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Entry
EC 2.7.11.25                Enzyme                                 

Name
mitogen-activated protein kinase kinase kinase;
cMos;
cRaf;
MAPKKK;
MAP3K;
MAP kinase kinase kinase;
MEKK;
MEKK1;
MEKK2;
MEKK3;
MEK kinase;
Mil/Raf;
MLK-like mitogen-activated protein triple kinase;
MLTK;
MLTKa;
MLTKb;
REKS;
STK28
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (MAPKKKK-activated)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
This enzyme phosphorylates and activates its downstream protein kinase, EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) but requires MAPKKKK for activation. Some members of this family can be activated by p21-activated kinases (PAK/STE20) or Ras. While c-Raf and c-Mos activate the classical MAPK/ERK pathway, MEKK1 and MEKK2 preferentially activate the c-Jun N-terminal protein kinase(JNK)/stress-activated protein kinase (SAPK) pathway [2]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
History
EC 2.7.11.25 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K04415  
mitogen-activated protein kinase kinase kinase 8
K04416  
mitogen-activated protein kinase kinase kinase 1
K04417  
mitogen-activated protein kinase kinase kinase 9
K04418  
mitogen-activated protein kinase kinase kinase 10
K04419  
mitogen-activated protein kinase kinase kinase 11
K04420  
mitogen-activated protein kinase kinase kinase 2
K04421  
mitogen-activated protein kinase kinase kinase 3
K04422  
mitogen-activated protein kinase kinase kinase 13
K04423  
mitogen-activated protein kinase kinase kinase 12
K04424  
sterile alpha motif and leucine zipper containing kinase AZK
K04425  
mitogen-activated protein kinase kinase kinase 6
K04426  
mitogen-activated protein kinase kinase kinase 5
K04427  
mitogen-activated protein kinase kinase kinase 7
K04428  
mitogen-activated protein kinase kinase kinase 4
K04466  
mitogen-activated protein kinase kinase kinase 14
K11230  
mitogen-activated protein kinase kinase kinase
K13414  
mitogen-activated protein kinase kinase kinase 1, plant
K13986  
mitogen-activated protein kinase kinase kinase 15
K17534  
mitogen-activated protein kinase kinase kinase MLK4
Genes
HSA: 
10746(MAP3K2) 1326(MAP3K8) 389840(MAP3K15) 4214(MAP3K1) 4215(MAP3K3) 4216(MAP3K4) 4217(MAP3K5) 4293(MAP3K9) 4294(MAP3K10) 4296(MAP3K11) 51776(ZAK) 6885(MAP3K7) 7786(MAP3K12) 84451(KIAA1804) 9020(MAP3K14) 9064(MAP3K6) 9175(MAP3K13)
PTR: 
450384(MAP3K8) 451326(MAP3K11) 451940(MAP3K12) 454750(MAP3K14) 456674(MAP3K6) 459745 462888(MAP3K7) 463023(MAP3K5) 463119(MAP3K4) 465526(MAP3K15) 467498(MAP3K9) 468286(MAP3K3) 468880(MAP3K10) 469711 471543(MAP3K1) 736244(MAP3K2) 737524(MAP3K13)
PPS: 
100969705(MAP3K3) 100971946 100973371(MAP3K2) 100974026(MAP3K7) 100975785(MAP3K15) 100977883(MAP3K10) 100978161(MAP3K8) 100981441(MAP3K4) 100983287(MAP3K12) 100984930(MAP3K14) 100985472(MAP3K13) 100985853(MAP3K11) 100990426(MAP3K9) 100991014(MAP3K5) 100992712(MAP3K6) 100994192 100994796(MAP3K1)
