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Entry
EC 2.7.11.25                Enzyme                                 

Name
mitogen-activated protein kinase kinase kinase;
cMos;
cRaf;
MAPKKK;
MAP3K;
MAP kinase kinase kinase;
MEKK;
MEKK1;
MEKK2;
MEKK3;
MEK kinase;
Mil/Raf;
MLK-like mitogen-activated protein triple kinase;
MLTK;
MLTKa;
MLTKb;
REKS;
STK28
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (MAPKKKK-activated)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway [2]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
History
EC 2.7.11.25 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04415  
mitogen-activated protein kinase kinase kinase 8
K04416  
mitogen-activated protein kinase kinase kinase 1
K04417  
mitogen-activated protein kinase kinase kinase 9
K04418  
mitogen-activated protein kinase kinase kinase 10
K04419  
mitogen-activated protein kinase kinase kinase 11
K04420  
mitogen-activated protein kinase kinase kinase 2
K04421  
mitogen-activated protein kinase kinase kinase 3
K04422  
mitogen-activated protein kinase kinase kinase 13
K04423  
mitogen-activated protein kinase kinase kinase 12
K04424  
sterile alpha motif and leucine zipper containing kinase AZK
K04425  
mitogen-activated protein kinase kinase kinase 6
K04426  
mitogen-activated protein kinase kinase kinase 5
K04427  
mitogen-activated protein kinase kinase kinase 7
K04428  
mitogen-activated protein kinase kinase kinase 4
K04466  
mitogen-activated protein kinase kinase kinase 14
K11230  
mitogen-activated protein kinase kinase kinase
K13414  
mitogen-activated protein kinase kinase kinase 1, plant
K13986  
mitogen-activated protein kinase kinase kinase 15
K17534  
mitogen-activated protein kinase kinase kinase MLK4
Genes
HSA: 
10746(MAP3K2) 1326(MAP3K8) 389840(MAP3K15) 4214(MAP3K1) 4215(MAP3K3) 4216(MAP3K4) 4217(MAP3K5) 4293(MAP3K9) 4294(MAP3K10) 4296(MAP3K11) 51776(ZAK) 6885(MAP3K7) 7786(MAP3K12) 84451(KIAA1804) 9020(MAP3K14) 9064(MAP3K6) 9175(MAP3K13)
PTR: 
450384(MAP3K8) 451326(MAP3K11) 451940(MAP3K12) 454750(MAP3K14) 456674(MAP3K6) 459745(ZAK) 462888(MAP3K7) 463023(MAP3K5) 463119(MAP3K4) 465526(MAP3K15) 467498(MAP3K9) 468286(MAP3K3) 468880(MAP3K10) 469711 471543(MAP3K1) 736244(MAP3K2) 737524(MAP3K13)
PPS: 
100969705(MAP3K3) 100971946 100973371(MAP3K2) 100974026(MAP3K7) 100975785(MAP3K15) 100977883(MAP3K10) 100978161(MAP3K8) 100981441(MAP3K4) 100983287(MAP3K12) 100984930(MAP3K14) 100985472(MAP3K13) 100985853(MAP3K11) 100990426(MAP3K9) 100991014(MAP3K5) 100992712(MAP3K6) 100994192 100994796(MAP3K1)
GGO: 
101128207(MAP3K13) 101129821(MAP3K15) 101130070 101133328(MAP3K8) 101135149(MAP3K9) 101136722(MAP3K1) 101137766(MAP3K6) 101144707(MAP3K7) 101147354(MAP3K5) 101147819(MAP3K14) 101148044(MAP3K3) 101148067(MAP3K10) 101148964(MAP3K11) 101149805(MAP3K2) 101151387(MAP3K12) 101152649(MAP3K4) 101154523
PON: 
