KEGG   ENZYME: 2.7.10.1Help
Entry
EC 2.7.10.1                 Enzyme                                 
Name
receptor protein-tyrosine kinase;
AATK;
AATYK;
AATYK2;
AATYK3;
ACH;
ALK;
anaplastic lymphoma kinase;
ARK;
ATP:protein-tyrosine O-phosphotransferase (ambiguous);
AXL;
Bek;
Bfgfr;
BRT;
Bsk;
C-FMS;
CAK;
CCK4;
CD115;
CD135;
CDw135;
Cek1;
Cek10;
Cek11;
Cek2;
Cek3;
Cek5;
Cek6;
Cek7;
CFD1;
CKIT;
CSF1R;
DAlk;
DDR1;
DDR2;
Dek;
DKFZp434C1418;
Drosophila Eph kinase;
DRT;
DTK;
Ebk;
ECK;
EDDR1;
Eek;
EGFR;
Ehk2;
Ehk3;
Elk;
EPH;
EPHA1;
EPHA2;
EPHA6;
EPHA7;
EPHA8;
EPHB1;
EPHB2;
EPHB3;
EPHB4;
EphB5;
ephrin-B3 receptor tyrosine kinase;
EPHT;
EPHT2;
EPHT3;
EPHX;
ERBB;
ERBB1;
ERBB2;
ERBB3;
ERBB4;
ERK;
Eyk;
FGFR1;
FGFR2;
FGFR3;
FGFR4;
FLG;
FLK1;
FLK2;
FLT1;
FLT2;
FLT3;
FLT4;
FMS;
Fv2;
HBGFR;
HEK11;
HEK2;
HEK3;
HEK5;
HEK6;
HEP;
HER2;
HER3;
HER4;
HGFR;
HSCR1;
HTK;
IGF1R;
INSR;
INSRR;
insulin receptor protein-tyrosine kinase;
IR;
IRR;
JTK12;
JTK13;
JTK14;
JWS;
K-SAM;
KDR;
KGFR;
KIA0641;
KIAA1079;
KIAA1459;
Kil;
Kin15;
Kin16;
KIT;
KLG;
LTK;
MCF3;
Mdk1;
Mdk2;
Mdk5;
MEhk1;
MEN2A/B;
Mep;
MER;
MERTK;
MET;
Mlk1;
Mlk2;
Mrk;
MST1R;
MTC1;
MUSK;
Myk1;
N-SAM;
NEP;
NET;
Neu;
neurite outgrowth regulating kinase;
NGL;
NOK;
nork;
novel oncogene with kinase-domain;
Nsk2;
NTRK1;
NTRK2;
NTRK3;
NTRK4;
NTRKR1;
NTRKR2;
NTRKR3;
Nuk;
NYK;
PCL;
PDGFR;
PDGFRA;
PDGFRB;
PHB6;
protein-tyrosine kinase (ambiguous);
protein tyrosine kinase (ambiguous);
PTK;
PTK3;
PTK7;
receptor protein tyrosine kinase;
RET;
RON;
ROR1;
ROR2;
ROS1;
RSE;
RTK;
RYK;
SEA;
Sek2;
Sek3;
Sek4;
Sfr;
SKY;
STK;
STK1;
TEK;
TIE;
TIE1;
TIE2;
TIF;
TKT;
TRK;
TRKA;
TRKB;
TRKC;
TRKE;
TYK1;
TYRO10;
Tyro11;
TYRO3;
Tyro5;
Tyro6;
TYRO7;
UFO;
VEGFR1;
VEGFR2;
VEGFR3;
Vik;
YK1;
Yrk
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-tyrosine kinases
BRITE hierarchy
Sysname
ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type)
Reaction(IUBMB)
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate [RN:R02584]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
[protein]-L-tyrosine [CPD:C00585]
Product
ADP [CPD:C00008];
[protein]-L-tyrosine phosphate [CPD:C01167]
Comment
The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in Metazoans [1]. In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
Orthology
K03176  
neurotrophic tyrosine kinase receptor type 1
K04360  
neurotrophic tyrosine kinase receptor type 2
K04361  
epidermal growth factor receptor
K04362  
fibroblast growth factor receptor 1
K04363  
platelet-derived growth factor receptor alpha
K04527  
insulin receptor
K05083  
receptor tyrosine-protein kinase erbB-2
K05084  
receptor tyrosine-protein kinase erbB-3
K05085  
receptor tyrosine-protein kinase erbB-4
K05086  
insulin receptor-related receptor
K05087  
insulin-like growth factor 1 receptor
K05088  
proto-oncogene tyrosine-protein kinase ROS
K05089  
platelet-derived growth factor receptor beta
K05090  
macrophage colony-stimulating factor 1 receptor
K05091  
proto-oncogene tyrosine-protein kinase Kit
K05092  
fms-related tyrosine kinase 3
K05093  
fibroblast growth factor receptor 2
K05094  
fibroblast growth factor receptor 3
K05095  
fibroblast growth factor receptor 4
K05096  
FMS-like tyrosine kinase 1
K05097  
FMS-like tyrosine kinase 4
K05098  
kinase insert domain protein receptor
K05099  
proto-oncogene tyrosine-protein kinase Met
K05100  
macrophage-stimulating 1 receptor
K05101  
neurotrophic tyrosine kinase, receptor type 3
K05102  
Eph receptor A1
K05103  
Eph receptor A2
K05104  
Eph receptor A3
K05105  
Eph receptor A4
K05106  
Eph receptor A5
K05107  
Eph receptor A6
K05108  
EphA7
K05109  
Eph receptor A8
K05110  
Eph receptor B1
K05111  
Eph receptor B2
K05112  
Eph receptor B3
K05113  
Eph receptor B4
K05114  
Eph receptor B6
K05115  
AXL receptor tyrosine kinase
K05116  
TYRO3 protein tyrosine kinase 3