GGO: 
101128207(MAP3K13) 101129821(MAP3K15) 101130070 101133328(MAP3K8) 101135149(MAP3K9) 101136722(MAP3K1) 101137766(MAP3K6) 101144707(MAP3K7) 101147354(MAP3K5) 101147819(MAP3K14) 101148044(MAP3K3) 101148067(MAP3K10) 101148964(MAP3K11) 101149805(MAP3K2) 101151387(MAP3K12) 101152649(MAP3K4) 101154523
PON: 
100171454(MAP3K7) 100172208(MAP3K12) 100172983(MAP3K13) 100433831(MAP3K9) 100434157 100436201(MAP3K14) 100440278 100442172(MAP3K4) 100444678(MAP3K3) 100445147(MAP3K6) 100450054(MAP3K2) 100450681(MAP3K10) 100452447(MAP3K15) 100453309(MAP3K1) 100456749(MAP3K11) 100458776(MAP3K5)
NLE: 
100579516(MAP3K8) 100583302(MAP3K6) 100587332(MAP3K5) 100587341(MAP3K13) 100588106(MAP3K11) 100588522(MAP3K10) 100589608(MAP3K9) 100590602(MAP3K15) 100595740 100596471(MAP3K7) 100596886(MAP3K12) 100600394(MAP3K14) 100601763(MAP3K3) 100601802(MAP3K2) 100602313(MAP3K4) 100603568 100606554(MAP3K1)
MCC: 
100424131(MAP3K2) 693835(MAP3K9) 695958 696936 698274(ZAK) 700477(MAP3K10) 701085 703059(MAP3K12) 703101(MAP3K7) 710360(MAP3K4) 710979(MAP3K1) 711382(MAP3K5) 712755(KIAA1804) 715911(MAP3K6) 716038(MAP3K11) 716258(MAP3K14) 717866(MAP3K3)
MCF: 
CJC: 
100385107(MAP3K8) 100385131(MAP3K9) 100387775(MAP3K11) 100389500(MAP3K1) 100395753(MAP3K13) 100395802(MAP3K10) 100396743(KIAA1804) 100401112(MAP3K14) 100401384(ZAK) 100403175(MAP3K7) 100404784(MAP3K6) 100406322(MAP3K5) 100406711(MAP3K2) 100408788(MAP3K12) 100409244(MAP3K15) 100409608(MAP3K3) 100413660(MAP3K4)
MMU: 
234878(Mlk4) 26401(Map3k1) 26403(Map3k11) 26404(Map3k12) 26405(Map3k2) 26406(Map3k3) 26407(Map3k4) 26408(Map3k5) 26409(Map3k7) 26410(Map3k8) 269881(Map3k10) 270672(Map3k15) 338372(Map3k9) 53608(Map3k6) 53859(Map3k14) 65964(Zak) 71751(Map3k13)
RNO: 
100910771 116596(Map3k8) 116667(Map3k1) 171492(Map3k2) 25579(Map3k12) 303604(Map3k3) 303823(Map3k13) 307950(RGD1306091) 308106(Map3k4) 308463(Map3k10) 309168(Map3k11) 311743(Zak) 313022(Map3k6) 313121(Map3k7) 360640(Map3k14) 365057(Map3k5) 500690(Map3k9) 501558(Map3k15)
CGE: 
100751831(Map3k15) 100752376(Map3k5) 100753508(Map3k3) 100754991(Map3k13) 100759538(Map3k8) 100760135(Map3k6) 100762677(Map3k11) 100762934(Map3k9) 100764060(Map3k4) 100765738(Map3k12) 100766459(Map3k14) 100768062(Map3k10) 100769818 100770540(Map3k1) 100771548 100772559(Map3k2) 100774341(Map3k7)
NGI: 
103724902(Map3k5) 103724991(Map3k11) 103725874(Map3k9) 103732132(Map3k2) 103732670(Map3k13) 103736239(Map3k15) 103737023(Map3k4) 103737078(Map3k6) 103738320(Map3k14) 103738660(Map3k12) 103739547(Map3k7) 103739909(Map3k1) 103743128 103744757(Map3k3) 103747991(Map3k8) 103750755(Map3k10) 103751744
HGL: 
101696673(Map3k9) 101697616(Map3k6) 101700680(Map3k13) 101701961(Map3k4) 101702332(Map3k12) 101702514(Map3k15) 101703313(Map3k14) 101704125 101704335(Map3k3) 101707762 101710286(Map3k8) 101712051(Map3k5) 101718269(Map3k7) 101718471(Map3k10) 101718575(Map3k11) 101720769(Map3k1) 101726195(Map3k2)