100171454(MAP3K7) 100172208(MAP3K12) 100172983(MAP3K13) 100433831(MAP3K9) 100434157(MAP3K8) 100436201(MAP3K14) 100440278 100442172(MAP3K4) 100444678(MAP3K3) 100445147(MAP3K6) 100450054(MAP3K2) 100450400 100450681(MAP3K10) 100452447(MAP3K15) 100453309(MAP3K1) 100456749(MAP3K11) 100458776(MAP3K5)
NLE: 
100579516(MAP3K8) 100583302(MAP3K6) 100587332(MAP3K5) 100587341(MAP3K13) 100588106(MAP3K11) 100588522(MAP3K10) 100589608(MAP3K9) 100590602(MAP3K15) 100595740 100596471(MAP3K7) 100596886(MAP3K12) 100600394(MAP3K14) 100601763(MAP3K3) 100601802(MAP3K2) 100602313(MAP3K4) 100603568 100606554(MAP3K1)
MCC: 
100424131(MAP3K2) 693835(MAP3K9) 695958(MAP3K15) 696936(MAP3K8) 698274(ZAK) 700477(MAP3K10) 701085(MAP3K13) 703059(MAP3K12) 703101(MAP3K7) 710360(MAP3K4) 710979(MAP3K1) 711382(MAP3K5) 712755(KIAA1804) 715911(MAP3K6) 716038(MAP3K11) 716258(MAP3K14) 717866(MAP3K3)
MCF: 
101865276(MAP3K4) 101925622(MAP3K12) 101925657(MAP3K5) 101926191(MAP3K11) 102116023 102119428(MAP3K13) 102123041(MAP3K1) 102123979(MAP3K9) 102124252(MAP3K6) 102124587(MAP3K15) 102129741 102132095(MAP3K3) 102132262(MAP3K10) 102132599(MAP3K8) 102138136(MAP3K2) 102139881 102140498(MAP3K7) 102145584(MAP3K14)
RRO: 
104657086(MAP3K1) 104657273(MAP3K8) 104657888(MAP3K7) 104660313(MAP3K9) 104662431(MAP3K2) 104664818(MAP3K11) 104669999(MAP3K4) 104670592(MAP3K12) 104672741(MAP3K13) 104673509 104675014(MAP3K5) 104675466(MAP3K3) 104675763(MAP3K6) 104676124(MAP3K10) 104678324 104678377(MAP3K14) 104682410(MAP3K15)
CJC: 
100385107(MAP3K8) 100385131(MAP3K9) 100387775(MAP3K11) 100389500(MAP3K1) 100395753(MAP3K13) 100395802(MAP3K10) 100396743(KIAA1804) 100401112(MAP3K14) 100401384(ZAK) 100403175(MAP3K7) 100404784(MAP3K6) 100406322(MAP3K5) 100406711(MAP3K2) 100408788(MAP3K12) 100409244(MAP3K15) 100409608(MAP3K3) 100413660(MAP3K4)
MMU: 
234878(Mlk4) 26401(Map3k1) 26403(Map3k11) 26404(Map3k12) 26405(Map3k2) 26406(Map3k3) 26407(Map3k4) 26408(Map3k5) 26409(Map3k7) 26410(Map3k8) 269881(Map3k10) 270672(Map3k15) 338372(Map3k9) 53608(Map3k6) 53859(Map3k14) 65964(Zak) 71751(Map3k13)
RNO: 
100910771 100912399 116596(Map3k8) 116667(Map3k1) 171492(Map3k2) 25579(Map3k12) 303604(Map3k3) 303823(Map3k13) 307950(RGD1306091) 308106(Map3k4) 308463(Map3k10) 309168(Map3k11) 311743(Zak) 313022(Map3k6) 313121(Map3k7) 360640(Map3k14) 365057(Map3k5) 500690(Map3k9) 501558(Map3k15)
CGE: 
100751831(Map3k15) 100752376(Map3k5) 100753508(Map3k3) 100754991(Map3k13) 100759538(Map3k8) 100760135(Map3k6) 100762677(Map3k11) 100762934(Map3k9) 100764060(Map3k4) 100765738(Map3k12) 100766459(Map3k14) 100768062(Map3k10) 100769818 100770540(Map3k1) 100771548 100772559(Map3k2) 100774341(Map3k7)
NGI: 
103724902(Map3k5) 103724991(Map3k11) 103725874(Map3k9) 103732132(Map3k2) 103732670(Map3k13) 103736239(Map3k15) 103737023(Map3k4) 103737078(Map3k6) 103738320(Map3k14) 103738660(Map3k12) 103739547(Map3k7) 103739909(Map3k1) 103743128 103744757(Map3k3) 103747991(Map3k8) 103750755(Map3k10) 103751744
HGL: 
