KEGG   ENZYME: 2.7.12.1Help
Entry
EC 2.7.12.1                 Enzyme                                 
Name
dual-specificity kinase;
ADK1;
Arabidopsis dual specificity kinase 1;
CLK1;
dDYRK2;
Mps1p
Class
Transferases;
Transferring phosphorus-containing groups;
Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
BRITE hierarchy
Sysname
ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)
Reaction(IUBMB)
ATP + a protein = ADP + a phosphoprotein [RN:R00162]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protein [CPD:C00017]
Product
ADP [CPD:C00008];
phosphoprotein [CPD:C00562]
Comment
This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
Orthology
K08287  
dual-specificity kinase
K08823  
CDC-like kinase
K08825  
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase
K08841  
testis-specific kinase 1
K08842  
testis-specific kinase 2
K08866  
serine/threonine-protein kinase TTK/MPS1
Genes
HSA: 
10420(TESK2) 1195(CLK1) 1196(CLK2) 1198(CLK3) 1859(DYRK1A) 57396(CLK4) 7016(TESK1) 7272(TTK) 8444(DYRK3) 8445(DYRK2) 8798(DYRK4) 9149(DYRK1B)
PTR: 
452061(DYRK2) 453742(CLK3) 456030(DYRK1B) 457364(CLK2) 458545(DYRK1A) 459865(CLK1) 462844(TTK) 465074(TESK1) 466926(DYRK4) 469142(DYRK3) 469181(TESK2) 471811(CLK4)
PPS: 
100969041(TTK) 100971488(CLK1) 100976158(DYRK1A) 100976974(CLK3) 100979421(DYRK2) 100985639(TESK1) 100986556(CLK2) 100988041(DYRK4) 100991095(DYRK3) 100992219(CLK4) 100993783(TESK2) 100994597(DYRK1B)
GGO: 
101126485(CLK1) 101127955(CLK3) 101128537(DYRK3) 101131468(TTK) 101132105(CLK2) 101134700(DYRK1B) 101138816(CLK4) 101141524(DYRK1A) 101141820(DYRK4) 101143765(TESK1) 101151392(DYRK2) 101151960(TESK2)
PON: 
100439443(DYRK1B) 100441314(TTK) 100442968 100443679(DYRK2) 100444946(CLK4) 100445721(TESK1) 100456193(CLK3) 100457524(TESK2) 100458378(CLK1) 100459126(DYRK1A) 100460796(DYRK4)
MCC: 
693812(DYRK1A) 695163(DYRK3) 697206(TESK1) 698848(DYRK1B) 700320(CLK1) 702511(CLK3) 702752(CLK4) 705907(TESK2) 710999 717671 717941(DYRK2) 718430
MMU: 
101320(Dyrk4) 102414(Clk3) 12747(Clk1) 12748(Clk2) 12750(Clk4) 13548(Dyrk1a) 13549(Dyrk1b) 21754(Tesk1) 22137(Ttk) 226419(Dyrk3) 230661(Tesk2) 69181(Dyrk2)
RNO: 
170908(Tesk2) 171305(Clk3) 25255(Dyrk1a) 287269(Clk4) 29460(Tesk1) 301434(Clk1) 304775(Dyrk3) 308468(Dyrk1b) 312721(Dyrk4) 314862(Dyrk2) 315852(Ttk) 365842(Clk2)
CFA: 
100688993(TESK1) 474645(CLK4) 477720(DYRK4) 478367(CLK3) 478866(CLK1) 480010(DYRK3) 481152(DYRK2) 481895(TTK) 484506(DYRK1B) 487755(DYRK1A) 490427(CLK2) 608657(TESK2)
AML: 
FCA: 
101083851(CLK3) 101086512(TESK1) 101087897(CLK4) 101088998(CLK2) 101090279(TESK2) 101091077(DYRK3) 101092384(CLK1) 101094686(DYRK2) 101095062(DYRK1B) 101100313(DYRK4) 101100581(DYRK1A) 101101566(TTK)
BTA: 
505149(DYRK3) 505499(CLK3) 507571(DYRK1B) 512737(CLK2) 514916(DYRK2) 524925(TTK) 527643(TESK1) 529633(CLK4) 531276(DYRK4) 532989(DYRK1A) 539979(TESK2) 613808(CLK1)