OCU: 
100340498(MAP3K5) 100341731(MAP3K9) 100343069(MAP3K6) 100343571(MAP3K7) 100343621(MAP3K10) 100345602(MAP3K13) 100345607 100348484(MAP3K1) 100351032(MAP3K14) 100351826 100355324(MAP3K3) 100355566(MAP3K8) 100355693(MAP3K2) 100356691(MAP3K11) 100357608(MAP3K15) 100358104(MAP3K4) 100358158(MAP3K12)
TUP: 
102470721(MAP3K9) 102471323(MAP3K10) 102474694(MAP3K12) 102477331(MAP3K7) 102477673(MAP3K3) 102478254(MAP3K13) 102479529 102479582(MAP3K4) 102483890(MAP3K1) 102485186(MAP3K2) 102490022(MAP3K11) 102493021(MAP3K8) 102495244(MAP3K5) 102500729(MAP3K14) 102501118 102503019(MAP3K15) 102503262(MAP3K6)
CFA: 
100685499(MAP3K13) 100688368(KIAA1804) 102156745 476215(MAP3K5) 476262(MAP3K4) 478061(MAP3K1) 478802(ZAK) 480481(MAP3K3) 483732(MAP3K11) 484504(MAP3K10) 487085(MAP3K8) 487345(MAP3K6) 490765(MAP3K9) 490926(MAP3K14) 491765(MAP3K15) 607170(MAP3K12) 612902(MAP3K2)
AML: 
UMR: 
103656496(MAP3K8) 103658571(MAP3K2) 103659570 103659895 103660092(MAP3K7) 103660898(MAP3K4) 103661092(MAP3K10) 103661981 103663496(MAP3K5) 103663891(MAP3K1) 103665628(MAP3K3) 103665883(MAP3K14) 103666761(MAP3K6) 103668259(MAP3K15) 103671518(MAP3K9) 103675534(MAP3K12) 103676070(MAP3K13) 103679581(MAP3K11)
FCA: 
101081315(MAP3K6) 101082912(MAP3K5) 101083468(MAP3K14) 101083633(MAP3K3) 101084717(MAP3K9) 101087164(MAP3K12) 101087784 101089731(MAP3K10) 101089836(MAP3K15) 101090328(MAP3K1) 101090624(MAP3K8) 101093205(MAP3K13) 101094038 101095899(MAP3K7) 101096406(MAP3K2) 101097977(MAP3K4) 101098654(MAP3K11)
PTG: 
102948678(MAP3K9) 102951991(MAP3K11) 102952700(MAP3K4) 102957300 102957925(MAP3K2) 102959520 102960317(MAP3K5) 102960849(MAP3K15) 102961042(MAP3K8) 102961509(MAP3K10) 102963341(MAP3K7) 102963818(MAP3K6) 102964388(MAP3K14) 102965107(MAP3K13) 102966576(MAP3K3) 102970826 102971191(MAP3K1)
BTA: 
504592(MAP3K2) 505369(MAP3K13) 505427(MAP3K12) 508367(MAP3K14) 508943(MAP3K3) 511779(MAP3K4) 514210(MAP3K11) 519251(ZAK) 523962(MAP3K1) 529146(MAP3K7) 529335(MAP3K15) 535622(MAP3K8) 537380(MAP3K5) 538340(MAP3K9) 614598(MAP3K6) 616014 781037(MAP3K10)
BOM: 
102264669(MAP3K6) 102264816(MAP3K7) 102267592(MAP3K1) 102268339(MAP3K14) 102271481(MAP3K9) 102273125(MAP3K2) 102274075 102274152 102275307(MAP3K3) 102276849(MAP3K5) 102278856(MAP3K8) 102279268(MAP3K11) 102281279(MAP3K12) 102282362(MAP3K15) 102283969(MAP3K4) 102285655(MAP3K13) 102288137
PHD: 
102316264(MAP3K7) 102319571(MAP3K5) 102321628(MAP3K12) 102323190(MAP3K11) 102324731(MAP3K10) 102324733 102326524(MAP3K14) 102328534(MAP3K4) 102329106(MAP3K1) 102329226(MAP3K6) 102329999(MAP3K8) 102332756(MAP3K2) 102332784(MAP3K3) 102333533(MAP3K9) 102338925(MAP3K15) 102341085 102341362(MAP3K13)
CHX: 