101696673(Map3k9) 101697616(Map3k6) 101700680(Map3k13) 101701961(Map3k4) 101702332(Map3k12) 101702514(Map3k15) 101703313(Map3k14) 101704125 101704335(Map3k3) 101707762 101710286(Map3k8) 101712051(Map3k5) 101718269(Map3k7) 101718471(Map3k10) 101718575(Map3k11) 101720769(Map3k1) 101726195(Map3k2)
OCU: 
100340498(MAP3K5) 100341731(MAP3K9) 100343069(MAP3K6) 100343571(MAP3K7) 100343621(MAP3K10) 100345602(MAP3K13) 100345607 100348484(MAP3K1) 100351032(MAP3K14) 100351826 100355324(MAP3K3) 100355566(MAP3K8) 100355693(MAP3K2) 100356691(MAP3K11) 100357608(MAP3K15) 100358104(MAP3K4) 100358158(MAP3K12)
TUP: 
102470721(MAP3K9) 102471323(MAP3K10) 102474694(MAP3K12) 102477331(MAP3K7) 102477673(MAP3K3) 102478254(MAP3K13) 102479529 102479582(MAP3K4) 102483890(MAP3K1) 102485186(MAP3K2) 102490022(MAP3K11) 102493021(MAP3K8) 102495244(MAP3K5) 102500729(MAP3K14) 102501118 102503019(MAP3K15) 102503262(MAP3K6)
CFA: 
100685499(MAP3K13) 100688368(KIAA1804) 102156745(MAP3K7) 476215(MAP3K5) 476262(MAP3K4) 478061(MAP3K1) 478802(ZAK) 480481(MAP3K3) 483732(MAP3K11) 484504(MAP3K10) 487085(MAP3K8) 487345(MAP3K6) 490765(MAP3K9) 490926(MAP3K14) 491765(MAP3K15) 607170(MAP3K12) 612902(MAP3K2)
AML: 
100465667(MAP3K4) 100466442(MAP3K1) 100466506(MAP3K7) 100467807(MAP3K13) 100469942(MAP3K12) 100472044(MAP3K9) 100472260(MAP3K14) 100473197(MAP3K10) 100475304(MAP3K5) 100475390 100475426(MAP3K2) 100475740(MAP3K3) 100479214(MAP3K6) 100479844 100480593(MAP3K8) 100480913(MAP3K11) 105241834(MAP3K15)
UMR: 
103656496(MAP3K8) 103658571(MAP3K2) 103659570 103659895 103660092(MAP3K7) 103660898(MAP3K4) 103661092(MAP3K10) 103661981 103663496(MAP3K5) 103663891(MAP3K1) 103665628(MAP3K3) 103665883(MAP3K14) 103666761(MAP3K6) 103668259(MAP3K15) 103671518(MAP3K9) 103675534(MAP3K12) 103676070(MAP3K13) 103679581(MAP3K11)
FCA: 
101081315(MAP3K6) 101082912(MAP3K5) 101083468(MAP3K14) 101083633(MAP3K3) 101084717(MAP3K9) 101087164(MAP3K12) 101087784 101089731(MAP3K10) 101089836(MAP3K15) 101090328(MAP3K1) 101090624(MAP3K8) 101093205(MAP3K13) 101094038 101095899(MAP3K7) 101096406(MAP3K2) 101097977(MAP3K4) 101098654(MAP3K11)
PTG: 
102948678(MAP3K9) 102952700(MAP3K4) 102957300(MAP3K12) 102957925(MAP3K2) 102959520 102960317(MAP3K5) 102960849(MAP3K15) 102961042(MAP3K8) 102961509(MAP3K10) 102963341(MAP3K7) 102963818(MAP3K6) 102964388(MAP3K14) 102965107(MAP3K13) 102966576(MAP3K3) 102970826 102971191(MAP3K1)
BTA: 
504592(MAP3K2) 505369(MAP3K13) 505427(MAP3K12) 508367(MAP3K14) 508943(MAP3K3) 511779(MAP3K4) 514210(MAP3K11) 519251(ZAK) 523962(MAP3K1) 529146(MAP3K7) 529335(MAP3K15) 535622(MAP3K8) 537380(MAP3K5) 538340(MAP3K9) 614598(MAP3K6) 616014 781037(MAP3K10)
BOM: 
102264669(MAP3K6) 102264816(MAP3K7) 102267592(MAP3K1) 102268339(MAP3K14) 102271481(MAP3K9) 102273125(MAP3K2) 102274075 102274152(MAP3K10) 102275307(MAP3K3) 102276849(MAP3K5) 102278856(MAP3K8) 102279268(MAP3K11) 102281279(MAP3K12) 102282362(MAP3K15) 102283969(MAP3K4) 102285655(MAP3K13) 102288137
PHD: 