K05117  
c-mer proto-oncogene tyrosine kinase
K05118  
leukocyte tyrosine kinase
K05119  
anaplastic lymphoma kinase
K05120  
tyrosine kinase receptor 1
K05121  
endothelial-specific receptor tyrosine kinase
K05122  
receptor tyrosine kinase-like orphan receptor 1
K05123  
receptor tyrosine kinase-like orphan receptor 2
K05124  
discoidin domain receptor family member 1
K05125  
discoidin domain receptor family member 2
K05126  
proto-oncogene tyrosine-protein kinase Ret
K05127  
PTK7 protein tyrosine kinase 7
K05128  
RYK receptor-like tyrosine kinase
K05129  
muscle, skeletal, receptor tyrosine kinase
K08252  
receptor protein-tyrosine kinase
K08897  
Eph receptor A10
K08898  
lemur tyrosine kinase 2
K08899  
lemur tyrosine kinase 3
K12378  
tyrosine-protein kinase receptor torso
K13415  
protein brassinosteroid insensitive 1
K13416  
brassinosteroid insensitive 1-associated receptor kinase 1
K13417  
somatic embryogenesis receptor kinase 4
K13418  
somatic embryogenesis receptor kinase 1
Genes
HSA: 
10461(MERTK) 114783(LMTK3) 1436(CSF1R) 1956(EGFR) 1969(EPHA2) 2041(EPHA1) 2042(EPHA3) 2043(EPHA4) 2044(EPHA5) 2045(EPHA7) 2046(EPHA8) 2047(EPHB1) 2048(EPHB2) 2049(EPHB3) 2050(EPHB4) 2051(EPHB6) 2064(ERBB2) 2065(ERBB3) 2066(ERBB4) 2260(FGFR1) 2261(FGFR3) 2263(FGFR2) 2264(FGFR4) 22853(LMTK2) 2321(FLT1) 2322(FLT3) 2324(FLT4) 238(ALK) 284656(EPHA10) 285220(EPHA6) 3480(IGF1R) 3643(INSR) 3645(INSRR) 3791(KDR) 3815(KIT) 4058(LTK) 4233(MET) 4486(MST1R) 4593(MUSK) 4914(NTRK1) 4915(NTRK2) 4916(NTRK3) 4919(ROR1) 4920(ROR2) 4921(DDR2) 5156(PDGFRA) 5159(PDGFRB) 558(AXL) 5754(PTK7) 5979(RET) 6098(ROS1) 6259(RYK) 7010(TEK) 7075(TIE1) 7301(TYRO3) 780(DDR1)
PTR: 
100612219(LMTK3) 100612888(RET) 451980(ERBB3) 452508(FLT3) 452512(FLT1) 453350(LTK) 453352(TYRO3) 453676(IGF1R) 454636(ERBB2) 455649(INSR) 456057(AXL) 456472(EPHA2) 456611(EPHA8) 456613(EPHB2) 456910(ROR1) 457407(INSRR) 457408(NTRK1) 457467(DDR2) 459127(ALK) 459492(MERTK) 459919(ERBB4) 460531(EPHA3) 460538(EPHA6) 460714(EPHB1) 460894(EPHB3) 461067(FGFR3) 461299(EPHA5) 461315(KDR) 461316(KIT) 461318(PDGFRA) 462187(CSF1R) 462188(PDGFRB) 462301(FGFR4) 462339(FLT4) 462548(DDR1) 462708(PTK7) 463415(EGFR) 463610(EPHB4) 463671(MET) 463799(EPHB6) 463808(EPHA1) 464122(FGFR1) 464589(ROR2) 464653(MUSK) 465028(TEK) 466220(FGFR2) 467751(NTRK3) 469284 469308(TIE1) 470660(EPHA4) 470931(RYK) 472073 472108(ROS1) 472454(LMTK2) 735394(NTRK2) 744480(MST1R)
PPS: 
100968380(EPHA6) 100968866(DDR1) 100969442(FLT4) 100970060(EPHA8) 100970403(EPHB2) 100970597(ROR1) 100970666(LMTK2) 100971077(ROS1) 100974215(EPHA10) 100974457(EPHA4) 100974494(ERBB3) 100974885(EGFR) 100974967(CSF1R) 100975853(PDGFRB) 100976551(FGFR3) 100976574(EPHA3) 100977050(EPHB3) 100977221(LMTK3) 100977227(ERBB2) 100977352(FLT1) 100979334(EPHB4) 100980629(TEK) 100981083(IGF1R) 100981139(FGFR2) 100981152(ALK) 100981335(EPHB1) 100981786(MERTK) 100981793 100982279(AXL) 100982321(EPHA1) 100982337(PDGFRA) 100982426(MST1R) 100982699(MUSK) 100985722(LTK) 100985931(EPHA2) 100985935(KIT) 100986594(KDR) 100986816(DDR2) 100986833(TYRO3) 100987392(ROR2) 100988001(TIE1) 100988115(FGFR1) 100988693(PTK7) 100989601(FLT3) 100990739(EPHB6) 100991315(FGFR4) 100991777 100991905(INSR) 100994039(RET) 100994282(NTRK3) 100994369 100994658(RYK) 100994887(NTRK2) 100995086(INSRR) 100995426(NTRK1) 100996186(ERBB4)
GGO: 
101124928(PDGFRA) 101125539(EPHB3) 101125625(INSRR) 101125993(NTRK1) 101126190(EGFR) 101126195(EPHA1) 101126389(KIT) 101126479(MERTK) 101127110(KDR) 101127399(MET) 101128109(AXL) 101128605(LMTK2) 101129131(RYK) 101129302(LMTK3) 101130379(FLT4) 101130800(ROR1) 101131773 101131781(FLT3) 101133010(EPHB1) 101133050(DDR1) 101133492(FLT1) 101134900(LTK) 101135271(TYRO3) 101135647(ROS1) 101135682 101137051(DDR2) 101139997(FGFR3) 101140115(NTRK3) 101140182(NTRK2) 101140676(EPHA8) 101140885(ERBB2) 101141461 101141559(RET) 101141580(ALK) 101141926(EPHA2) 101142406(EPHB4) 101142675(ROR2) 101142789(EPHB2) 101144499 101144696(INSR) 101145205(FGFR4) 101146239(MST1R) 101146594 101147955(EPHA7) 101148916(EPHB6) 101150104(PTK7) 101150577(PDGFRB) 101150665(EPHA4) 101150868(TIE1) 101151662(CSF1R) 101152179(FGFR1) 101152720 101153046(FGFR2) 101153211 101153987(TEK) 101154546(IGF1R)
