KEGG   ENZYME: 2.7.10.2Help
Entry
EC 2.7.10.2                 Enzyme                                 
Name
non-specific protein-tyrosine kinase;
ABL;
ABL1;
ABL2;
ABLL;
ACK1;
ACK2;
AGMX1;
ARG;
ATK;
ATP:protein-tyrosine O-phosphotransferase (ambiguous);
BLK;
Bmk;
BMX;
BRK;
Bruton's tyrosine kinase;
Bsk;
BTK;
BTKL;
CAKb;
Cdgip;
CHK;
CSK;
CTK;
CYL;
cytoplasmic protein tyrosine kinase;
EMT;
ETK;
Fadk;
FAK;
FAK2;
FER;
Fert1/2;
FES;
FGR;
focal adhesion kinase;
FPS;
FRK;
FYN;
HCK;
HCTK;
HYL;
IMD1;
ITK;
IYK;
JAK1;
JAK2;
JAK3;
Janus kinase 1;
Janus kinase 2;
Janus kinase 3;
JTK1;
JTK9;
L-JAK;
LCK;
LSK;
LYN;
MATK;
Ntk;
p60c-src protein tyrosine kinase;
PKB;
protein-tyrosine kinase (ambiguous);
PSCTK;
PSCTK1;
PSCTK2;
PSCTK4;
PSCTK5;
PTK2;
PTK2B;
PTK6;
PYK2;
RAFTK;
RAK;
Rlk;
Sik;
SLK;
SRC;
SRC2;
SRK;
SRM;
SRMS;
STD;
SYK;
SYN;
Tck;
TEC;
TNK1;
Tsk;
TXK;
TYK2;
TYK3;
YES1;
YK2;
ZAP70
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-tyrosine kinases
BRITE hierarchy
Sysname
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Reaction(IUBMB)
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate [RN:R02584]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
[protein]-L-tyrosine [CPD:C00585]
Product
ADP [CPD:C00008];
[protein]-L-tyrosine phosphate [CPD:C01167]
Comment
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
Orthology
K04447  
Janus kinase 2
K05703  
tyrosine-protein kinase Fyn
K05704  
tyrosine-protein kinase Src
K05705  
tyrosine-protein kinase Yes
K05725  
focal adhesion kinase 1
K05728  
c-src tyrosine kinase
K05854  
tyrosine-protein kinase Lyn
K05855  
spleen tyrosine kinase
K05856  
lymphocyte cell-specific protein tyrosine kinase
K05871  
focal adhesion kinase 2
K06619  
abelson tyrosine-protein kinase 1
K07360  
tyrosine-protein kinase ZAP-70
K07363  
IL2-inducible T-cell kinase
K07364  
tyrosine-protein kinase Tec
K07370  
Bruton agammaglobulinemia tyrosine kinase
K07527  
tyrosine-protein kinase Fes/Fps
K08016  
tyrosine-protein kinase TXK
K08253  
non-specific protein-tyrosine kinase
K08885  
non-receptor tyrosine-protein kinase TNK1
K08886  
activated CDC42 kinase 1
K08887  
abelson tyrosine-protein kinase 2
K08888  
megakaryocyte-associated tyrosine kinase
K08889  
tyrosine-protein kinase Fer
K08890  
B lymphoid tyrosine kinase
K08891  
tyrosine-protein kinase Fgr
K08892  
fyn-related kinase
K08893  
hemopoietic cell kinase
K08894  
protein tyrosine kinase 6
K08895  
tyrosine-protein kinase Srms
K08896  
cytoplasmic tyrosine-protein kinase BMX
K11217  
Janus kinase 1
K11218  
Janus kinase 3
K11219  
non-receptor tyrosine-protein kinase TYK2
Genes
HSA: 