102316264(MAP3K7) 102319571(MAP3K5) 102321628(MAP3K12) 102323190(MAP3K11) 102324731(MAP3K10) 102324733 102326524(MAP3K14) 102328534(MAP3K4) 102329106(MAP3K1) 102329226(MAP3K6) 102329999(MAP3K8) 102332756(MAP3K2) 102332784(MAP3K3) 102333533(MAP3K9) 102338925(MAP3K15) 102341085 102341362(MAP3K13)
CHX: 
102168436(MAP3K15) 102172156(MAP3K5) 102172543(MAP3K4) 102172719(MAP3K7) 102173036(MAP3K3) 102173267(MAP3K11) 102174723(MAP3K12) 102175623(MAP3K2) 102178859(MAP3K13) 102180599(MAP3K9) 102183919 102186147(MAP3K10) 102186443(MAP3K6) 102187530(MAP3K1) 102188512(MAP3K8) 102189617(MAP3K14) 102191110
OAS: 
101102889(MAP3K12) 101103160(MAP3K9) 101104888(MAP3K15) 101108056(MAP3K7) 101108969(MAP3K11) 101109858(MAP3K2) 101111776 101112260(MAP3K1) 101113246(MAP3K4) 101113737(MAP3K6) 101115427 101117036(MAP3K13) 101117094(MAP3K8) 101118723(MAP3K10) 101118799(MAP3K14) 101121018(MAP3K5) 101122537(MAP3K3)
SSC: 
100135663(MAP3K7) 100152572 100154002 100154202(MAP3K4) 100155753(MAP3K9) 100512235(MAP3K6) 100513491(MAP3K3) 100515448(MAP3K13) 100517714(MAP3K12) 100518455(MAP3K4) 100520402(MAP3K14) 100521453(MAP3K10) 100621234(MAP3K2) 100622217(MAP3K8) 100622769(MAP3K5) 100624078 100627235(MAP3K11) 100739216(MAP3K15) 396617(MAP3K1)
CFR: 
102504523(MAP3K14) 102505073(MAP3K2) 102505358(MAP3K1) 102505759(MAP3K3) 102506410(MAP3K13) 102506717(MAP3K11) 102509143(MAP3K10) 102509815(MAP3K4) 102513589(MAP3K9) 102518335(MAP3K8) 102518433(MAP3K12) 102518953(MAP3K6) 102519538(MAP3K7) 102520465 102522243(MAP3K5) 102523391 106730942
BACU: 
102999255(MAP3K3) 102999328(MAP3K5) 103001803 103002185(MAP3K1) 103004845(MAP3K11) 103005548(MAP3K10) 103006512(MAP3K4) 103010611(MAP3K8) 103011832(MAP3K12) 103015628(MAP3K6) 103015859(MAP3K14) 103016499(MAP3K15) 103017845(MAP3K2) 103018600 103019037(MAP3K9) 103019299(MAP3K7) 103020592(MAP3K13)
LVE: 
103070441(MAP3K8) 103073201(MAP3K13) 103075340(MAP3K7) 103075844(MAP3K4) 103076636(MAP3K3) 103079692 103081325(MAP3K6) 103082490(MAP3K14) 103083140(MAP3K2) 103083385(MAP3K1) 103083922(MAP3K9) 103085713(MAP3K10) 103089110(MAP3K11) 103089504(MAP3K15) 103089656
ECB: 
100050140(MAP3K14) 100050628(MAP3K2) 100053153 100054289(MAP3K9) 100057319(MAP3K11) 100058153(MAP3K4) 100058434(MAP3K15) 100059237(MAP3K13) 100059834 100061688(MAP3K1) 100063602(MAP3K8) 100064002(MAP3K12) 100064751(MAP3K3) 100065841(MAP3K7) 100070933(MAP3K6) 100073186(MAP3K5)
MYB: 
102239254(MAP3K13) 102240442(MAP3K10) 102242281(MAP3K6) 102242308(MAP3K3) 102243445(MAP3K9) 102245865(MAP3K2) 102248363(MAP3K8) 102252114(MAP3K12) 102253871(MAP3K11) 102254118(MAP3K7) 102255496(MAP3K15) 102256847(MAP3K5) 102258632(MAP3K1) 102259842 102262247(MAP3K14) 102262729(MAP3K4) 102263045
MYD: 
102751509(MAP3K10) 102753581(MAP3K2) 102753720(MAP3K13) 102753749 102756379(MAP3K9) 102757393(MAP3K4) 102762787(MAP3K3) 102762988(MAP3K14) 102763786(MAP3K1) 102763957(MAP3K7) 102770852 102770934(MAP3K6) 102771069(MAP3K15) 102771311(MAP3K5) 102771577(MAP3K11) 102772527(MAP3K13) 102773021(MAP3K12) 102774051 102775461(MAP3K8)
PALE: 