PON: 
100137030(MET) 100171516(TYRO3) 100171540(FGFR2) 100171862(MERTK) 100172156(IGF1R) 100174431(ERBB3) 100174545(FGFR1) 100189890(DKFZP469L125) 100431735(PDGFRA) 100432564(EPHB2) 100433386(CSF1R) 100435506(PTK7) 100435582(EPHA8) 100437110(KIT) 100437693 100438421 100438830(EPHA5) 100439679(EPHA3) 100441031(LMTK3) 100441207(NTRK2) 100441340(ROR2) 100442682(RET) 100443857(DDR1) 100445141(LTK) 100445389 100445925(MST1R) 100447775 100449745 100450033(DDR2) 100450048 100450307(ERBB2) 100450679(EPHB1) 100451664(EPHA2) 100451898(INSRR) 100451963(LMTK2) 100452269(NTRK1) 100453089(EPHB6) 100454731(FLT3) 100456061(FLT1) 100457813(ROS1) 100458012 100458085(MUSK) 100458353(NTRK3) 100458355(EPHA10) 100458368(ALK) 100458982(EPHA4) 100459280(EGFR) 100459900(EPHA1) 100460001(PDGFRB) 100461105(FGFR4) 100461451(AXL) 100461743(EPHB4) 100462098 100462446(KDR) 100938677(ERBB4)
MCC: 
574133(FLT1) 613027(EGFR) 692343(EPHA2) 694583(EPHA3) 696491(EPHA6) 696759(KIT) 697002(PDGFRA) 697573(ERBB2) 697615(NTRK3) 698293(KDR) 698330(MERTK) 698494(FGFR4) 699791(PTK7) 700126(FGFR1) 700760(ROR1) 701811(EPHB3) 702208(TIE1) 703466(RET) 704437(MST1R) 704562(MET) 704601(ALK) 704823 704857(EPHA4) 704886(EPHB6) 706009(INSR) 706295(EPHA1) 707295 707455(TEK) 708227(IGF1R) 708378(EPHA8) 709397(MUSK) 709757(NTRK2) 710624(LTK) 710902(TYRO3) 711353(PDGFRB) 711407(ERBB3) 711512(CSF1R) 712074(EPHA5) 712829(FGFR3) 713584(ERBB4) 714233(DDR1) 715284(ROS1) 715482(ROR2) 715949(FGFR2) 716412(FLT4) 717211(EPHB1) 718570(EPHB2) 718670(INSRR) 718710 718950(RYK) 719320(EPHB4) 719670(NTRK1) 720124(DDR2) 721712(FLT3)
MMU: 
11682(Alk) 12305(Ddr1) 12978(Csf1r) 13649(Egfr) 13835(Epha1) 13836(Epha2) 13837(Epha3) 13838(Epha4) 13839(Epha5) 13840(Epha6) 13841(Epha7) 13842(Epha8) 13844(Ephb2) 13845(Ephb3) 13846(Ephb4) 13848(Ephb6) 13866(Erbb2) 13867(Erbb3) 13869(Erbb4) 14182(Fgfr1) 14183(Fgfr2) 14184(Fgfr3) 14186(Fgfr4) 14254(Flt1) 14255(Flt3) 14257(Flt4) 16001(Igf1r) 16337(Insr) 16542(Kdr) 16590(Kit) 17005(Ltk) 17289(Mertk) 17295(Met) 18198(Musk) 18211(Ntrk1) 18212(Ntrk2) 18213(Ntrk3) 18214(Ddr2) 18595(Pdgfra) 18596(Pdgfrb) 19713(Ret) 19882(Mst1r) 19886(Ros1) 20187(Ryk) 21687(Tek) 21846(Tie1) 22174(Tyro3) 231876(Lmtk2) 23920(Insrr) 26362(Axl) 26563(Ror1) 26564(Ror2) 270190(Ephb1) 381983(Lmtk3) 71461(Ptk7)
RNO: 
100911280 114110(Flt4) 140585(Ryk) 140635(Flt3) 171287(Epha7) 24329(Egfr) 24337(Erbb2) 24338(Ephb1) 24553(Met) 24629(Pdgfrb) 24716(Ret) 24954(Insr) 25022(Fgfr2) 25054(Ntrk2) 25114(Fgfr4) 25232(Tyro3) 25267(Pdgfra) 25346(Ros1) 25589(Kdr) 25678(Ddr1) 25718(Igf1r) 266802(Alk) 287989(Ephb3) 29202(Epha6) 29210(Epha3) 29496(Erbb3) 29613(Ntrk3) 298528(Epha10) 300999(Mst1r) 301242(Ptk7) 304286(Lmtk2) 306782(Ror2) 307403(Csf1r) 308444(Axl) 311337(Ltk) 312275(Ephb6) 312279(Epha1) 313633(Ephb2) 316539(Epha4) 362550(Ror1) 366492(Epha2) 54251(Flt1) 59109(Ntrk1) 59323(Erbb4) 60589(Epha8) 60663(Insrr) 64030(Kit) 65037(Mertk) 685781(Ddr2) 686310 691056 79114(Fgfr1) 79208(Epha5) 81725(Musk) 84489(Fgfr3) 89804(Tek) 89806(Tie1)
CFA: 
100683761(LMTK3) 100684553(EPHA5) 100688547(LTK) 100856261 100856477 100856512 403438(MET) 403494(RET) 403714(TEK) 403727(FLT1) 403811(KIT) 403883(ERBB2) 404306(EGFR) 415125(FGFR2) 442860(PDGFRA) 442951(IGF1R) 442985(PDGFRB) 444854(MST1R) 474997(EPHA7) 475519(EPHB6) 477074(RYK) 478925(EPHA4) 478987(DDR2) 481105(ERBB3) 481464(FLT4) 481662(MUSK) 481808(PTK7) 482154(KDR) 482471(EPHA10) 482535(TIE1) 482735(EPHA1) 483021(ALK) 483060(MERTK) 484098(ROS1) 484147(NTRK2) 484193(ROR2) 484490(AXL) 484990(INSR) 485671(EPHB1) 486025(FLT3) 487380(EPHB2) 487383(EPHA8) 487421(EPHA2) 487509(TYRO3) 487930(EPHA3) 488108(EPHB3) 488508(ERBB4) 488808(FGFR3) 489095(FGFR4) 489188(CSF1R) 489557(ROR1) 489830(EPHB4) 490404(NTRK1) 490405(INSRR) 607935(EPHA6) 608946(LMTK2)