SSC: 
100141471(CLK1) 100155149(CLK2) 100155632(TESK1) 100155768(CLK3) 100157649(TTK) 100513361(TESK2) 100514684(DYRK1A) 100515779 100521252(CLK4) 100524805 100625631(DYRK1B) 100739107
ECB: 
100051707(DYRK1A) 100052478(TESK2) 100055466 100058051(CLK4) 100058666 100062320(CLK3) 100063546(CLK2) 100067832(CLK1) 100068022(TESK1) 100069586(TTK)
MDO: 
100012195(DYRK1B) 100014844 100016512(CLK1) 100016917 100017157(CLK3) 100019452 100019775(DYRK1A) 100020463(TESK1) 100023737(TTK) 100024763(TESK2) 100028029(CLK4)
SHR: 
100913260(DYRK3) 100915339(TESK2) 100916574 100917213(CLK4) 100918185(TESK1) 100924333(CLK3) 100926299(CLK1) 100927245(DYRK1A) 100928823(TTK) 100930270(CLK2) 100934455(DYRK4)
OAA: 
100073357(CLK4) 100077034(TESK2) 100078677(DYRK1A) 100078999 100080193 100081719(TTK) 100082260 100083283(CLK1) 100088491
GGA: 
100858275 100858576(CLK1) 395233(DYRK1A) 415295(CLK3) 416295(CLK4) 419846(DYRK3) 421849(TTK) 424596(TESK2) 425060(CLK2) 427864(DYRK2) 429878
MGP: 
100540197 100541315 100543346 100545151 100546514(CLK3) 100546641 100548368 100548964(TESK2) 100549572(CLK1)
TGU: 
100219962(CLK2) 100220334(TESK2) 100221086(DYRK3) 100222285(TESK1) 100223984(TTK) 100226613(DYRK2) 100227944(DYRK4) 100229079(CLK4) 100230197(DYRK1A)
ACS: 
100552555 100552654(tesk2) 100555938 100556988 100558324(ttk) 100559770(clk1) 100562279(dyrk1a) 100564086 100565585 100566538(clk4)
XLA: 
100049134(clk1) 100101302(clk3) 379763(clk2) 379954(dyrk1a.2) 398219(ttk) 446302(dyrk1a) 496058(dyrk3) 734822(clk2)
XTR: 
100145447(dyrk1a.2) 100485120 493520(dyrk3) 496828(clk2) 496952(clk3) 549675(clk1) 779733(dyrk1a) 779799(tesk2) 780054(ttk)
DRE: 
100141364 317763(ttk) 321857(clk4a) 327466(dyrk1ab) 503607(clk4b) 556048(tesk1) 556212(dyrk1b) 557602(dyrk2) 558981(clk2a) 564976(dyrk4) 568213(tesk2) 767784(clk2b)
TRU: 
101063291 101065002 101066450 101067913 101070521 101070608 101073214 101073411 101073921 101074711
OLA: 
101155587 101157613 101158994 101159741 101161565 101162379 101167568 101168985 101169628 101170635 101172935
BFO: 
BRAFLDRAFT_126370 BRAFLDRAFT_199312 BRAFLDRAFT_203631 BRAFLDRAFT_211971 BRAFLDRAFT_281921
CIN: 
100176767 100176899 100180070 100182816 100186554
SPU: 
579475 581224(dyrk1a) 591292 591647 592598 594612 757175
DME: 
Dmel_CG40478(Dyrk3) Dmel_CG42320(Doa) Dmel_CG4551(smi35A) Dmel_CG6027(cdi) Dmel_CG7643(ald)
DPO: 
Dpse_GA18250 Dpse_GA20501 Dpse_GA20611 Dpse_GA30162
DAN: 
Dana_GF15600 Dana_GF17019 Dana_GF17020 Dana_GF17824 Dana_GF20860
DER: 
Dere_GG10156 Dere_GG11625 Dere_GG11626 Dere_GG16414 Dere_GG18154 Dere_GG22427
DPE: 
Dper_GL14559 Dper_GL18373 Dper_GL21056 Dper_GL21521 Dper_GL24199
DSE: 
Dsec_GM12746 Dsec_GM12747 Dsec_GM13004 Dsec_GM14885 Dsec_GM15256 Dsec_GM22846
DSI: 