102878894(MAP3K11) 102880315(MAP3K13) 102880422(MAP3K2) 102880725(MAP3K9) 102882452(MAP3K7) 102882855(MAP3K6) 102885138(MAP3K10) 102885530 102886741(MAP3K1) 102888506(MAP3K4) 102888994(MAP3K5) 102889570(MAP3K3) 102893121(MAP3K12) 102895694 102896654(MAP3K8) 102897183(MAP3K15) 102897751(MAP3K14)
MDO: 
100014185(MAP3K15) 100014282(MAP3K13) 100017378(MAP3K6) 100017495(MAP3K10) 100018494 100018684(MAP3K8) 100019975(MAP3K7) 100020082(MAP3K9) 100020668(MAP3K14) 100025970(MAP3K3) 100026735(MAP3K2) 100028987 100030111(MAP3K11) 100031527(MAP3K5) 100032065(MAP3K1) 100032495(MAP3K4)
SHR: 
100913571(MAP3K1) 100913706(MAP3K12) 100913796(MAP3K13) 100916246(MAP3K9) 100916713(MAP3K2) 100917439(MAP3K5) 100918124(MAP3K14) 100920997(MAP3K7) 100924042 100925633(MAP3K8) 100927077(MAP3K6) 100928208(MAP3K4) 100932009(MAP3K10) 100932862(MAP3K15) 100932989(MAP3K11) 100933813 100933837(MAP3K3)
OAA: 
GGA: 
100858193(MAP3K6) 101750513 418609(MAP3K15) 419954(MAP3K3) 419964(MAP3K14) 420419 420479(MAP3K8) 421579(MAP3K4) 421688(MAP3K5) 421808(MAP3K7) 424149(ZAK) 424225(MAP3K2) 424876(MAP3K13) 425792 427144(MAP3K1) 428586
MGP: 
100538760(MAP3K14) 100539648 100539749(MAP3K7) 100541097(MAP3K8) 100542691 100542719(MAP3K3) 100543830(MAP3K2) 100547994(MAP3K13) 100548383(MAP3K4) 100550623(MAP3K1) 100550901(MAP3K9) 100551250(MAP3K5) 104911778 104914275(MAP3K6)
CJO: 
107306009(MAP3K1) 107306938(MAP3K12) 107308787 107308936(MAP3K8) 107311414 107311515(MAP3K4) 107311662(MAP3K5) 107311964(MAP3K7) 107314878(MAP3K9) 107316691 107316800(MAP3K2) 107317933(MAP3K13) 107324060(MAP3K6) 107325016(MAP3K14) 107325133(MAP3K3) 107325422(MAP3K15)
APLA: 
101791236(MAP3K14) 101791519(MAP3K15) 101791769(MAP3K8) 101792050(MAP3K13) 101793656 101795869 101795899(MAP3K4) 101796310(MAP3K9) 101798043(MAP3K2) 101799109(MAP3K5) 101800996(MAP3K7) 101801284(MAP3K3) 101801810 101803181 101803306 101803838
TGU: 
100217837(MAP3K14) 100219311(MAP3K15) 100219827(MAP3K2) 100221443(MAP3K7) 100223633(MAP3K3) 100224192(MAP3K5) 100225400(MAP3K13) 100225825(MAP3K1) 100226503 100228461 100228874 100229586(MAP3K9) 100229845(MAP3K4) 100230596(MAP3K8)
GFR: 
102032306(MAP3K3) 102033648(MAP3K2) 102033703 102034507(MAP3K5) 102034934(MAP3K9) 102035976(MAP3K8) 102038763(MAP3K14) 102038921(MAP3K15) 102039929(MAP3K7) 102040792(MAP3K13) 102041684 102043718(MAP3K4) 102044243 102044899(MAP3K1)
FAB: 
101807474(MAP3K12) 101807669(MAP3K1) 101810116 101810453(MAP3K15) 101811653(MAP3K2) 101812702(MAP3K9) 101812912(MAP3K13) 101813386(MAP3K14) 101813811(MAP3K5) 101813992(MAP3K3) 101814532(MAP3K7) 101814940(MAP3K4) 101816945 101817004 101819414(MAP3K8)
PHI: 
102101107(MAP3K4) 102102554 102102657(MAP3K11) 102103765(MAP3K1) 102104081(MAP3K5) 102106417 102107403(MAP3K7) 102108460 102111999(MAP3K9) 102112025(MAP3K13) 102112033(MAP3K3) 102113050(MAP3K2) 102113463(MAP3K14) 102113468(MAP3K12) 102113721(MAP3K15) 102114163(MAP3K8)
CCW: 
