037(astC)
ECZ: ECS88_1800(astC)
ELO: EC042_1913(astC)
ELH: ETEC_1780
ESE: ECSF_1609
ESO: O3O_14395
ESM: O3M_11200
ESL: O3K_11220
EBR: ECB_01717(astC)
EBD: ECBD_1897
EKF: KO11_13995(astC)
EAB: ECABU_c20050(astC)
EDJ: ECDH1ME8569_1692(astC)
EIH: ECOK1_1868(argM)
ENA: ECNA114_1793(argD)
EUN: UMNK88_2212(astC)
ELW: ECW_m1917(astC)
ELL: WFL_09400(astC)
ELC: i14_1967(argD)
ELD: i02_1967(argD)
ELP: P12B_c1335(cstC)
EBL: ECD_01717(astC)
EBE: B21_01705(astC)
ELF: LF82_0182(astC)
ECOI: ECOPMV1_01846(astC)
ECOJ: P423_09305
ECOO: ECRM13514_2245(argD)
ECOH: ECRM13516_2150(argD)
ECOS: EC958_1968(astC)
EFE: EFER_1317(astC)
EAL: EAKF1_ch4303(astC)
STY: STY1811(astC)
STT: t1182(astC)
STM: STM1303(astC)
SEO: STM14_1582(argD_1)
SEY: SL1344_1238(argDa)
SEJ: STMUK_1270(argD)
SEB: STM474_1307(argD)
SEF: UMN798_1359(argD)
SENR: STMDT2_12361(argD)
SEND: DT104_12791(astC)
SENI: CY43_06635
SPT: SPA1541(astC)
SEK: SSPA1432
SEI: SPC_2428(argD)
SEC: SCH_1326(astC)
SEH: SeHA_C1430(astC)
SHB: SU5_01922
SEA: SeAg_B1871(astC)
SENS: Q786_08740
SED: SeD_A2043
SEG: SG1813(astC)
SEL: SPUL_1118(astC)
SEGA: SPUCDC_1118(astC)
SET: SEN1740(astC)
SENA: AU38_09005
SENO: AU37_09010
SENV: AU39_09015
SENQ: AU40_10060
SENL: IY59_09210
SEEP: I137_05140
SENE: IA1_06430
SBG: SBG_1156(astC)
SBZ: A464_1258
SFT: NCTC1_01594(astC_1) NCTC1_01595(astC_2)
SSN: SSON_1409(cstC)
SBO: SBO_1342(cstC)
SBC: SbBS512_E1995(astC)
ENC: ECL_02449
EEC: EcWSU1_01779(astC)
ECLX: LI66_09000
ECLY: LI62_09775
ECLZ: LI64_09065
ENF: AKI40_2723(astC)
ESA: ESA_02157
CSK: ES15_2307(astC)
CTU: CTU_18160(astC)
KPN: KPN_01221(argD) KPN_01493
KPU: KP1_2251(argD) KP1_2498
KPE: KPK_2968 KPK_3222(astC)
KPX: PMK1_03600(astC_1) PMK1_03811(astC_2)
KPNU: LI86_14155(argD) LI86_15910
KPNK: BN49_2356(astC) BN49_2555(astC2)
KOX: KOX_18140
KOE: A225_2484
CKO: CKO_01774
CRO: ROD_13091(astC)
CAMA: F384_05915
ICP: BAH83492.1(astC)
EBF: D782_2555
PSTS: E05_12070
YPE: YPO1962(argD)
YPK: y2349(cstC)
YPA: YPA_1344
YPM: YP_1707(cstC)
YPG: YpAngola_A2520(argM)
YPD: YPD4_1727(argD)
YPX: YPD8_1821(argD)
YPW: CH59_3760(astC)
YPV: BZ15_1579(astC)
YPL: CH46_3152(astC)
YPS: YPTB1959(astC)
YPO: BZ17_510(astC)
YPI: YpsIP31758_2121(argM)
YPY: YPK_2229
YPB: YPTS_2011
YPQ: DJ40_354(astC)
YPU: BZ21_1232(astC)
YPR: BZ20_156(astC)
YPC: BZ23_1516(astC)
YPF: BZ19_1307(astC)
YEN: YE2469(argM)
YEY: Y11_12271
YEW: CH47_1817(astC)
YET: CH48_3482(astC)
YEE: YE5303_21291(argM)
YAL: AT01_648(astC)
YFR: AW19_982(astC)
YIN: CH53_3733(astC)
YKR: CH54_681(astC)
YRO: CH64_338(astC)
YRU: BD65_121(astC)
SPE: Spro_2844
SRL: SOD_c26870(astC)
SPLY: Q5A_014905(astC)
SMAF: D781_2663
SMW: SMWW4_v1c28620(astC)
SMAR: SM39_2326(astC)
SMAC: SMDB11_2120(astC)
SERF: L085_14480
RAA: Q7S_08160
ETA: ETA_18590(argM)
EPY: EpC_19470(argM)
EPR: EPYR_02104(argD)
EBI: EbC_18580(astC)
ERJ: EJP617_27710(argM)
EGE: EM595_1635(astC)