102168436(MAP3K15) 102172156(MAP3K5) 102172543(MAP3K4) 102172719(MAP3K7) 102173036(MAP3K3) 102173267(MAP3K11) 102174723(MAP3K12) 102175623(MAP3K2) 102178859(MAP3K13) 102180599(MAP3K9) 102183919 102186147(MAP3K10) 102186443(MAP3K6) 102187530(MAP3K1) 102188512(MAP3K8) 102189617(MAP3K14) 102191110
OAS: 
101102889(MAP3K12) 101103160(MAP3K9) 101104888(MAP3K15) 101108056(MAP3K7) 101108969(MAP3K11) 101109858(MAP3K2) 101111776 101112260(MAP3K1) 101113246(MAP3K4) 101113737(MAP3K6) 101115427 101117036(MAP3K13) 101117094(MAP3K8) 101118723(MAP3K10) 101118799(MAP3K14) 101121018(MAP3K5) 101122537(MAP3K3)
SSC: 
100135663(MAP3K7) 100152572 100154002 100154202(MAP3K4) 100155753(MAP3K9) 100512235(MAP3K6) 100513491(MAP3K3) 100515448(MAP3K13) 100517714(MAP3K12) 100520402(MAP3K14) 100521453(MAP3K10) 100621234(MAP3K2) 100622769 100624078 100627235(MAP3K11) 100739216(MAP3K15) 396617(MAP3K1)
CFR: 
102504523(MAP3K14) 102505073(MAP3K2) 102505358(MAP3K1) 102505759(MAP3K3) 102506410(MAP3K13) 102506717(MAP3K11) 102509143 102509815(MAP3K4) 102513589(MAP3K9) 102518335(MAP3K8) 102518433(MAP3K12) 102518953(MAP3K6) 102519538(MAP3K7) 102520465 102522243(MAP3K5) 102523391
BACU: 
102999255(MAP3K3) 102999328(MAP3K5) 103001803 103002185(MAP3K1) 103004845(MAP3K11) 103005548(MAP3K10) 103006512(MAP3K4) 103010611(MAP3K8) 103011832(MAP3K12) 103015628(MAP3K6) 103015859(MAP3K14) 103016499(MAP3K15) 103017845(MAP3K2) 103018600 103019037(MAP3K9) 103019299(MAP3K7) 103020592(MAP3K13)
LVE: 
103070441(MAP3K8) 103073201(MAP3K13) 103075340(MAP3K7) 103075844(MAP3K4) 103076636(MAP3K3) 103079692 103081325(MAP3K6) 103082490(MAP3K14) 103083140(MAP3K2) 103083385(MAP3K1) 103083922(MAP3K9) 103085713(MAP3K10) 103089110(MAP3K11) 103089504(MAP3K15) 103089656
ECB: 
100050140(MAP3K14) 100050628(MAP3K2) 100053153 100054289(MAP3K9) 100057319(MAP3K11) 100058153(MAP3K4) 100058434(MAP3K15) 100059237(MAP3K13) 100059834 100061688(MAP3K1) 100063602(MAP3K8) 100064002(MAP3K12) 100064751(MAP3K3) 100065841(MAP3K7) 100070933(MAP3K6) 100073186(MAP3K5)
MYB: 
102239254(MAP3K13) 102240442(MAP3K10) 102242281(MAP3K6) 102242308(MAP3K3) 102243445(MAP3K9) 102245865(MAP3K2) 102248363(MAP3K8) 102252114(MAP3K12) 102253871(MAP3K11) 102254118(MAP3K7) 102255496(MAP3K15) 102256847(MAP3K5) 102258632(MAP3K1) 102259842 102262247(MAP3K14) 102262729(MAP3K4) 102263045
MYD: 
102751509(MAP3K10) 102753581(MAP3K2) 102753749 102756379(MAP3K9) 102757393(MAP3K4) 102762787(MAP3K3) 102762988(MAP3K14) 102763786(MAP3K1) 102763957(MAP3K7) 102770852 102770934(MAP3K6) 102771069(MAP3K15) 102771311(MAP3K5) 102771577(MAP3K11) 102772527(MAP3K13) 102773021(MAP3K12) 102775461(MAP3K8)
PALE: 
102878894(MAP3K11) 102880315(MAP3K13) 102880422(MAP3K2) 102880725(MAP3K9) 102882452(MAP3K7) 102882855(MAP3K6) 102885138(MAP3K10) 102885530 102886741(MAP3K1) 102888506(MAP3K4) 102888994(MAP3K5) 102889570(MAP3K3) 102890764 102893121(MAP3K12) 102895694 102896654(MAP3K8) 102897183(MAP3K15) 102897751(MAP3K14)
MDO: 