AML: 
FCA: 
100127108(INSR) 100500937(IGF1R) 100510799(EGFR) 101080281(EPHA5) 101080986(TIE1) 101081155(EPHA4) 101081603(NTRK1) 101081861(INSRR) 101083854(TYRO3) 101084099(MERTK) 101084113(LTK) 101084600(PDGFRB) 101085267(DDR2) 101085310(EPHA3) 101085388(ERBB3) 101085481(EPHA2) 101085548(NTRK3) 101085965(EPHB6) 101086055(FGFR1) 101086086(EPHB1) 101086688(AXL) 101086838(RYK) 101087117(LMTK3) 101087597(EPHA6) 101087689(ROR2) 101088292(FLT1) 101089993(MST1R) 101090260(KDR) 101090765(PDGFRA) 101091689(ALK) 101091977(TEK) 101092154(MUSK) 101093437(ROS1) 101093606(PTK7) 101094200(EPHB3) 101094226(EPHB4) 101094727(FLT4) 101095030(EPHB2) 101095198(FGFR2) 101095669(EPHA8) 101096728(DDR1) 101097774(LMTK2) 101099264(FLT3) 101100073(ERBB4) 101100200(EPHA1) 101100306 101100864(FGFR4) 101100987(ROR1) 101101086(RET) 101101347(NTRK2) 493669(MET) 493706(CSF1R) 493766(KIT) 751824(ERBB2)
BTA: 
100140306(LMTK3) 100336601(EPHA6) 100336768 100337226(EPHA5) 280832(KIT) 280855(MET) 280939(TEK) 280941(TIE1) 281768(FGFR1) 281769(FGFR3) 281848(IGF1R) 282301(PDGFRA) 317696(FGFR4) 338031(FLT4) 353111(NTRK1) 404193(FGFR2) 407170(KDR) 407217(EGFR) 408017(INSR) 503620(FLT1) 504429(MERTK) 505709 505824(NTRK2) 509418(CSF1R) 512290(LMTK2) 512700(FLT3) 512798(EPHA2) 514819(PTK7) 515756(EPHB4) 515924(RET) 516598(AXL) 517368(EPHA8) 520192(EPHA4) 522419(ERBB4) 525504(MST1R) 525946(EPHA1) 527165(PDGFRB) 529800(EPHB6) 533523(DDR2) 534092(DDR1) 534731(EPHB1) 535137(EPHB2) 536642(ALK) 537951(EPHA3) 538797(EPHA7) 539126(NTRK3) 540052(MUSK) 540439(EPHA10) 540907(EPHB3) 781353(RYK) 783965(ROR1) 785655(ERBB3) 785924(ROR2) 787068(INSRR) 788224(TYRO3) 788253(LTK)
SSC: 
100126842(PDGFRB) 100127133(FGFR4) 100144462(DDR1) 100144875(AXL) 100153248(FGFR1) 100153873(PTK7) 100154199(DDR2) 100154208(ROR2) 100154222(EPHA7) 100154471(NTRK1) 100155702(INSRR) 100156650 100157538 100188979(EPHA4) 100337658(EPHA3) 100337659(EPHB3) 100511463(EPHA5) 100511727(EPHB6) 100514115 100515121 100515445(FLT3) 100515870(TYRO3) 100516641 100517028(EPHB4) 100517086(CSF1R) 100518179 100518378(EPHA8) 100518423(ALK) 100519209(NTRK2) 100519549(EPHB2) 100519652 100519989(EPHA1) 100520620(ROR1) 100521078(LMTK2) 100522873 100523513(RYK) 100524006 100524585 100525789 100623034(LMTK3) 100624433 100626292(MST1R) 100628205 396729(TEK) 396755(INSR) 396762(FGFR2) 396763(FLT1) 396810(KIT) 397070(EGFR) 397311(KDR) 397350(IGF1R) 397511(NTRK3) 494022(TIE-1) 654328(MET)
ECB: 
100009704(KIT) 100033956(FGFR2) 100033957(FLT1) 100033959(KDR) 100034114(FGFR3) 100050182(ERBB4) 100050861(DDR1) 100053254(EPHB1) 100053644(EPHA2) 100054527(EPHA3) 100054739(ERBB2) 100055465(EPHB6) 100055698(IGF1R) 100056013(MET) 100056221 100057614(FGFR1) 100058300(DDR2) 100058619(MUSK) 100059216(ERBB3) 100059815(PDGFRA) 100060325(EPHA4) 100060422(CSF1R) 100061700(NTRK2) 100061780(FLT3) 100062492(MST1R) 100064594(NTRK1) 100064718(ROR2) 100064727 100064907(AXL) 100065602 100065867(EPHA7) 100066188(EPHA5) 100066248(INSR) 100066563 100066773 100066963 100067115 100067287(PTK7) 100067381(EPHB3) 100067755(EGFR) 100068679(FGFR4) 100069098(EPHB4) 100069107 100069852(NTRK3) 100069962(ROR1) 100070891(ALK) 100071144 100071149 100071661(EPHB2) 100071665 100071673(EPHA8) 100072575(EPHA6) 100629931(LMTK2)
MDO: 