10188(TNK2) 1445(CSK) 2185(PTK2B) 2241(FER) 2242(FES) 2268(FGR) 2444(FRK) 25(ABL1) 2534(FYN) 27(ABL2) 3055(HCK) 3702(ITK) 3716(JAK1) 3717(JAK2) 3718(JAK3) 3932(LCK) 4067(LYN) 4145(MATK) 55359(STYK1) 5747(PTK2) 5753(PTK6) 640(BLK) 660(BMX) 6714(SRC) 6725(SRMS) 6850(SYK) 695(BTK) 7006(TEC) 7294(TXK) 7297(TYK2) 7525(YES1) 7535(ZAP70) 8711(TNK1)
PTR: 
100611576(TNK2) 453654(FES) 453745(CSK) 455225(TNK1) 455322(YES1) 455592 455703(TYK2) 455848(JAK3) 456715(LCK) 457552(ABL2) 458163(HCK) 458229(SRC) 458409(PTK6) 459427(ZAP70) 461343(TEC) 461344(TXK) 461981(FER) 462944(FYN) 462953(FRK) 463991(BLK) 464073(PTK2B) 464422(PTK2) 464586(SYK) 464802(ABL1) 464979(JAK2) 465510(BMX) 465759(BTK) 470000(SRMS) 472771(LYN) 473363(STYK1) 735556(ITK) 739516(FGR) 743373(JAK1)
PPS: 
100968853(BMX) 100971372(ZAP70) 100971932(FYN) 100972035(JAK3) 100972202(JAK1) 100972904(PTK6) 100973246(SRMS) 100975059(FER) 100975065(CSK) 100975763(HCK) 100976235(TEC) 100976579(TXK) 100978064(FES) 100978194(SYK) 100979090(TYK2) 100979625(TNK2) 100979670(LCK) 100979742(JAK2) 100980496(FGR) 100981091(ITK) 100981295(YES1) 100981818(TNK1) 100985139 100986423 100987761(STYK1) 100989642(ABL2) 100989728(BLK) 100989953(PTK2) 100991936(PTK2B) 100992660(MATK) 100992723(BTK) 100993183(FRK) 100994981(ABL1) 100996017(LYN)
GGO: 
PON: 
100172517(JAK2) 100174263(YES1) 100174613(PTK2B) 100432500(BMX) 100432977(TNK2) 100433477(JAK1) 100433988(JAK3) 100436326(LCK) 100436498(SRC) 100436714(TNK1) 100437449(ABL2) 100437723(MATK) 100438236(PTK6) 100438875(SYK) 100439493(TYK2) 100439712(FYN) 100439938(SRMS) 100442468(FGR) 100442545(BLK) 100443503(BTK) 100447326(LYN) 100447871(FES) 100447959(PTK2) 100448548(FRK) 100451782(ZAP70) 100453058(FER) 100453216(ABL1) 100455620(HCK) 100455862(TXK) 100457311(TEC) 100458964(CSK) 100459632(ITK) 100462028(STYK1)
MCC: 
574130(TYK2) 574214(FYN) 677689(JAK1) 694184(JAK2) 697099(YES1) 698553(LYN) 700634(PTK2) 701057(SRC) 702868(CSK) 703000(BTK) 704102(SYK) 705104(TXK) 705357(TEC) 707555(ZAP70) 711220(FER) 711655(TNK2) 712722(BMX) 712787(PTK2B) 715180(TNK1) 715471(ITK) 715723 715764(FES) 716267(FRK) 716296(FGR) 717037(ABL2) 717704(LCK) 717844(STYK1) 719587(SRMS) 720040 722449(ABL1)
MMU: 
11350(Abl1) 11352(Abl2) 12143(Blk) 12169(Bmx) 12229(Btk) 12988(Csk) 14083(Ptk2) 14158(Fert2) 14159(Fes) 14191(Fgr) 14302(Frk) 14360(Fyn) 15162(Hck) 16428(Itk) 16451(Jak1) 16452(Jak2) 16453(Jak3) 16818(Lck) 17096(Lyn) 17179(Matk) 19229(Ptk2b) 20459(Ptk6) 20779(Src) 20811(Srms) 20963(Syk) 21682(Tec) 22165(Txk) 22612(Yes1) 22637(Zap70) 243659(Styk1) 51789(Tnk2) 54721(Tyk2) 666513(Gm11787) 83813(Tnk1)
RNO: 