100014185(MAP3K15) 100014282(MAP3K13) 100017378(MAP3K6) 100017495(MAP3K10) 100018494 100018684(MAP3K8) 100019975(MAP3K7) 100020082(MAP3K9) 100020668(MAP3K14) 100025970(MAP3K3) 100026735(MAP3K2) 100028987 100030111(MAP3K11) 100031527(MAP3K5) 100032065(MAP3K1) 100032495(MAP3K4)
SHR: 
100913571(MAP3K1) 100913706(MAP3K12) 100913796(MAP3K13) 100916246(MAP3K9) 100916713(MAP3K2) 100917439(MAP3K5) 100918124(MAP3K14) 100920997(MAP3K7) 100924042 100925633(MAP3K8) 100927077(MAP3K6) 100928208(MAP3K4) 100932009 100932862(MAP3K15) 100932989(MAP3K11) 100933813 100933837(MAP3K3)
OAA: 
GGA: 
100858193(MAP3K6) 418609(MAP3K15) 419954(MAP3K3) 419964(MAP3K14) 420419 420479(MAP3K8) 421579(MAP3K4) 421688(MAP3K5) 421808(MAP3K7) 424149(ZAK) 424225(MAP3K2) 424876(MAP3K13) 425792 427144(MAP3K1) 428586
MGP: 
APLA: 
101791236(MAP3K14) 101791519(MAP3K15) 101791769(MAP3K8) 101792050(MAP3K13) 101793656 101795869 101795899(MAP3K4) 101796310(MAP3K9) 101798043(MAP3K2) 101799109(MAP3K5) 101800996(MAP3K7) 101801284(MAP3K3) 101801810 101803181 101803838
TGU: 
100217837(MAP3K14) 100219311(MAP3K15) 100219827(MAP3K2) 100221443(MAP3K7) 100223633(MAP3K3) 100224192(MAP3K5) 100225400(MAP3K13) 100225825(MAP3K1) 100226503(MAP3K3) 100228461 100228874 100229586(MAP3K9) 100229845(MAP3K4) 100230596(MAP3K8)
FAB: 
101807474(MAP3K12) 101807669(MAP3K1) 101810116 101810453(MAP3K15) 101811653(MAP3K2) 101812702(MAP3K9) 101812912(MAP3K13) 101813386(MAP3K14) 101813811(MAP3K5) 101813992(MAP3K3) 101814532(MAP3K7) 101814940(MAP3K4) 101816945 101817004 101819414(MAP3K8)
PHI: 
102101107(MAP3K4) 102102554 102102657(MAP3K11) 102103765(MAP3K1) 102104081(MAP3K5) 102106417 102107403(MAP3K7) 102108460 102111999(MAP3K9) 102112025(MAP3K13) 102112033(MAP3K3) 102113050(MAP3K2) 102113463(MAP3K14) 102113468(MAP3K12) 102113721(MAP3K15) 102114163(MAP3K8)
FPG: 
101910755 101911178(MAP3K1) 101911552(MAP3K5) 101911986(MAP3K6) 101912446(MAP3K3) 101914815 101915193(MAP3K15) 101916440(MAP3K13) 101917746(MAP3K7) 101918017(MAP3K4) 101918542(MAP3K9) 101919762(MAP3K14) 101921040(MAP3K8) 101921462(MAP3K2) 101921723(MAP3K12) 101923251
FCH: 
102045898(MAP3K1) 102046644(MAP3K12) 102047801(MAP3K3) 102048037(MAP3K4) 102048630(MAP3K14) 102050351 102050412(MAP3K13) 102051326 102052421 102052615(MAP3K15) 102052668(MAP3K2) 102055830(MAP3K8) 102057038(MAP3K5) 102057922(MAP3K9) 102058816(MAP3K7) 102060113(MAP3K6)
CLV: 
102085051(MAP3K5) 102085060(MAP3K3) 102085165 102086335(MAP3K9) 102086486(MAP3K4) 102087091(MAP3K8) 102087262(MAP3K7) 102087971(MAP3K15) 102088147 102088332(MAP3K14) 102088715(MAP3K12) 102089200 102091011(MAP3K13) 102092494(MAP3K2) 102097744(MAP3K1)
ASN: 
102368682(MAP3K15) 102368863 102371337(MAP3K11) 102374958(MAP3K3) 102375647 102375722(MAP3K5) 102376392(MAP3K12) 102376941(MAP3K1) 102379177(MAP3K6) 102379289(MAP3K2) 102380826 102381053(MAP3K13) 102381161 102382136(MAP3K4) 102382735(MAP3K9) 102386999(MAP3K7) 102387437(MAP3K8) 102388858(MAP3K14)