PAM: PANA_1674(argM)
PLF: PANA5342_2540(astC)
PAJ: PAJ_1024(argM)
PVA: Pvag_1114(astC)
PCK: BMSBPS_p0005(astC)
PSTW: DSJ_12755
PLU: plu3110(argM)
PAY: PAU_01497(argM)
XBO: XBJ1_2942(argM)
XBV: XBW1_3141(astC)
XNM: XNC2_2684
XDO: XDD1_2670(astC)
XPO: XPG1_1214(astC)
PAE: PA0895(aruC)
PAEV: N297_923(aruC)
PAEI: N296_923(aruC)
PAU: PA14_52720(aruC)
PAP: PSPA7_4620(aruC)
PAG: PLES_44211(aruC)
PAF: PAM18_4144(aruC)
PNC: NCGM2_1673(argD)
PAEB: NCGM1900_1827(argD)
PDK: PADK2_21225(argD)
PSG: G655_20875(argD)
PRP: M062_04365(argD)
PAEP: PA1S_21965(argD)
PAEM: U769_21335(argD)
PAEL: T223_22600(argD)
PAEU: BN889_00933(argD)
PAEG: AI22_11975(argD)
PAEC: M802_919(aruC)
PAEO: M801_923(aruC)
PMY: Pmen_2911
PMK: MDS_1747
PRE: PCA10_42420(argD)
PPSE: BN5_1490(argD1) BN5_1906(argD3)
PALC: A0T30_14685(argD)
PCQ: PcP3B5_15710(aruC)
PPU: PP_4481(astC)
PPF: Pput_1434
PPT: PPS_3826
PPB: PPUBIRD1_1421(argD)
PPI: YSA_07941
PPX: T1E_2407
PPUH: B479_19015(argD)
PPUT: L483_24480(argD)
PPUN: PP4_13390(argD)
PPUD: DW66_4260
PMON: X969_18420(argD)
PMOT: X970_18055(argD)
PMOS: O165_015745(argD)
POR: APT59_07515(argD)
PST: PSPTO_1832(argD-1)
PSB: Psyr_3565(argD)
PSYR: N018_07595(argD)
PSP: PSPPH_3521(argD2)
PFL: PFL_4515
PPRC: PFLCHA0_c45870(argD2)
PPRO: PPC_4619
PFO: Pfl01_4285(argD)
PFS: PFLU_4758
PFN: HZ99_09915(argD)
PFW: PF1751_v1c42620(argD)
PFF: PFLUOLIPICF714840(argD)
PFX: A7318_20635(argD)
PPZ: H045_14830(argD)
PFB: VO64_1607
PMAN: OU5_5001
PTV: AA957_21045(argD)
PCG: AXG94_08500(argD)
PAZO: AYR47_30585(argD)
PEN: PSEEN3882(aruC)
PSA: PST_1649(argD)
PSZ: PSTAB_1559(argD)
PSR: PSTAA_1677(argD)
PSC: A458_09080(argD)
PSJ: PSJM300_06735(argD)
PSTU: UIB01_13720(argD)
PSTT: CH92_13795(argD)
PBM: CL52_12050(argD)
PBC: CD58_22825(argD)
PPUU: PputUW4_04175(argD2)
PDR: H681_08610(argD)
PSV: PVLB_17545(argD)
PSK: U771_24735(argD)
PKC: PKB_1592(aruC)
PCH: EY04_22900(argD)
PCP: JM49_08280(argD)
PFZ: AV641_17230(argD)
PRH: LT40_01090(argD)
PSW: LK03_12230(argD)
PPV: NJ69_11265(argD)
PSES: PSCI_0166(argD)
PSEM: TO66_23580(argD)
PSEC: CCOS191_1434(argD)
PPSY: AOC04_14475(argD)
PSOS: POS17_4581
PKR: AYO71_23445(argD)
PANR: A7J50_4520
AVN: Avin_34500(argD)
AVL: AvCA_34500(argD)
AVD: AvCA6_34500(argD)
ACX: Achr_13870(argD)
PBB: AKN87_04330(argD)
ACB: A1S_3132
ABM: ABSDF0355(astC)
ABY: ABAYE0352(astC)
ABX: ABK1_3382
ABAD: ABD1_05420(astC) ABD1_11040(astC) ABD1_30200(astC)
ABK: LX00_05545(argD) LX00_16830(argD)
ABAU: IX87_05430(argD) IX87_12425(argD)
ABAA: IX88_00435(argD) IX88_07710(argD)
ABW: BL01_04040(argD)
ACC: BDGL_000368(astC) BDGL_002597(astC)
ANO: RR32_01915(argD) RR32_12680(argD)
ACI: ACIAD1284(astC)
AEI: AOY20_02695(argD)
AJO: RZ95_12830(argD)
ACW: A0J50_01720(argD) A0J50_12005(argD)
MAQ: Maqu_3319
MHC: MARHY3164(argD)
MAD: HP15_3042
MBS: MRBBS_3290(argD)
MSR: AU15_11045(argD)
MSX: AU14_04390(argD)
HCH: HCH_01947(aruC)