100361294(Tyk2) 100909750 24514(Jak2) 24884(Yes1) 25150(Fyn) 25155(Syk) 25326(Jak3) 25614(Ptk2) 25734(Hck) 296472(Srms) 301348(Zap70) 301737(Fert2) 303247(Tnk1) 303882(Tnk2) 304883(Abl2) 305311(Txk) 311860(Abl1) 313050(Lck) 315707(Csk) 361597(Fes) 363577(Itk) 364403(Blk) 366275(Ptk6) 367786(Bmx) 367901(Btk) 500340(Styk1) 50646(Ptk2b) 60450(Matk) 79113(Fgr) 79209(Frk) 81515(Lyn) 83805(Src) 84492(Tec) 84598(Jak1)
CFA: 
100271860(ZAP70) 403754(FER) 403917(YES1) 442952(JAK1) 475032(FYN) 475108(PTK2) 476714(TYK2) 477286(SRMS) 477886(LYN) 478151(LCK) 480052(ABL2) 481970(FRK) 482139(TXK) 482140(TEC) 484185(JAK2) 484196(SYK) 485828(HCK) 485864(SRC) 486080(BLK) 486102(PTK2B) 486689(STYK1) 487341(FGR) 487649(CSK) 488025(TNK2) 489159(ITK) 489470(TNK1) 491292(ABL1) 491750(BMX) 492019(BTK) 609483(FES) 610004(JAK3) 611999(MATK)
AML: 
FCA: 
101080757(ABL2) 101083340(CSK) 101083781(FGR) 101084104(BLK) 101084377(JAK1) 101085720(FYN) 101087013(SYK) 101087622(ABL1) 101088062(BTK) 101088668(FRK) 101088762(STYK1) 101088959(JAK2) 101090171(TYK2) 101090724(YES1) 101091691(PTK2B) 101092339(JAK3) 101094235(FER) 101095493(TEC) 101095739(TXK) 101095795(BMX) 101095952(PTK2) 101096181(TNK1) 101096633(LYN) 101097059(ZAP70) 101098805(LCK) 101098817(TNK2) 101099024(MATK) 101100042(SRMS) 101100294(PTK6) 101100378(SRC) 101100568(FES) 101100785(ITK) 101101207(HCK)
BTA: 
280710(TNK2) 280814(HCK) 504509(ZAP70) 504668(MATK) 504733(TEC) 504782(TXK) 506270(PTK2) 507304(FES) 507632(YES1) 508890(LCK) 509227(FRK) 509246(CSK) 510356(TNK1) 511845(ABL2) 512484(TYK2) 513920(STYK1) 515515(SYK) 516133(FGR) 521816(SRMS) 522311(ITK) 525246(JAK2) 527263(FYN) 529814(PTK6) 531514(BMX) 532587(BLK) 533459(BTK) 534996(LYN) 535742(SRC) 536759(FER) 537201(JAK1) 538276(JAK3) 540876(ABL1) 541008(PTK2B)
SSC: 
100125540(SYK) 100152890 100154110(CSK) 100154503(SRC) 100155631 100157507(PTK2B) 100157810(FRK) 100233188(LCK) 100513310(TNK2) 100513738 100513914 100516528(BMX) 100517988 100518649(JAK3) 100521543(MATK) 100523437(STYK1) 100523474(ITK) 100524544(ABL1) 100526085 100621720 100623761(BLK) 100627019(ABL2) 100627308(BTK) 100739325 397201(JAK2) 397202(JAK1) 397363(TYK2) 404277(TEC) 444993(TXK) 791125(FYN)
ECB: 
100051025(BMX) 100051462(CSK) 100051487 100053033(ABL2) 100053129(LYN) 100054008(JAK1) 100054343(TXK) 100054547(PTK2B) 100056804(FGR) 100057626(BTK) 100058245(PTK2) 100060532(PTK6) 100060563(SRMS) 100061075(YES1) 100061381(TEC) 100061776(TNK1) 100063237(STYK1) 100063383(SYK) 100064643 100065099(BLK) 100068557 100069715(ABL1) 100071232(ITK) 100072625 100146139(LCK) 100146548 100146891(FES) 100147296 100147451(JAK3)
MDO: 