100010976(EPHB6) 100011082(PTK7) 100011941(EPHA1) 100013088(PDGFRA) 100013655(EPHA5) 100013667(NTRK3) 100013788 100014865(ERBB4) 100015989(DDR2) 100016017 100016023 100017172(ERBB2) 100017247 100017311(KDR) 100017469 100017501 100019022 100020059(EPHA7) 100020095(IGF1R) 100022968 100022973 100023250 100023287 100023496(EPHB1) 100023690(INSRR) 100024433 100025262 100025304(FLT1) 100025347 100025548(EPHA8) 100025707 100025727(FGFR2) 100026421 100027215(INSR) 100027453(LMTK2) 100028034(ROR2) 100028072 100028103(ERBB3) 100028150(MST1R) 100028926(CSF1R) 100028943 100029389 100029625(EGFR) 100029852(FGFR1) 100030762 100031107(EPHA6) 100031373(ALK) 100031390 100031762(EPHA10) 100031838(FGFR4) 100032078 100032131(LTK) 100033216(MERTK) 100617294 100618744(NTRK1) 100619759
SHR: 
100913293(LTK) 100913662(MST1R) 100913819(TYRO3) 100913979(FGFR3) 100914017(EGFR) 100914142(EPHB6) 100914347(FGFR1) 100914727(ERBB2) 100916388(NTRK1) 100916484(EPHA1) 100916652(EPHB4) 100916673(IGF1R) 100916950(CSF1R) 100917007(MET) 100917212(PDGFRB) 100918028(ROR1) 100919819(FGFR4) 100919972(EPHA5) 100920310(DDR1) 100920982(EPHA4) 100921027 100921061(RYK) 100921758(LMTK2) 100922033(EPHB1) 100922785(ROR2) 100923681(EPHB2) 100924212(EPHA8) 100924586(ERBB3) 100924671(EPHA7) 100925116(PDGFRA) 100925966(DDR2) 100926082 100926118 100926384(EPHA2) 100926757(INSRR) 100927200(RET) 100927322(NTRK2) 100928520 100929091(KDR) 100929204(INSR) 100929208 100929346(KIT) 100929593(TIE1) 100929912(FLT3) 100930178(EPHA10) 100930426(FLT1) 100931663(ERBB4) 100931895(ALK) 100932094(AXL) 100932215(FGFR2) 100932306 100932539(PTK7) 100933006(MERTK) 100933655 100934716(EPHB3)
OAA: 
100073935(EPHA7) 100074264 100074435 100075317(KIT) 100075389(KDR) 100075894(EGFR) 100076319 100077054(PTK7) 100077130 100077353(ERBB4) 100077556 100077671 100077783(MUSK) 100078146 100078902(ALK) 100079104(INSR) 100079345(MET) 100079459(PDGFRB) 100079886(EPHA5) 100080080 100081606(LMTK2) 100082038(TIE1) 100084066 100084071 100084432(PDGFRA) 100084577(EPHA3) 100084628 100084641(FGFR2) 100085618(DDR2) 100087557 100087714(ROR1) 100088514(ROS1) 100089864 100090467(FLT3) 100090501(FLT1) 100090796 100090952(EPHA2) 100091691 100092326 100093589(EPHB4)
GGA: 
100858422 373897(MUSK) 374008(EPHA6) 374100(FLT1) 378782(EPHA1) 378783(KIT) 395179(ROR1) 395323(KDR) 395336(TYRO3) 395409(RYK) 395509(PDGFRA) 395559(EPHA4) 395603(FGFR4) 395671(ERBB4) 395742(FLT4) 395836(MERTK) 395889(IGF1R) 395967(EPHA7) 395997(EPHA5) 396081(NTRK3) 396107(RET) 396134(MET) 396157(NTRK2) 396177(EPHB1) 396179(EPHB3) 396192(ROS1) 396259(FGFR2) 396337(NTRK1) 396402(EPHA3) 396404(DDR2) 396406(CSF1R) 396494(EGFR) 396513(EPHB2) 396515(FGFR3) 396516(FGFR1) 417256(GTF2H4) 418308(EPHB6) 420133(INSR) 421257(PTK7) 421297(ALK) 422316 423216(LTK) 424562(TIE1) 426130(ERBB2) 427368(TEK) 427573(MST1R) 428198 428219(EPHA10) 693245(ERBB3) 769200(LMTK2) 769516(ROR2) 770488(PDGFRB) 771550(EPHA2)
MGP: 
100538637 100539288 100539508 100539720(IGF1R) 100540905 100541074 100541093 100541106(RYK) 100541244 100541385 100541803 100541926 100542010 100542012 100542111(FLT3) 100542482 100542630 100542786 100543111 100543252 100543352 100543461 100543705(EPHA1) 100543792(LMTK2) 100543911 100544000 100544894 100545335 100545621 100546817 100547083 100547264 100547498 100548043 100548412 100549479 100549842 100550007(INSR) 100550243 100550580 100550611 100550885 100551074 100551116
TGU: 
100218237 100218302 100218346(EPHB2) 100218381(LMTK2) 100218386(PDGFRA) 100218462(EPHA6) 100218470 100218649(EPHA4) 100218924(FGFR3) 100219161(MERTK) 100219340(RET) 100219587(FLT3) 100219935(ROR2) 100219948(DDR2) 100220482(CSF1R) 100221035(EGFR) 100221054(ALK) 100221238(KIT) 100221243(FGFR1) 100221497(EPHB1) 100221929(ALK) 100222368(EPHA3) 100222452(RYK) 100223375(PDGFRB) 100223379(FGFR2) 100223395(ROS1) 100223459(FLT1) 100224370(EPHA7) 100224636(MUSK) 100224857(PTK7) 100225118(ROR1) 100225537(TEK) 100226243(FGFR4) 100227363 100227374(IGF1R) 100227403 100227998(MET) 100228094 100229347 100230643(MST1R) 100231016(ERBB4) 100231082 100231598(TYRO3) 100231766(EPHA1) 100231818(TIE1) 100231879(KDR) 100232783(EPHA8) 751985(NTRK2)