BMA: BMA0591(argD)
BMV: BMASAVP1_A2425(astC)
BML: BMA10229_A2866(astC)
BMN: BMA10247_1736(astC)
BMAL: DM55_1965(astC)
BMAE: DM78_1183(astC)
BMAQ: DM76_1940(astC)
BMAI: DM57_2606
BMAF: DM51_377(astC)
BMAZ: BM44_1454(astC)
BMAB: BM45_1017(astC)
BPS: BPSL2390(argD)
BPM: BURPS1710b_2847(astC)
BPL: BURPS1106A_2785(astC)
BPD: BURPS668_2727(astC)
BPSE: BDL_3100(astC)
BPSM: BBQ_922(astC)
BPSU: BBN_1049(astC)
BPSD: BBX_1501(astC)
BPK: BBK_2567(astC)
BPSH: DR55_2131(astC)
BPSA: BBU_3171(astC)
BPSO: X996_1774(astC)
BUT: X994_47(astC)
BTE: BTH_I1775
BTQ: BTQ_2140(astC)
BTJ: BTJ_171(astC)
BTZ: BTL_1466(astC)
BTD: BTI_1244(astC)
BTV: BTHA_1570(astC)
BTHE: BTN_3309(astC)
BTHM: BTRA_1692(astC)
BTHA: DR62_79
BTHL: BG87_1679(astC)
BOK: DM82_2004(astC)
BOC: BG90_2708(astC)
BVE: AK36_2749(astC)
BCN: Bcen_0701
BCJ: BCAL1059(argM)
BCEN: DM39_1027(astC)
BCEW: DM40_1844(astC)
BCEO: I35_1051(argD)
BAM: Bamb_1061
BMU: Bmul_2124
BMJ: BMULJ_01120(argD)
BMK: DM80_457(astC)
BMUL: NP80_1290(astC)
BCT: GEM_2334
BCED: DM42_542(astC)
BDL: AK34_1966(astC)
BCON: NL30_09740
BUB: BW23_551(astC)
BLAT: WK25_05625
BTEI: WS51_16165
BSEM: WJ12_05790
BPSL: WS57_23495
BMEC: WJ16_05565
BSTG: WT74_05920
BGP: BGL_1c10430(argD)
BGU: KS03_1942(astC)
BGO: BM43_2488(astC)
BUK: MYA_1076
BUO: BRPE64_ACDS10840(argD)
BUE: BRPE67_ACDS09970(argD)
BUL: BW21_1393(astC)
BXE: Bxe_A2923
BXB: DR64_605(astC)
BPH: Bphy_1787
BFN: OI25_163(astC)
PPNO: DA70_03080(argD)
PPNM: LV28_03255
PPUL: RO07_22135
PSPU: NA29_14785
PAPI: SG18_21385
JAG: GJA_307(astC)
JAZ: YQ44_00420(argD)
MNR: ACZ75_21145(argD)
MASW: AM586_26275(argD)
OFO: BRW83_0372(aruC)
 » show all
Taxonomy
Reference
1  [PMID:2865249]
  Authors
Vander Wauven C, Stalon V.
  Title
Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia.
  Journal
J. Bacteriol. 164 (1985) 882-6.
Reference
2  [PMID:9696779]
  Authors
Schneider BL, Kiupakis AK, Reitzer LJ.
  Title
Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli.
  Journal
J. Bacteriol. 180 (1998) 4278-86.
  Sequence
[eco:b1748]
Reference
3  [PMID:3534538]
  Authors
Cunin R, Glansdorff N, Pierard A, Stalon V.
  Title
Biosynthesis and metabolism of arginine in bacteria.
  Journal
Microbiol. Rev. 50 (1986) 314-52.
Reference
4  [PMID:9393691]
  Authors
Itoh Y.
  Title
Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa.
  Journal
J. Bacteriol. 179 (1997) 7280-90.
  Sequence
[pae:PA0895]
Reference
5  [PMID:3129535]
  Authors
Stalon V, Vander Wauven C, Momin P, Legrain C.
  Title
Catabolism of arginine, citrulline and ornithine by Pseudomonas and related bacteria.
  Journal
J. Gen. Microbiol. 133 (1987) 2487-95.
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.81
IUBMB Enzyme Nomenclature: 2.6.1.81
ExPASy - ENZYME nomenclature database: 2.6.1.81
BRENDA, the Enzyme Database: 2.6.1.81

DBGET integrated database retrieval system