100010539 100010720 100011164(FER) 100011754 100012931(TYK2) 100016915(ABL2) 100017323(CSK) 100017930 100019062(STYK1) 100019245(TEC) 100019276(TXK) 100021602 100022459(FYN) 100022866 100022891 100025024 100025045 100025175(PTK2B) 100025187(ZAP70) 100025680 100027188(PTK2) 100028356 100029391 100030005(ITK) 100031307(JAK1) 100032697(BLK) 100616821 100616925 100617717(FES) 100619549(ABL1)
SHR: 
100913836 100913992(HCK) 100915904(SRMS) 100916088(MATK) 100916163(PTK6) 100916187(ZAP70) 100916890(TNK2) 100916991(JAK1) 100918989(FGR) 100920108(JAK3) 100921465(FES) 100922118(LCK) 100923088(FYN) 100923306(BLK) 100923387(PTK2B) 100924855(CSK) 100926529 100927092(FRK) 100927237 100927630(TEC) 100927743(TYK2) 100929183(BTK) 100929196(LYN) 100930047(ABL1) 100930926(ITK) 100931158(STYK1) 100931177(TXK) 100931666(BMX) 100932859 100933019(PTK2) 100934520(ABL2)
OAA: 
100073798 100074305 100075250 100075283 100075676(ABL1) 100075949(ITK) 100076789(PTK2) 100076997 100078190 100079507 100079584 100080912(BTK) 100081307 100081824(ABL2) 100084852(ZAP70) 100084998(TEC) 100085161(PTK2B) 100085207(BMX) 100087316 100087433 100089244 100092688(FGR)
GGA: 
374075(BTK) 374199(JAK2) 395410(ABL2) 395681(JAK1) 395845(JAK3) 396238(YES1) 396294(FYN) 396396(CSK) 396407(TEC) 396416(PTK2) 396442(SRC) 396460(LCK) 415614(FER) 416247(ITK) 417181(ABL1) 418310(STYK1) 419246(SRMS) 419280(HCK) 420086(ZAP70) 421127(LYN) 421747(FRK) 421998(PTK2B) 422035(BLK) 427272(SYK) 428003(BMX) 429374(FES) 430113(TYK2) 431014(TNK2) 769076(MATK) 770387(TXK)
MGP: 
100538364 100538871 100539811 100540531 100540680(FRK) 100541340 100541640 100542141(TYK2) 100542877(ZAP70) 100543723(ABL2) 100543739 100543914 100544594 100544807(TEC) 100544879(ITK) 100544958(TXK) 100546361 100547597 100549540 100549921 100550407(ABL1) 100551221 100551269
TGU: 
100218088 100219243 100220059(HCK) 100220350(TEC) 100221659(PTK2) 100222116(YES1) 100222117(FER) 100223146 100223292(BLK) 100223450(ABL1) 100223825(ABL2) 100225452(JAK2) 100227106(TXK) 100227812(SRC) 100228210(FRK) 100228220(FYN) 100228859(TNK2) 100228920(JAK1) 100229024(MATK) 100229084(ITK) 100229485(SYK) 100229988(ZAP70) 100230728(LYN)
ACS: 
100552375 100554114(itk) 100554372 100554562(fer) 100554859 100554871 100557336 100557530(abl1) 100558035 100558561(abl2) 100559328(jak1) 100559457 100559493(blk) 100559709 100561192 100561566 100563819(tec) 100563957 100565102(bmx) 100565945 100566714
XLA: 
100036955 373593(csk-A) 373609(fyn) 373647(src-a) 373649(lyn) 373700(hck) 379169(MGC53012) 379629(yes1) 379812(fyn) 380430(src-b) 399022 399286(ptk2) 403362 432072 443637(jak2) 444089(tyk2) 444292 446500(syk) 446697(jak1) 446840(zap70) 734996
XTR: 