104683461(MAP3K9) 104684293 104684463(MAP3K4) 104686340(MAP3K15) 104686414 104686470(MAP3K8) 104686679(MAP3K1) 104689448(MAP3K5) 104692210(MAP3K7) 104693868 104693990(MAP3K2) 104696697(MAP3K13) 104698524(MAP3K14) 104698629(MAP3K3)
FPG: 
101910755 101911178(MAP3K1) 101911552(MAP3K5) 101911986(MAP3K6) 101912446(MAP3K3) 101914815 101915193(MAP3K15) 101916440(MAP3K13) 101917746(MAP3K7) 101918017(MAP3K4) 101918542(MAP3K9) 101919762(MAP3K14) 101921040(MAP3K8) 101921462(MAP3K2) 101921723(MAP3K12) 101923251 106112587
FCH: 
102045898(MAP3K1) 102046644(MAP3K12) 102047801(MAP3K3) 102048037(MAP3K4) 102048630(MAP3K14) 102050351 102050412(MAP3K13) 102051326 102052421 102052615(MAP3K15) 102052668(MAP3K2) 102055830(MAP3K8) 102057038(MAP3K5) 102057922(MAP3K9) 102058816(MAP3K7) 102060113(MAP3K6)
CLV: 
102085051(MAP3K5) 102085060(MAP3K3) 102085165 102086335(MAP3K9) 102086486(MAP3K4) 102087091(MAP3K8) 102087262(MAP3K7) 102087971(MAP3K15) 102088147 102088332(MAP3K14) 102088715(MAP3K12) 102089200 102091011(MAP3K13) 102092494(MAP3K2) 102097744(MAP3K1)
AAM: 
106486799(MAP3K4) 106487372 106489299 106489690(MAP3K7) 106489958(MAP3K8) 106490809(MAP3K15) 106493178(MAP3K13) 106493720(MAP3K10) 106494548 106494844 106495649(MAP3K14) 106496933 106497426(MAP3K3) 106497979(MAP3K5) 106498093(MAP3K9) 106498914(MAP3K1) 106499249 106499278(MAP3K2)
ASN: 
102368682(MAP3K15) 102368863 102371337(MAP3K11) 102374958(MAP3K3) 102375647 102375722(MAP3K5) 102376392(MAP3K12) 102376941(MAP3K1) 102379177(MAP3K6) 102379289(MAP3K2) 102380826 102381053(MAP3K13) 102381161 102382136(MAP3K4) 102382735(MAP3K9) 102386999(MAP3K7) 102387437(MAP3K8) 102388858(MAP3K14)
AMJ: 
102558220(MAP3K10) 102559099(MAP3K9) 102560853(MAP3K6) 102561424(MAP3K12) 102562794(MAP3K1) 102566049(MAP3K13) 102566471(MAP3K8) 102568383(ZAK) 102569201(MAP3K7) 102570911(MAP3K11) 102572648(MAP3K3) 102573024(MAP3K5) 102573918(MAP3K4) 102574412(MAP3K2) 102574455 102575720(MAP3K14) 106736664(MAP3K9) 106736858(MAP3K15) 106736961(MAP3K3)
PSS: 
102443925(MAP3K11) 102444358 102446659(MAP3K4) 102448094(MAP3K2) 102449623(MAP3K8) 102450041(MAP3K7) 102451227(MAP3K5) 102453748(MAP3K13) 102454634(MAP3K3) 102454880 102455384 102456989(MAP3K6) 102459971(MAP3K9) 102462962(MAP3K15) 102463619(MAP3K1) 102464024(MAP3K14)
CMY: 
102930570(MAP3K3) 102931859 102933894(MAP3K6) 102935713(MAP3K15) 102936034(MAP3K5) 102936052(MAP3K7) 102936228(MAP3K4) 102936511(MAP3K8) 102936755 102938448(MAP3K1) 102939329(MAP3K13) 102939834(MAP3K14) 102940369(MAP3K9) 102941356(MAP3K2) 102941563 102943511(MAP3K12) 102946051(MAP3K11)
ACS: 
100551616(map3k5) 100552553(map3k6) 100553164(map3k12) 100554725(map3k7) 100556486(map3k9) 100557698(map3k3) 100558170(map3k2) 100558270(map3k13) 100558842 100560027(map3k4) 100560190(map3k14) 100561745(map3k1) 100562159 100562883(map3k8) 100565973(map3k10) 100566960 100568169(map3k15) 103280338
PBI: 
103048285(MAP3K1) 103049938(MAP3K2) 103051131(MAP3K11) 103052010(MAP3K5) 103053098(MAP3K13) 103053351(MAP3K12) 103054161 103059578(MAP3K4) 103060188 103061668 103061999(MAP3K15) 103064348(MAP3K8) 103064885 103065661(MAP3K6) 103066049(MAP3K14) 103066986(MAP3K3) 103067160(MAP3K9) 103067633(MAP3K7)