ACS: 
100551543 100551738 100552167(epha8) 100552233 100553323(axl) 100553426 100554064(igf1r) 100554153 100554214(ror2) 100555132(ryk) 100555528 100555784 100555979 100556326 100556373 100556611 100556703 100556999(insrr) 100557093 100558067 100558197 100558986(erbb4) 100559018 100559348 100559550(epha5) 100560122 100560280 100560737 100561015 100561163 100561425(mst1r) 100561443 100561490 100562231 100562611 100563038 100563381 100563549 100563969(alk) 100564676(lmtk2) 100565655 100565697 100565834 100565910(erbb2) 100565961(epha6) 100566968 100567130 100567217
XLA: 
100101336 100191023(ephb4-b) 100191024 373551(met) 373579(kit-a) 373625(ret) 373772(kit-b) 373789(vegf-b) 379148(epha4-b) 379266(ntrk2-b) 379546 380245(pdgfra) 397701(fgfr4-a) 397782(xfgfra2) 397834(ephb3) 397974(mst1r) 398006(insr) 398022(igf1r) 398181(fgfr4-b) 398301(tyro3) 398399(ror2) 398862(ptk7) 398941(insrr) 398981(ddr1) 399288(ephb1) 399325(fgfr2) 399347(fgfr3) 399444(fgfr1-b) 444707 724070(erbb4) 724075(erbb2) 734241(ephb3) 734495(ryk) 779062(epha4-a) 779173(ntrk2-a) 779370(fgfr3)
XTR: 
100036629(axl) 100124862 100124910(fgfr2) 100125078(lmtk3) 100196923(fgfr3) 100216090(kit) 100216124(epha4) 100329112(igf1r) 100485502 100485743 100485823 100486526 100487501 100487523 100487541 100487595 100488002(epha5) 100488573 100489199 100489240 100489637 100490498(insrr) 100492078 100492432(tek) 100492718 100492965 100492992(flt1) 100493234 100493384(erbb3) 100493801 100494929 100495045 100495109 100495504 100495902(ret) 100496572 100496664 100497889 100497963 100498306(alk) 100498561 448450(epha2) 493336(ephb1) 493543(csf1r) 548551(ror2) 548648(fgfr1) 549077(fgfr4) 550026(ryk) 779954(ddr2) 780110(ntrk2) 780188(tyro3)
DRE: 
100000160(fgfr4) 100005538(epha6) 100007346(ddr1) 100007677(erbb4a) 100134855(mst1rb) 100149258 100150664(met) 100322133(mertk) 100333537(ephb1) 245699(insra) 245700(insrb) 245701(igf1ra) 245702(igf1rb) 245951(ros1) 30121(flt4) 30256(kita) 30311(ek1) 30313(ephb3a) 30512(ret) 30546(ntrk1) 30688(ephb4a) 30689(epha2) 30705(fgfr1a) 30709(tyro3) 30746(tie1) 30747(tek) 334526(musk) 352940(fgfr2) 378478(egfra) 386635(erbb3a) 386966(erbb2) 497629(kitb) 544664(erbb3b) 544667(flt1) 554230(kdr) 555957 556380(ddr2a) 558502(ryk) 559529(pdgfrb) 561183 562176(ephb2) 562195(epha7) 563509(alk) 564470(ltk) 564666 565029(tnk2b) 565333(ddr2b) 566708 568282(ror1) 568405 568668(ntrk3a) 570240(ntrk2b) 570677(epha8) 571431 58129(fgfr3) 64270(epha4b) 64271(epha4a) 64274(csf1ra) 65090(ntrk2a) 796537(kdrl) 797595
TRU: 
100137507(met) 101061551 101061632 101062160 101062349 101063427 101063860 101064051 101064431 101064846 101067410 101067733 101068538 101069322 101069394 101069728 101069784 101069940 101069987 101069994 101070188 101070937 101071103 101071220 101071361 101071871 101073457 101073543 101073665 101073765 101073836 101073989 101074083 101074407 101074724 101074842 101075368 101075560 101076706 101076954 101077091 101077811 101078202 101078564 101078910 101078954 101079004 101079080 101079286 101079402 101079603
OLA: 
100049280(pdgfr) 100049424(mfr3) 100049480(vegfr) 100049483(mfr2) 100049521(mfr4) 100125448(fgfr1) 100335137(flt4) 101155039 101156037 101156423 101156784 101157786 101158315 101158510 101159665 101159776 101159930 101160228 101160333 101161682 101161722 101161874 101161964 101162237 101162304 101162439 101162466 101164184 101164312 101164489 101164524 101164793 101165379 101165486 101165761 101165974 101166016 101166254 101166863 101168359 101168573 101171316 101171572 101172356 101172402 101172605 101172940 101172978 101173092 101173298 101174230 101174570 101175393
BFO: 
BRAFLDRAFT_100956 BRAFLDRAFT_107287 BRAFLDRAFT_118213 BRAFLDRAFT_118327 BRAFLDRAFT_125708 BRAFLDRAFT_128154 BRAFLDRAFT_128184 BRAFLDRAFT_208614 BRAFLDRAFT_216804 BRAFLDRAFT_225535 BRAFLDRAFT_262134 BRAFLDRAFT_68888 BRAFLDRAFT_84835 BRAFLDRAFT_86594