AMJ: 
102558220(MAP3K10) 102559099(MAP3K9) 102560853(MAP3K6) 102561323(MAP3K5) 102561424(MAP3K12) 102562086 102562794(MAP3K1) 102565629 102566049(MAP3K13) 102566471(MAP3K8) 102568383 102569201 102570911(MAP3K11) 102572648(MAP3K3) 102573024(MAP3K15) 102573918(MAP3K4) 102574412(MAP3K2) 102575720(MAP3K14)
PSS: 
102443925(MAP3K11) 102444358 102446659(MAP3K4) 102448094(MAP3K2) 102449623(MAP3K8) 102450041(MAP3K7) 102451227(MAP3K5) 102453748(MAP3K13) 102454634(MAP3K3) 102454880 102455384 102456989(MAP3K6) 102459971(MAP3K9) 102462962(MAP3K15) 102463619(MAP3K1) 102464024(MAP3K14)
CMY: 
102930570(MAP3K3) 102931859 102933894(MAP3K6) 102935713(MAP3K15) 102936034(MAP3K5) 102936052(MAP3K7) 102936228(MAP3K4) 102936511(MAP3K8) 102936755 102938448(MAP3K1) 102939329(MAP3K13) 102939834(MAP3K14) 102940369(MAP3K9) 102941356(MAP3K2) 102941563 102943511(MAP3K12) 102946051(MAP3K11)
ACS: 
100551616(map3k5) 100552553(map3k6) 100553164(map3k12) 100554725(map3k7) 100556486(map3k9) 100557698(map3k3) 100558170(map3k2) 100558270(map3k13) 100558842 100560027(map3k4) 100560190(map3k14) 100561745(map3k1) 100562159 100562883(map3k8) 100565973(map3k10) 100566960 100568169(map3k15) 103280338
PBI: 
103048285(MAP3K1) 103049938(MAP3K2) 103051131(MAP3K11) 103052010(MAP3K5) 103053098(MAP3K13) 103053351(MAP3K12) 103054161 103056655(MAP3K10) 103059578(MAP3K4) 103060188 103061668 103061999(MAP3K15) 103064348(MAP3K8) 103064885 103065661(MAP3K6) 103066049(MAP3K14) 103066986(MAP3K3) 103067160(MAP3K9) 103067633
XLA: 
100113430(map3k12-a) 100337576(map3k12-b) 100337577(map3k13-b) 100337578(map3k13-a) 101027301 379399(MGC53150) 398612(map3k10) 399459(map3k7) 734336(map3k3)
XTR: 
100101764(map3k7) 100488058(map3k10) 100488307(map3k12) 100488360 100488949(map3k9) 100489201(map3k14) 100490021(map3k3) 100490504(map3k1) 100493069(map3k8) 100493570(map3k2) 100493878 100495797 100497217(map3k4) 100497692
DRE: 
100004261 100005496(fa92h04) 100334289(map3k15) 100334486(map3k1) 325488(map3k4) 404626(map3k12) 553788(map3k7) 555703(map3k5) 558321(map3k2) 559247 560211(map3k3) 560639 560932(map3k10) 561518 563727(map3k8) 568412 570051 795766
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102346861(MAP3K5) 102347264 102350357 102350566(MAP3K2) 102351315 102352283 102353974(MAP3K3) 102355070(MAP3K1) 102356869(MAP3K9) 102358159(MAP3K7) 102358237(MAP3K15) 102362205(MAP3K12) 102364487(MAP3K11) 102364913 102366133(MAP3K4) 102367402 102367513(MAP3K8)
CMK: 
103175928(map3k4) 103176455 103177506(map3k15) 103177870(map3k1) 103178276(map3k7) 103178324(map3k5) 103178584(map3k9) 103179260 103183630(map3k7cl) 103186428(map3k8) 103187330 103187711(map3k3) 103189809(map3k2) 103189852 103190243(map3k10) 103190572(map3k13) 103190676(map3k12)
BFO: 
CIN: 
100174992 100177364 100185230 778771(tak1/mapkkk7) 778975(mapkkk4) 778976(mltk)
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