Dsim_GD15658 Dsim_GD19180 Dsim_GD21389 Dsim_GD21392 Dsim_GD21393 Dsim_GD22014 Dsim_GD24405
DWI: 
Dwil_GK10086 Dwil_GK13492 Dwil_GK13652 Dwil_GK15100 Dwil_GK22547
DYA: 
Dyak_GE14483 Dyak_GE15563 Dyak_GE23811 Dyak_GE23813 Dyak_GE23814 Dyak_GE25082 Dyak_GE25491
DGR: 
Dgri_GH10596 Dgri_GH12565 Dgri_GH13234 Dgri_GH18102
DMO: 
Dmoj_GI14115 Dmoj_GI16344 Dmoj_GI17385 Dmoj_GI22371 Dmoj_GI24602
DVI: 
Dvir_GJ15681 Dvir_GJ18062 Dvir_GJ22665 Dvir_GJ24405
AGA: 
AgaP_AGAP000847 AgaP_AGAP002075 AgaP_AGAP002119 AgaP_AGAP008241
AAG: 
AaeL_AAEL001504 AaeL_AAEL001731 AaeL_AAEL003370 AaeL_AAEL003400 AaeL_AAEL007949 AaeL_AAEL008078 AaeL_AAEL011118
CQU: 
CpipJ_CPIJ008998 CpipJ_CPIJ010268 CpipJ_CPIJ013391 CpipJ_CPIJ014802
AME: 
100577120 409111 411812 412917
NVI: 
100120622(NV12442) 100121588(NV13449) 100123054(NV11530) 100124191(NV10468)
TCA: 
659421 659807 661419 662564(ald)
API: 
100161326 100161688 100166978 100167783 100169157
PHU: 
Phum_PHUM284180 Phum_PHUM357590 Phum_PHUM463810 Phum_PHUM574200 Phum_PHUM580220
ISC: 
IscW_ISCW005620 IscW_ISCW018301 IscW_ISCW019686 IscW_ISCW022190
CEL: 
CELE_E02H4.3(tag-172) CELE_F49E11.1(mbk-2) CELE_F52C9.7(F52C9.7) CELE_T04C10.1(mbk-1)
CBR: 
CBG07253(Cbr-tag-172) CBG07597(Cbr-mbk-1) CBG23998(Cbr-mbk-2)
BMY: 
Bm1_30560 Bm1_36970 Bm1_38345 Bm1_52540
TSP: 
Tsp_04349 Tsp_07542 Tsp_09297 Tsp_09747
SMM: 
Smp_134560 Smp_141230 Smp_171610
NVE: 
NEMVE_v1g120202 NEMVE_v1g175874 NEMVE_v1g200667 NEMVE_v1g20898 NEMVE_v1g235840 NEMVE_v1g240002
HMG: 
100200777 100204319 100207538 100211421 100213931
TAD: 
TRIADDRAFT_18415 TRIADDRAFT_2504 TRIADDRAFT_25361 TRIADDRAFT_33914 TRIADDRAFT_64191
AQU: 
100634809 100636198 100639014 100639250 100642056
ATH: 
AT1G77720(PPK1) AT4G24740(FC2)
ALY: 
ARALYDRAFT_476935 ARALYDRAFT_493647 ARALYDRAFT_914113(AFC2)
GMX: 
100780144 100788990 100792777 100804452 100816674
MTR: 
MTR_3g072990 MTR_3g076540 MTR_5g059280
CSV: 
101208356 101210441 101214794 101228333
RCU: 
RCOM_1032370 RCOM_1508280 RCOM_1517440
POP: 
POPTR_242255 POPTR_760879 POPTR_792448 POPTR_798716 POPTR_824707
VVI: 
100240775 100262634 100263937
OSA: 
4327372 4333851 4352182
DOSA: 
Os03t0704400-01(Os03g0704400) Os12t0460800-03(Os12g0460800)
BDI: 
100831083 100831362
SBI: 
SORBI_01g010730(SORBIDRAFT_01g010730) SORBI_06g027605(SORBIDRAFT_06g027605)
ZMA: 
100382570 100501620
SMO: 
SELMODRAFT_111790 SELMODRAFT_410118 SELMODRAFT_70574 SELMODRAFT_86665
PPP: 
PHYPADRAFT_142488 PHYPADRAFT_147019 PHYPADRAFT_150031 PHYPADRAFT_153778 PHYPADRAFT_22621
CRE: 
CHLREDRAFT_130269(DYRK1) CHLREDRAFT_145963
VCN: 
VOLCADRAFT_121018 VOLCADRAFT_30949 VOLCADRAFT_61790
OLU: 
OSTLU_2597 OSTLU_50484
OTA: 
Ot05g02300 Ot10g03620 Ot18g01860
CME: 
CMB064C CMB108C CMR245C
SCE: 
YDL028C(MPS1) YLL019C(KNS1)
AGO: 
AGOS_ADL043C AGOS_ADR317C
ERC: 
Ecym_5236
KLA: 
KLLA0A05819g KLLA0C03828g KLLA0F22297g