GJA: 
107107052 107107352 107107364(MAP3K10) 107107910(MAP3K8) 107113333(MAP3K4) 107114874(MAP3K7) 107115849(MAP3K15) 107116392 107116647(MAP3K6) 107117647 107117807(MAP3K2) 107119674(MAP3K12) 107121069(MAP3K11) 107122639(MAP3K9) 107123377(MAP3K1) 107123584(MAP3K13) 107125527(MAP3K14)
XLA: 
100113430(map3k12-a) 100337576(map3k12-b) 100337577(map3k13-b) 100337578(map3k13-a) 101027301 379399(MGC53150) 398612(map3k10) 399459(map3k7) 734336(map3k3)
XTR: 
100101764(map3k7) 100488058(map3k10) 100488307(map3k12) 100488360 100488949(map3k9) 100489201(map3k14) 100490021(map3k3) 100490504(map3k1) 100493069(map3k8) 100493570(map3k2) 100493878(map3k13) 100495797(zak) 100497217(map3k4) 100497692(map3k5)
DRE: 
100004261(map3k14a) 100005496(fa92h04) 100334289(map3k15) 100334486(map3k1) 325488(map3k4) 404626(map3k12) 553788(map3k7) 555703(map3k5) 558321(map3k2) 559247(zak) 560211(map3k3) 560639(map3k9) 560932(map3k10) 561518 563727(map3k8) 568412 795766(map3k14)
TRU: 
101061432(map3k5) 101061953 101062891(map3k9) 101063413(map3k13) 101063524(map3k7) 101064896 101067596(map3k14) 101068242(map3k10) 101068369 101069247(map3k8) 101069629 101069746(map3k2) 101070474 101071039 101072543(map3k3) 101075070 101076353(map3k15) 101076799(map3k4) 101078679 101079141(map3k11)
MZE: 
101463743(map3k13) 101463885(map3k11) 101464541(map3k2) 101468082(map3k3) 101468753(map3k14) 101468797 101472093 101472971(map3k9) 101473117(map3k5) 101475626 101475992 101477145(map3k10) 101478940(map3k12) 101481641 101482122 101484222(map3k8) 101484425 101484784(map3k15) 101484924(map3k7) 101485830(map3k4) 101486282
OLA: 
XMA: 
LCM: 
102346861(MAP3K5) 102347264 102350357 102350566(MAP3K2) 102351315(MAP3K14) 102352283(MAP3K6) 102353974(MAP3K3) 102355070(MAP3K1) 102356869(MAP3K9) 102358159(MAP3K7) 102358237(MAP3K15) 102362205(MAP3K12) 102364487(MAP3K11) 102364913 102366133(MAP3K4) 102367402(MAP3K13) 102367513(MAP3K8)
CMK: 
103175928(map3k4) 103176455 103177506(map3k15) 103177870(map3k1) 103178276(map3k7) 103178324(map3k5) 103178584(map3k9) 103179260 103183630(map3k7cl) 103186428(map3k8) 103187330 103187711(map3k3) 103189809(map3k2) 103189852 103190572(map3k13) 103190676(map3k12)
BFO: 
CIN: 
100174992 100177364 778771(tak1/mapkkk7) 778975(mapkkk4) 778976(mltk)
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD12264(Dsim_GD12264) Dsimw501_GD18431(Dsim_GD18431) Dsimw501_GD19320(Dsim_GD19320) Dsimw501_GD20035(Dsim_GD20035) Dsimw501_GD20154(Dsim_GD20154) Dsimw501_GD27793(Dsim_GD27793)
DWI: 
DYA: 
Dyak_GE15342(Dyak_Tak1) Dyak_GE17470(dyak_GLEANR_18797) Dyak_GE22480(dyak_GLEANR_6151) Dyak_GE22767(dyak_GLEANR_6518) Dyak_GE25175(dyak_GLEANR_8804) Dyak_GE25632(dyak_GLEANR_9246)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
408533(GB14238) 409125(Mekk1) 411566(MAPKKK9) 413809(Tak1)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