408533(GB14238) 411566(MAPKKK9) 413809(Tak1)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_B0414.7(mtk-1) CELE_F33E2.2(dlk-1) CELE_R13F6.6(zak-1) CELE_Y105C5A.24(Y105C5A.24)
CBR: 
CBG02299(Cbr-nsy-1) CBG04061(Cbr-mtk-1) CBG08707(Cbr-dlk-1) CBG16544(Cbr-zak-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0002s08950g(POPTRDRAFT_1071643) POPTR_0005s16210g(POPTRDRAFT_1078383) POPTR_0006s24580g(POPTRDRAFT_717923) POPTR_0018s05140g(POPTRDRAFT_778792)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0220700-01(Os02g0220700) Os03t0262200-00(Os03g0262200) Os03t0703400-01(Os03g0703400)
OBR: 
BDI: 
SBI: 
SORBI_01g010800(SORBIDRAFT_01g010800) SORBI_01g040360(SORBIDRAFT_01g040360) SORBI_04g007770(SORBIDRAFT_04g007770) SORBI_04g034410(SORBIDRAFT_04g034410)
ZMA: 
100272734(cl17799_1) 100275358 100279294 100304418(pco069828(336)) 100383481
SITA: 
PDA: 
ATR: 
s00064p00110890(AMTR_s00064p00110890) s00156p00048240(AMTR_s00156p00048240)
SMO: 
PPP: 
CRE: 
VCN: 
OLU: 
MIS: 
CVR: 
GSL: 
SCE: 
YCR073C(SSK22) YNR031C(SSK2)
AGO: 
ERC: 
KLA: 
LTH: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0A05370(NCAS0A05370) NCAS_0D04600(NCAS0D04600)
NDI: 
NDAI_0I00340(NDAI0I00340)
TPF: 
TPHA_0M01840(TPHA0M01840)
TBL: 
TBLA_0I02400(TBLA0I02400)
TDL: 
TDEL_0A07560(TDEL0A07560)
KAF: 
KAFR_0C04590(KAFR0C04590) KAFR_0F04340(KAFR0F04340)
PPA: 
DHA: 
PIC: 
PGU: 
SPAA: 
LEL: 
CAL: 
CTP: 
COT: 
CDU: 
CTEN: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
CTHR: 
MGR: 
TMN: 
FGR: 
NHE: 
TRE: 
MAW: 
MAJ: 
CMT: 
VAL: 
ELA: 
SSL: 
BFU: 
MBE: 
ANI: 
AFM: 
AOR: 
AOR_1_520074(AO090038000313)
ANG: 
ANI_1_450074(An08g03240)
AFV: 
ACT: 
NFI: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
BZE: 
BSC: 
BOR: 
ZTR: 
PFJ: 
BCOM: 
NPA: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
TMS: 
PPL: 
DSQ: 
PCO: 
SHS: 
PSQ: 
ADL: 
FME: 
GTR: 
LBC: 
MRR: 
CCI: 
SCM: 
ABP: 
AGABI1DRAFT117102(AGABI1DRAFT_117102)
ABV: 
AGABI2DRAFT214884(AGABI2DRAFT_214884)
CPUT: 
SLA: 
UMA: 
PFP: 
MGL: 
PGR: 
MLR: 
WSE: 
MBR: 
DDI: 
DPP: 
DFA: 
DFA_02737(drkD)
ACAN: 
TET: 
PIF: 
EHX: 
GTT: 
NGR: 
 » show all
Taxonomy
Reference
1  [PMID:8940179]
  Authors
Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, Yao Z.
  Title
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
  Journal
J. Biol. Chem. 271 (1996) 31607-11.
  Sequence
[hsa:4217]
Reference
2  [PMID:11042189]
  Authors
Gotoh I, Adachi M, Nishida E.
  Title
Identification and characterization of a novel MAP kinase kinase kinase, MLTK.
  Journal
J. Biol. Chem. 276 (2001) 4276-86.
  Sequence
[hsa:51776] [mmu:65964]
Reference
3  [PMID:8334704]
  Authors
Vojtek AB, Hollenberg SM, Cooper JA.
  Title
Mammalian Ras interacts directly with the serine/threonine kinase Raf.
  Journal
Cell. 74 (1993) 205-14.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
146702-84-3

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