100036599(jak2) 100038172(jak1) 100124754(tnk2) 100135373(jak3) 100170477(btk) 100170540(styk1) 100216174(csk) 100486846(syk) 100487790 100488004 100488362(frk) 100489191 100489432 100490771(abl1) 100491303 100491653(tec) 100492561 100494243 100497656 448557(zap70) 493548(yes1) 496459(ptk2b) 496893(src) 548439(hck) 549656(fer) 549989(lyn) 733890(ptk2)
DRE: 
100000720(abl1) 100192213(zgc:194283) 100536675(tyk2) 142986(ptk2.1) 245950(ptk2bb) 30280(jak1) 30298(jak2b) 30307(jak2a) 324714(styk1) 325084(src) 337571(yrk) 373872(fyna) 386705(ptk2.2) 405769(syk) 407620(yes1) 414333(lck) 447804(lyn) 553615(zap70) 555232(ptk6a) 556454(csk) 559119 561155(lyn) 565199(fer) 566739(fes) 567405 567549 567764(blk) 568653(btk) 570636(abl2) 571588(tec) 574422(fynb) 767734(ptk6b) 798906(itk)
TRU: 
101061819 101062908 101063191 101063503 101064177 101064341 101065281 101067606 101067815 101067972 101068778 101069105 101069639 101071372 101071846 101072065 101072875 101073533(btk) 101074039 101075909 101075948 101076125 101076835 101078472 101078547 101078640 101079027 101079928 101080190
OLA: 
100170631(lck) 101155127 101155287 101155713 101155851 101157019 101158271 101158313 101158511 101160398 101162804 101163900 101164299 101164480 101167766 101167902 101168007 101168468 101168549 101169425 101169671 101170171 101170708 101171107 101172000 101173856 101174481 101175389
BFO: 
BRAFLDRAFT_115498 BRAFLDRAFT_123556 BRAFLDRAFT_262126 BRAFLDRAFT_79049
CIN: 
100175548 100176191 100177580 100180374 100181565 100184615 100187468(fer) 778659(jak)
SPU: 
100887937 373187(abl) 574936 577286(SFK7) 581102 583220 583550(FRK) 589201 590498(SFK5) 590654 590852 594771 594826 752814
DME: 
Dmel_CG10023(Fak) Dmel_CG1594(hop) Dmel_CG18247(shark) Dmel_CG4032(Abl) Dmel_CG42317(Csk) Dmel_CG44128(Src42A) Dmel_CG7524(Src64B) Dmel_CG8049(Btk29A)
DPO: 
Dpse_GA10015(Dpse_fak) Dpse_GA14036 Dpse_GA14852 Dpse_GA17894 Dpse_GA20789 Dpse_GA24271 Dpse_GA30184
DAN: 
Dana_GF10512 Dana_GF11039 Dana_GF12607 Dana_GF15268 Dana_GF16628 Dana_GF21804 Dana_GF24724
DER: 
Dere_GG14172 Dere_GG15861 Dere_GG17208 Dere_GG18859 Dere_GG20908 Dere_GG23190 Dere_GG23459
DPE: 
Dper_GL11168 Dper_GL12720 Dper_GL14993 Dper_GL16696 Dper_GL17941 Dper_GL19386 Dper_GL21706
DSE: 
Dsec_GM11243 Dsec_GM11244 Dsec_GM13100 Dsec_GM13963(Dsec_Src64B) Dsec_GM16530 Dsec_GM19830 Dsec_GM24379 Dsec_GM26085
DSI: 
Dsim_GD10390 Dsim_GD12452 Dsim_GD13245(Dsim_Src64B) Dsim_GD20649 Dsim_GD22424
DWI: 
Dwil_GK14320 Dwil_GK15708 Dwil_GK17605 Dwil_GK20085 Dwil_GK21551 Dwil_GK23856 Dwil_GK25609
DYA: 
Dyak_GE10101 Dyak_GE11074 Dyak_GE13847 Dyak_GE17301 Dyak_GE20600 Dyak_GE20659 Dyak_GE22200
DGR: 