CEL: 
CELE_B0414.7(mtk-1) CELE_F33E2.2(dlk-1) CELE_F59A6.1(nsy-1) CELE_K11D12.10(mlk-1) CELE_R13F6.6(zak-1) CELE_Y105C5A.24(Y105C5A.24)
CBR: 
CBG02299(Cbr-nsy-1) CBG04061(Cbr-mtk-1) CBG08663(Cbr-mlk-1) CBG08707(Cbr-dlk-1) CBG16544(Cbr-zak-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
EGR: 
GMX: 
PVU: 
VRA: 
MTR: 
CAM: 
ADU: 
AIP: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
JCU: 
POP: 
POPTR_0002s08950g(POPTRDRAFT_1071643) POPTR_0005s16210g(POPTRDRAFT_1078383) POPTR_0006s24580g(POPTRDRAFT_717923) POPTR_0018s05140g(POPTRDRAFT_778792)
VVI: 
SLY: 
SPEN: 
SOT: 
SIND: 
BVG: 
NNU: 
OSA: 
DOSA: 
Os02t0220700-01(Os02g0220700) Os03t0262200-00(Os03g0262200) Os03t0703400-01(Os03g0703400)
OBR: 
BDI: 
SBI: 
SORBI_01g010800(SORBIDRAFT_01g010800) SORBI_01g040360(SORBIDRAFT_01g040360) SORBI_04g007770(SORBIDRAFT_04g007770)
ZMA: 
100272734(cl17799_1) 100275358(GRMZM2G158860) 100279294(GRMZM2G044557) 100383481(GRMZM2G180555) 103625964(GRMZM2G130927) 103654795
SITA: 
PDA: 
EGU: 
MUS: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
MIS: 
CVR: 
APRO: 
GSL: 
SCE: 
YCR073C(SSK22) YNR031C(SSK2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A05370(NCAS0A05370) NCAS_0D04600(NCAS0D04600)
NDI: 
NDAI_0I00340(NDAI0I00340)
TPF: 
TPHA_0M01840(TPHA0M01840)
TBL: 
TBLA_0I02400(TBLA0I02400)
TDL: 
TDEL_0A07560(TDEL0A07560)
KAF: 
KAFR_0C04590(KAFR0C04590) KAFR_0F04340(KAFR0F04340)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
NCU03071(os-4)
NTE: 
NEUTE1DRAFT91407(NEUTE1DRAFT_91407)
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
FPU: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
VDA: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_520074(AO090038000313)
ANG: 
ANI_1_450074(An08g03240)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
PBN: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
DSQ: 
PCO: 
SHS: 
HIR: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT117102(AGABI1DRAFT_117102)
ABV: 
AGABI2DRAFT214884(AGABI2DRAFT_214884)
CPUT: 
SLA: 
WSE: 
WIC: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
DFA_02737(drkD)
EIV: 
ACAN: 
PTM: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:8940179]
  Authors
Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, Yao Z.
  Title
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
  Journal
J. Biol. Chem. 271 (1996) 31607-11.
  Sequence
[hsa:4217]
Reference
2  [PMID:11042189]
  Authors
Gotoh I, Adachi M, Nishida E.
  Title
Identification and characterization of a novel MAP kinase kinase kinase, MLTK.
  Journal
J. Biol. Chem. 276 (2001) 4276-86.
  Sequence
[hsa:51776] [mmu:65964]
Reference
3  [PMID:8334704]
  Authors
Vojtek AB, Hollenberg SM, Cooper JA.
  Title
Mammalian Ras interacts directly with the serine/threonine kinase Raf.
  Journal
Cell. 74 (1993) 205-14.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
146702-84-3

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