CIN: 
100176053 100177957 100179439 100181956 100183778 100184478 100187091 445706(fgfr) 445708(ephd) 445709(ephg) 445767(rtkX) 445797(ddr) 778651(insulinr) 778954(vegfr) 778955(egfr1)
SPU: 
373310(FGFR) 577336 578737 579152(ir) 579837 583375 586488 587396 588763 589012 590851(ptk7) 592402(TIE1/2) 753560 763766
DME: 
Dmel_CG10079(Egfr) Dmel_CG10244(Cad96Ca) Dmel_CG1389(tor) Dmel_CG14396(Ret) Dmel_CG14992(Ack) Dmel_CG1511(Eph) Dmel_CG17348(drl) Dmel_CG17559(dnt) Dmel_CG18085(sev) Dmel_CG18402(InR) Dmel_CG32134(btl) Dmel_CG3915(Drl-2) Dmel_CG4007(Nrk) Dmel_CG4926(Ror) Dmel_CG7223(htl) Dmel_CG7525(Tie) Dmel_CG8222(Pvr) Dmel_CG8250(Alk) Dmel_CG8967(otk)
DPO: 
Dpse_GA10056 Dpse_GA12603 Dpse_GA12952 Dpse_GA14473 Dpse_GA14553 Dpse_GA14783 Dpse_GA17849 Dpse_GA20192 Dpse_GA20413 Dpse_GA20908 Dpse_GA20930 Dpse_GA21443 Dpse_GA22544
DAN: 
Dana_GF11696 Dana_GF12649 Dana_GF12821 Dana_GF12938 Dana_GF13459 Dana_GF14513 Dana_GF14710 Dana_GF15151 Dana_GF15200 Dana_GF15270 Dana_GF15271 Dana_GF15756 Dana_GF20397 Dana_GF22840 Dana_GF24725
DER: 
Dere_GG10097 Dere_GG10400 Dere_GG10716 Dere_GG14176 Dere_GG16395 Dere_GG18882 Dere_GG20358 Dere_GG21167 Dere_GG21515 Dere_GG21639 Dere_GG22118 Dere_GG22256 Dere_GG22613 Dere_GG23464
DPE: 
Dper_GL11237 Dper_GL11534 Dper_GL11545 Dper_GL11825 Dper_GL16982 Dper_GL17943 Dper_GL18177 Dper_GL18312 Dper_GL19173 Dper_GL19392 Dper_GL21115 Dper_GL21194 Dper_GL25514 Dper_GL25857
DSE: 
Dsec_GM11266 Dsec_GM13122 Dsec_GM13965 Dsec_GM15842 Dsec_GM17017 Dsec_GM17332 Dsec_GM18059 Dsec_GM20045 Dsec_GM20393 Dsec_GM20762 Dsec_GM21445 Dsec_GM23267 Dsec_GM26803 Dsec_GM26804
DSI: 
Dsim_GD10226 Dsim_GD10943 Dsim_GD11601 Dsim_GD13248 Dsim_GD21645 Dsim_GD21767 Dsim_GD22428 Dsim_GD23398 Dsim_GD23669 Dsim_GD24191 Dsim_GD24409 Dsim_GD25528 Dsim_GD25868
DWI: 
Dwil_GK10731 Dwil_GK10766 Dwil_GK13696 Dwil_GK14750 Dwil_GK17606 Dwil_GK19476 Dwil_GK19895 Dwil_GK21110 Dwil_GK21680 Dwil_GK21983 Dwil_GK23115 Dwil_GK23825 Dwil_GK23845 Dwil_GK23859
DYA: 
Dyak_GE11101 Dyak_GE12201 Dyak_GE12517 Dyak_GE12658 Dyak_GE12994 Dyak_GE13238 Dyak_GE13482 Dyak_GE14049 Dyak_GE14555 Dyak_GE17323 Dyak_GE18911 Dyak_GE20603 Dyak_GE23684
DGR: 
Dgri_GH10187 Dgri_GH10299 Dgri_GH10734 Dgri_GH13441 Dgri_GH13473 Dgri_GH13860 Dgri_GH15801 Dgri_GH17594 Dgri_GH18121 Dgri_GH20010 Dgri_GH20314 Dgri_GH21837 Dgri_GH22710 Dgri_GH23930
DMO: 
Dmoj_GI11477 Dmoj_GI12584 Dmoj_GI14000 Dmoj_GI14095 Dmoj_GI14251 Dmoj_GI16459 Dmoj_GI17225 Dmoj_GI17995 Dmoj_GI18496 Dmoj_GI18649 Dmoj_GI19081 Dmoj_GI19175 Dmoj_GI19986
DVI: 
Dvir_GJ12739 Dvir_GJ14241 Dvir_GJ15489 Dvir_GJ15936(Dvir_sev) Dvir_GJ17984 Dvir_GJ18109 Dvir_GJ18248 Dvir_GJ19593 Dvir_GJ20054 Dvir_GJ20256 Dvir_GJ20603 Dvir_GJ21235 Dvir_GJ21359 Dvir_GJ21665 Dvir_GJ23294
AGA: 
AgaP_AGAP000015 AgaP_AGAP000489 AgaP_AGAP003108 AgaP_AGAP005763 AgaP_AGAP006219 AgaP_AGAP006490 AgaP_AGAP006988 AgaP_AGAP008009 AgaP_AGAP008813 AgaP_AGAP008819(EGFR) AgaP_AGAP008899 AgaP_AGAP011489 AgaP_AGAP012070 AgaP_AGAP012424(INR)
AAG: 
AaeL_AAEL000324 AaeL_AAEL001370 AaeL_AAEL002172 AaeL_AAEL002317 AaeL_AAEL002404 AaeL_AAEL002640 AaeL_AAEL003928 AaeL_AAEL003969 AaeL_AAEL004319 AaeL_AAEL007123 AaeL_AAEL007742 AaeL_AAEL007876 AaeL_AAEL008301 AaeL_AAEL010374 AaeL_AAEL010923
CQU: 
CpipJ_CPIJ000058 CpipJ_CPIJ000270 CpipJ_CPIJ000502 CpipJ_CPIJ001844 CpipJ_CPIJ002245 CpipJ_CPIJ003860 CpipJ_CPIJ009203 CpipJ_CPIJ010280 CpipJ_CPIJ011455 CpipJ_CPIJ012087 CpipJ_CPIJ013924 CpipJ_CPIJ014812
AME: 
100577393 408312(Nrk) 408489(EphR) 408718 410190(Dnt) 410671(sev) 410685 411213 411297(IR-B) 412667 413200(htl) 413303(Pvr) 413616(Ror) 725827(InR-2)
NVI: 
100114847(NV18480) 100116425(NV14991) 100116943(NV18138) 100117494(NV11060) 100118818(NV16625) 100118970(Egfr) 100119087(NV14367) 100120219(NV17174) 100120941(NV13214) 100122409(NV13488) 100122567(INSR) 100122986(NV11238) 100123205(NV14036)