Dgri_GH10183 Dgri_GH12542 Dgri_GH12950 Dgri_GH15800 Dgri_GH16452 Dgri_GH19324 Dgri_GH21475 Dgri_GH21684
DMO: 
Dmoj_GI12582 Dmoj_GI14244 Dmoj_GI14899 Dmoj_GI16710 Dmoj_GI18838 Dmoj_GI19952 Dmoj_GI23933
DVI: 
Dvir_GJ10294 Dvir_GJ12453 Dvir_GJ15330 Dvir_GJ15487 Dvir_GJ17854 Dvir_GJ20581 Dvir_GJ21866
AGA: 
AgaP_AGAP003986 AgaP_AGAP004989 AgaP_AGAP006270 AgaP_AGAP006510 AgaP_AGAP008317 AgaP_AGAP008354 AgaP_AGAP011118
AAG: 
AaeL_AAEL001017 AaeL_AAEL002471 AaeL_AAEL003937 AaeL_AAEL004592 AaeL_AAEL004666 AaeL_AAEL008777 AaeL_AAEL012553 AaeL_AAEL012752
CQU: 
CpipJ_CPIJ000833 CpipJ_CPIJ003985 CpipJ_CPIJ007227 CpipJ_CPIJ007458 CpipJ_CPIJ017573
AME: 
409127 409908(Csk) 410649 412588 413464 724973(PTK2) 726002(hop)
NVI: 
100117794(NV14273) 100118711(NV17221) 100118996(NV16630) 100122717(NV14486)
TCA: 
656565 656701 656886 657095 657585 660208 663266 664221
API: 
100160433 100160649 100160998 100164910 100166139 100167312 100168763 100169504
PHU: 
Phum_PHUM048780 Phum_PHUM118390 Phum_PHUM202560 Phum_PHUM257990 Phum_PHUM259640 Phum_PHUM378190 Phum_PHUM538010 Phum_PHUM551930
ISC: 
IscW_ISCW000295 IscW_ISCW001854 IscW_ISCW002928 IscW_ISCW006822 IscW_ISCW007829 IscW_ISCW012174 IscW_ISCW016158 IscW_ISCW017584
CEL: 
CELE_B0523.1(kin-31) CELE_C30F8.4(kin-32) CELE_F49B2.5(src-2) CELE_M79.1(abl-1) CELE_T06C10.6(kin-26) CELE_Y48G1C.2(csk-1) CELE_Y92H12A.1(src-1) CELE_ZK622.1(ZK622.1)
CBR: 
CBG03911(Cbr-csk-1) CBG04507(Cbr-abl-1) CBG08738(Cbr-src-2) CBG10801(Cbr-kin-32)
BMY: 
Bm1_01945 Bm1_30590 Bm1_41725 Bm1_48220 Bm1_56715
TSP: 
Tsp_09251 Tsp_11623 Tsp_11837
SMM: 
Smp_124850 Smp_125360 Smp_128790 Smp_136300(Tk5) Smp_137610 Smp_149460 Smp_164930
NVE: 
NEMVE_v1g194745
HMG: 
100192269(fak) 100198593 100200752 100208784 100210535
TAD: 
TRIADDRAFT_24853 TRIADDRAFT_27547 TRIADDRAFT_50482 TRIADDRAFT_61274
AQU: 
100633213 100634439 100636074 100639277 100640238 100640289 100640682 100640949
MBR: 
MONBRDRAFT_33686(MbCsk) MONBRDRAFT_44312 MONBRDRAFT_44322
PPF: 
Pput_2587
GUR: 
Gura_2363 Gura_2579
BRA: 
BRADO0927 BRADO2514 BRADO3825
SAH: 
SaurJH1_2744
SAJ: 
SaurJH9_2687
FRE: 
Franean1_1272
FAL: 
FRAAL0753 FRAAL0755 FRAAL3292
KRA: 
Krad_0012
RCA: 
Rcas_1353 Rcas_3668
DGE: 
Dgeo_0342
 » show all
Taxonomy
Reference
1  [PMID:11114734]
  Authors
Robinson DR, Wu YM, Lin SF.
  Title
The protein tyrosine kinase family of the human genome.
  Journal
Oncogene. 19 (2000) 5548-57.
  Organism
Homo sapiens [GN:hsa]
Reference
2  [PMID:15504335]
  Authors
Roskoski R Jr.
  Title
Src protein-tyrosine kinase structure and regulation.
  Journal
Biochem. Biophys. Res. Commun. 324 (2004) 1155-64.
  Organism
Homo sapiens [GN:hsa]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system