LTH: 
KLTH0E07128g KLTH0F05522g KLTH0F06468g
PPA: 
PAS_chr1-1_0051 PAS_chr2-2_0103 PAS_chr3_0459 PAS_chr3_0873
VPO: 
Kpol_1027p1 Kpol_1032p10 Kpol_1060p53
ZRO: 
ZYRO0B00638g ZYRO0B04906g ZYRO0D02970g
CGR: 
CAGL0D06600g CAGL0K01617g
NCS: 
NCAS_0I02080(NCAS0I02080) NCAS_0I02680(NCAS0I02680)
NDI: 
NDAI_0A06620(NDAI0A06620) NDAI_0G06240(NDAI0G06240)
TPF: 
TPHA_0A04570(TPHA0A04570) TPHA_0M00300(TPHA0M00300)
TBL: 
TBLA_0B06510(TBLA0B06510) TBLA_0F00860(TBLA0F00860)
TDL: 
TDEL_0D04600(TDEL0D04600) TDEL_0H00890(TDEL0H00890)
KAF: 
KAFR_0F01940(KAFR0F01940) KAFR_0F02220(KAFR0F02220)
DHA: 
DEHA2B06336g DEHA2B08690g DEHA2C14080g
PIC: 
PICST_34686(KNS1) PICST_47887(MPS1) PICST_81803(YAK1)
PGU: 
PGUG_00780 PGUG_01459 PGUG_02154 PGUG_03603
LEL: 
LELG_00684 LELG_01952 LELG_03420 LELG_05346
CAL: 
CaO19.12446(KNS1) CaO19.12718 CaO19.4979(KNS1) CaO19.5253 CaO19.7293(MPS1)
CTP: 
CTRG_01613 CTRG_03439 CTRG_03622 CTRG_05954
CDU: 
CD36_11350 CD36_12480 CD36_19240 CD36_34440
COT: 
CORT_0A06850 CORT_0B05220 CORT_0D01330
YLI: 
YALI0C04587g YALI0C16665g YALI0D04114g YALI0F07557g
CLU: 
CLUG_00077 CLUG_00089 CLUG_00713 CLUG_02605
NCR: 
NCU00230 NCU00978 NCU06638
SMP: 
SMAC_00255 SMAC_02146 SMAC_05293 SMAC_06567
PAN: 
PODANSg4139 PODANSg4777 PODANSg5502 PODANSg7848
TTT: 
THITE_2106343 THITE_2112311 THITE_2151577
MTM: 
MYCTH_2296876 MYCTH_2300221 MYCTH_2303514
MGR: 
MGG_00760 MGG_06399 MGG_10826
FGR: 
FG01137.1 FG05418.1 FG06637.1 FG10095.1
NHE: 
NECHADRAFT_31352 NECHADRAFT_41140 NECHADRAFT_60475 NECHADRAFT_95623
VAL: 
VDBG_00285 VDBG_06126 VDBG_07006
SSL: 
SS1G_00098 SS1G_00874 SS1G_01433 SS1G_12527
BFU: 
BC1G_03734 BC1G_06208 BC1G_07955 BC1G_09015
ANI: 
AN0988.2 AN2927.2 AN7104.2 AN7678.2
NFI: 
NFIA_008580 NFIA_029550 NFIA_033810 NFIA_069040
AFM: 
AFUA_1G16780 AFUA_2G01520 AFUA_3G08100 AFUA_4G03850
AOR: 
AOR_1_1746114(AO090701000798) AOR_1_1760174(AO090005001004) AOR_1_2550174(AO090005001468) AOR_1_580054(AO090011000341)
ANG: 
ANI_1_178124(An14g01050) ANI_1_2966014(An01g10170) ANI_1_3070024(An02g11590) ANI_1_614034(An03g04960)
AFV: 
AFLA_041740 AFLA_062530 AFLA_082570 AFLA_087000
ACT: 
ACLA_018700 ACLA_036060 ACLA_054590 ACLA_093410
PCS: 
Pc13g07030 Pc20g05590 Pc20g06510 Pc21g23400
CIM: 
CIMG_00136 CIMG_03007 CIMG_07588 CIMG_07885
CPW: 
CPC735_000210 CPC735_041360 CPC735_043470 CPC735_060020
PBL: 
PAAG_00695 PAAG_05865 PAAG_06490
URE: 
UREG_00241 UREG_02203 UREG_02935 UREG_07696
ABE: 
ARB_00528 ARB_02215 ARB_05125 ARB_05747
TVE: 
TRV_00396 TRV_00465 TRV_04494 TRV_07844
AJE: 
HCAG_01158 HCAG_01159 HCAG_04266 HCAG_08703
PNO: 
SNOG_02021 SNOG_02138 SNOG_04481 SNOG_10576
PTE: 
PTT_07648 PTT_12765 PTT_13464 PTT_18334
ZTR: 
MYCGRDRAFT_29871(POM1) MYCGRDRAFT_67924(YAK1)
TML: 
GSTUM_00004439001 GSTUM_00005395001 GSTUM_00009635001 GSTUM_00010377001
SPO: 