TCA: 
652945(Torso) 655103 657382 657445 657748 658460 658635 659434 660037(Egfr) 660815 661524 662470 663368
API: 
100159169 100159640 100160948 100162339 100162767 100163146 100164983 100166161(EPHA7) 100168353 100168659 100169221 100572899 100573169 100573904
PHU: 
Phum_PHUM006460 Phum_PHUM363300 Phum_PHUM495270 Phum_PHUM499580 Phum_PHUM506080 Phum_PHUM515380 Phum_PHUM523320 Phum_PHUM542980 Phum_PHUM576020 Phum_PHUM581050 Phum_PHUM583770 Phum_PHUM599640 Phum_PHUM613930
ISC: 
IscW_ISCW000831 IscW_ISCW001963 IscW_ISCW005359 IscW_ISCW007787 IscW_ISCW009358 IscW_ISCW010222 IscW_ISCW015459 IscW_ISCW021718 IscW_ISCW022590 IscW_ISCW022934 IscW_ISCW023666
CEL: 
CELE_C01G6.8(cam-1) CELE_C24G6.2(C24G6.2) CELE_F09A5.2(F09A5.2) CELE_F11D5.3(ddr-2) CELE_F11E6.8(F11E6.8) CELE_F59F3.1(ver-3) CELE_M03A1.1(vab-1) CELE_M176.7(kin-16) CELE_T17A3.1(ver-1) CELE_ZK1067.1(let-23)
CBR: 
CBG00911(Cbr-let-23) CBG11320(Cbr-rol-3) CBG13447(Cbr-vab-1) CBG14186(Cbr-ddr-2) CBG14316(Cbr-lin-18) CBG15732(Cbr-daf-2) CBG17536 CBG18982(Cbr-scd-2)
BMY: 
Bm1_27830 Bm1_37445 Bm1_37575 Bm1_42855 Bm1_48745 Bm1_51870 Bm1_52030
TSP: 
Tsp_00087 Tsp_00617 Tsp_02986 Tsp_03680 Tsp_05936 Tsp_06967 Tsp_06991 Tsp_08284 Tsp_08443 Tsp_09342 Tsp_09728 Tsp_12077
SMM: 
Smp_139480 Smp_173380
NVE: 
NEMVE_v1g229403 NEMVE_v1g234961 NEMVE_v1g31143 NEMVE_v1g85808
HMG: 
100192228 100192229 100198815 100200773 100206606 100209153 100214111 100214305
TAD: 
TRIADDRAFT_12344 TRIADDRAFT_21564 TRIADDRAFT_22855 TRIADDRAFT_52193
AQU: 
100631643 100631815 100632318 100633399 100634036 100637905 100639009 100639849
ATH: 
AT1G34210(SERK2) AT1G71830(SERK1) AT2G13790(SERK4) AT4G33430(BAK1) AT4G39400(BRI1)
ALY: 
ARALYDRAFT_491347(BAK1) ARALYDRAFT_895025 ARALYDRAFT_899604 ARALYDRAFT_912402
GMX: 
100499629 100789884 100799772 100800522
MTR: 
MTR_2g008360 MTR_3g095100
CSV: 
101208695 101209118 101216389
RCU: 
RCOM_0186340 RCOM_0478150 RCOM_1534760
POP: 
POPTR_562744 POPTR_650846 POPTR_913861
VVI: 
100247683 100252647 100253855
OSA: 
4324691 4344785
DOSA: 
Os01t0718300-01(Os01g0718300) Os08t0174700-01(Os08g0174700)
BDI: 
100825302 100834508
SBI: 
SORBI_03g012040(SORBIDRAFT_03g012040) SORBI_03g032990(SORBIDRAFT_03g032990) SORBI_04g023810(SORBIDRAFT_04g023810)
ZMA: 
542016(serk2)
SMO: 
SELMODRAFT_443356(SERK2b-2) SELMODRAFT_444590(SERK2b-1) SELMODRAFT_85471(SERK2a-1)
PPP: 
PHYPADRAFT_121223
MBR: 
MONBRDRAFT_27552
TET: 
TTHERM_00051780 TTHERM_00260780 TTHERM_00388610 TTHERM_00392920 TTHERM_00426220 TTHERM_00697080 TTHERM_00720110 TTHERM_00777360 TTHERM_01100450 TTHERM_01111050 TTHERM_01251240 TTHERM_01639960
PAT: 
Patl_1168 Patl_4000
BVI: 
Bcep1808_4770
HAR: 
HEAR0716
AZO: 
azo2240(wzc1) azo3281(wzc2)
MFA: 
Mfla_2024
PPD: 
Ppro_2473
DVL: 
Dvul_3069
RSH: 
Rsph17029_3692
MGM: 
Mmc1_0586
DRM: 
Dred_3000
MVA: 
Mvan_1681
MGI: 
Mflv_4771
MJL: 
Mjls_0956
RHA: 
RHA1_ro05453 RHA1_ro05735 RHA1_ro07020
NCA: 
Noca_4185
FAL: 
FRAAL1244
RXY: 
Rxyl_1943
SUS: 
Acid_1649 Acid_4855 Acid_4881
TER: 
Tery_1925
 » show all
Taxonomy
Reference
1  [PMID:11114734]
  Authors
Robinson DR, Wu YM, Lin SF.
  Title
The protein tyrosine kinase family of the human genome.
  Journal
Oncogene. 19 (2000) 5548-57.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:9053841]
  Authors
Iwahara T, Fujimoto J, Wen D, Cupples R, Bucay N, Arakawa T, Mori S, Ratzkin B, Yamamoto T.
  Title
Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.
  Journal
Oncogene. 14 (1997) 439-49.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu]
Reference
3  [PMID:11442633]
  Authors
Loren CE, Scully A, Grabbe C, Edeen PT, Thomas J, McKeown M, Hunter T, Palmer RH.
  Title
Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo.
  Journal
Genes. Cells. 6 (2001) 531-44.
  Organism
Drosophila melanogaster [GN:dme]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system