SPAC1D4.11c(lkh1) SPAC2F7.03c(pom1) SPBC106.01(mph1)
CNE: 
CNA06620 CNF03190 CNI01240 CNI03350
CNB: 
CNBA6430 CNBF1610 CNBH1180 CNBH3210
CGI: 
CGB_F2290W CGB_H1770W CGB_H4650C
LBC: 
LACBIDRAFT_143523 LACBIDRAFT_143963 LACBIDRAFT_230208 LACBIDRAFT_247281
MPR: 
MPER_01921 MPER_03145 MPER_07015
CCI: 
CC1G_03033 CC1G_06417 CC1G_13957 CC1G_14245
SCM: 
SCHCODRAFT_55905 SCHCODRAFT_58492 SCHCODRAFT_66650 SCHCODRAFT_74346
UMA: 
UM04543.1
MGL: 
MGL_0026 MGL_1598 MGL_2847 MGL_3470
PGR: 
PGTG_03918 PGTG_10743
ECU: 
ECU02_0510
EIN: 
Eint_020440 Eint_110050
EHE: 
EHEL_020430 EHEL_110060
NCE: 
NCER_102027
MBR: 
MONBRDRAFT_14418 MONBRDRAFT_25473 MONBRDRAFT_32541
NGR: 
NAEGRDRAFT_31364 NAEGRDRAFT_69434 NAEGRDRAFT_81801 NAEGRDRAFT_82249
DDI: 
DDB_G0277485(dyrk1) DDB_G0280995(mps1) DDB_G0281179(clkA) DDB_G0293750(dyrk2)
DPP: 
DICPUDRAFT_154263 DICPUDRAFT_40649 DICPUDRAFT_91968 DICPUDRAFT_97778
EHI: 
EHI_141870(48.t00021) EHI_158590(277.t00007)
EDI: 
EDI_036660 EDI_270260
PFA: 
PF14_0431(LAMMER)
PYO: 
PY06874
PKN: 
PKH_126090
TAN: 
TA19110
TPV: 
TP01_0149
BBO: 
BBOV_IV001230(21.m02985)
CHO: 
Chro.50371
TGO: 
TGME49_024480 TGME49_083480
TET: 
TTHERM_00348940
PTM: 
GSPATT00002247001 GSPATT00006707001 GSPATT00007193001 GSPATT00016487001 GSPATT00023947001 GSPATT00035109001
LMA: 
LMJF_09_0400 LMJF_15_0180
LBZ: 
LBRM_15_0170
GLA: 
GL50803_17417 GL50803_4405 GL50803_92741
TVA: 
TVAG_003360 TVAG_267290 TVAG_335520
PTI: 
PHATRDRAFT_12339 PHATRDRAFT_14003 PHATRDRAFT_14553
TPS: 
THAPSDRAFT_264854 THAPSDRAFT_33772 THAPSDRAFT_38736
PIF: 
PITG_00178 PITG_14626 PITG_17333
 » show all
Taxonomy
Reference
1  [PMID:7527390]
  Authors
Ali N, Halfter U, Chua NH.
  Title
Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine.
  Journal
J. Biol. Chem. 269 (1994) 31626-9.
  Organism
Arabidopsis thaliana [GN:ath]
Reference
2  [PMID:7737118]
  Authors
Lauze E, Stoelcker B, Luca FC, Weiss E, Schutz AR, Winey M.
  Title
Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase.
  Journal
EMBO. J. 14 (1995) 1655-63.
  Organism
Saccharomyces cerevisiae [GN:sce]
Reference
3  [PMID:10954422]
  Authors
Menegay HJ, Myers MP, Moeslein FM, Landreth GE.
  Title
Biochemical characterization and localization of the dual specificity kinase CLK1.
  Journal
J. Cell. Sci. 113 ( Pt 18) (2000) 3241-53.
  Organism
Homo sapiens [GN:hsa], Mus musculus [GN:mmu], Arabidopsis thaliana [GN:ath], Drosophila melanogaster [GN:dme]
Reference
4  [PMID:12786602]
  Authors
Lochhead PA, Sibbet G, Kinstrie R, Cleghon T, Rylatt M, Morrison DK, Cleghon V.
  Title
dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila.
  Journal
Biochem. J. 374 (2003) 381-91.
  Organism
Homo sapiens [GN:hsa], Drosophila melanogaster [GN:dme]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
DBGET integrated database retrieval system